KEGG   ORTHOLOGY: K12330
Entry
K12330                      KO                                     
Symbol
ARHGEF1
Name
Rho guanine nucleotide exchange factor 1
Pathway
map04270  Vascular smooth muscle contraction
map04611  Platelet activation
map04810  Regulation of actin cytoskeleton
map04928  Parathyroid hormone synthesis, secretion and action
map05130  Pathogenic Escherichia coli infection
map05135  Yersinia infection
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05417  Lipid and atherosclerosis
Disease
H02526  Disorders of adaptive immunity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
   05205 Proteoglycans in cancer
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
   05135 Yersinia infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
Membrane trafficking [BR:ko04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
Other DBs
GO: 0005089
Genes
HSA: 9138(ARHGEF1)
PTR: 456067(ARHGEF1)
PPS: 100972918(ARHGEF1)
GGO: 101131951(ARHGEF1)
PON: 100438951(ARHGEF1)
NLE: 100581841(ARHGEF1)
MCC: 722198(ARHGEF1)
MCF: 102143411(ARHGEF1)
CSAB: 103234745(ARHGEF1)
CATY: 105598037(ARHGEF1)
PANU: 101013796(ARHGEF1)
TGE: 112612103(ARHGEF1)
RRO: 104676067(ARHGEF1)
RBB: 108513891(ARHGEF1)
TFN: 117075630(ARHGEF1)
PTEH: 111554072(ARHGEF1)
CJC: 100409602(ARHGEF1)
SBQ: 101043419(ARHGEF1)
CSYR: 103273601(ARHGEF1)
MMUR: 105867983(ARHGEF1)
OGA: 100951083(ARHGEF1)
MMU: 16801(Arhgef1)
MCAL: 110297443(Arhgef1)
MPAH: 110336315(Arhgef1)
RNO: 60323(Arhgef1)
MCOC: 116101825(Arhgef1)
MUN: 110566357(Arhgef1)
CGE: 100758784(Arhgef1)
PLEU: 114686813(Arhgef1)
NGI: 103744614(Arhgef1)
HGL: 101721865(Arhgef1)
CPOC: 100713259(Arhgef1)
CCAN: 109688529(Arhgef1)
DORD: 105998061(Arhgef1)
DSP: 122097417(Arhgef1)
NCAR: 124967283
OCU: 103347573(ARHGEF1)
OPI: 101527019(ARHGEF1)
TUP: 102484536(ARHGEF1)
CFA: 100856354(ARHGEF1)
VVP: 112931193(ARHGEF1)
VLG: 121484950(ARHGEF1)
AML: 100477081(ARHGEF1)
UMR: 103680187(ARHGEF1)
UAH: 113243505(ARHGEF1)
UAR: 123778847(ARHGEF1)
ELK: 111139489
LLV: 125088803
MPUF: 101676161(ARHGEF1)
ORO: 101377895(ARHGEF1)
EJU: 114197097(ARHGEF1)
ZCA: 113936356(ARHGEF1)
MLX: 117998070(ARHGEF1)
FCA: 101083892(ARHGEF1)
PYU: 121018519(ARHGEF1)
PBG: 122493965(ARHGEF1)
PTG: 102956204(ARHGEF1)
PPAD: 109257994(ARHGEF1)
AJU: 106987699(ARHGEF1)
HHV: 120241163(ARHGEF1)
BTA: 513377(ARHGEF1)
BOM: 102271873(ARHGEF1)
BIU: 109572733(ARHGEF1)
BBUB: 102401949(ARHGEF1)
CHX: 102180150(ARHGEF1)
OAS: 101104265(ARHGEF1)
ODA: 120872371(ARHGEF1)
CCAD: 122420164(ARHGEF1)
SSC: 100518073(ARHGEF1)
CFR: 102504201(ARHGEF1)
CBAI: 105062465(ARHGEF1)
CDK: 105090229(ARHGEF1)
VPC: 102528528(ARHGEF1)
BACU: 103011772(ARHGEF1)
LVE: 103091388(ARHGEF1)
OOR: 101279717(ARHGEF1)
DLE: 111180799(ARHGEF1)
PCAD: 102984815(ARHGEF1)
PSIU: 116744408(ARHGEF1)
ECB: 102150569(ARHGEF1)
EPZ: 103563986(ARHGEF1)
EAI: 106847953(ARHGEF1)
MYB: 102242342(ARHGEF1)
MYD: 102767102(ARHGEF1)
MMYO: 118674379(ARHGEF1)
MLF: 102440463(ARHGEF1)
MNA: 107534237(ARHGEF1)
PKL: 118702293(ARHGEF1)
HAI: 109374465(ARHGEF1)
DRO: 112320150(ARHGEF1)
SHON: 119000475(ARHGEF1)
AJM: 119060125(ARHGEF1)
PDIC: 114511610(ARHGEF1)
PHAS: 123818238(ARHGEF1)
MMF: 118638816(ARHGEF1)
RFQ: 117035062(ARHGEF1)
PALE: 102894194(ARHGEF1)
PGIG: 120592367(ARHGEF1)
PVP: 105307342(ARHGEF1)
