KEGG ORTHOLOGY: K04453

ORTHOLOGY: K04453

Entry

K04453                      KO

Symbol

MAX

Name

Max protein

Pathway

map03083

Polycomb repressive complex

map04010

MAPK signaling pathway

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05222

Small cell lung cancer

Disease

H01510

Malignant paraganglioma

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K04453  MAX; Max protein
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04453  MAX; Max protein
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04453  MAX; Max protein
   05202 Transcriptional misregulation in cancer
    K04453  MAX; Max protein
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K04453  MAX; Max protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04453  MAX; Max protein
   03036 Chromosome and associated proteins
    K04453  MAX; Max protein
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Mad/Max
    K04453  MAX; Max protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     K04453  MAX; Max protein

Genes

HSA:

4149(MAX)

PTR:	452972(MAX)

PPS:	100993044(MAX)

GGO:	101153449(MAX)

PON:	100436950(MAX)

PPYG:

129013341(MAX)

NLE:	100601755(MAX)

HMH:	116484930(MAX)

SSYN:

129487765(MAX)

MCC:	708228(MAX)

MCF:	101866471(MAX)

MTHB:

126959765

MNI:	105473705(MAX)

CSAB:

103229182(MAX)

CATY:

105582838(MAX)

PANU:

101016934(MAX)

TGE:	112628931(MAX)

MLEU:

105538450(MAX)

RRO:	104678435(MAX)

RBB:	108542424(MAX)

TFN:	117069468(MAX)

PTEH:

111555948(MAX)

CANG:

105517267(MAX) 105526262

CJC:	100389089(MAX) 103793292

SBQ:	101027820(MAX)

CIMI:

108308255(MAX)

ANAN:

105725175(MAX)

CSYR:

103264144(MAX) 103268641

MMUR:

105878355(MAX)

LCAT:

123647856(MAX)

PCOQ:

105819899(MAX)

OGA:	100943049(MAX)

MMU:	17187(Max)

MCAL:

110306748(Max)

MPAH:

110324327(Max)

RNO:	60661(Max)

MCOC:

116079888(Max)

ANU:	117697364(Max)

ASYL:

127683572 127687210(Max)

MUN:	110547767(Max)

CGE:	100752515(Max)

MAUA:

101828909(Max) 121140006

PROB:

127230719(Max)

PLEU:

114697754(Max)

MORG:

121452541(Max)

MFOT:

126508433

AAMP:

119805389 119820001(Max) 119825996

NGI:	103749276(Max)

HGL:	101699034(Max)

CPOC:

100718960(Max)

CCAN:

109691135(Max)

DORD:

105986278(Max)

DSP:	122117976(Max)

PLOP:

125363063(Max)

NCAR:

124978146

MMMA:

107143410(Max)

ITI:	101954385 101977815(Max)

OCU:

100342232

OPI:	101524869(MAX)

TUP:	102480187(MAX)

GVR:	103598878(MAX)

CFA:	609969(MAX)

CLUD:

112657138(MAX)

VVP:	112927173(MAX)

VLG:	121493521(MAX)

NPO:	129496198(MAX)

AML:	100468226(MAX)

UMR:	103672194(MAX)

UAH:	113246305(MAX)

UAR:	123800635(MAX)

ELK:

111161903

LLV:

125104744

MPUF:

101682511(MAX)

MNP:	132000038(MAX)

MLK:	131836691(MAX)

NVS:	122893141(MAX)

ORO:	101385122(MAX)

EJU:	114219260(MAX)

ZCA:	113909959(MAX) 113928522

MLX:	118002293(MAX)

NSU:	110585644 110590511(MAX)

LWW:	102737289(MAX)

FCA:	493947(MAX)

PYU:	121031911(MAX)

PCOO:

112856021(MAX)

PBG:	122469223(MAX)

PVIV:

125168176(MAX)

LRUF:

124512113

LGF:	123583992(MAX)

