KEGG   PATHWAY: csci00260
Entry
csci00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Clostridium scindens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
csci00260  Glycine, serine and threonine metabolism
csci00260

Module
csci_M00621  Glycine cleavage system [PATH:csci00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Clostridium scindens [GN:csci]
Gene
HDCHBGLK_00025  lysC_1; Aspartokinase [KO:K00928] [EC:2.7.2.4]
HDCHBGLK_00026  [KO:K15635] [EC:5.4.2.12]
HDCHBGLK_00027  hom_1; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HDCHBGLK_00149  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
HDCHBGLK_00173  [KO:K17103] [EC:2.7.8.8]
HDCHBGLK_00189  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
HDCHBGLK_00190  tdh_1; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
HDCHBGLK_00455  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HDCHBGLK_00625  sdhA; L-serine dehydratase, alpha chain [KO:K01752] [EC:4.3.1.17]
HDCHBGLK_00626  sdhB; L-serine dehydratase, beta chain [KO:K01752] [EC:4.3.1.17]
HDCHBGLK_00750  yoaD_1; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HDCHBGLK_00752  yoaD_2; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HDCHBGLK_01777  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
HDCHBGLK_02184  pdhD_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HDCHBGLK_02238  yoaD_3; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HDCHBGLK_02457  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
HDCHBGLK_02850  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
HDCHBGLK_02851  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HDCHBGLK_02920  tdcB; L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
HDCHBGLK_03060  yclM; Aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
HDCHBGLK_03157  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HDCHBGLK_03225  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HDCHBGLK_03303  pdhD_2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HDCHBGLK_03304  gcvPB; putative glycine dehydrogenase (decarboxylating) subunit 2 [KO:K00283] [EC:1.4.4.2]
HDCHBGLK_03305  gcvPA; putative glycine dehydrogenase (decarboxylating) subunit 1 [KO:K00282] [EC:1.4.4.2]
HDCHBGLK_03306  gcvH; Glycine cleavage system H protein [KO:K02437]
HDCHBGLK_03307  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
HDCHBGLK_03404  hom_2; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HDCHBGLK_03534  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HDCHBGLK_03727  lysC_2; Aspartokinase [KO:K00928] [EC:2.7.2.4]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
csci00010  Glycolysis / Gluconeogenesis
csci00020  Citrate cycle (TCA cycle)
csci00230  Purine metabolism
csci00250  Alanine, aspartate and glutamate metabolism
csci00270  Cysteine and methionine metabolism
csci00290  Valine, leucine and isoleucine biosynthesis
csci00300  Lysine biosynthesis
csci00330  Arginine and proline metabolism
csci00460  Cyanoamino acid metabolism
csci00470  D-Amino acid metabolism
csci00564  Glycerophospholipid metabolism
csci00620  Pyruvate metabolism
csci00630  Glyoxylate and dicarboxylate metabolism
csci00640  Propanoate metabolism
csci00680  Methane metabolism
csci00860  Porphyrin metabolism
csci00920  Sulfur metabolism
KO pathway
ko00260   

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