KEGG   PATHWAY: est00260
Entry
est00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Echinicola strongylocentroti
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
est00260  Glycine, serine and threonine metabolism
est00260

Module
est_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:est00260]
est_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:est00260]
est_M00621  Glycine cleavage system [PATH:est00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Echinicola strongylocentroti [GN:est]
Gene
DN752_12725  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DN752_15130  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DN752_15675  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
DN752_09910  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DN752_01740  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DN752_15680  homoserine kinase [KO:K00872] [EC:2.7.1.39]
DN752_15685  threonine synthase [KO:K01733] [EC:4.2.3.1]
DN752_11965  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DN752_00950  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DN752_03785  glycerate kinase [KO:K00865] [EC:2.7.1.165]
DN752_10430  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DN752_20235  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DN752_07455  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DN752_15005  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DN752_03365  pyridoxal phosphate-dependent aminotransferase family protein [KO:K00639] [EC:2.3.1.29]
DN752_07265  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
DN752_10065  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
DN752_07015  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
DN752_10200  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DN752_06195  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DN752_04105  gcvH; glycine cleavage system protein GcvH [KO:K02437]
DN752_15970  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
DN752_20470  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DN752_06430  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
DN752_16050  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
DN752_09355  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
DN752_20505  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta [KO:K01752] [EC:4.3.1.17]
DN752_01570  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
DN752_11955  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
DN752_18575  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
DN752_18570  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
est00010  Glycolysis / Gluconeogenesis
est00020  Citrate cycle (TCA cycle)
est00230  Purine metabolism
est00250  Alanine, aspartate and glutamate metabolism
est00270  Cysteine and methionine metabolism
est00290  Valine, leucine and isoleucine biosynthesis
est00300  Lysine biosynthesis
est00330  Arginine and proline metabolism
est00460  Cyanoamino acid metabolism
est00470  D-Amino acid metabolism
est00564  Glycerophospholipid metabolism
est00600  Sphingolipid metabolism
est00620  Pyruvate metabolism
est00630  Glyoxylate and dicarboxylate metabolism
est00640  Propanoate metabolism
est00680  Methane metabolism
est00860  Porphyrin metabolism
est00920  Sulfur metabolism
KO pathway
ko00260   
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