KEGG   PATHWAY: dya03008
Entry
dya03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Drosophila yakuba
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
dya03008  Ribosome biogenesis in eukaryotes
dya03008

Organism
Drosophila yakuba [GN:dya]
Gene
Dyak_GE10905  [KO:K14559]
Dyak_GE11170  [KO:K14284]
Dyak_GE11426  [KO:K14573]
Dyak_GE11447  [KO:K03115]
Dyak_GE11531  Dyak_Nxt1; Nxt1 [KO:K14285]
Dyak_GE11610  Dyak_Fib; Fib [KO:K14563] [EC:2.1.1.-]
Dyak_GE11676  [KO:K14560]
Dyak_GE11866  [KO:K14560]
Dyak_GE12088  [KO:K14575]
Dyak_GE12102  [KO:K03115]
Dyak_GE12842  [KO:K14558]
Dyak_GE13004  [KO:K14552]
Dyak_GE13075  [KO:K11130]
Dyak_GE13438  [KO:K18532] [EC:2.7.4.3]
Dyak_GE13493  [KO:K14572]
Dyak_GE13743  [KO:K11128]
Dyak_GE13986  [KO:K14537]
Dyak_GE14067  [KO:K14553]
Dyak_GE14165  [KO:K14550]
Dyak_GE14198  [KO:K12619] [EC:3.1.13.-]
Dyak_GE14387  [KO:K11131] [EC:5.4.99.-]
Dyak_GE15102  [KO:K07936]
Dyak_GE15368  [KO:K14284]
Dyak_GE15667  [KO:K03115]
Dyak_GE16254  [KO:K14549]
Dyak_GE16338  [KO:K03539] [EC:3.1.26.5]
Dyak_GE16352  [KO:K14568] [EC:2.1.1.260]
Dyak_GE16413  [KO:K01164] [EC:3.1.26.5]
Dyak_GE16528  [KO:K14539] [EC:3.6.1.-]
Dyak_GE16711  [KO:K14570] [EC:3.1.-.-]
Dyak_GE16971  [KO:K07562]
Dyak_GE17106  [KO:K11108]
Dyak_GE17316  Dyak_ran; ran [KO:K07936]
Dyak_GE17387  [KO:K12618] [EC:3.1.13.-]
Dyak_GE17419  [KO:K14557]
Dyak_GE17433  [KO:K14521] [EC:2.3.1.-]
Dyak_GE17829  [KO:K11883]
Dyak_GE18393  [KO:K14565]
Dyak_GE18770  Dyak_emb; emb [KO:K14290]
Dyak_GE18862  [KO:K12845]
Dyak_GE18875  [KO:K14566]
Dyak_GE18957  [KO:K14545]
Dyak_GE19070  [KO:K14525] [EC:3.1.26.5]
Dyak_GE19158  [KO:K03685] [EC:3.1.26.3]
Dyak_GE19236  [KO:K14546]
Dyak_GE19308  [KO:K14555]
Dyak_GE19832  [KO:K14567]
Dyak_GE19857  [KO:K14536] [EC:3.6.5.-]
Dyak_GE19894  [KO:K14569]
Dyak_GE20000  Dyak_NHP2; NHP2 [KO:K11129]
Dyak_GE20191  [KO:K07178] [EC:2.7.11.1]
Dyak_GE20379  [KO:K03538] [EC:3.1.26.5]
Dyak_GE21570  [KO:K14570] [EC:3.1.-.-]
Dyak_GE21574  [KO:K14574]
Dyak_GE21612  [KO:K14571]
Dyak_GE22171  [KO:K03537] [EC:3.1.26.5]
Dyak_GE22256  [KO:K14567]
Dyak_GE22324  [KO:K06943]
Dyak_GE22581  [KO:K14548]
Dyak_GE22657  Dyak_CkIIalpha; casein kinase II alpha subunit, isoform C [KO:K03097] [EC:2.7.11.1]
Dyak_GE23555  [KO:K14561]
Dyak_GE23582  [KO:K07179] [EC:2.7.11.1]
Dyak_GE23757  [KO:K14570] [EC:3.1.-.-]
Dyak_GE23924  [KO:K13288] [EC:3.1.-.-]
Dyak_GE24041  [KO:K14564]
Dyak_GE24446  [KO:K14554]
Dyak_GE24480  [KO:K14563] [EC:2.1.1.-]
Dyak_GE24923  [KO:K14284]
Dyak_GE25531  [KO:K14556]
Dyak_GE26110  [KO:K14538]
Dyak_GE26326  [KO:K14544]
Dyak_GE26467  Dyak_5SrRNA:GE26467; 5S ribosomal RNA [KO:K01981]
Dyak_GE26468  Dyak_5SrRNA:GE26468; 5S ribosomal RNA [KO:K01981]
Dyak_GE26469  Dyak_5SrRNA:GE26469; 5S ribosomal RNA [KO:K01981]
Dyak_GE26470  Dyak_5SrRNA:GE26470; 5S ribosomal RNA [KO:K01981]
Dyak_GE26471  Dyak_5SrRNA:GE26471; 5S ribosomal RNA [KO:K01981]
Dyak_GE26472  Dyak_5SrRNA:GE26472; 5S ribosomal RNA [KO:K01981]
Dyak_GE26473  Dyak_5SrRNA:GE26473; 5S ribosomal RNA [KO:K01981]
Dyak_GE26474  Dyak_5SrRNA:GE26474; 5S ribosomal RNA [KO:K01981]
Dyak_GE26475  Dyak_5SrRNA:GE26475; 5S ribosomal RNA [KO:K01981]
Dyak_GE26476  Dyak_5SrRNA:GE26476; 5S ribosomal RNA [KO:K01981]
Dyak_GE26477  Dyak_5SrRNA:GE26477; 5S ribosomal RNA [KO:K01981]
Dyak_GE26478  Dyak_5SrRNA:GE26478; 5S ribosomal RNA [KO:K01981]
Dyak_GE26479  Dyak_5SrRNA:GE26479; 5S ribosomal RNA [KO:K01981]
