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Entry
Name
ABC transporters - Escherichia coli SMS-3-5 (environmental)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Other DBs
Organism
Escherichia coli SMS-3-5 (environmental) [GN:
ecm ]
Gene
EcSMS35_0071 thiP; thiamine/thiamine pyrophosphate ABC transporter, permease protein [KO:K02063 ]
EcSMS35_0072 thiB; thiamin/thiamin pyrophosphate ABC transporter, periplasmic thiamin/thiamin pyrophospate-binding protein [KO:K02064 ]
EcSMS35_0170 btuF; cobalamin ABC transporter, periplasmic cobalamin-binding protein [KO:K06858 ]
EcSMS35_0209 metQ; D-methionine ABC transporter, periplasmic D-methionine-binding lipoprotein [KO:K02073 ]
EcSMS35_0394 tauA; taurine ABC transporter, periplasmic taurine-binding protein [KO:K15551 ]
EcSMS35_0607 fepC; ferric enterobactin ABC transporter, ATP-binding protein FepC [KO:K23188 ]
EcSMS35_0612 fepB; ferrienterobactin ABC transporter, ferrienterobactin-binding periplasmic protein FepB [KO:K23185 ]
EcSMS35_0676 gltI; glutamate/aspartate ABC transporter, periplasmic glutamate/aspartate-binding protein [KO:K10001 ]
EcSMS35_0786 modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
EcSMS35_0835 glnH; glutamine ABC transporter, glutamine-binding periplasmic protein [KO:K10036 ]
EcSMS35_0855 gsiB; glutathione ABC transporter, periplasmic glutathione-binding protein GsiB [KO:K13889 ]
EcSMS35_0882 potF; putrescine ABC transporter, periplasmic putrescine-binding protein [KO:K11073 ]
EcSMS35_0888 artJ; arginine ABC transporter, periplasmic arginine-binding protein ArtJ [KO:K09996 ]
EcSMS35_0891 artI; arginine ABC transporter, periplasmic arginine-binding protein ArtI [KO:K09997 ]
EcSMS35_1285 araF; L-arabinose ABC transporter, periplasmic L-arabinose-binding protein [KO:K10537 ]
EcSMS35_1656 lsrB; autoinducer-2 ABC transporter, periplasmic autoinducer-2-binding protein LsrB [KO:K10555 ]
EcSMS35_1828 sapA; peptide ABC transporter, periplasmic peptide-binding protein [KO:K19226 ]
EcSMS35_1897 oppA; oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580 ]
EcSMS35_2001 potB; spermidine/putrescine ABC transporter, permease protein PotB [KO:K11071 ]
EcSMS35_2002 potC; spermidine/putrescine ABC transporter, permease protein PotC [KO:K11070 ]
EcSMS35_2003 potD; spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein [KO:K11069 ]
EcSMS35_2009 lolD; lipoprotein releasing system, ATP-binding protein [KO:K09810 ] [EC:7.6.2.-]
EcSMS35_2234 cydD; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013 ]
EcSMS35_2235 cudC; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012 ]
EcSMS35_2281 macB; macrolide-specific ABC-type efflux carrier protein MacB [KO:K05685 ] [EC:7.6.2.-]
EcSMS35_2297 mglB; galactose ABC transporter, periplasmic galactose-binding protein [KO:K10540 ]
EcSMS35_2465 hisJ; histidine ABC transporter, periplasmic histidine-binding protein [KO:K10014 ]
EcSMS35_2580 cysP; sulfate/thiosulfate ABC transporter, periplasmic sulfate/thiosulfate-binding protein [KO:K02048 ]
EcSMS35_2800 proW; glycine betaine/L-proline ABC transporter, permease protein [KO:K02001 ]
EcSMS35_2801 proX; glycine betaine/L-proline ABC transporter, periplasmic glycine betaine-binding protein [KO:K02002 ]
EcSMS35_3170 sitA_2; iron/manganese transport system periplasmic binding protein SitA [KO:K11604 ]
EcSMS35_3171 sitB_2; iron/manganese transport system inner membrane protein SitB [KO:K11607 ]
EcSMS35_3172 sitC_2; iron/manganese transport system inner membrane protein SitC [KO:K11605 ]
EcSMS35_3235 kpsM; polysialic acid capsule biosynthesis transport protein KpsM [KO:K09688 ]
EcSMS35_3731 ugpA; sn-glycerol-3-phosphate transport system permease protein UgpA [KO:K05814 ]
EcSMS35_3735 livF; high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF [KO:K01996 ]
EcSMS35_3737 livG; high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivG [KO:K01995 ]
EcSMS35_3738 livM; high-affinity branched-chain amino acid ABC transporter, permease protein LivM [KO:K01998 ]
EcSMS35_3739 livH; high-affinity branched-chain amino acid transport system permease protein livH [KO:K01997 ]
EcSMS35_3740 livK; high-affinity branched-chain amino acid ABC transporter, periplasmic leucine-specific-binding protein LivK [KO:K01999 ]
EcSMS35_3743 livJ; high-affinity branched-chain amino acid ABC transporter, periplasmic Leu/Ile/Val-binding protein LivJ [KO:K01999 ]
EcSMS35_3760 nikA; nickel ABC transporter, periplasmic nickel-binding protein NikA [KO:K15584 ]
EcSMS35_3863 dppA; dipeptide ABC transporter, periplasmic dipeptide-binding protein [KO:K12368 ]
EcSMS35_3889 xylF; D-xylose ABC transporter, periplasmic D-xylose-binding protein [KO:K10543 ]
EcSMS35_4092 pstS; phosphate ABC transporter, periplasmic phosphate-binding protein PstS [KO:K02040 ]
EcSMS35_4494 malG; maltose/maltodextrin ABC transporter, permease protein MalG [KO:K10110 ]
EcSMS35_4495 malF; maltose/maltodextrin ABC transporter, permease protein MalF [KO:K10109 ]
EcSMS35_4497 malK; maltose/maltodextrin ABC transporter, ATP-binding protein MalK [KO:K10111 ] [EC:7.5.2.-]
EcSMS35_4570 phnD; phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044 ]
EcSMS35_A0084 sitA_1; iron/manganese transport system periplasmic binding protein SitA [KO:K11604 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway