KEGG   PATHWAY: elc00053
Entry
elc00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Escherichia coli clone D i14
Class
Metabolism; Carbohydrate metabolism
Pathway map
elc00053  Ascorbate and aldarate metabolism
elc00053

Module
elc_M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:elc00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Escherichia coli clone D i14 [GN:elc]
Gene
i14_3373a  kfiD; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
i14_2355  ugd; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
i14_1829  uidA; beta-D-glucuronidase [KO:K01195] [EC:3.2.1.31]
i14_4953  hypothetical protein [KO:K23007] [EC:1.1.1.414]
i14_4787  ptxA; L-ascorbate-specific enzyme IIA component [KO:K02821] [EC:2.7.1.194]
i14_0324  PTS system, mannitol (Cryptic)-specific IIA [KO:K02821] [EC:2.7.1.194]
i14_4786  sgaB; L-ascorbate-specific enzyme IIB component [KO:K02822] [EC:2.7.1.194]
i14_0323  hypothetical protein [KO:K02822] [EC:2.7.1.194]
i14_4785  ulaA; ascorbate-specific PTS system enzyme IIC [KO:K03475]
i14_0322  ulaA; ascorbate-specific PTS system enzyme IIC [KO:K03475]
i14_4784  yjfR; putative L-ascorbate 6-phosphate lactonase [KO:K03476] [EC:3.1.1.-]
i14_4788  ulaD; 3-keto-L-gulonate-6-phosphate decarboxylase [KO:K03078] [EC:4.1.1.85]
i14_4070  sgbH; 3-keto-L-gulonate-6-phosphate decarboxylase [KO:K03078] [EC:4.1.1.85]
i14_4789  sgaU; L-xylulose 5-phosphate 3-epimerase [KO:K03079] [EC:5.1.3.22]
i14_4071  sgbU; putative L-xylulose 5-phosphate 3-epimerase [KO:K03079] [EC:5.1.3.22]
i14_4790  sgaE; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
i14_0063  araD; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
i14_4072  sgbE; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
i14_4063  yiaK; 2,3-diketo-L-gulonate reductase [KO:K08092] [EC:1.1.1.130]
i14_4069  lyxK; Cryptic L-xylulose kinase [KO:K00880] [EC:2.7.1.53]
i14_3076  ygcX; glucarate dehydratase [KO:K01706] [EC:4.2.1.40]
i14_3570  yhaF; alpha-dehydro-beta-deoxy-D-glucarate aldolase [KO:K01630] [EC:4.1.2.20]
i14_3573  yhaG; D-galactarate dehydratase [KO:K01708] [EC:4.2.1.42]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
elc00020  Citrate cycle (TCA cycle)
elc00040  Pentose and glucuronate interconversions
elc00051  Fructose and mannose metabolism
elc00520  Amino sugar and nucleotide sugar metabolism
elc00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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