AJU:

106971305

PTG:	102965935(MAX)

PPAD:

109268318(MAX)

PUC:

125908721

PLEZ:

122222834(MAX)

HHV:	120238410(MAX)

BTA:	540616(MAX)

BOM:	102288254(MAX)

BIU:	109565255(MAX)

BBUB:

102403823 102407719(MAX)

BBIS:

104993471(MAX)

CHX:	102176130(MAX)

OAS:	101120670(MAX)

BTAX:

128054008(MAX)

CSUM:

138072855(MAX)

ODA:	120852828(MAX)

CCAD:

122443760(MAX) 122449871

MREE:

136172011(MAX)

OVR:	110128421(MAX)

MBEZ:

129562905(MAX)

SSC:	100517170(MAX)

CFR:	102505857(MAX)

CBAI:

105074678(MAX)

CDK:	105086182(MAX)

VPC:	102545898(MAX)

BACU:

102999653(MAX)

BMUS:

118884875 118890293(MAX)

LVE:	103073636(MAX)

OOR:	101278435(MAX)

LALB:

132515111(MAX)

DLE:	111173064(MAX)

PCAD:

102989857(MAX)

PSIU:

116749058(MAX)

PPHC:

136118600(MAX)

NASI:

112403389(MAX)

ECB:	100062536(MAX)

EPZ:	103550221(MAX)

EAI:	106844892(MAX)

MYB:	102261098(MAX)

MYD:	102775328(MAX)

MMYO:

118656510(MAX) 118666425

MLF:	102422986(MAX)

MDT:	132233171(MAX) 132242482

MYUM:

139012390(MAX)

PKL:	118716611(MAX)

EFUS:

103283651(MAX) 103299482

MNA:	107545703(MAX)

DRO:	112311197(MAX)

SHON:

118976606(MAX)

AJM:	119034798(MAX)

PDIC:

114491606(MAX)

PHAS:

123808565(MAX)

MMF:	118629292(MAX)

PPAM:

129065957(MAX)

HAI:	109382105(MAX)

RFQ:	117022982(MAX)

PALE:

102881979(MAX)

PGIG:

120612751(MAX)

PVP:	105308374(MAX)

RAY:	107509313(MAX)

MJV:	108406934(MAX)

TOD:	119239195(MAX)

SARA:

101554854(MAX)

SFUM:

130023336 130041528(MAX)

SETR:

126004094(MAX)

LAV:	100656577(MAX)

TMU:

101353979

ETF:	101647489(MAX)

DNM:	101424026(MAX) 101436647 111761346

MDO:	100022806(MAX)

GAS:	123237731(MAX)

SHR:	100919026(MAX)

AFZ:

127549633

PCW:	110220610(MAX)

TVP:	118830018(MAX) 118837413

PBRV:

138156894(MAX)

OAA:	100084460(MAX)

TACU:

119944682(MAX)

GGA:	100858676(MAX)

PCOC:

116237864(MAX)

MGP:	100548488(MAX)

CJO:	107314155(MAX)

TPAI:

128087126(MAX)

LMUT:

125695346(MAX)

APLA:

113843846(MAX)

ACYG:

125180837(MAX)

CATA:

118244719(MAX)

AFUL:

116490171(MAX)

TGU:	115495675(MAX)

LSR:	110485007(MAX)

SCAN:

103822169(MAX)

PMOA:

120503649(MAX)

OTC:	121336794(MAX)

PRUF:

121352344(MAX)

ATRC:

139590424(MAX)

GFR:	102043365(MAX)

FAB:	101810608(MAX)

OMA:	130254519(MAX)

PHI:	102102208(MAX)

PMAJ:

107205598(MAX)

CCAE:

111944162(MAX)

CCW:	120410007(MAX)

CBRC:

103615249

ACOE:

138111249(MAX)

ETL:	114067988(MAX)

ZAB:	102072039(MAX)

