KEGG   Homo sapiens (human): 1509
Entry
1509              CDS       T01001                                 
Symbol
CTSD, CLN10, CPSD, HEL-S-130P
Name
(RefSeq) cathepsin D preproprotein
  KO
K01379  cathepsin D [EC:3.4.23.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04071  Sphingolipid signaling pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04210  Apoptosis
hsa04915  Estrogen signaling pathway
hsa05152  Tuberculosis
hsa05415  Diabetic cardiomyopathy
Network
nt06227  Nuclear receptor signaling (cancer)
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06551  Lysosome
  Element
N00286  Nuclear-initiated estrogen signaling pathway
N02036  Prosaposin (PSAP) cleavage into saposins
N02037  PGRN activation of cathepsin D
Disease
H00149  Neuronal ceroid lipofuscinosis
H02279  Neuronal ceroid lipofuscinosis due to Cathepsin D deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    1509 (CTSD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1509 (CTSD)
   04142 Lysosome biogenesis
    1509 (CTSD)
   04140 Autophagy - animal
    1509 (CTSD)
  09143 Cell growth and death
   04210 Apoptosis
    1509 (CTSD)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    1509 (CTSD)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1509 (CTSD)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1509 (CTSD)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1509 (CTSD)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1509 (CTSD)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.5  cathepsin D
     1509 (CTSD)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   1509 (CTSD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1509 (CTSD)
SSDB
Motif
Pfam: Asp TAXi_N A1_Propeptide TAXi_C DUF3011
Other DBs
NCBI-GeneID: 1509
NCBI-ProteinID: NP_001900
OMIM: 116840
HGNC: 2529
Ensembl: ENSP00000236671.2
UniProt: P07339 V9HWI3
Structure
LinkDB
Position
11:complement(1752755..1763927)
AA seq 412 aa
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
NT seq 1239 nt   +upstreamnt  +downstreamnt
atgcagccctccagccttctgccgctcgccctctgcctgctggctgcacccgcctccgcg
ctcgtcaggatcccgctgcacaagttcacgtccatccgccggaccatgtcggaggttggg
ggctctgtggaggacctgattgccaaaggccccgtctcaaagtactcccaggcggtgcca
gccgtgaccgaggggcccattcccgaggtgctcaagaactacatggacgcccagtactac
ggggagattggcatcgggacgcccccccagtgcttcacagtcgtcttcgacacgggctcc
tccaacctgtgggtcccctccatccactgcaaactgctggacatcgcttgctggatccac
cacaagtacaacagcgacaagtccagcacctacgtgaagaatggtacctcgtttgacatc
cactatggctcgggcagcctctccgggtacctgagccaggacactgtgtcggtgccctgc
cagtcagcgtcgtcagcctctgccctgggcggtgtcaaagtggagaggcaggtctttggg
gaggccaccaagcagccaggcatcaccttcatcgcagccaagttcgatggcatcctgggc
atggcctacccccgcatctccgtcaacaacgtgctgcccgtcttcgacaacctgatgcag
cagaagctggtggaccagaacatcttctccttctacctgagcagggacccagatgcgcag
cctgggggtgagctgatgctgggtggcacagactccaagtattacaagggttctctgtcc
tacctgaatgtcacccgcaaggcctactggcaggtccacctggaccaggtggaggtggcc
agcgggctgaccctgtgcaaggagggctgtgaggccattgtggacacaggcacttccctc
atggtgggcccggtggatgaggtgcgcgagctgcagaaggccatcggggccgtgccgctg
attcagggcgagtacatgatcccctgtgagaaggtgtccaccctgcccgcgatcacactg
aagctgggaggcaaaggctacaagctgtccccagaggactacacgctcaaggtgtcgcag
gccgggaagaccctctgcctgagcggcttcatgggcatggacatcccgccacccagcggg
ccactctggatcctgggcgacgtcttcatcggccgctactacactgtgtttgaccgtgac
aacaacagggtgggcttcgccgaggctgcccgcctctag

KEGG   Homo sapiens (human): 1508
Entry
1508              CDS       T01001                                 
Symbol
CTSB, APPS, CPSB, KWE, RECEUP
Name
(RefSeq) cathepsin B isoform 1 preproprotein
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04924  Renin secretion
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Disease
H00932  Tropical calcific pancreatitis
H02920  Keratolytic winter erythema
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1508 (CTSB)
   04142 Lysosome biogenesis
    1508 (CTSB)
   04140 Autophagy - animal
    1508 (CTSB)
  09143 Cell growth and death
   04210 Apoptosis
    1508 (CTSB)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    1508 (CTSB)
   04612 Antigen processing and presentation
    1508 (CTSB)
  09152 Endocrine system
