KEGG T01001: 23269

Homo sapiens (human): 23269

Entry

23269             CDS       T01001

Symbol

MGA, MAD5, MXD5, POF26

Name

(RefSeq) MAX dimerization protein MGA

K23399

MAX gene-associated protein

Organism

hsa Homo sapiens (human)

Pathway

hsa03083

Polycomb repressive complex

Network

nt06523 Epigenetic regulation by Polycomb complexes

Element

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

Disease

H00627

Premature ovarian failure

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    23269 (MGA)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23269 (MGA)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     23269 (MGA)
   Other histone modification proteins
    23269 (MGA)

SSDB

Motif

Pfam:

T-box MGA_dom HLH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

15:41621224..41769940

AA seq 3065 aa
MEEKQQIILANQDGGTVAGAAPTFFVILKQPGNGKTDQGILVTNQDACALASSVSSPVKS
KGKICLPADCTVGGITVTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNLK
YILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLK
LTNNTLDQEGHIILHSMHRYLPRLHLVPAEKAVEVIQLNGPGVHTFTFPQTEFFAVTAYQ
NIQITQLKIDYNPFAKGFRDDGLNNKPQRDGKQKNSSDQEGNNISSSSGHRVRLTEGQGS
EIQPGDLDPLSRGHETSGKGLEKTSLNIKRDFLGFMDTDSALSEVPQLKQEISECLIASS
FEDDSRVASPLDQNGSFNVVIKEEPLDDYDYELGECPEGVTVKQEETDEETDVYSNSDDD
PILEKQLKRHNKVDNPEADHLSSKWLPSSPSGVAKAKMFKLDTGKMPVVYLEPCAVTRST
VKISELPDNMLSTSRKDKSSMLAELEYLPTYIENSNETAFCLGKESENGLRKHSPDLRVV
QKYPLLKEPQWKYPDISDSISTERILDDSKDSVGDSLSGKEDLGRKRTTMLKIATAAKVV
NANQNASPNVPGKRGRPRKLKLCKAGRPPKNTGKSLISTKNTPVSPGSTFPDVKPDLEDV
DGVLFVSFESKEALDIHAVDGTTEESSSLQASTTNDSGYRARISQLEKELIEDLKTLRHK
QVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGTNPASPDAGFPFV
SRTGKTNDFTKIKGWRGKFHSASASRNEGGNSESSLKNRSAFCSDKLDEYLENEGKLMET
SMGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPPVSRKAKS
QNRQATFSGRTKSSYKSILPYPVSPKQKYSHVILGDKVTKNSSGIISENQANNFVVPTLD
ENIFPKQISLRQAQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVS
LTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGC
TCLKRKVVLVKGGSKTKHFQRKAAHRDPVFYDTLGEEAREEEEGIREEEEQLKEKKKRKK
LEYTICETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSPTVKG
KLLTGIKSPRSYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEDQRQPSSSSSP
SPSFQQQTSCHSSPENHNNAKEPDSEQQPLKQLTCDLEDDSDKLQEKSWKSSCNEGESSS
TSYMHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQR
KSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMEDISPVQTDALDSV
RERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVASNAKVAASRKPRTLLPSTSN
SKMASSSGTATNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQ
TLAGTQKFSIRPSPVMVVTPVVSSEPVQVCSPVTAAVTTTTPQVFLENTTAVTPMTAISD
VETKETTYSSGATTTGVVEVSETNTSTSVTSTQSTATVNLTKTTGITTPVASVAFPKSLV
ASPSTITLPVASTASTSLVVVTAAASSSMVTTPTSSLGSVPIILSGINGSPPVSQRPENA
AQIPVATPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVSNTQLQGHRMVLQPVRSPSGMNL
FRHPNGQIVQLLPLHQLRGSNTQPNLQPVMFRNPGSVMGIRLPAPSKPSETPPSSTSSSA
FSVMNPVIQAVGSSSAVNVITQAPSLLSSGASFVSQAGTLTLRISPPEPQSFASKTGSET
KITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQMKRESQNPDQKDE
TNSIKREQETKKVLQSEGEAVDPEANVIKQNSGAATSEETLNDSLEDRGDHLDEECLPEE
GCATVKPSEHSCITGSHTDQDYKDVNEEYGARNRKSSKEKVAVLEVRTISEKASNKTVQN
LSKVQHQKLGDVKVEQQKGFDNPEENSSEFPVTFKEESKFELSGSKVMEQQSNLQPEAKE
KECGDSLEKDRERWRKHLKGPLTRKCVGASQECKKEADEQLIKETKTCQENSDVFQQEQG
ISDLLGKSGITEDARVLKTECDSWSRISNPSAFSIVPRRAAKSSRGNGHFQGHLLLPGEQ
IQPKQEKKGGRSSADFTVLDLEEDDEDDNEKTDDSIDEIVDVVSDYQSEEVDDVEKNNCV
EYIEDDEEHVDIETVEELSEEINVAHLKTTAAHTQSFKQPSCTHISADEKAAERSRKAPP
IPLKLKPDYWSDKLQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSK
SLILTRAFSEIQGLTDQADKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAK
QQALEAQKRKKKMGSDEFDISPRISKQQEGSSASSVDLGQMFINNRRGKPLILSRKKDQA
TENTSPLNTPHTSANLVMTPQGQLLTLKGPLFSGPVVAVSPDLLESDLKPQVAGSAVALP
ENDDLFMMPRIVNVTSLATEGGLVDMGGSKYPHEVPDSKPSDHLKDTVRNEDNSLEDKGR
ISSRGNRDGRVTLGPTQVFLANKDSGYPQIVDVSNMQKAQEFLPKKISGDMRGIQYKWKE
SESRGERVKSKDSSFHKLKMKDLKDSSIEMELRKVTSAIEEAALDSSELLTNMEDEDDTD
ETLTSLLNEIAFLNQQLNDDSVGLAELPSSMDTEFPGDARRAFISKVPPGSRATFQVEHL
GTGLKELPDVQGESDSISPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDSLLS
NKKAIDGGKNTSGLPAEPESVSSPPTLHMKTGLENSNSTDTLWRPMPKLAPLGLKVANPS
SDADGQSLKVMPCLAPIAAKVGSVGHKMNLTGNDQEGRESKVMPTLAPVVAKLGNSGASP
SSAGK

