KEGG   Homo sapiens (human): 23365
Entry
23365             CDS       T01001                                 
Symbol
ARHGEF12, LARG, PRO2792
Name
(RefSeq) Rho guanine nucleotide exchange factor 12
  KO
K07532  Rho guanine nucleotide exchange factor 12
Organism
hsa  Homo sapiens (human)
Pathway
hsa04270  Vascular smooth muscle contraction
hsa04360  Axon guidance
hsa04611  Platelet activation
hsa04625  C-type lectin receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05130  Pathogenic Escherichia coli infection
hsa05135  Yersinia infection
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
Network
nt06124  Chemokine signaling (viruses)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00405  CXCR4-GNA12/13-Rho signaling pathway
N00406  HCMV US28 to GNA12/13-Rho signaling pathway
N01088  Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway
N01097  LPA-GNA12/13-RhoA signaling pathway
N01104  LPA-GNAQ/11-RhoA signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    23365 (ARHGEF12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    23365 (ARHGEF12)
   04625 C-type lectin receptor signaling pathway
    23365 (ARHGEF12)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    23365 (ARHGEF12)
  09158 Development and regeneration
   04360 Axon guidance
    23365 (ARHGEF12)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    23365 (ARHGEF12)
   05205 Proteoglycans in cancer
    23365 (ARHGEF12)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    23365 (ARHGEF12)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    23365 (ARHGEF12)
   05135 Yersinia infection
    23365 (ARHGEF12)
   05152 Tuberculosis
    23365 (ARHGEF12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23365 (ARHGEF12)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    23365 (ARHGEF12)
SSDB
Motif
Pfam: RGS-like PH_16 RhoGEF PDZ PDZ_6 PDZ_2 Peptidase_M50 Ribonuc_2-5A Tricorn_PDZ AAA_23
Other DBs
NCBI-GeneID: 23365
NCBI-ProteinID: NP_056128
OMIM: 604763
HGNC: 14193
Ensembl: ENSG00000196914
Pharos: Q9NZN5(Tbio)
UniProt: Q9NZN5 B4E2K6
Structure
LinkDB
Position
11:120336413..120489937
AA seq 1544 aa
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS
RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR
IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY
LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ
VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK
PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS
GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK
QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH
FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ
PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ
SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS
NT seq 4635 nt   +upstreamnt  +downstreamnt
atgagtggcacacagtctactatcaccgacaggtttcccctcaaaaaacctataaggcat
ggaagtattttgaaccgagagtcaccaacagataagaagcagaaagttgagcgcattgca
tcacatgattttgaccccacagatagctcctccaagaagacaaagtctagttcagaggag
agtagatccgagatatatggtcttgttcagcgttgcgtaatcatccagaaagatgacaat
ggatttgggctgacggtcagtggagacaatccagtcttcgtacagtctgtcaaagaagat
ggagcagccatgcgggctggagtacagacaggtgatcgaatcatcaaggtgaatggaact
ctggtgactcattcaaatcatctggaggtggtgaagctaatcaaatctggttcctatgta
gctctcactgttcagggacgcccacctgggtcgccccagattccacttgccgactctgaa
gtagagccgtcagtcattggacatatgtctcccatcatgacatctcctcattcacctgga
gcatctgggaatatggagagaatcactagtcctgtgctcatgggggaggaaaacaatgtg
gttcataaccagaaagtagaaattctgagaaaaatgttacagaaagaacaggaacggcta
