KEGG   Homo sapiens (human): 22861
Entry
22861             CDS       T01001                                 
Symbol
NLRP1, AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, JRRP, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1
Name
(RefSeq) NLR family pyrin domain containing 1
  KO
K12798  NACHT, LRR and PYD domains-containing protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
Network
nt06521  NLR signaling
  Element
N01567  NLRP1 inflammasome signaling pathway
Disease
H01372  Vitiligo
H02588  NLRP1-associated autoinflammation with arthritis and dyskeratosis
H02756  Congenital juvenile recurrent respiratory papillomatosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    22861 (NLRP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    22861 (NLRP1)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    22861 (NLRP1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   TRIM-directed selective autophagy
    22861 (NLRP1)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   22861 (NLRP1)
SSDB
Motif
Pfam: NACHT FIIND UPA-FIIND NLRC4_HD2 CARD PYRIN LRR_6 WHD_NOD2 AAA_16 LRR_1 LRR_4 Birna_VP5 NB-ARC NPHP3_N AAA_22 nSTAND_NTPase5 nSTAND3 AAA_30 AAA_14 AAA_5 Zeta_toxin Herpes_U30
Other DBs
NCBI-GeneID: 22861
NCBI-ProteinID: NP_127497
OMIM: 606636
HGNC: 14374
Ensembl: ENSG00000091592
UniProt: Q9C000
Structure
LinkDB
Position
17:complement(5501396..5584509)
AA seq 1473 aa
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
NT seq 4422 nt   +upstreamnt  +downstreamnt
atggctggcggagcctggggccgcctggcctgttacttggagttcctgaagaaggaggag
ctgaaggagttccagcttctgctcgccaataaagcgcactccaggagctcttcgggtgag
acacccgctcagccagagaagacgagtggcatggaggtggcctcgtacctggtggctcag
tatggggagcagcgggcctgggacctagccctccatacctgggagcagatggggctgagg
tcactgtgcgcccaagcccaggaaggggcaggccactctccctcattcccctacagccca
agtgaaccccacctggggtctcccagccaacccacctccaccgcagtgctaatgccctgg
atccatgaattgccggcggggtgcacccagggctcagagagaagggttttgagacagctg
cctgacacatctggacgccgctggagagaaatctctgcctcactcctctaccaagctctt
ccaagctccccagaccatgagtctccaagccaggagtcacccaacgcccccacatccaca
gcagtgctggggagctggggatccccacctcagcccagcctagcacccagagagcaggag
gctcctgggacccaatggcctctggatgaaacgtcaggaatttactacacagaaatcaga
gaaagagagagagagaaatcagagaaaggcaggcccccatgggcagcggtggtaggaacg
cccccacaggcgcacaccagcctacagccccaccaccacccatgggagccttctgtgaga
gagagcctctgttccacatggccctggaaaaatgaggattttaaccaaaaattcacacag
ctgctacttctacaaagacctcaccccagaagccaagatcccctggtcaagagaagctgg
cctgattatgtggaggagaatcgaggacatttaattgagatcagagacttatttggccca
ggcctggatacccaagaacctcgcatagtcatactgcagggggctgctggaattgggaag
tcaacactggccaggcaggtgaaggaagcctgggggagaggccagctgtatggggaccgc
ttccagcatgtcttctacttcagctgcagagagctggcccagtccaaggtggtgagtctc
gctgagctcatcggaaaagatgggacagccactccggctcccattagacagatcctgtct
aggccagagcggctgctcttcatcctcgatggtgtagatgagccaggatgggtcttgcag
gagccgagttctgagctctgtctgcactggagccagccacagccggcggatgcactgctg
ggcagtttgctggggaaaactatacttcccgaggcatccttcctgatcacggctcggacc
acagctctgcagaacctcattccttctttggagcaggcacgttgggtagaggtcctgggg