NT seq 9198 nt +upstreamnt +downstreamnt
atggaggagaaacagcagattatattggctaatcaagatggtggaacagtggcaggagca
gcacctaccttctttgtcatcttaaagcagccaggaaatggcaaaactgatcaaggaatt
ttggttactaatcaggatgcctgtgctttggctagtagtgtgtcatcaccagtaaaatct
aaagggaagatttgccttccagctgattgtactgtgggtggaatcactgttaccctcgat
aacaatagtatgtggaatgagttctatcatcgaagcacagagatgattctgaccaagcaa
ggaagacgcatgtttccttactgtcgttattggataacaggtttagattcaaatttgaag
tatattcttgtcatggatatatctcctgtggataaccatcgttataagtggaatggtcgt
tggtgggaacctagtgggaaggctgaacctcatgttttggggagggttttcattcatcca
gaatctccttccacaggtcattattggatgcatcaaccagtatctttctataaactcaaa
cttaccaacaatacactggaccaagaagggcatatcatcttgcactctatgcatcgttac
ctgccgaggcttcatttggtgcctgcagaaaaggctgtggaggtgatacaattaaatggc
cctggtgtccacacttttaccttcccacagactgaattctttgcagtaacagcttatcag
aacattcagattactcagctgaaaatagattacaatccatttgccaaaggctttcgggat
gatgggctgaataataagccccagagagatggaaaacaaaagaacagctctgaccaagaa
gggaataatatttccagttcttctggtcatcgggtccgtcttacagaaggtcaggggtca
gagatacaaccaggtgatttggatcctttgtcaaggggtcatgaaacatcaggcaagggt
ttggagaagacttcccttaatataaaacgagactttcttggtttcatggatactgattca
gcacttagtgaagttcctcaattgaagcaagagatttctgaatgtcttattgccagcagt
tttgaagatgactcccgtgtagcctcaccgttagaccagaacggaagcttcaatgttgtt
attaaagaggaacctctagatgattatgactacgaacttggtgagtgcccagaaggggtc
actgtgaaacaggaagagacagatgaagagacggatgtatactcaaacagtgatgatgat
cctatactagagaaacagctaaagaggcacaataaagttgacaacccagaagctgaccat
ctatcttctaaatggcttccaagcagcccatcaggtgttgctaaagctaaaatgttcaaa
ttagacactggaaagatgccagtagtctatctggagccctgtgctgtcaccagaagcaca
gttaagatttctgaactccccgataacatgctttccacatctcgaaaggataaatcttct
atgttggcagaattggaatatttgcctacatacattgaaaattccaatgagactgccttc
tgcttaggcaaggaatcagaaaatggtcttagaaaacattcaccagatctcagagtggta
caaaaatatcccttactgaaagagcctcagtggaaatatcctgatatatctgacagcatt
agcacagaaagaatactcgacgattcaaaggattcagttggagactcactttcaggaaaa
gaggacttgggcagaaagagaacaactatgcttaagattgcaacagccgcaaaggtagtg
aatgctaatcagaatgcctctccaaatgtccctggaaaaagaggaaggccacgaaaattg
aaactctgtaaggcaggacgaccacctaagaacacaggaaagtctttaatttctacaaag
aatacacctgtaagccctgggagtacctttccagatgtgaagcctgatctggaagatgtg
gatggtgttctctttgtttcctttgaatcaaaggaagctctagacattcatgcagttgat
gggacaacagaagaatcttctagtctccaggcatcaaccacaaatgactcaggttacaga
gcaagaatttcccagttggaaaaggaattgatagaagatttgaagactttgcggcacaag
caggtgatacatcctggtcttcaagaagtgggcttaaaattgaattcagtggatccaaca
atgagcattgatcttaaatacttgggagtacagttacctttggctccagctactagcttt
