Entry Name ABC transporters - Crotalus tigris (Tiger rattlesnake)
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Crotalus tigris (Tiger rattlesnake) [GN:
ctig ]
Gene 120303143 ABCB5; ATP-binding cassette sub-family B member 5 isoform X1 [KO:K05660 ]
120303386 ABCB10; ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
120305590 ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673 ]
120306468 ABCA4; retinal-specific phospholipid-transporting ATPase ABCA4 isoform X1 [KO:K05644 ]
120307727 ABCC10; multidrug resistance-associated protein 7 isoform X1 [KO:K05674 ]
120308162 ABCC3; canalicular multispecific organic anion transporter 2 isoform X1 [KO:K05667 ]
120308497 ABCC8; ATP-binding cassette sub-family C member 8 isoform X1 [KO:K05032 ]
120308643 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
120309701 ABCC5; multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
120309797 ABCC9; ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
120311282 ABCG4; ATP-binding cassette sub-family G member 4 isoform X1 [KO:K05680 ]
120311453 ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641 ]
120314215 ABCC2; canalicular multispecific organic anion transporter 1 isoform X1 [KO:K05666 ]
120316697 ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656 ]
120318092 ABCB7; ATP-binding cassette sub-family B member 7, mitochondrial isoform X1 [KO:K05662 ]
120318325 ABCB6; ATP-binding cassette sub-family B member 6, mitochondrial [KO:K05661 ]
120319816 ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679 ]
120320273 ABCB8; mitochondrial potassium channel ATP-binding subunit [KO:K05655 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
