KEGG   PATHWAY: efus03013
Entry
efus03013                   Pathway                                
Name
Nucleocytoplasmic transport - Eptesicus fuscus (big brown bat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
efus03013  Nucleocytoplasmic transport
efus03013

Other DBs
GO: 0050658
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103285345  AAAS; aladin [KO:K14320]
129149338  aladin-like [KO:K14320]
103291996  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
103296047  GLE1; mRNA export factor GLE1 [KO:K18723]
103284655  DDX19A; ATP-dependent RNA helicase DDX19A isoform X3 [KO:K18655] [EC:5.6.2.7]
103284656  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
103285771  RAE1; mRNA export factor RAE1 [KO:K14298]
103293654  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
103296012  NUP214; nuclear pore complex protein Nup214 [KO:K14317]
103299867  NUP88; nuclear pore complex protein Nup88 isoform X8 [KO:K14318]
103297413  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
103288829  RANGAP1; ran GTPase-activating protein 1 isoform X3 [KO:K14319]
103290464  UBE2I; SUMO-conjugating enzyme UBC9 isoform X2 [KO:K10577]
103287656  SUMO-conjugating enzyme UBC9-like [KO:K10577]
103289775  small ubiquitin-related modifier 3 [KO:K12160]
103298297  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
129152153  small ubiquitin-related modifier 2-like [KO:K12160]
114232328  LOW QUALITY PROTEIN: small ubiquitin-related modifier 2-like [KO:K12160]
103290609  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
103290820  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
103298296  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
103295570  SEC13; protein SEC13 homolog [KO:K14004]
103292570  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
103301634  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
103302535  SEH1L; nucleoporin SEH1 isoform X2 [KO:K14299]
103302351  NUP43; nucleoporin Nup43 isoform X2 [KO:K14305]
103288958  NUP37; nucleoporin Nup37 [KO:K14302]
103301093  AHCTF1; protein ELYS [KO:K25129]
103297613  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
103296730  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
103287928  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
103294116  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
103296178  NUP188; nucleoporin NUP188 [KO:K14311]
103298811  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
103295840  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
103283466  NUP35; nucleoporin NUP35 [KO:K14313]
103284003  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
103299025  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
103301575  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
103286032  nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
103304025  POM121L2; POM121-like protein 2 [KO:K14316]
103284929  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
103290033  TPR; nucleoprotein TPR [KO:K09291]
103298683  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
103290159  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
103300664  SENP2; sentrin-specific protease 2 isoform X2 [KO:K03345] [EC:3.4.22.68]
103290748  KPNA1; importin subunit alpha-5 [KO:K23940]
103290188  KPNA7; importin subunit alpha-8 [KO:K15043]
103293128  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
103300720  importin subunit alpha-1-like [KO:K15043]
103286695  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
103295628  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
103283700  KPNA5; importin subunit alpha-6 [KO:K15042]
103300149  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
103297110  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
103305184  TNPO1; transportin-1 [KO:K18752]
103301020  TNPO2; transportin-2 isoform X3 [KO:K18727]
103297335  TNPO3; transportin-3 [KO:K15436]
103301485  IPO4; importin-4 isoform X1 [KO:K20221]
103288265  IPO5; importin-5 [KO:K20222]
103294633  IPO7; importin-7 isoform X1 [KO:K20223]
103285180  IPO8; importin-8 isoform X1 [KO:K18755]
103302953  IPO9; importin-9 [KO:K20224]
103305145  IPO11; importin-11 [KO:K25201]
103294814  IPO13; importin-13 [KO:K25202]
103300178  SNUPN; snurportin-1 isoform X1 [KO:K13151]
103305373  XPO1; exportin-1 [KO:K14290]
103285730  CSE1L; exportin-2 [KO:K18423]
103292496  XPOT; exportin-T isoform X3 [KO:K14288]
103301237  XPO4; exportin-4 isoform X1 [KO:K25203]
103296634  XPO5; exportin-5 [KO:K14289]
103300793  XPO6; exportin-6 isoform X3 [KO:K25204]
103295086  XPO7; exportin-7 [KO:K18460]
103291557  RANBP17; ran-binding protein 17 [KO:K24115]
103300349  RAN; GTP-binding nuclear protein Ran [KO:K07936]
103286041  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
103303654  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
103302186  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
103300248  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
103285943  PHAX; phosphorylated adapter RNA export protein isoform X2 [KO:K14291]
103286407  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
103303538  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
129150641  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
103286793  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
103296532  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
103284007  MAGOH; protein mago nashi homolog [KO:K12877]
103285088  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
103288988  CASC3; protein CASC3 [KO:K14323]
103298370  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103301518  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
103304102  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
103290513  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X2 [KO:K14325]
103303808  PNN; pinin isoform X1 [KO:K13114]
103298348  ALYREF; THO complex subunit 4 [KO:K12881]
103299528  UPF1; regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103294021  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
103288297  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
103299982  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
103303729  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103299724  nuclear RNA export factor 2 [KO:K14284]
103302184  NXF3; nuclear RNA export factor 3 [KO:K14284]
103302189  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
103299725  nuclear RNA export factor 2-like [KO:K14284]
103285718  NXT1; NTF2-related export protein 1 [KO:K14285]
103288242  NTF2-related export protein 1-like [KO:K14285]
103288954  NTF2-related export protein 1-like [KO:K14285]
103303099  NXT2; NTF2-related export protein 2 [KO:K14285]
103300482  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
103291939  SRRM1; serine/arginine repetitive matrix protein 1 isoform X5 [KO:K13171]
103292402  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
103303127  THOC1; THO complex subunit 1 [KO:K12878]
103284186  THO complex subunit 2 [KO:K12879]
103301905  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
103286864  THOC5; THO complex subunit 5 homolog [KO:K13174]
103286175  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
103290380  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
103291535  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
efus03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

DBGET integrated database retrieval system