cctttttggaaccttacaggaaccaaccctgcctctcctgatgcgggatttccctttgtt
tctaggacagggaaaaccaatgatttcactaagatcaagggatggaggggaaaatttcat
agtgcttctgcatctaggaatgaaggtggaaattcagaaagttcactgaaaaatcgttct
gctttctgtagtgataagctagatgaatacttggaaaatgaaggcaagctgatggaaaca
agcatgggtttttcttctaatgctcccacatctcctgtggtgtaccagcttcccactaag
agtaccagttatgtacgaacacttgatagtgtactaaagaagcaatctactatttcccct
tctacctcttattctttgaaacctcattctgtaccccctgtctctcgaaaggcaaagtct
caaaacagacaggcaactttcagtggccgaactaaatcatcttataaatccattttacca
taccctgtttcaccaaagcagaaatactctcatgtgattctaggagataaggttaccaag
aattcttcaggcatcatctcagaaaatcaggcgaataactttgttgtgccaactttggat
gaaaatatatttccaaagcagattagtttgcggcaggcacagcagcagcagcaacagcaa
cagggaagtcgccctccaggcttgtctaaatctcaggtgaagctaatggacctggaagac
tgtgcactttgggaaggaaaaccaaggacatacatcacagaagagcgagcagatgtatcc
ttaacaactctacttacagctcaagcatccctcaaaactaaacctatccacacaatcata
aggaaacgagcccctccctgcaacaatgacttctgtcgactgggttgtgtatgttccagt
ctagctttggagaagcgccaacctgctcactgccgccgaccagactgcatgtttggttgt
acttgtttgaaaagaaaagttgtacttgttaaaggaggatccaaaactaagcattttcag
aggaaggctgctcatcgagatccagtattttatgatactctgggagaggaggcaagggag
gaggaagaaggaatcagggaggaggaggaacaattgaaagagaaaaagaagagaaagaag
ctagaatacactatatgtgagacagagcctgaacagcctgttcgacattacccattatgg
gtaaaagtagaaggtgaagtagatccagaaccagtttatatccccacgccttctgtcatt
gagcctatgaaaccattgttattgcctcagccagaagttttatctcctactgtgaagggc
aaactgctcactggaattaaatctccacggtcatatactcccaaacccaatcctgtgatt
cgggaagaggacaaagatccagtctacttgtactttgaaagtatgatgacttgtgctcga
gttcgagtatatgagcgaaaaaaagaggaccagagacaaccatcttcctcctcctcccca
tctccatcatttcagcagcaaacttcatgtcattctagccctgagaaccataataatgca
aaggaacctgattctgaacagcagcccttaaaacaactcacctgtgacttggaggatgat
tctgataaattacaagaaaagagctggaagtcttcctgcaatgaaggagaatcctcttct
acttcttatatgcatcagaggtcacctggtggtcccaccaaactgattgagatcatctca
gactgcaactgggaggaagatcggaacaagattttgagcatcttatcccagcacatcaat
agcaacatgccacaatcacttaaggtgggcagcttcatcattgagttggcttctcagcga
aagagccggggtgagaagaaccctcctgtttattcttctcgtgtgaaaatctctatgcca
tcatgtcaagaccaagatgatatggctgagaaatctggatcagagactcctgatggtcca
ttgtcccctgggaaaatggaggatatctctcctgtgcagacagatgccctggattcagtg
agggagagattacatggaggcaaaggtctgcctttttatgcagggctttctcctgcaggg
aagcttgtggcctataaacgtaaacccagttcaagtacatctgggcttatccaggtagca
tccaatgccaaggtggctgcatccaggaaaccacgtaccctgttgccttcaacatccaat
tccaaaatggcatcctcctctggcactgcaacaaatcgccctgggaagaatctgaaggcg