   04924 Renin secretion
    1508 (CTSB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1508 (CTSB)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1508 (CTSB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1508 (CTSB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1508 (CTSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     1508 (CTSB)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1508 (CTSB)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1508 (CTSB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   1508 (CTSB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   1508 (CTSB)
SSDB
Motif
Pfam: Peptidase_C1 Propeptide_C1 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1508
NCBI-ProteinID: NP_001371643
OMIM: 116810
HGNC: 2527
UniProt: P07858 A0A024R374
Structure
LinkDB
Position
8:complement(11842524..11868087)
AA seq 339 aa
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
NT seq 1020 nt   +upstreamnt  +downstreamnt
atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg
ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg
tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt
accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg
cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga
gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg
atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca
tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac
ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga
ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg
gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa
caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg
gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg
ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc
cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg
aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga
atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

KEGG   Homo sapiens (human): 1510
Entry
1510              CDS       T01001                                 
Symbol
CTSE, CATE
Name
(RefSeq) cathepsin E isoform a preproprotein
  KO
K01382  cathepsin E [EC:3.4.23.34]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome biogenesis
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    1510 (CTSE)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1510 (CTSE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.34  cathepsin E
     1510 (CTSE)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   1510 (CTSE)
SSDB
Motif
Pfam: Asp TAXi_N A1_Propeptide
Other DBs
NCBI-GeneID: 1510
NCBI-ProteinID: NP_001901
OMIM: 116890
HGNC: 2530
Ensembl: ENSP00000350911.2
UniProt: P14091
Structure
LinkDB
Position
1:complement(206009264..206023895)
AA seq 396 aa
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
NT seq 1191 nt   +upstreamnt  +downstreamnt
atgaaaacgctccttcttttgctgctggtgctcctggagctgggagaggcccaaggatcc
cttcacagggtgcccctcaggaggcatccgtccctcaagaagaagctgcgggcacggagc
cagctctctgagttctggaaatcccataatttggacatgatccagttcaccgagtcctgc
tcaatggaccagagtgccaaggaacccctcatcaactacttggatatggaatacttcggc
actatctccattggctccccaccacagaacttcactgtcatcttcgacactggctcctcc
aacctctgggtcccctctgtgtactgcactagcccagcctgcaagacgcacagcaggttc
cagccttcccagtccagcacatacagccagccaggtcaatctttctccattcagtatgga
accgggagcttgtccgggatcattggagccgaccaagtctctgtggaaggactaaccgtg
gttggccagcagtttggagaaagtgtcacagagccaggccagacctttgtggatgcagag
tttgatggaattctgggcctgggatacccctccttggctgtgggaggagtgactccagta
tttgacaacatgatggctcagaacctggtggacttgccgatgttttctgtctacatgagc
agtaacccagaaggtggtgcggggagcgagctgatttttggaggctacgaccactcccat
ttctctgggagcctgaattgggtcccagtcaccaagcaagcttactggcagattgcactg
gataacatccaggtgggaggcactgttatgttctgctccgagggctgccaggccattgtg
gacacagggacttccctcatcactggcccttccgacaagattaagcagctgcaaaacgcc
attggggcagcccccgtggatggagaatatgctgtggagtgtgccaaccttaacgtcatg
ccggatgtcaccttcaccattaacggagtcccctataccctcagcccaactgcctacacc
ctactggacttcgtggatggaatgcagttctgcagcagtggctttcaaggacttgacatc
caccctccagctgggcccctctggatcctgggggatgtcttcattcgacagttttactca
gtctttgaccgtgggaataaccgtgtgggactggccccagcagtcccctaa