RAY: 107502587(ARHGEF1)
MJV: 108393666(ARHGEF1)
TOD: 119249370(ARHGEF1)
SARA: 101542367(ARHGEF1)
LAV: 100674589(ARHGEF1)
TMU: 101360283
DNM: 101437125(ARHGEF1)
GAS: 123255110(ARHGEF1)
SHR: 105750075(ARHGEF1)
PCW: 110219909(ARHGEF1)
OAA: 100078658(ARHGEF1)
NMEL: 110391747(ARHGEF1)
PHI: 102104245(ARHGEF1)
AROW: 112971738(ARHGEF1)
ASN: 102387901(ARHGEF1)
AMJ: 106737254(ARHGEF1)
CPIC: 101943841
MRV: 120390119(ARHGEF1)
ACS: 103282674(arhgef1)
PVT: 110086745(ARHGEF1)
SUND: 121915353(ARHGEF1)
PBI: 103053216(ARHGEF1)
PMUR: 107289707(ARHGEF1)
TSR: 106542680
PGUT: 117677585
VKO: 123025821(ARHGEF1)
PMUA: 114603358(ARHGEF1)
ZVI: 118086198(ARHGEF1)
GJA: 107123495
XLA: 108696695(arhgef1.L) 108697757(arhgef1.S)
XTR: 100037905(arhgef1)
NPR: 108785651(ARHGEF1)
RTEM: 120916386(ARHGEF1)
BBUF: 120982707(ARHGEF1)
BGAR: 122923979(ARHGEF1)
DRE: 557983(arhgef1b)
SRX: 107706396 107723498
SANH: 107657708 107699443
SGH: 107593668(arhgef1) 107595767
CCAR: 109105937 109105941
CAUA: 113059874 113116657
IPU: 108256375(arhgef1b)
PHYP: 113532549(arhgef1)
SMEO: 124403686(arhgef1b)
TFD: 113659368(arhgef1b)
AMEX: 103031326(arhgef1)
EEE: 113571897(arhgef1)
TRU: 101072427(arhgef1)
TNG: GSTEN00015596G001
LCO: 104927335(arhgef1)
CGOB: 115020983
ELY: 117265379(arhgef1b)
PLEP: 121945096(arhgef1b)
SLUC: 116042422(arhgef1b)
ECRA: 117945619(arhgef1b)
PFLV: 114556965(arhgef1)
GAT: 120811072(arhgef1b)
PPUG: 119197022(arhgef1b)
MSAM: 119897343(arhgef1b)
CUD: 121513728(arhgef1b)
MZE: 101483769(arhgef1)
ONL: 102081168(arhgef1)
OAU: 116309530(arhgef1b)
OLA: 101157484(arhgef1)
OML: 112143802(arhgef1b)
XMA: 102216423(arhgef1)
XCO: 114140709(arhgef1)
XHE: 116716804(arhgef1)
PRET: 103477916(arhgef1)
PFOR: 103139232(arhgef1)
PLAI: 106960060(arhgef1)
PMEI: 106916840(arhgef1)
GAF: 122830735(arhgef1b)
CVG: 107083568(arhgef1)
CTUL: 119771895(arhgef1b)
GMU: 124865436(arhgef1b)
NFU: 107379672(arhgef1)
KMR: 108235505(arhgef1b)
ALIM: 106523737(arhgef1)
NWH: 119409954(arhgef1b)
AOCE: 111564210(arhgef1)
CSEM: 103388802(arhgef1)
POV: 109633391(arhgef1)
SSEN: 122774371(arhgef1b)
HHIP: 117777500(arhgef1b)
LCF: 108880744(arhgef1)
SDU: 111236046(arhgef1)
SLAL: 111657270(arhgef1)
XGL: 120784154(arhgef1b)
HCQ: 109531672(arhgef1)
BPEC: 110174263(arhgef1)
MALB: 109954623(arhgef1)
SASA: 106595078 106605705(arhgef1)
OTW: 112235289 112244209
OMY: 110503633 110537658(arhgef1b)
OGO: 123998057 124018383
SALP: 111964599(arhgef1)
SNH: 120048654 120048774
ELS: 105024273(arhgef1)
SFM: 108922228(arhgef1)
PKI: 111854845(arhgef1)
AANG: 118229804(arhgef1b) 118233650
LOC: 102698314
PSPA: 121298908 121304200
ARUT: 117434043 117964870
LCM: 102347979(ARHGEF1)
BANY: 112056088
PPOT: 106100053
HRF: 124115694
 » show all
Reference
PMID:20098430
  Authors
Guilluy C, Bregeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G
  Title
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
  Journal
Nat Med 16:183-90 (2010)
DOI:10.1038/nm.2079
  Sequence
[hsa:9138] [mmu:16801]
Reference
PMID:8810315
  Authors
Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G
  Title
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase.
  Journal
J Biol Chem 271:25452-8 (1996)
DOI:10.1074/jbc.271.41.25452
  Sequence
[hsa:9138]
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