tttgtcccagcaaaacggccaattgcggctcgaccctctcctggtggtgtgttcacacag
tttgtgatgagtaaagttggagccttgcagcagaagatacctggagttagcacaccccaa
accctggcagggacacagaagttcagtatcagaccttctccagtaatggtcgtcacacct
gtggtttcttctgagccagttcaggtgtgcagccctgtgactgctgctgtcactactacc
acccctcaagtgtttttagaaaatactactgctgtgacacctatgactgctatttctgac
gtggaaactaaagaaactacttattcttctggtgccaccactacaggggttgttgaggtc
tctgaaactaataccagcacctctgtaacatctacccagtctacagccactgtgaacctt
accaaaaccactgggataactacccctgtggcttcagttgcttttcctaagtctttggta
gcatctccttcaaccataactcttcctgttgcttccactgcttccacctccttagtcgtg
gtgactgcagctgcatcttcctccatggtgaccacaccaacttcatctctgggctctgtt
cctattatactctcaggaattaatgggagtccaccagtgagccagagaccagaaaatgct
gctcaaattccagtggctactccacaggtctctcctaacacagtgaaacgtgctggacct
cgattgttgttgattccagtgcagcagggttctcctactcttagacctgtctcaaacaca
caacttcagggacatcggatggtcttgcagcctgttaggagtccaagtggaatgaactta
ttcaggcaccctaatgggcagattgtccagcttctacctttgcatcagcttcgaggctct
aatacccagcccaacttacagcctgtcatgtttcggaacccagggtctgtgatgggaatc
cggttacctgctccttccaaaccctctgagactccgccatcttccacttcgtcctctgct
ttctctgtcatgaatcctgtaattcaagctgttgggtcttcttcagcagtgaatgttatc
actcaggcaccatcattgctttcctctggagctagttttgtgtctcaggctggtacattg
accctgaggatttctcctcctgaaccacaaagctttgcaagtaaaacaggctctgaaacc
aaaataacttatagctcaggaggacagcctgttggtacagccagtcttattcctctccag
tctggtagttttgccttgttacagctcccaggacaaaagcctgttcctagctccattctt
cagcatgttgcttcccttcagatgaagagagaatctcagaatccagaccagaaagatgaa
acaaactcaataaaaagagagcaagaaacgaagaaggttctacagtcagaaggagaggct
gtagaccctgaggctaatgtaataaaacaaaactcaggagctgctacctcagaagaaact
ctgaatgattccttggaagataggggtgatcatttggatgaagaatgccttccagaagaa
ggttgtgcaactgtcaaaccatctgagcattcctgtatcactgggtcacatacagatcaa
gattataaagatgttaatgaagaatatggggctaggaatcgtaagagttccaaagaaaaa
gtggctgttctggaagttaggaccatttctgaaaaagccagtaataagacagtccaaaat
ttaagtaaagtacagcatcaaaaacttggtgatgtgaaggtggaacagcagaaaggattt
gacaatccagaagaaaactcaagtgaatttccagtcacctttaaggaagaaagtaaattt
gaattgtcaggaagcaaagttatggagcagcaatctaatctacagccagaggccaaagag
aaggaatgtggagactctctggagaaagacagggaaagatggagaaaacatctgaagggc
cccttaaccaggaaatgtgttggagcttcacaggaatgtaagaaagaggcagacgagcag
ttaattaaagaaacaaagacatgtcaggaaaattcagatgtgtttcagcaagaacaaggc
atctctgacttacttggaaaaagtggaattactgaagatgccagagttttgaaaactgaa
tgtgattcttggagtaggatttctaatccttcagccttctccattgttcctaggagagct
gcaaaaagcagcagagggaatggacattttcagggtcacttactgctacctggagaacag
atacaaccaaagcaagagaagaagggtgggagaagcagtgctgacttcactgttttggat