ZLE:	135448864(MAX)

ACHL:

103810858

SVG:	106854750(MAX)

HRT:	120753787(MAX)

SATI:

136362312(MAX)

FPG:	101910897(MAX)

FCH:	102059179(MAX)

NNT:	104402542(MAX)

SHAB:

115607005(MAX)

TALA:

116962513(MAX)

ACHC:

115338447(MAX)

HLE:	104829816(MAX)

AGEN:

126047143

HHAR:

128153123(MAX)

GCL:

127017393

DPUB:

104299810

PPUS:

135186026(MAX)

NNI:	104020565 104021538

CBOY:

140653667(MAX)

CLV:	102096163(MAX)

CNIC:

135989284(MAX)

MUI:	104543366(MAX)

PLET:

104624460

CUCA:

104064422(MAX)

TEO:

104373496

RTD:	128908129(MAX)

CRID:

134514979(MAX)

AAM:	106487921(MAX)

AROW:

112971564(MAX)

NPD:	112954044(MAX)

DNE:	112993460(MAX)

SCAM:

104146982

ASN:	102385382(MAX)

AMJ:	102574691(MAX)

CPOO:

109318230(MAX)

PSS:	102452427(MAX)

CMY:	102937444(MAX)

CCAY:

125639151(MAX)

DCC:	119857757(MAX)

CPIC:

101937840(MAX)

TST:	117873113(MAX)

CABI:

116822173(MAX)

MRV:	120404691(MAX)

ACS:	100558914(max)

ASAO:

132765949 132769940 132773323(MAX) 132777087

PVT:	110085640(MAX)

SUND:

121931685(MAX)

PBI:	103048485(MAX)

PMUR:

107295134(MAX)

CTIG:

120312958(MAX)

TSR:	106538905(MAX)

PGUT:

117675323(MAX)

PTEX:

113441118(MAX)

NSS:	113410860(MAX)

VKO:	123027365(MAX)

PMUA:

114602294(MAX)

PRAF:

128419484(MAX)

ZVI:	118090400(MAX)

HCG:	128341137(MAX)

GJA:	107121946(MAX)

STOW:

125426491(MAX)

EMC:	129324905(MAX)

XLA:	373652(max.S) 504192(max.L)

XTR:	493570(max)

NPR:	108801671(MAX)

RTEM:

120920881(MAX)

ACAT:

141117049(MAX)

BBUF:

120981978(MAX)

BGAR:

122921958 122921962(MAX)

DTC:	141055622(MAX)

PWL:	138260425(MAX)

MUO:	115477377(MAX)

GSH:	117364149(MAX)

DRE:	30467(max)

SRX:	107721316 107756603

SANH:

107668248 107671780

SGH:	107549084(max) 107602050

CCAR:

109076649(max)

CAUA:

113063074 113120887

CGIB:

127938484 127983848

PTET:

122324482(max)

LROH:

127182965(max)

GRF:	141348919(max)

OMC:	131527339(max)

PPRM:

120493785(max)

RKG:	130075906(max)

MAMB:

125277965(max)

CIDE:

127502025

CERY:

137019001(max)

MASI:

127410021 127416272

TROS:

130565565(max)

TDW:	130434733(max)

MANU:

129429163(max)

PDAB:

135738791(max)

IPU:	108257598 108269635

IFU:	128600940(max) 128612360

PHYP:

113531907 113538763

SMEO:

124377005(max) 124390224

TFD:	113658048(max) 113659516

TVC:	132843049(max) 132852755

CGAR:

128514992(max) 128535909

NGRA:

132882694(max) 132894328

TRN:	134320775(max) 134325498

AMEX:

103034487(max) 103037189

CMAO:

118815693(max) 118823232

EEE:	113570159 113579858

CHAR:

105889819(max) 105909807

SPIL:

134068201 134097675

TRU:	101062892 101074290(max)

TFS:	130515833(max) 130539835

TNG:	GSTEN00030422G001

LCO:

