Entry Name Homologous recombination - Drosophila melanogaster (fruit fly)
Description Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class Genetic Information Processing; Replication and repairBRITE hierarchy
Pathway map Other DBs Organism Drosophila melanogaster (fruit fly) [GN:
dme ]
Gene Reference Authors Maloisel L, Fabre F, Gangloff S.
Title DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal Reference Authors Haruta-Takahashi N, Iwasaki H.
Title [Recombination mediators]
Journal Seikagaku 79:449-53 (2007)
Reference Authors Ouyang KJ, Woo LL, Ellis NA.
Title Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal Reference Authors Kawabata M, Kawabata T, Nishibori M.
Title Role of recA/RAD51 family proteins in mammals.
Journal Reference Authors Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title Mitotic recombination in Saccharomyces cerevisiae.
Journal Reference Authors Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title Rad54: the Swiss Army knife of homologous recombination?
Journal Reference Authors Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title Recombination proteins and rescue of arrested replication forks.
Journal Reference Authors Ayora S, Carrasco B, Cardenas PP, Cesar CE, Canas C, Yadav T, Marchisone C, Alonso JC
Title Double-strand break repair in bacteria: a view from Bacillus subtilis.
Journal Reference Authors Savage KI, Harkin DP
Title BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
Journal Reference Authors Schwertman P, Bekker-Jensen S, Mailand N
Title Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.
Journal Reference Authors Zhao W, Wiese C, Kwon Y, Hromas R, Sung P
Title The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.
Journal Reference Authors Mota MBS, Carvalho MA, Monteiro ANA, Mesquita RD
Title DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.
Journal Reference Authors Huselid E, Bunting SF
Title The Regulation of Homologous Recombination by Helicases.
Journal Reference Authors Kelliher J, Ghosal G, Leung JWC
Title New answers to the old RIDDLE: RNF168 and the DNA damage response pathway.
Journal Reference Authors Raimundo L, Calheiros J, Saraiva L
Title Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target.
Journal Reference Authors Bianco PR
Title The Role of the RecFOR Complex in Genome Stability.
Journal Reference Authors Greenhough LA, Galanti L, Liang CC, Boulton SJ, West SC
Title Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.
Journal Related KO pathway
