KEGG   PATHWAY: dnm03015
Entry
dnm03015                    Pathway                                
Name
mRNA surveillance pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
dnm03015  mRNA surveillance pathway
dnm03015

Other DBs
GO: 0071028
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410694  [KO:K03456]
101411009  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101411046  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
101411226  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
101411315  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
101411471  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
101411952  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
101412130  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
101412849  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
101412934  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
101413382  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101413618  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
101413743  PELO; protein pelota homolog [KO:K06965]
101415090  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
101416154  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X2 [KO:K14398]
101416200  [KO:K14407]
101416613  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
101416653  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
101416864  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
101417095  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101417117  [KO:K14962]
101417983  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
101418794  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
101418984  [KO:K14284]
101419136  CSTF1; cleavage stimulation factor subunit 1 isoform X2 [KO:K14406]
101420251  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101420952  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101421761  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
101421779  [KO:K13126]
101421946  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
101422407  WDR33; pre-mRNA 3' end processing protein WDR33 [KO:K15542]
101422842  [KO:K18655] [EC:5.6.2.7]
101423528  SMG7; LOW QUALITY PROTEIN: protein SMG7 [KO:K14409]
101424579  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101424894  [KO:K18655] [EC:5.6.2.7]
101425540  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
101425904  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101426833  CPSF3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
101426927  MAGOH; protein mago nashi homolog [KO:K12877]
101427560  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X2 [KO:K14400]
101427743  [KO:K03267]
101428348  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
101428514  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
101429612  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X2 [KO:K14405]
101430233  NXT1; NTF2-related export protein 1 [KO:K14285]
101430534  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101430585  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101431581  MSI2; RNA-binding protein Musashi homolog 2 isoform X2 [KO:K14411]
101431840  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
101432451  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
101433564  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101434080  [KO:K14284]
101434268  [KO:K11584]
101434877  [KO:K14285]
101434933  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
101435270  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
101435398  PNN; pinin [KO:K13114]
101435926  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
101436060  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
101437079  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
101437422  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101437617  NXF1; nuclear RNA export factor 1 [KO:K14284]
101438302  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
101438696  [KO:K11583]
101438850  GLE1; nucleoporin GLE1 [KO:K18723]
101439531  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
101439707  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
101439777  [KO:K12877]
101439892  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
101440198  CASC3; protein CASC3 isoform X1 [KO:K14323]
101440357  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101440765  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101441254  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101441270  CPSF1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
101441773  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
101441805  ALYREF; THO complex subunit 4 [KO:K12881]
101442726  RNGTT; LOW QUALITY PROTEIN: mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
101443397  SMG5; protein SMG5 [KO:K11125]
101444108  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101444310  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
101444508  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
101444762  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101444857  PABPN1; polyadenylate-binding protein 2 [KO:K14396]
101445037  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
101445092  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
101445856  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
101446038  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101446408  SYMPK; symplekin [KO:K06100]
101446439  PABPC4; polyadenylate-binding protein 4 isoform X3 [KO:K13126]
101447728  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
101447865  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
101447883  RBM8A; RNA-binding protein 8A [KO:K12876]
105745704  PAPOLB; LOW QUALITY PROTEIN: poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
dnm03013  Nucleocytoplasmic transport
dnm03018  RNA degradation
dnm03040  Spliceosome
KO pathway
ko03015   

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