104926710

NCC:	104948940 104963193(max)

TBEN:

117481798 117486937(max)

CGOB:

115027838 115028760

PGEO:

117439919(max) 117467703

GACU:

117549220(max) 117550122

EMAC:

134876575(max) 134881037

ELY:	117267233 117270460(max)

EFO:	125896731(max) 125901043

PLEP:

121953689 121955156(max)

SLUC:

116035744 116065982(max)

ECRA:

117935588 117961465(max)

ESP:	116670481 116706070(max)

PFLV:

114546402 114572764

GAT:	120807711(max) 120832598

PPUG:

119195126 119227208

AFB:	129103251 129107633(max)

CLUM:

117727179(max) 117751675

PSWI:

130201384 130202644(max)

CANA:

137785434 137788147

CVE:	137880428(max)

MSAM:

119903309 119908498(max) 119910476

SCHU:

122861882 122863227(max)

CUD:	121521085(max) 121526626

SPUL:

138591490 138613779(max)

LMIX:

132984791(max) 132992866

ALAT:

119005040 119012178(max)

ASTR:

137610773 137613190(max)

MZE:	101480189(max) 101485218

ONL:	100701192 100708975

OAU:	116312759(max) 116322347

OLA:	101169155 101172048

OML:	112140985(max) 112157417

CSAI:

133418628(max) 133462753

XMA:	102218347 102235228(max)

XCO:	114134657 114158538(max)

XHE:	116709476 116733997

PRET:

103457350 103458515

PFOR:

103130525(max) 103136133

PLAI:

106960041 106960864(max)

PMEI:

106909317 106932452(max)

GAF:	122824897(max) 122846578

PPRL:

129365243 129375457(max)

CVG:	107093666(max) 107097826

CTUL:

119785635(max) 119787578

GMU:	124855516 124882029(max)

NFU:	107374062 107377824 107392435

KMR:	108232653 108233473(max)

ALIM:

106511380 106522426

NWH:	119418600(max) 119427610

AOCE:

111569562(max) 111588183

EJA:	138199825 138205572(max)

BFRE:

138626677(max) 138632824

MCEP:

124998938(max) 125024065

CSEM:

103381206(max) 103393388

POV:	109627792 109636083(max)

SSEN:

122783178 122783809(max)

SSOE:

131443271(max) 131445243

HHIP:

117755916 117758535(max)

HSP:	118099471(max) 118116721

PPLT:

128451182 128460009(max)

SMAU:

118286582 118289780(max)

LCF:	108887267 108892591

SDU:	111226078 111238651(max)

SLAL:

111661445(max) 111663215

XGL:	120789036(max) 120795423

HCQ:	109516016 109523737(max)

SSCV:

125980425 125990283(max)

SBIA:

133496409(max) 133513603

PEE:	133412405 133416723(max)

PTAO:

133468135(max) 133488055

BPEC:

110155505 110168499(max)

ENY:	140360420(max) 140370392

MALB:

109962355 109967965

BSPL:

114848955 114849347(max)

SJO:	128375210(max)

SSCO:

133997645(max) 134000728

GMH:	115534509 115543862

SASA:

106571089 106588122(MAX) 106608157(MAX) 106611077

STRU:

115155633 115162357 115172642 115175134

OTW:	112233144 112235215 112236025 112256670

OMY:	110497944 110505517 110522592 110529304

OGO:	123990501 123995411 124001888 124046435

ONE:	115120425 115138482 115146245

OKI:	109878702 109880262 109894518 109904031

OKE:	118362464 118368336 118374180 118377164(max)

OMM:	135506231 135508237 135525898 135557944

OCLA:

139375241 139383865 139407400 139414904

SALP:

111968758 112073676 112080566

SNH:	120023545 120024281 120060156 120060226

CCLU:

121539258 121544930 121548532 121552946

ELS:	105015679 105024334(max)