Dyak_GE26480  Dyak_5SrRNA:GE26480; 5S ribosomal RNA [KO:K01981]
Dyak_GE26481  Dyak_5SrRNA:GE26481; 5S ribosomal RNA [KO:K01981]
Dyak_GE26482  Dyak_5SrRNA:GE26482; 5S ribosomal RNA [KO:K01981]
Dyak_GE26483  Dyak_5SrRNA:GE26483; 5S ribosomal RNA [KO:K01981]
Dyak_GE26487  Dyak_5.8SrRNA:GE26487; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26488  Dyak_5.8SrRNA:GE26488; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26489  Dyak_5.8SrRNA:GE26489; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26490  Dyak_5.8SrRNA:GE26490; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26491  Dyak_5.8SrRNA:GE26491; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26492  Dyak_5.8SrRNA:GE26492; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26493  Dyak_5.8SrRNA:GE26493; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26494  Dyak_5.8SrRNA:GE26494; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26495  Dyak_5SrRNA:GE26495; 5S ribosomal RNA [KO:K01981]
Dyak_GE26497  Dyak_5.8SrRNA:GE26497; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26498  Dyak_5.8SrRNA:GE26498; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26499  Dyak_5.8SrRNA:GE26499; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26500  Dyak_5.8SrRNA:GE26500; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26501  Dyak_5.8SrRNA:GE26501; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26502  Dyak_5.8SrRNA:GE26502; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26503  Dyak_5.8SrRNA:GE26503; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26504  Dyak_5.8SrRNA:GE26504; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26505  Dyak_5SrRNA:GE26505; 5S ribosomal RNA [KO:K01981]
Dyak_GE26506  Dyak_5SrRNA:GE26506; 5S ribosomal RNA [KO:K01981]
Dyak_GE26507  Dyak_5SrRNA:GE26507; 5S ribosomal RNA [KO:K01981]
Dyak_GE26508  Dyak_5.8SrRNA:GE26508; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26509  Dyak_5.8SrRNA:GE26509; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26510  Dyak_5.8SrRNA:GE26510; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26511  Dyak_5.8SrRNA:GE26511; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26513  Dyak_5.8SrRNA:GE26513; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26514  Dyak_5.8SrRNA:GE26514; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26516  Dyak_5.8SrRNA:GE26516; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26517  Dyak_5.8SrRNA:GE26517; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26518  Dyak_5.8SrRNA:GE26518; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26519  Dyak_5SrRNA:GE26519; 5S ribosomal RNA [KO:K01981]
Dyak_GE26520  Dyak_5SrRNA:GE26520; 5S ribosomal RNA [KO:K01981]
Dyak_GE26521  Dyak_5.8SrRNA:GE26521; 5.8S ribosomal RNA [KO:K01986]
Dyak_GE26522  Dyak_5SrRNA:GE26522; 5S ribosomal RNA [KO:K01981]
Dyak_GE26523  Dyak_5SrRNA:GE26523; 5S ribosomal RNA [KO:K01981]
Dyak_GE26524  Dyak_5SrRNA:GE26524; 5S ribosomal RNA [KO:K01981]
Dyak_GE27082  Dyak_snoRNA:GE27082; snoRNA:GE27082 [KO:K14483]
Dyak_GE27083  Dyak_snoRNA:GE27083; snoRNA:GE27083 [KO:K14483]
Dyak_GE27279  Dyak_18SrRNA:GE27279; 18S ribosomal RNA [KO:K01979]
Dyak_GE27280  Dyak_28SrRNA:GE27280; 28S ribosomal RNA [KO:K01982]
Dyak_GE27362  [KO:K03264]
Dyak_GE28487  [KO:K14527] [EC:3.1.26.5]
Dyak_GE28616  [KO:K14284]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
dya03010  Ribosome
KO pathway
ko03008   

DBGET integrated database retrieval system