cagttattgcaggaagattacaaccgaacacctgcccaaagattgctaaaagagatccaa
gaggccaagaaacacattcctcagctgcaagagcagttatccaaagccacaggctctgct
caggatggagctgtagttacaccctccagacctttaggggacaccctaacagtcagtgag
gcagaaacagatcctggagatgtactgggcaggactgactgtagcagtggagatgcttct
cggcccagtagtgacaatgcagatagtcccaagagtggcccaaaagagagaatttatcta
gaggaaaacccagagaaaagtgaaacaattcaggacactgacactcaatcacttgtcgga
agtccctcaacccgtatagcacctcatattattggagcagaagatgatgattttggtact
gaacatgaacagatcaatggacagtgcagctgtttccagagcattgaattactaaaatct
cgcccggctcatttggctgttttcttacaccatgtagtttcacaatttgaccctgcgact
ttgctctgttatctctattcagacctgtataaacataccaattccaaagaaactcgtcgc
atcttccttgagtttcatcagttctttctagatcgatcagcacacctgaaagtttctgtt
cctgatgaaatgtctgcagatctagaaaagagaagacctgagctcattcctgaggatctg
catcgccactatatccaaactatgcaagaaagagtccatccagaagttcaaaggcactta
gaagattttcggcagaaacgtagtatgggactgaccttggctgaaagcgagctgactaaa
cttgatgcagagcgagacaaggaccgattgactttggagaaggagcggacatgtgcagaa
cagattgttgccaaaattgaagaagtattgatgactgctcaggctgtagaggaagataag
agctccaccatgcagtatgttattctcatgtatatgaagcatttgggagtaaaagtgaaa
gagcctcgaaatttggagcacaaacggggtcggattggatttcttcccaaaatcaagcaa
agtatgaagaaagataaagaaggggaagaaaaagggaagcgaagaggattccccagcatc
ctgggacccccacggagaccaagccgtcatgacaacagtgcaattggcagagccatggaa
ctacagaaggcgcgccaccctaagcacttatccacaccctcatctgtgagtcctgaacct
caggactctgccaagttgcgccagagtgggttagcaaatgaaggaacagacgctggatac
ctgcctgccaattccatgtcttctgtagcttcaggggcctctttttcccaggaaggaggg
aaagagaatgatacaggatcaaagcaagttggagaaacatcagcacctggagacacctta
gatggcacacctcgtactctcaatactgtctttgatttcccaccacctccattagaccaa
gtgcaggaggaggaatgtgaagtagaaagggtgactgaacatgggacaccaaagcccttt
cgaaagtttgacagtgtagcttttggagaaagtcaaagtgaggatgaacaatttgaaaat
gacttagagacagatccacccaactggcagcagcttgttagtcgagaagtgttactggga
ctaaaaccttgtgaaatcaaaagacaggaagtgattaatgaattgttctacactgaaaga
gctcatgttcgaacactgaaggttcttgatcaagtgttctatcagcgagtatccagagaa
ggaattctgtcaccctcagagctacggaaaattttttcaaacttggaagatattcttcaa
cttcatattggattgaatgaacaaatgaaggctgttcgaaagagaaatgagacctctgtt
atcgatcagattggggaagatttgctgacatggttcagcggaccaggagaggagaaattg
aaacatgctgctgctaccttttgcagtaaccaacctttcgccctggaaatgatcaaatct
cgtcagaaaaaggattctcgatttcagacttttgtgcaagatgctgaaagtaatccactg
tgtcgtcgtcttcaactgaaggatattattcccactcaaatgcaaaggcttactaagtac
ccacttctgttggataatattgccaaatacacagaatggccaacagaaagggagaaggtg
aagaaagctgcagatcactgtcgtcagatcttaaattatgtaaatcaggctgtcaaggag
gcagaaaacaagcagcgcctagaagattatcagcgtcgccttgatacctccagcctgaag
ttgtcagagtacccaaatgttgaagagctcaggaatttggatttaacaaaaaggaagatg
attcatgaagggccattggtttggaaggtgaatagagataaaactattgatttatacacg
ttgctgctggaagacattcttgtattgttacaaaagcaggatgatagactggttttaagg
tgtcatagtaagattctggcatctacagctgatagcaaacacacgtttagccctgtcatt
aagttgagtacagtgttggttcgacaagtggcaacagataacaaagctttattcgtcatt
tccatgtcagacaatggcgctcagatttatgaactggtggcacagacagtttctgaaaag
actgtctggcaggacctaatctgtcggatggctgcatcagtgaaggagcaatccacaaag
ccaattccattaccacagtcaacacctggcgaaggagataatgatgaagaagatccttca
aaattaaaagaggagcagcatggcatttcagtcactggtttgcagagtccagacagagat
ttgggattagaatctaccttaatatcgtcaaaacctcagtctcattcactgagtacctct
gggaaatcagaggtacgtgatctgtttgtggctgagagacagtttgcaaaggaacaacat
acagatgggacactaaaggaagttggagaagattatcaaatcgcaatcccagattcacac
ctgcctgtctcagaagaacggtgggcattggatgcactaagaaatttgggtttgttgaag
cagttgctggtgcaacagctaggtttgactgagaagagcgttcaggaagactggcaacat
ttcccaagatacagaacagcctctcaggggccgcagacagacagtgtcatccagaactct
gaaaatattaaggcctatcattctggtgaaggacatatgccctttagaactggaactggt
gacattgcaacttgttacagtccacggacttcaactgaatcttttgctccacgggattca
gtgggactggcaccccaggatagccaggcaagtaacattttagtaatggaccacatgatt