ttctctgagtccagcaggaaggaatatttctacagatatttcacagatgaaaggcaagca
attagagcctttaggttggtcaaatcaaacaaagagctctgggccctgtgtcttgtgccc
tgggtgtcctggctggcctgcacttgcctgatgcagcagatgaagcggaaggaaaaactc
acactgacttccaagaccaccacaaccctctgtctacattaccttgcccaggctctccaa
gctcagccattgggaccccagctcagagacctctgctctctggctgctgagggcatctgg
caaaaaaagacccttttcagtccagatgacctcaggaagcatgggttagatggggccatc
atctccaccttcttgaagatgggtattcttcaagagcaccccatccctctgagctacagc
ttcattcacctctgtttccaagagttctttgcagcaatgtcctatgtcttggaggatgag
aaggggagaggtaaacattctaattgcatcatagatttggaaaagacgctagaagcatat
ggaatacatggcctgtttggggcatcaaccacacgtttcctattgggcctgttaagtgat
gagggggagagagagatggagaacatctttcactgccggctgtctcaggggaggaacctg
atgcagtgggtcccgtccctgcagctgctgctgcagccacactctctggagtccctccac
tgcttgtacgagactcggaacaaaacgttcctgacacaagtgatggcccatttcgaagaa
atgggcatgtgtgtagaaacagacatggagctcttagtgtgcactttctgcattaaattc
agccgccacgtgaagaagcttcagctgattgagggcaggcagcacagatcaacatggagc
cccaccatggtagtcctgttcaggtgggtcccagtcacagatgcctattggcagattctc
ttctccgtcctcaaggtcaccagaaacctgaaggagctggacctaagtggaaactcgctg
agccactctgcagtgaagagtctttgtaagaccctgagacgccctcgctgcctcctggag
accctgcggttggctggctgtggcctcacagctgaggactgcaaggaccttgcctttggg
ctgagagccaaccagaccctgaccgagctggacctgagcttcaatgtgctcacggatgct
ggagccaaacacctttgccagagactgagacagccgagctgcaagctacagcgactgcag
ctggtcagctgtggcctcacgtctgactgctgccaggacctggcctctgtgcttagtgcc
agccccagcctgaaggagctagacctgcagcagaacaacctggatgacgttggcgtgcga
ctgctctgtgaggggctcaggcatcctgcctgcaaactcatacgcctggggctggaccag
acaactctgagtgatgagatgaggcaggaactgagggccctggagcaggagaaacctcag
ctgctcatcttcagcagacggaaaccaagtgtgatgacccctactgagggcctggatacg
ggagagatgagtaatagcacatcctcactcaagcggcagagactcggatcagagagggcg
gcttcccatgttgctcaggctaatctcaaactcctggacgtgagcaagatcttcccaatt
gctgagattgcagaggaaagctccccagaggtagtaccggtggaactcttgtgcgtgcct
tctcctgcctctcaaggggacctgcatacgaagcctttggggactgacgatgacttctgg
ggccccacggggcctgtggctactgaggtagttgacaaagaaaagaacttgtaccgagtt
cacttccctgtagctggctcctaccgctggcccaacacgggtctctgctttgtgatgaga
gaagcggtgaccgttgagattgaattctgtgtgtgggaccagttcctgggtgagatcaac
ccacagcacagctggatggtggcagggcctctgctggacatcaaggctgagcctggagct
gtggaagctgtgcacctccctcactttgtggctctccaagggggccatgtggacacatcc
ctgttccaaatggcccactttaaagaggaggggatgctcctggagaagccagccagggtg
gagctgcatcacatagttctggaaaaccccagcttctcccccttgggagtcctcctgaaa
atgatccataatgccctgcgcttcattcccgtcacctctgtggtgttgctttaccaccgc
gtccatcctgaggaagtcaccttccacctctacctgatcccaagtgactgctccattcgg
aaggccatagatgatctagaaatgaaattccagtttgtgcgaatccacaagccacccccg
ctgaccccactttatatgggctgtcgttacactgtgtctgggtctggttcagggatgctg
gaaatactccccaaggaactggagctctgctatcgaagccctggagaagaccagctgttc
tcggagttctacgttggccacttgggatcagggatcaggctgcaagtgaaagacaagaaa
gatgagactctggtgtgggaggccttggtgaaaccaggagatctcatgcctgcaactact
ctgatccctccagcccgcatagccgtaccttcacctctggatgccccgcagttgctgcac
tttgtggaccagtatcgagagcagctgatagcccgagtgacatcggtggaggttgtcttg
gacaaactgcatggacaggtgctgagccaggagcagtacgagagggtgctggctgagaac
acgaggcccagccagatgcggaagctgttcagcttgagccagtcctgggaccggaagtgc
aaagatggactctaccaagccctgaaggagacccatcctcacctcattatggaactctgg