KEGG   Homo sapiens (human): 1511
Entry
1511              CDS       T01001                                 
Symbol
CTSG, CATG, CG
Name
(RefSeq) cathepsin G preproprotein
  KO
K01319  cathepsin G [EC:3.4.21.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04613  Neutrophil extracellular trap formation
hsa04614  Renin-angiotensin system
hsa05146  Amoebiasis
hsa05322  Systemic lupus erythematosus
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1511 (CTSG)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1511 (CTSG)
   04142 Lysosome biogenesis
    1511 (CTSG)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    1511 (CTSG)
  09152 Endocrine system
   04614 Renin-angiotensin system
    1511 (CTSG)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    1511 (CTSG)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    1511 (CTSG)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1511 (CTSG)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1511 (CTSG)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.20  cathepsin G
     1511 (CTSG)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   1511 (CTSG)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   1511 (CTSG)
SSDB
Motif
Pfam: Trypsin Trypsin_2 Nudel LYSC_C
Other DBs
NCBI-GeneID: 1511
NCBI-ProteinID: NP_001902
OMIM: 116830
HGNC: 2532
Ensembl: ENSP00000216336.2
UniProt: P08311
Structure
LinkDB
Position
14:complement(24573518..24576250)
AA seq 255 aa
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
TMRSFKLLDQMETPL
NT seq 768 nt   +upstreamnt  +downstreamnt
atgcagccactcctgcttctgctggcctttctcctacccactggggctgaggcaggggag
atcatcggaggccgggagagcaggccccactcccgcccctacatggcgtatcttcagatc
cagagtccagcaggtcagagcagatgtggagggttcctggtgcgagaagactttgtgctg
acagcagctcattgctggggaagcaatataaatgtcaccctgggcgcccacaatatccag
agacgggaaaacacccagcaacacatcactgcgcgcagagccatccgccaccctcaatat
aatcagcggaccatccagaatgacatcatgttattgcagctgagcagaagagtcagacgg
aatcgaaacgtgaacccagtggctctgcctagagcccaggagggactgagacccgggacg
ctgtgcactgtggccggctggggcagggtcagcatgaggaggggaacagatacactccga
gaggtgcagctgagagtgcagagggataggcagtgcctccgcatcttcggttcctacgac
ccccgaaggcagatttgtgtgggggaccggcgggaacggaaggctgccttcaagggggat
tccggaggccccctgctgtgtaacaatgtggcccacggcatcgtctcctatggaaagtcg
tcaggggttcctccagaagtcttcaccagggtctcaagtttcctgccctggataaggaca
acaatgagaagcttcaaactgctggatcagatggagacccccctgtga

KEGG   Homo sapiens (human): 1513
Entry
1513              CDS       T01001                                 
Symbol
CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
Name
(RefSeq) cathepsin K preproprotein
  KO
K01371  cathepsin K [EC:3.4.22.38]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa05323  Rheumatoid arthritis
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Disease
H00273  Pycnodysostosis
H00425  Lysosomal cysteine protease deficiencies
Drug target
Odanacatib: D08955
Relacatib: D06634
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1513 (CTSK)
   04142 Lysosome biogenesis
    1513 (CTSK)
  09143 Cell growth and death
   04210 Apoptosis
    1513 (CTSK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    1513 (CTSK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1513 (CTSK)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    1513 (CTSK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1513 (CTSK)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1513 (CTSK)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     1513 (CTSK)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1513 (CTSK)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1513 (CTSK)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1513
NCBI-ProteinID: NP_000387
OMIM: 601105
HGNC: 2536
Ensembl: ENSP00000271651.3
UniProt: P43235
Structure
LinkDB
Position
1:complement(150796208..150808260)
AA seq 329 aa
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
NT seq 990 nt   +upstreamnt  +downstreamnt
atgtgggggctcaaggttctgctgctacctgtggtgagctttgctctgtaccctgaggag
atactggacacccactgggagctatggaagaagacccacaggaagcaatataacaacaag
gtggatgaaatctctcggcgtttaatttgggaaaaaaacctgaagtatatttccatccat
