KEGG   PATHWAY: dnm03013
Entry
dnm03013                    Pathway                                
Name
Nucleocytoplasmic transport - Dasypus novemcinctus (nine-banded armadillo)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
dnm03013  Nucleocytoplasmic transport
dnm03013

Other DBs
GO: 0050658
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101411226  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
101411609  [KO:K14299]
101411614  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
101411952  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
101412185  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
101412794  NUP188; nucleoporin NUP188 homolog [KO:K14311]
101412849  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
101412895  [KO:K12160]
101413618  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
101413924  NUP160; LOW QUALITY PROTEIN: nuclear pore complex protein Nup160 [KO:K14303]
101414692  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
101415090  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
101415102  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
101415676  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
101415750  IPO11; importin-11 [KO:K25201]
101417042  IPO9; importin-9 isoform X1 [KO:K20224]
101417095  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101417145  XPO6; exportin-6 isoform X2 [KO:K25204]
101417932  AAAS; aladin [KO:K14320]
101418387  [KO:K18727]
101418984  [KO:K14284]
101419456  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
101419610  XPO5; exportin-5 [KO:K14289]
101419668  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
101419771  KPNB1; LOW QUALITY PROTEIN: importin subunit beta-1 [KO:K14293]
101420261  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
101420672  NUP107; LOW QUALITY PROTEIN: nuclear pore complex protein Nup107 [KO:K14301]
101420701  [KO:K14313]
101421080  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
101421761  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
101421923  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
101422486  RAE1; mRNA export factor [KO:K14298]
101422842  [KO:K18655] [EC:5.6.2.7]
101423328  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
101423536  IPO7; importin-7 [KO:K20223]
101424403  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
101424724  KPNA6; importin subunit alpha-7 [KO:K15042]
101424894  [KO:K18655] [EC:5.6.2.7]
101425357  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
101426286  TNPO1; transportin-1 [KO:K18752]
101426328  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
101426927  MAGOH; protein mago nashi homolog [KO:K12877]
101427547  RANBP17; ran-binding protein 17 [KO:K24115]
101427577  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
101428348  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
101428369  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
101428514  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
101429037  [KO:K12172] [EC:2.3.2.-]
101429330  CSE1L; exportin-2 [KO:K18423]
101429386  XPOT; exportin-T [KO:K14288]
101429674  THOC3; THO complex subunit 3 [KO:K12880]
101429833  THOC7; THO complex subunit 7 homolog [KO:K13176]
101430233  NXT1; NTF2-related export protein 1 [KO:K14285]
101430314  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
101430526  POM121L2; POM121-like protein 2 [KO:K14316]
101430534  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101431149  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
101431765  SEC13; protein SEC13 homolog [KO:K14004]
101431984  TNPO3; transportin-3 [KO:K15436]
101432228  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
101432451  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
101432780  NUP43; nucleoporin Nup43 [KO:K14305]
101433533  SEH1L; nucleoporin SEH1 isoform X2 [KO:K14299]
101433665  TPR; LOW QUALITY PROTEIN: nucleoprotein TPR [KO:K09291]
101434070  IPO13; importin-13 [KO:K25202]
101434080  [KO:K14284]
101434089  THOC2; THO complex subunit 2 [KO:K12879]
101434153  AHCTF1; protein ELYS [KO:K25129]
101434176  NUPL2; nucleoporin-like protein 2 [KO:K14321]
101434877  [KO:K14285]
101435032  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
101435173  RAN; GTP-binding nuclear protein Ran [KO:K07936]
101435398  PNN; pinin [KO:K13114]
101435457  [KO:K12160]
101436897  TMEM33; transmembrane protein 33 [KO:K20724]
101436935  [KO:K14316]
101437093  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
101437203  THOC1; THO complex subunit 1 [KO:K12878]
101437609  NDC1; nucleoporin NDC1 [KO:K14315]
101437617  NXF1; nuclear RNA export factor 1 [KO:K14284]
101437834  [KO:K15043]
101438805  XPO1; exportin-1 [KO:K14290]
101438850  GLE1; nucleoporin GLE1 [KO:K18723]
101439439  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
101439705  KPNA7; importin subunit alpha-8 [KO:K15043]
101439777  [KO:K12877]
101440198  CASC3; protein CASC3 isoform X1 [KO:K14323]
101440862  XPO7; exportin-7 isoform X1 [KO:K18460]
101441617  IPO4; importin-4 isoform X1 [KO:K20221]
101441805  ALYREF; THO complex subunit 4 [KO:K12881]
101441967  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
101442026  [KO:K12160]
101442183  IPO8; LOW QUALITY PROTEIN: importin-8 [KO:K18755]
101442215  IPO5; importin-5 [KO:K20222]
101442587  SNUPN; snurportin-1 isoform X1 [KO:K13151]
101442874  KPNA5; importin subunit alpha-6 [KO:K15042]
101442948  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
101443085  KPNA4; importin subunit alpha-3 [KO:K23583]
101443608  [KO:K15043]
101444045  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
101444310  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
101444508  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
101444797  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
101444935  KPNA1; importin subunit alpha-5 [KO:K23940]
101445310  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
101445391  [KO:K14291]
101446038  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101446890  XPO4; exportin-4 isoform X1 [KO:K25203]
101447101  THOC6; LOW QUALITY PROTEIN: THO complex subunit 6 homolog [KO:K13175]
101447647  KPNA3; importin subunit alpha-4 [KO:K23583]
101447883  RBM8A; RNA-binding protein 8A [KO:K12876]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
dnm03015  mRNA surveillance pathway
KO pathway
ko03013   

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