ttggaagaagatgatgaagatgataatgagaaaactgatgattctattgatgaaattgtg
gatgttgtttctgactaccagagtgaggaggttgatgatgtagaaaagaataactgtgta
gaatacattgaggatgatgaggagcacgtggacattgagactgtagaagagctctcagag
gaaattaatgttgctcacctgaagaccacagcggcccacacacagtcattcaaacagccg
tcctgtactcacatctctgcagatgaaaaagcagctgaaaggagtcgaaaggctccacca
attcctctaaaactgaagcctgattactggagtgacaaactacagaaagaagcagaagcg
tttgcttattatcgccggacacacactgccaatgagcggcggcggcgtggtgaaatgagg
gatctctttgagaaattaaagatcacattgggattacttcattcttccaaggtttccaaa
agtctcattcttactcgagccttcagtgaaattcagggactaacagatcaggcagacaaa
ttgataggacagaaaaatctcctgactcgaaaacggaatattctgatacggaaagtatcg
tctctttcaggtaagacagaagaagtggtcctgaagaagctagagtatatttatgcaaaa
cagcaagcactagaggcacaaaaaagaaaaaagaagatgggatcagatgagtttgacata
tctcccagaattagcaaacagcaggaaggatcttctgcatcatctgtagatcttggacag
atgtttataaataacaggagggggaaacctttgattctttccagaaaaaaagaccaggcc
acagaaaatacctcacccttgaacactccacacacctctgccaaccttgtgatgactccg
caagggcaattgctcaccctaaaaggtcccctattctcaggaccagtggtagctgtttct
cctgatctcttagaatctgatcttaagcctcaagttgccggtagtgctgtggctctacca
gaaaatgacgacttatttatgatgccacgaattgttaatgtgacatcattggccacagag
ggaggtttggtagatatgggtggcagcaaatatcctcatgaagttcctgatagcaagcca
tctgaccatctgaaagacaccgtcaggaatgaagataattccttagaggataagggtaga
atctcttccagaggaaacagagatggcagagtgacgttgggtccaacgcaggtttttctg
gcaaacaaagattctggttatccacaaatagttgacgtttccaatatgcagaaagcacaa
gagttcttacctaaaaagatttctggtgatatgagagggattcagtataaatggaaagag
agtgaatcaagaggggagagagtgaagtcaaaggattcttcatttcataaattaaagatg
aaagatctcaaggactcaagcatagagatggaactgaggaaagtaacatcagctatagag
gaagcagctcttgattccagtgaactgctgactaacatggaagatgaggatgatactgat
gagacactgacttcactgctcaatgaaattgcctttcttaatcaacaactaaatgatgac
tctgttggcctggctgaactacccagctctatggatacagagttcccaggggatgctcgg
cgggcttttattagtaaggttcctcctggaagcagagcaactttccaggttgagcacttg
ggaactggtttgaaagagttgcctgatgttcaaggggagagtgactctatcagtcccctc
ctcttgcacttggaagacgatgacttttctgagaatgaaaaacaacttgcagaaccagcc
tctgagccagatgtccttaagattgttattgactctgaaataaaggattccctcctttcc
aacaagaaagctattgatggagggaagaatacttctggcctccctgcagagcccgaaagt
gtgtcctcaccccccaccctacacatgaagactggcttggagaacagcaacagcacagac
actttgtggaggcctatgccaaagttggcccctctaggtttaaaagtagctaatccttcc
agtgatgcagatggtcagagtctcaaggtgatgccttgtttggcacctatagctgccaaa
gttgggtcagttggacacaaaatgaacttaacagggaatgaccaggaaggccgggaaagc
aaggtgatgcctacattggcacctgttgtggctaaattgggcaactcgggggcctcacca
agttctgcagggaaatga