OEP:	134024575(max) 134026978

SFM:	108919347(max)

PKI:	111838905(max)

AANG:

118229682(max) 118237164

AROT:

135250593 135257168

CCOG:

133105666 133128807(max)

LOC:	102688783(max)

PSPA:

121323818 121329756

ARUT:

117419511 117421915

PSEX:

120519150(max)

LCM:	102349973(MAX)

CMK:	103175219(max)

RTP:	109925396(max)

CPLA:

122553768(max)

HOC:	132817845(max)

LERI:

129700357(max)

HAKA:

140725136(max)

PMRN:

116948515 116953925

LRJ:	133352570 133356160(MAX)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG9648(Max)

DER:

6543554

DSE:

6618399

DSI:	Dsimw501_GD12293(Dsim_GD12293)

DYA:	Dyak_GE22514 Dyak_GE22918

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13548

DNV:

108652479

DHE:

111604513

DVI:	6622397(Max)

CCAT:

101456967

BOD:

106618565

BDR:

105222530

RZE:	108369047 108382551

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119610553 119612788

CVJ:	135954383(Max)

GFS:	119639077 119643293

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003297

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:	100744584 100744705

BBIF:

117217043 117217045

BVK:	117236503 117236516

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139106087(Max)

TLN:	139821554(Max)

HST:	105184362 105190379 112588035 112589884

DQU:

106742948

CFO:

105255666

FEX:

115242186

PMEC:

138931744(Max)

LHU:	105672297 105674939 137001541 137001542

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:	103570981 103575907

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217994(Max)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138124661(Max)

DPA:	109542684 109542685

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:	111418892 111422839

BMOR:

101744549

BMAN:

114247803

MSEX:

115443429

DPL:	KGM_202288

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137919684(Max)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141432645 141432982(Max)

CFEL:

113380199 113385775 113385780 113390997 113391005

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM220200

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_230745

DMK:

116935223

DPZ:

124316560

AFRA:

136029206

PVM:	113818098(Max)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123758372(Max)

CQD:	128694189(Max)

PTRU:

ESN:

MNZ:

MRJ:

PORN:

139746492(Max)

HAZT:

LSM:

TCF:

PPOI:

DSV:	119435538 119436749 119446819 119456607 119456609 119456610 119457984

RSAN:

119373987 119395012

RMP:	119167219 119172853

VDE:

VJA:

GOE:

TUT:

CSCU:

CVS:	136968242(Max)

PTEP:

107439766

ABRU:

129974859 129976572

UDV:

129216914

SDM:	118183794 118185588

LPOL:

106466890 106471589

PMEO:

129589913

CEL:	CELE_F46G10.6(mxl-3) CELE_T19B10.11(mxl-1)

CBR:	CBG_07781(Cbr-mxl-3) CBG_23147(Cbr-mxl-1)

CRQ:	GCK72_016672 GCK72_025483

NAI:	NECAME_05371

BMY:	BM_BM5839(Bma-mxl-1)

LOA:	LOAG_06802

HRO:	HELRODRAFT_85565

LGI:	LOTGIDRAFT_133235 LOTGIDRAFT_88480

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111130850 111130852

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115222535 115229045

LJP:

LAK:

LLON:

EPA:

ATEN:

ADF:	107332995 107333389

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114525600 114541954

XEN:

124453169

HMG:	100215471(max) 105845881

HSY:	130612185 130641516

RES:

135681315

TAD:	TRIADDRAFT_51792

MBR:	MONBRDRAFT_44311(MbMAX)

SPIB:

PPE:

PPEN:

Reference

PMID:16908182

Authors

Hurlin PJ, Huang J

Title

The MAX-interacting transcription factor network.

Journal

Semin Cancer Biol 16:265-74 (2006)
DOI:10.1016/j.semcancer.2006.07.009

Sequence

[hsa:4149]

LinkDB

DBGET integrated database retrieval system