gagaagggcagcaaaaagggactcctgccactcagcagctga

KEGG   Homo sapiens (human): 29108
Entry
29108             CDS       T01001                                 
Symbol
PYCARD, ASC, CARD5, TMS, TMS-1, TMS1
Name
(RefSeq) PYD and CARD domain containing
  KO
K12799  apoptosis-associated speck-like protein containing a CARD
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05417  Lipid and atherosclerosis
Network
nt06170  Influenza A virus (IAV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06521  NLR signaling
  Element
N00742  NLRP3 inflammasome signaling pathway
N00743  IAV NS1 to NLRP3 inflammasome signaling pathway
N00864  Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865  Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866  Yersinia YopM to Pyrin Inflammasome signaling pathway
N00867  NLRC4 inflammasome signaling pathway
N00868  Pyrin inflammasome signaling pathway
N00933  Escherichia NleA to NLRP3 inflammasome signaling pathway
N00934  Non-canonical inflammasome signaling pathway
N00948  Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949  Shigella IpaB to NLRC4 Inflammasome signaling pathway
N01567  NLRP1 inflammasome signaling pathway
N01568  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
N01569  NALP12 inflammasome signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    29108 (PYCARD)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    29108 (PYCARD)
   04623 Cytosolic DNA-sensing pathway
    29108 (PYCARD)
   04625 C-type lectin receptor signaling pathway
    29108 (PYCARD)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    29108 (PYCARD)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    29108 (PYCARD)
   05132 Salmonella infection
    29108 (PYCARD)
   05131 Shigellosis
    29108 (PYCARD)
   05135 Yersinia infection
    29108 (PYCARD)
   05133 Pertussis
    29108 (PYCARD)
   05134 Legionellosis
    29108 (PYCARD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    29108 (PYCARD)
SSDB
Motif
Pfam: CARD PYRIN DUF7545
Other DBs
NCBI-GeneID: 29108
NCBI-ProteinID: NP_037390
OMIM: 606838
HGNC: 16608
Ensembl: ENSG00000103490
UniProt: Q9ULZ3
Structure
LinkDB
Position
16:complement(31201486..31202760)
AA seq 195 aa
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
LRESQSYLVEDLERS
NT seq 588 nt   +upstreamnt  +downstreamnt
atggggcgcgcgcgcgacgccatcctggatgcgctggagaacctgaccgccgaggagctc
aagaagttcaagctgaagctgctgtcggtgccgctgcgcgagggctacgggcgcatcccg
cggggcgcgctgctgtccatggacgccttggacctcaccgacaagctggtcagcttctac
ctggagacctacggcgccgagctcaccgctaacgtgctgcgcgacatgggcctgcaggag
atggccgggcagctgcaggcggccacgcaccagggctctggagccgcgccagctgggatc
caggcccctcctcagtcggcagccaagccaggcctgcactttatagaccagcaccgggct
gcgcttatcgcgagggtcacaaacgttgagtggctgctggatgctctgtacgggaaggtc
ctgacggatgagcagtaccaggcagtgcgggccgagcccaccaacccaagcaagatgcgg
aagctcttcagtttcacaccagcctggaactggacctgcaaggacttgctcctccaggcc
ctaagggagtcccagtcctacctggtggaggacctggagcggagctga

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