aaccttgaggcttctcttggtgtccatacatatgaactggctatgaaccacctgggggac
atgaccagtgaagaggtggttcagaagatgactggactcaaagtacccctgtctcattcc
cgcagtaatgacaccctttatatcccagaatgggaaggtagagccccagactctgtcgac
tatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtgtggttcctgttgg
gcttttagctctgtgggtgccctggagggccaactcaagaagaaaactggcaaactctta
aatctgagtccccagaacctagtggattgtgtgtctgagaatgatggctgtggagggggc
tacatgaccaatgccttccaatatgtgcagaagaaccggggtattgactctgaagatgcc
tacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagctaaa
tgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtggcc
cgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttacagc
aaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcagttttggca
gtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggagaa
aactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggcatt
gccaacctggccagcttccccaagatgtga

KEGG   Homo sapiens (human): 1514
Entry
1514              CDS       T01001                                 
Symbol
CTSL, CATL, CTSL1, MEP
Name
(RefSeq) procathepsin L isoform 1 preproprotein
  KO
K01365  cathepsin L [EC:3.4.22.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05205  Proteoglycans in cancer
hsa05323  Rheumatoid arthritis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Drug target
Olgotrelvir (DG03293): D12777 D12778
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1514 (CTSL)
   04142 Lysosome biogenesis
    1514 (CTSL)
   04140 Autophagy - animal
    1514 (CTSL)
  09143 Cell growth and death
   04210 Apoptosis
    1514 (CTSL)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1514 (CTSL)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    1514 (CTSL)
  09163 Immune disease
   05323 Rheumatoid arthritis
    1514 (CTSL)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1514 (CTSL)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1514 (CTSL)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1514 (CTSL)
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    1514 (CTSL)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.15  cathepsin L
     1514 (CTSL)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1514 (CTSL)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1514 (CTSL)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Others
  1514 (CTSL)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin
Other DBs
NCBI-GeneID: 1514
NCBI-ProteinID: NP_001244900
OMIM: 116880
HGNC: 2537
UniProt: P07711
Structure
LinkDB
Position
9:87726119..87731469
AA seq 333 aa
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
NT seq 1002 nt   +upstreamnt  +downstreamnt
atgaatcctacactcatccttgctgccttttgcctgggaattgcctcagctactctaaca
tttgatcacagtttagaggcacagtggaccaagtggaaggcgatgcacaacagattatac
ggcatgaatgaagaaggatggaggagagcagtgtgggagaagaacatgaagatgattgaa
ctgcacaatcaggaatacagggaagggaaacacagcttcacaatggccatgaacgccttt
ggagacatgaccagtgaagaattcaggcaggtgatgaatggctttcaaaaccgtaagccc
aggaaggggaaagtgttccaggaacctctgttttatgaggcccccagatctgtggattgg
agagagaaaggctacgtgactcctgtgaagaatcagggtcagtgtggttcttgttgggct
tttagtgctactggtgctcttgaaggacagatgttccggaaaactgggaggcttatctca
ctgagtgagcagaatctggtagactgctctgggcctcaaggcaatgaaggctgcaatggt
ggcctaatggattatgctttccagtatgttcaggataatggaggcctggactctgaggaa
tcctatccatatgaggcaacagaagaatcctgtaagtacaatcccaagtattctgttgct
aatgacaccggctttgtggacatccctaagcaggagaaggccctgatgaaggcagttgca
actgtggggcccatttctgttgctattgatgcaggtcatgagtccttcctgttctataaa
gaaggcatttattttgagccagactgtagcagtgaagacatggatcatggtgtgctggtg
gttggctacggatttgaaagcacagaatcagataacaataaatattggctggtgaagaac
agctggggtgaagaatggggcatgggtggctacgtaaagatggccaaagaccggagaaac
cattgtggaattgcctcagcagccagctaccccactgtgtga

KEGG   Homo sapiens (human): 1515
Entry
1515              CDS       T01001                                 
Symbol
CTSV, CATL2, CTSL2, CTSU
Name
(RefSeq) cathepsin L2 preproprotein
  KO
K01375  cathepsin V [EC:3.4.22.43]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome biogenesis
hsa04210  Apoptosis
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    1515 (CTSV)
  09143 Cell growth and death
   04210 Apoptosis
