Homo sapiens (human): 1020
Help
Entry
1020 CDS
T01001
Symbol
CDK5, LIS7, PSSALRE
Name
(RefSeq) cyclin dependent kinase 5
KO
K02090
cyclin-dependent kinase 5 [EC:
2.7.11.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04360
Axon guidance
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06541
Cytoskeleton in neurons
Element
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01414
Iron to anterograde axonal transport
N01832
NTN1-MAP1B axon guidance signaling
N01835
SEMA3-CRMP2/MAPT axon guidance signaling
N01847
Regulation of dynein-mediated retrograde transport
N01857
SEMA3A-DCX axon guidance signaling
Disease
H00268
Lissencephaly
Drug target
Dinaciclib:
D09604
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09158 Development and regeneration
04360 Axon guidance
1020 (CDK5)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
1020 (CDK5)
05022 Pathways of neurodegeneration - multiple diseases
1020 (CDK5)
09165 Substance dependence
05030 Cocaine addiction
1020 (CDK5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1020 (CDK5)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
1020 (CDK5)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.22 cyclin-dependent kinase
1020 (CDK5)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CMGC group
CDK family
1020 (CDK5)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
1020 (CDK5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Haspin_kinase
Seadorna_VP7
Kinase-like
APH
Motif
Other DBs
NCBI-GeneID:
1020
NCBI-ProteinID:
NP_004926
OMIM:
123831
HGNC:
1774
Ensembl:
ENSG00000164885
UniProt:
Q00535
A0A090N7W4
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:complement(151053815..151057897)
Genome browser
AA seq
292 aa
AA seq
DB search
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
NT seq
879 nt
NT seq
+upstream
nt +downstream
nt
atgcagaaatacgagaaactggaaaagattggggaaggcacctacggaactgtgttcaag
gccaaaaaccgggagactcatgagatcgtggctctgaaacgggtgaggctggatgacgat
gatgagggtgtgccgagttccgccctccgggagatctgcctactcaaggagctgaagcac
aagaacatcgtcaggcttcatgacgtcctgcacagcgacaagaagctgactttggttttt
gaattctgtgaccaggacctgaagaagtattttgacagttgcaatggtgacctcgatcct
gagattgtaaagtcattcctcttccagctactaaaagggctgggattctgtcatagccgc
aatgtgctacacagggacctgaagccccagaacctgctaataaacaggaatggggagctg
aaattggctgattttggcctggctcgagcctttgggattcccgtccgctgttactcagct
gaggtggtcacactgtggtaccgcccaccggatgtcctctttggggccaagctgtactcc
acgtccatcgacatgtggtcagccggctgcatctttgcagagctggccaatgctgggcgg
cctctttttcccggcaatgatgtcgatgaccagttgaagaggatcttccgactgctgggg
acgcccaccgaggagcagtggccctctatgaccaagctgccagactataagccctatccg
atgtacccggccacaacatccctggtgaacgtcgtgcccaaactcaatgccacagggagg
gatctgctgcagaaccttctgaagtgtaaccctgtccagcgtatctcagcagaagaggcc
ctgcagcacccctacttctccgacttctgtccgccctag
Homo sapiens (human): 8851
Help
Entry
8851 CDS
T01001
Symbol
CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Name
(RefSeq) cyclin dependent kinase 5 regulatory subunit 1
KO
K11716
cyclin-dependent kinase 5 activator 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06541
Cytoskeleton in neurons
Element
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01835
SEMA3-CRMP2/MAPT axon guidance signaling
N01847
Regulation of dynein-mediated retrograde transport
N01857
SEMA3A-DCX axon guidance signaling
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
8851 (CDK5R1)
05022 Pathways of neurodegeneration - multiple diseases
8851 (CDK5R1)
09165 Substance dependence
05030 Cocaine addiction
8851 (CDK5R1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
8851 (CDK5R1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
8851 (CDK5R1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CDK5_activator
MTBP_C
Motif
Other DBs
NCBI-GeneID:
8851
NCBI-ProteinID:
NP_003876
OMIM:
603460
HGNC:
1775
Ensembl:
ENSG00000176749
UniProt:
Q15078
Q8N619
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:32486993..32491253
Genome browser
AA seq
307 aa
AA seq
DB search
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
LLLGLDR
NT seq
924 nt
NT seq
+upstream
nt +downstream
nt
atgggcacggtgctgtccctgtctcccagctaccggaaggccacgctgtttgaggatggc
gcggccaccgtgggccactatacggccgtacagaacagcaagaacgccaaggacaagaac
ctgaagcgccactccatcatctccgtgctgccttggaagagaatcgtggccgtgtcggcc
aagaagaagaactccaagaaggtgcagcccaacagcagctaccagaacaacatcacgcac
ctcaacaatgagaacctgaagaagtcgctgtcgtgcgccaacctgtccacattcgcccag
cccccaccggcccagccgcctgcacccccggccagccagctctcgggttcccagaccggg
ggctcctcctcagtcaagaaagcccctcaccctgccgtcacctccgcagggacgcccaaa
cgggtcatcgtccaggcgtccaccagtgagctgcttcgctgcctgggtgagtttctctgc
cgccggtgctaccgcctgaagcacctgtcccccacggaccccgtgctctggctgcgcagc
gtggaccgctcgctgcttctgcagggctggcaggaccagggcttcatcacgccggccaac
gtggtcttcctctacatgctctgcagggatgttatctcctccgaggtgggctcggatcac
gagctccaggccgtcctgctgacatgcctgtacctctcctactcctacatgggcaacgag
atctcctacccgctcaagcccttcctggtggagagctgcaaggaggccttttgggaccgt
tgcctctctgtcatcaacctcatgagctcaaagatgctgcagataaatgccgacccacac
tacttcacacaggtcttctccgacctgaagaacgagagcggccaggaggacaagaagcgg
ctcctcctaggcctggatcggtga
DBGET
integrated database retrieval system