Homo sapiens (human): 4149

Entry

4149              CDS       T01001

Symbol

MAX, PDMCS, bHLHd4

Name

(RefSeq) MYC associated factor X

K04453

Max protein

Organism

hsa Homo sapiens (human)

Pathway

hsa03083

Polycomb repressive complex

hsa04010

MAPK signaling pathway

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05222

Small cell lung cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06240  Transcription (cancer)
nt06267  Small cell lung cancer
nt06523  Epigenetic regulation by Polycomb complexes
nt06526  MAPK signaling

Element

N00088

Amplified MYC to p15-cell cycle G1/S

N00089

Amplified MYC to cell cycle G1/S

N00090

p15-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00131

Amplified MYCN to transcriptional activation

N00132

Amplified MYCN to transcriptional repression

N01602

ERK-MYC signaling pathway

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

Disease

H01510

Malignant paraganglioma

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    4149 (MAX)
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4149 (MAX)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4149 (MAX)
   05202 Transcriptional misregulation in cancer
    4149 (MAX)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    4149 (MAX)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4149 (MAX)
   03036 Chromosome and associated proteins [BR:hsa03036]
    4149 (MAX)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Mad/Max
    4149 (MAX)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     4149 (MAX)

SSDB

Motif

Pfam:

HLH JetA Filament bZIP_2 bHLH_INO4 SlyX bHLH_INO2 SLX9 GAGA_bind DUF7801 DUF4763 XhlA Csm1_N ATG16

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

14:complement(65006101..65102695)

