KEGG   PATHWAY: geh00010
Entry
geh00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Gemmobacter aquarius
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
geh00010  Glycolysis / Gluconeogenesis
geh00010

Module
geh_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:geh00010]
Other DBs
GO: 0006096 0006094
Organism
Gemmobacter aquarius [GN:geh]
Gene
HYN69_08050  glucokinase [KO:K00845] [EC:2.7.1.2]
HYN69_08810  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
HYN69_13645  sugar kinase [KO:K16370] [EC:2.7.1.11]
HYN69_04145  glpX; fructose-bisphosphatase class II [KO:K11532] [EC:3.1.3.11 3.1.3.37]
HYN69_10845  class I fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
HYN69_11630  fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
HYN69_09540  triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
HYN69_07825  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
HYN69_07830  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
HYN69_00865  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
HYN69_01035  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HYN69_10800  phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
HYN69_16185  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
HYN69_11405  pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
HYN69_10855  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00161] [EC:1.2.4.1]
HYN69_10860  pyruvate dehydrogenase complex E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
HYN69_10865  pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
HYN69_07775  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HYN69_13170  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HYN69_01075  S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
HYN69_16320  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
HYN69_09725  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
HYN69_02655  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
HYN69_15525  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
HYN69_03585  galactose-1-epimerase [KO:K01785] [EC:5.1.3.3]
HYN69_00815  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
HYN69_08880  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
HYN69_01715  phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
geh00020  Citrate cycle (TCA cycle)
geh00030  Pentose phosphate pathway
geh00500  Starch and sucrose metabolism
geh00620  Pyruvate metabolism
geh00640  Propanoate metabolism
geh00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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