atgaccccagagatgcctaccatggagccagaagggggtcttgatgacagtggagagcac
ttttttgatgcccgtgaagcacatagtgatgagaatccatcagaaggtgatggagcagtt
aacaaggaagagaaggatgttaatttacgcatctcaggaaactatttgatccttgatggc
tatgacccagtgcaggagagttccacagatgaggaggttgcttcctcacttaccctgcag
cccatgacaggcatccctgctgtggaatccacccaccagcagcaacattctcctcagaat
actcactccgatggggcaatttcaccattcacccccgaatttctggtccagcagcgctgg
ggagctatggagtattcctgttttgagatccagagtccctcctcttgtgcagattcacag
agccagatcatggagtacattcataagatagaggctgaccttgaacacttaaagaaggtg
gaggaaagttacaccattctttgccaaaggctggctggatcagccctcacagacaagcac
tcagataaaagttag

KEGG   Homo sapiens (human): 64283
Entry
64283             CDS       T01001                                 
Symbol
ARHGEF28, RGNEF, RIP2, p190RHOGEF
Name
(RefSeq) Rho guanine nucleotide exchange factor 28
  KO
K21072  A-kinase anchor protein 28
Organism
hsa  Homo sapiens (human)
Pathway
hsa05135  Yersinia infection
Network
nt06135  Cytoskeletal regulation (viruses and bacteria)
  Element
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    64283 (ARHGEF28)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64283 (ARHGEF28)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    64283 (ARHGEF28)
SSDB
Motif
Pfam: PH_16 RhoGEF C1_1 PH C1_2 PHD Prok-RING_1 PH_13
Other DBs
NCBI-GeneID: 64283
NCBI-ProteinID: NP_001171164
OMIM: 612790
HGNC: 30322
Ensembl: ENSG00000214944
Pharos: Q8N1W1(Tbio)
UniProt: Q8N1W1
Structure
LinkDB
Position
5:73626196..73941990
AA seq 1705 aa
MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP
GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT
PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ
FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL
HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE
TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA
GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT
ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD
ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS
NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE
EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF
SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS
FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH
NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC
NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL
LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE
AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER
TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL
MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK
LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE
SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI
KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG
SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT
RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV
HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY
QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC
HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS
NVSHKLWTAAGSGHQILPFHESSKDSCKNDLDTSHTESPTPHDSNSHRPQLQAFITEAKL
NLPTRTMTRQDGETGDGAKENIVYL
NT seq 5118 nt   +upstreamnt  +downstreamnt
atggagttgagctgcagcgaagcacctctttacgggcagatgatgatctatgcgaagttt
gacaaaaatgtgtatcttcctgaagatgctgagttttactttacttatgacggatctcat
cagcgacatgtcatgattgcagagcgcatcgaggataacgttctccagtccagcgtccca
ggccatgggcttcaggagacggtgacggtatctgtgtgcctctgctcggaaggttactct
ccggtgaccatgggctctggctcagtgacctacgtggacaacatggcttgcaggctggct
cgtctgctggtgacgcaggccaatcgcctcacagcctgcagccaccagaccctgctgacc