AA seq 160 aa
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS

NT seq 483 nt +upstreamnt +downstreamnt
atgagcgataacgatgacatcgaggtggagagcgacgaagagcaaccgaggtttcaatct
gcggctgacaaacgggctcatcataatgcactggaacgaaaacgtagggaccacatcaaa
gacagctttcacagtttgcgggactcagtcccatcactccaaggagagaaggcatcccgg
gcccaaatcctagacaaagccacagaatatatccagtatatgcgaaggaaaaaccacaca
caccagcaagatattgacgacctcaagcggcagaatgctcttctggagcagcaagtccgt
gcactggagaaggcgaggtcaagtgcccaactgcagaccaactacccctcctcagacaac
agcctctacaccaacgccaagggcagcaccatctctgccttcgatgggggctcggactcc
agctcggagtctgagcctgaagagccccaaagcaggaagaagctccggatggaggccagc
taa

Homo sapiens (human): 83746

Entry

83746             CDS       T01001

Symbol

L3MBTL2, H-l(3)mbt-l, L3MBT

Name

(RefSeq) L3MBTL histone methyl-lysine binding protein 2

K24387

lethal(3)malignant brain tumor-like protein

Organism

hsa Homo sapiens (human)

Pathway

hsa03083

Polycomb repressive complex

Network

nt06506 Double-strand break repair
nt06523 Epigenetic regulation by Polycomb complexes

Element

N01439

Double-strand break signaling

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    83746 (L3MBTL2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    83746 (L3MBTL2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    83746 (L3MBTL2)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Zinc finger
   Cys2HisCys zinc factors
    83746 (L3MBTL2)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     83746 (L3MBTL2)

SSDB

Motif

Pfam:

MBT zf-FCS_1 MSL3_chromo-like

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

22:41205312..41231271

AA seq 705 aa
MEKPRSIEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDRE
AGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSS
NSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFD
WGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAG
YRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKR
LVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDG
DSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRA
VYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHAS
SHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGM
KLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQ
LQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKI
SSEPVPGEIIAVRVKEEHLDVASPDKASSPELPVSVENIKQETDD

NT seq 2118 nt +upstreamnt +downstreamnt
atggagaagccccggagtattgaggagaccccatcttcagaaccaatggaggaagaggaa
gatgacgacttggagctgtttggtggctatgatagtttccggagttataacagcagtgtg
ggcagtgagagcagctcctatctggaggagtcaagtgaagcagaaaatgaggatcgggaa
gcaggggaactgccgacctccccgctgcatttgctcagccctgggactcctcgctccttg
gatggcagtggttctgagccagctgtctgtgagatgtgtggtatcgtgggtacaagggaa
gccttcttctccaagaccaagaggttctgcagcgtctcctgctccaggagctactcctcc
aactccaagaaagccagtatcttggctaggttacagggaaaaccaccgaccaaaaaagcc
aaagtcctgcacaaggctgcctggtctgccaaaattggagccttcctccactctcaaggg
acaggacagctggcagatgggacaccaacaggacaagacgctctggtcttgggcttcgac
tgggggaagttcctgaaggatcacagttacaaggctgctcccgtcagctgtttcaagcac
gtcccactctatgaccagtgggaggatgtgatgaaagggatgaaggtggaggtgctcaac
agtgatgctgtgctccccagccgggtgtactggatcgcctctgtcatccagacagcaggg
tatcgggtgctgcttcggtatgaaggctttgaaaatgacgccagccatgacttctggtgc
aacctgggaacagtggatgtccaccccattggctggtgtgccatcaacagcaagatccta
gtgcccccacggaccatccatgccaagttcaccgactggaagggctacctcatgaaacgg
ctggtgggctccaggacgcttcccgtggatttccacatcaagatggtggagagcatgaag
tacccctttaggcagggcatgcggctggaagtggtggacaagtcccaggtgtcacgcact
cgcatggctgtggtggacacagtaatcgggggtcgcctacggctcctctacgaggatggt
gacagtgacgacgacttctggtgccacatgtggagccccctgatccacccagtgggttgg
tcacgacgtgtgggccacggcatcaagatgtcagagaggcgaagtgacatggcccatcac
cccaccttccggaagatctactgtgatgccgttccttacctcttcaagaaggtacgagca
gtctacacagaaggcggttggtttgaggaagggatgaagctggaggccattgaccccctg
aatctgggcaacatctgcgtggcaactgtctgtaaggttctcctggatggatacctgatg
atctgtgtggacggggggccctccacagatggcttggactggttctgctaccatgcctct
tcccacgccatcttcccggccaccttctgtcagaagaatgacattgagctcacaccgcca
aaaggttatgaggcacagactttcaactgggagaactacttggagaagaccaagtcgaaa
gccgctccatcgagactctttaacatggattgcccaaaccatggcttcaaggtgggcatg
aagctggaggccgtggacctgatggagccccggctcatctgtgtggccacggtgaaacga
gtggtgcatcggctcctcagcatccactttgacggctgggacagcgagtacgaccagtgg
gtggactgcgagtccccagacatctaccccgtcggctggtgtgagctcaccggctaccag
ctccagcctcctgtggccgcagaaccggccacaccgctgaaggccaaagaggccacaaag
aagaaaaagaaacagtttgggaagaaaaggaaaagaatcccgcccactaagacgcgaccc
ctcagacaggggtccaagaagcccctgctggaggacgaccctcagggtgccaggaagatc
tcgtcggagcctgttcctggcgagatcattgctgtgcgtgtgaaggaagagcatctagac
gtggcctcgcccgacaaggcttcaagtccagagctgcctgtctccgtcgagaacatcaag
caggaaacagacgactga