    1515 (CTSV)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1515 (CTSV)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.43  cathepsin V
     1515 (CTSV)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1515 (CTSV)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin
Other DBs
NCBI-GeneID: 1515
NCBI-ProteinID: NP_001188504
OMIM: 603308
HGNC: 2538
UniProt: O60911 B2R717
Structure
LinkDB
Position
9:complement(97029677..97039643)
AA seq 334 aa
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
NT seq 1005 nt   +upstreamnt  +downstreamnt
atgaatctttcgctcgtcctggctgccttttgcttgggaatagcctccgctgttccaaaa
tttgaccaaaatttggatacaaagtggtaccagtggaaggcaacacacagaagattatat
ggcgcgaatgaagaaggatggaggagagcagtgtgggaaaagaatatgaaaatgattgaa
ctgcacaatggggaatacagccaagggaaacatggcttcacaatggccatgaatgctttt
ggtgacatgaccaatgaagaattcaggcagatgatgggttgctttcgaaaccagaaattc
aggaaggggaaagtgttccgtgagcctctgtttcttgatcttcccaaatctgtggattgg
agaaagaaaggctacgtgacgccagtgaagaatcagaaacagtgtggttcttgttgggct
tttagtgcgactggtgctcttgaaggacagatgttccggaaaactgggaaacttgtctca
ctgagcgagcagaatctggtggactgttcgcgtcctcaaggcaatcagggctgcaatggt
ggcttcatggctagggccttccagtatgtcaaggagaacggaggcctggactctgaggaa
tcctatccatatgtagcagtggatgaaatctgtaagtacagacctgagaattctgttgct
aatgacactggcttcacagtggtcgcacctggaaaggagaaggccctgatgaaagcagtc
gcaactgtggggcccatctccgttgctatggatgcaggccattcgtccttccagttctac
aaatcaggcatttattttgaaccagactgcagcagcaaaaacctggatcatggtgttctg
gtggttggctacggctttgaaggagcaaattcgaataacagcaagtattggctcgtcaaa
aacagctggggtccagaatggggctcgaatggctatgtaaaaatagccaaagacaagaac
aaccactgtggaatcgccacagcagccagctaccccaatgtgtga

KEGG   Homo sapiens (human): 1520
Entry
1520              CDS       T01001                                 
Symbol
CTSS
Name
(RefSeq) cathepsin S isoform 1 preproprotein
  KO
K01368  cathepsin S [EC:3.4.22.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome biogenesis
hsa04145  Phagocytosis
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05152  Tuberculosis
Network
nt06551  Lysosome
  Element
N02036  Prosaposin (PSAP) cleavage into saposins
Drug target
Petesicatib: D11376
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1520 (CTSS)
   04142 Lysosome biogenesis
    1520 (CTSS)
  09143 Cell growth and death
   04210 Apoptosis
    1520 (CTSS)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1520 (CTSS)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1520 (CTSS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1520 (CTSS)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1520 (CTSS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.27  cathepsin S
     1520 (CTSS)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1520 (CTSS)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1520 (CTSS)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1520
NCBI-ProteinID: NP_004070
OMIM: 116845
HGNC: 2545
Ensembl: ENSP00000357981.3
UniProt: P25774
Structure
LinkDB
Position
1:complement(150730188..150765778)
AA seq 331 aa
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
NT seq 996 nt   +upstreamnt  +downstreamnt
atgaaacggctggtttgtgtgctcttggtgtgctcctctgcagtggcacagttgcataaa
gatcctaccctggatcaccactggcatctctggaagaaaacctatggcaaacaatacaag
gaaaagaatgaagaagcagtacgacgtctcatctgggaaaagaatctaaagtttgtgatg
cttcacaacctggagcattcaatgggaatgcactcatacgatctgggcatgaaccacctg
ggagacatgaccagtgaagaagtgatgtctttgatgagttccctgagagttcccagccag
tggcagagaaatatcacatataagtcaaaccctaatcggatattgcctgattctgtggac
tggagagagaaagggtgtgttactgaagtgaaatatcaaggttcttgtggtgcttgctgg
gctttcagtgctgtgggggccctggaagcacagctgaagctgaaaacaggaaagctggtg
tctctcagtgcccagaacctggtggattgctcaactgaaaaatatggaaacaaaggctgc
aatggtggcttcatgacaacggctttccagtacatcattgataacaagggcatcgactca
gacgcttcctatccctacaaagccatggatcagaaatgtcaatatgactcaaaatatcgt
gctgccacatgttcaaagtacactgaacttccttatggcagagaagatgtcctgaaagaa
gctgtggccaataaaggcccagtgtctgttggtgtagatgcgcgtcatccttctttcttc
ctctacagaagtggtgtctactatgaaccatcctgtactcagaatgtgaatcatggtgta
cttgtggttggctatggtgatcttaatgggaaagaatactggcttgtgaaaaacagctgg
ggccacaactttggtgaagaaggatatattcggatggcaagaaataaaggaaatcattgt
gggattgctagctttccctcttacccagaaatctag

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