ccatttgccttgacggcaggagcactgcctgccttggatgaggagctcgtgctggctctg
acccatctggaattgcctctagagtggactgtgttgggaagttcttcacttgaagtatct
tctcacagagaatctcttctacacctggctatgagatggggcctggctaaactttcccag
ttcttcttgtgtctcccggggggagtccaggccttggctttacccaacgaagagggtgcc
acaccattagacttagctttacgtgaaggacactccaagctggtggaagacgtcacaaat
tttcagggcagatggtccccaagcttctcccgagtgcagctcagtgaagaagcctccttg
cattacattcactcatcggaaacgctgaccctgaccctgaaccacacagccgagcatttg
ttggaggcagatattaaactcttccggaaatacttttgggatagagcctttcttgtcaag
gcctttgagccagaagccaggccagaggaaagaacagctatgccctccagcggtgcagaa
actgaagaagagattaagaattcagtgtccagcagatcagcagctgaaaaggaagatata
aagcgtgtcaaaagcctggtggttcaacacaatgaacatgaagaccagcacagcctagat
ttggatcgctccttcgatatcctaaaaaaatccaagccgccctcgacattgcttgctgca
ggccggctttcagacatgctgaatggaggtgatgaagtctacgctaactgtatggtgatt
gatcaggttggtgatttggatatcagctatattaatatagagggaatcactgccactacc
agccctgaatccagaggttgcactctgtggcctcagagcagcaaacacacccttcctaca
gaaaccagtcccagtgtgtacccacttagtgaaaatgtcgaagggacagcacacactgaa
gcccagcagtccttcatgtcaccatcaagttcgtgtgcttccaacttgaatctttctttt
ggttggcatggatttgaaaaggaacaaagtcatctaaagaaaagaagttctagccttgat
gccttggacgccgacagtgaaggggaagggcattctgagccatcccacatctgttacact
ccagggtctcagagctcctcaagaactgggattcctagtggggatgaattggactctttt
gagactaacactgaaccggattttaatatctccagggctgaatcccttcctctatcaagt
aatctacagtcgaaggaatcactgctttctggagttcgctcacgttcttattcttgctca
tcacccaaaatttctttaggaaaaactcgtttggtgcgtgaattaacagtatgcagttca
agtgaagagcaaagagcttacagcttatcggagccaccaagagaaaacagaattcaggaa
gaagaatgggataaatacatcatacctgccaaatcagagtctgaaaaatataaagtgagt
cgaactttcagtttcctcatgaataggatgactagccctcggaataaatcaaagacaaaa
agcaaggatgccaaagataaagagaagctgaatcgacatcagtttgccccaggaacattc
tctggggttctgcagtgtttggtttgtgataaaacactcctggggaaagagtcactgcag
tgttctaactgtaatgcaaatgtgcacaaaggttgtaaagatgctgcgcctgcatgcacc
aagaaattccaagagaaatataacaagaacaaaccacagaccatccttggaaattcttca
tttagagacatcccacagcctggtctctccttgcacccttcttcctccgtgcctgttgga
ttgccgactggaaggagggagactgtgggacaggtccatccattgtccagaagtgttcca
ggcaccaccttggaaagcttcaggaggtcagccacatccttggagtctgagagtgaccat
aacagctgcagaagcaggtctcattctgatgagctgctacagtccatgggctcttctccc
tctacagagtctttcataatggaagatgttgtggattcttctctgtggagtgacctcagc
agtgatgcccaggagtttgaagcagaatcttggagtcttgtggtggatccctcattttgt
aataggcaggagaaggatgtcatcaaaagacaggatgtcatttttgagctaatgcaaaca
gagatgcatcacatccagaccctgttcatcatgtctgagatcttcaggaaaggcatgaaa
gaggagctgcagctggaccacagcaccgtggataaaattttcccctgtttagatgagttg
cttgaaatccacaggcatttcttctacagtatgaaggaacgaaggcaggaatcctgtgct
ggcagcgacaggaattttgtgatcgaccgaattggagatattttggtacaacagttttca
gaagaaaatgcaagtaaaatgaagaaaatatatggagaattctgttgccatcataaagaa
gctgttaacctctttaaagaactccagcagaataaaaagtttcagaattttattaagctc
cgaaatagtaatcttttggctcgacgccgaggaattccagaatgcattctgttggtcact
cagcgtattacaaaataccctgtcttggtggaaaggatattgcagtacacaaaggaaaga
actgaggaacataaagacttacgcaaagcgctttgcttaattaaagacatgattgcaaca
gtggatttaaaagtcaatgaatatgagaaaaaccaaaaatggcttgagatcctaaataag
attgaaaacaaaacatacacgaagctcaaaaatggacatgtgtttaggaagcaggcactg
atgagtgaagaaaggactctgttatatgatggccttgtttactggaaaactgctacaggt
cgtttcaaagatatcctagctctacttctaactgatgtgctgctctttttacaagaaaaa
gaccagaaatacatctttgcagccgttgatcagaagccatcagttatttcccttcaaaag
cttattgctagagaagttgctaatgaggagagaggaatgtttctgatcagtgcttcatct
gctggtcctgagatgtatgaaattcacaccaattccaaggaggaacgcaataactggatg
agacggatccagcaggctgtagaaagttgtcctgaagaaaaagggggaaggacaagtgaa
tctgatgaagacaagaggaaagctgaagccagagtggccaaaattcagcaatgtcaagaa
atactcactaaccaagaccaacaaatttgtgcgtatttggaggagaagctgcatatctat
gctgaacttggagaactgagcggatttgaggacgtccatctagagccccacctccttatt