Homo sapiens (human): 1876

Entry

1876              CDS       T01001

Symbol

E2F6, E2F-6

Name

(RefSeq) E2F transcription factor 6

K09390

transcription factor E2F6

Organism

hsa Homo sapiens (human)

Pathway

hsa03083

Polycomb repressive complex

Network

nt06523 Epigenetic regulation by Polycomb complexes

Element

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    1876 (E2F6)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1876 (E2F6)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1876 (E2F6)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1876 (E2F6)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     1876 (E2F6)

SSDB

Motif

Pfam:

E2F_CC-MB E2F_TDP TrmB BRCA-2_OB3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

2:complement(11444375..11466161)

AA seq 281 aa
MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVK
RPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKS
KNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERL
AYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQ
GQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN

NT seq 846 nt +upstreamnt +downstreamnt
atgagtcagcagcggccggcgaggaagttacccagtctcctcctggacccgacggaggag
acggttcgccgtcggtgccgagaccccatcaacgtggagggcctgctgccatcaaaaata
aggattaatttagaagataatgtacaatatgtgtccatgagaaaagctctaaaagtgaag
agacctcgttttgatgtatcgctggtttatttaactcgaaaatttatggatcttgtcaga
tctgctcccgggggtattcttgacttaaacaaggttgcaacgaaactgggagtccgaaag
cggagagtgtatgacatcaccaatgtcttagatggaatcgacctcgttgaaaagaaatcc
aagaaccatattagatggataggatctgatcttagcaattttggagcagttccccaacaa
aagaagctacaggaggaactttctgacttatcagcaatggaagatgctttggatgagtta
attaaggattgtgctcagcagctgtttgagttaacagatgacaaagaaaatgaaagacta
gcatatgtgacctatcaagacattcatagcattcaggccttccatgaacagatcgtcatt
gcagttaaagctccagcagaaaccagattggatgttccagctcccagagaagactctatc
acagtgcacataaggagcaccaacggacctatcgatgtctatttgtgtgaagtggagcag
ggtcagaccagtaacaaaaggtctgaaggtgtcgggacctcttcatctgagagcactcat
ccagaaggccctgaggaagaagaaaatcctcagcaaagtgaagaattgcttgaagtaagc
aactga

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