aaacctgacccaggcgagcctccccaggcagcctcattactggcagcagcactgaaagaa
gctgagagcctacaagttgcagtgaaggcctcacagatgggcgccgtgagtcaatcatgt
gaggacagttgtggagactctgtcttggcggacacactcagttctcatgatgtaccagga
tcaccgactgcctcattagtcacaggagggagagaaggaagaggctgttcggatgtggat
cccgggatccagggtgtggtaaccgacttggccgtctctgatgcaggggagaaggtggaa
tgtagaaattttccaggttcttcacaatcagagattatacaagccatacagaatttaacc
cgtctcttatacagccttcaggccgccttgaccattcaggacagccacattgagatccac
aggctggttctccagcagcaggagggcctgtctctcggccactctatcctccgaggcggc
cccttgcaggaccagaagtctcgcgacgcggacaggcagcatgaggagctggccaatgtg
caccagcttcagcaccagctccagcaggagcagcggcgctggctgcgcaggtgtgagcag
cagcagcgggcgcaggcgaccagggagagctggctgcaggagcgggagcgggagtgccag
tcgcaggaggagctgctgctgcggagccggggcgagctggacctccagctccaggagtac
cagcacagcctggagcggctgagggagggccagcgcctggtggagagggagcaggcgagg
atgcgggcccagcagagcctgctgggccactggaagcacggccggcagaggagcctgccc
gcggtgctccttccgggtggccccgaggtaatggaacttaatcgatctgagagtttatgt
catgaaaactcattcttcatcaatgaagctttagtacaaatgtcatttaacactttcaac
aaactgaatccatcagttatccatcaggatgccacttaccctacaactcaatctcattct
gacttggtgaggactagtgaacatcaagtagacctcaaggtggacccttctcagccttcg
aatgtcagtcacaaactgtggacagccgctggttccggccatcagatacttcctttccat
gaaagcagcaaggattcttgtaaaaatgatttggacacctcccacactgagtccccaacc
ccccatgactcaaattcacaccgccctcaactgcaggcgtttataacagaagcaaagcta
aatctaccgacaaggacaatgaccagacaagatggggaaactggagatggagccaaagaa
aatattgtttacctctaa

KEGG   Homo sapiens (human): 9138
Entry
9138              CDS       T01001                                 
Symbol
ARHGEF1, GEF1, IMD62, LBCL2, LSC, P115-RHOGEF, SUB1.5
Name
(RefSeq) Rho guanine nucleotide exchange factor 1
  KO
K12330  Rho guanine nucleotide exchange factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
hsa04810  Regulation of actin cytoskeleton
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05130  Pathogenic Escherichia coli infection
hsa05135  Yersinia infection
hsa05163  Human cytomegalovirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06124  Chemokine signaling (viruses)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00405  CXCR4-GNA12/13-Rho signaling pathway
N00406  HCMV US28 to GNA12/13-Rho signaling pathway
N01088  Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway
N01097  LPA-GNA12/13-RhoA signaling pathway
Disease
H02526  Disorders of adaptive immunity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    9138 (ARHGEF1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    9138 (ARHGEF1)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    9138 (ARHGEF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    9138 (ARHGEF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    9138 (ARHGEF1)
   05205 Proteoglycans in cancer
    9138 (ARHGEF1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    9138 (ARHGEF1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    9138 (ARHGEF1)
   05135 Yersinia infection
    9138 (ARHGEF1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    9138 (ARHGEF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9138 (ARHGEF1)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    9138 (ARHGEF1)
SSDB
Motif
Pfam: RGS-like PH_16 RhoGEF PH_13 AbiJ_NTD3
Other DBs
NCBI-GeneID: 9138
NCBI-ProteinID: NP_004697
OMIM: 601855
HGNC: 681
Ensembl: ENSG00000076928
Pharos: Q92888(Tbio)
UniProt: Q92888 A0A024R0R1
Structure
LinkDB
Position
19:41883184..41930141
AA seq 912 aa
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF
ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD
RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL
APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV
ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK
RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV
QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH
HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK
DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT
DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST
REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP
AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ
LGGNSVPQPGCT
NT seq 2739 nt   +upstreamnt  +downstreamnt
atggaagacttcgcccgaggggcggcctccccaggcccctcccggcctggcctggttccc
gtcagcatcatcggggctgaggatgaggattttgagaacgagctggagacaaactcagaa
gagcaaaacagccagttccagagcctggagcaggtgaagcggcgcccagcccacctcatg
gccctcctgcagcacgtggccctgcagtttgagccaggacccctgctttgctgtctgcat
gccgacatgctgggctcactgggccccaaggaggccaagaaggccttcctggacttctac
cacagcttcctggagaagacagcggttctccgggtgccggtccctcccaacgtcgccttt
gaacttgaccgcactagggctgacctcatctccgaggatgtccagcggcggttcgtgcag
gaggtggtgcaaagccagcaggtagccgtgggccggcagctggaggacttccgttccaag
cggctcatgggcatgacgccctgggagcaggagctggcccagctggaggcttgggttggg
cgggaccgagccagctacgaggcccgggagcggcacgtggcggagcggctgctcatgcac
ctggaggagatgcaacataccatctctaccgacgaagaaaagagtgctgccgtggtcaac
gccattggcctgtacatgcgccaccttggggtgcggaccaagagtggagacaagaagtcg
gggaggaacttcttccggaaaaaggtgatggggaaccggcggtcggacgagcctgccaag
accaagaaggggctgagcagcatcctggatgccgcccgctggaaccggggagagccccag
gttccagattttcgacacctcaaagcagaggttgatgccgagaagccaggtgctacagac
cggaagggaggcgtggggatgccctctcgggaccggaatatcggggctcctgggcaggac
acccctggagtctctctgcaccctctgtccctggacagcccagaccgggaaccaggtgct
gacgcccccctggagctgggggactcatccccgcagggcccaatgagcctggagtccttg
gcgcccccagagagtaccgacgagggggccgaaaccgagagccccgagcctggagatgag
ggggagccggggcggtcgggactggagcttgaaccagaagagcctcccggctggcgggaa
ctcgtccccccagacaccctgcacagcctgcccaagagccaggtgaagcggcaggaggtc
atcagcgagctgctggtgacagaggcggcccacgtgcgcatgctgcgggtgctgcacgac
ctcttcttccagcccatggcagaatgcctgttcttccccttggaggagctgcagaacatc
ttccccagcctggacgagctcatcgaggtgcattccctgttcctcgatcgcctgatgaag
cggaggcaggagagtggctacctcatcgaggagatcggagacgtgctgctggcccggttt
gatggtgctgagggctcctggttccagaaaatctcctcccgcttctgcagccgccagtca
tttgccttagagcagctcaaagccaagcaacgcaaggaccctcggttctgtgccttcgtg
caggaagctgagagccgcccgcggtgccgccgcctgcagctgaaggacatgatccccacg
gagatgcagcggctgaccaagtaccccctgctcctgcagagcatcgggcagaacacagaa
gagcccacagaacgggagaaagtggagctggcagccgagtgctgccgggaaattctacac
cacgtcaaccaagccgtgcgtgacatggaggacctgctgaggctcaaggactatcagcgg
cgcctggacttgtcccaccttcggcagagcagcgaccctatgctgagcgagttcaagaac
ctggacatcaccaagaagaaattggtccacgagggcccactgacgtggcgggtgactaag
gacaaggcagtggaggtgcatgtgctgctgctggacgacctgctgctgctgctccagcgc
caggacgagcggctgctgctcaagtcccatagccggacactgacgcccacgcccgatggc
aagaccatgctgcggcccgtgctgcggctcacctccgccatgacccgcgaggtggccacc
gatcacaaagccttctacgtcctttttacctgggaccaggaggcccagatatacgagctg
gtggcacagactgtgtcggagcggaaaaactggtgtgctctcatcactgagactgccgga
tccctgaaagtccctgcccctgcctctcgccctaagccccggcccagcccgagcagcacc
cgagaacccctcctcagcagctctgagaacggcaatggtggccgagagacgtctccagct
gatgcccggaccgagagaatcctcagtgacctcctgcccttctgcagaccaggccccgag
ggccagctcgctgccacggcccttcggaaagtgctgtccctgaagcagcttctgtttccg
gcggaggaagacaatggggcggggcctcctcgagatggggatggggtcccagggggcggc
cccctgagcccagcacggacccaggaaatccaggagaacctgctcagcttggaggagacc
atgaagcagctggaggagttggaggaggaattttgccgcctgagacccctcctgtctcag
cttggggggaactctgtcccccagcctggctgcacttga

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