KEGG   Homo sapiens (human): 23586
Entry
23586             CDS       T01001                                 
Symbol
RIGI, DDX58, RIG-I, RIG1, RLR-1, SGMRT2
Name
(RefSeq) RNA sensor RIG-I
  KO
K12646  ATP-dependent RNA helicase DDX58 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06263  Hepatocellular carcinoma
nt06519  RLR signaling
  Element
N00469  RIG-I-IRF7/3 signaling pathway
N00565  HSV US11 to RIG-I-like receptor signaling pathway
N00688  RIG-I-NFKB signaling pathway
N00727  IAV NS1 to RIG-I-like receptor signaling pathway
N00728  IAV NS1 to RIG-I-like receptor signaling pathway
N01564  Post-translational modifications of RIG-I and MDA5
Disease
H01571  Singleton-Merten syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    23586 (RIGI)
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    23586 (RIGI)
   04623 Cytosolic DNA-sensing pathway
    23586 (RIGI)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    23586 (RIGI)
   05160 Hepatitis C
    23586 (RIGI)
   05171 Coronavirus disease - COVID-19
    23586 (RIGI)
   05164 Influenza A
    23586 (RIGI)
   05162 Measles
    23586 (RIGI)
   05168 Herpes simplex virus 1 infection
    23586 (RIGI)
   05169 Epstein-Barr virus infection
    23586 (RIGI)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    23586 (RIGI)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     23586 (RIGI)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   23586 (RIGI)
SSDB
Motif
Pfam: CARD_2 RIG-I_C RIG-I_C-RD DEAD ResIII Helicase_C AAA_25 Syntaxin_2
Other DBs
NCBI-GeneID: 23586
NCBI-ProteinID: NP_055129
OMIM: 609631
HGNC: 19102
Ensembl: ENSG00000107201
Pharos: O95786(Tbio)
UniProt: O95786
Structure
LinkDB
Position
9:complement(32455302..32526196)
AA seq 925 aa
MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKF
LLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIP
TDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERN
KFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSP
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI
PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTI
PSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNT
DEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMR
DTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFL
YTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGI
LTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGN
VIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKI
LHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKE
CFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAEMSK
NT seq 2778 nt   +upstreamnt  +downstreamnt
atgaccaccgagcagcgacgcagcctgcaagccttccaggattatatccggaagaccctg
gaccctacctacatcctgagctacatggccccctggtttagggaggaagaggtgcagtat
attcaggctgagaaaaacaacaagggcccaatggaggctgccacactttttctcaagttc
ctgttggagctccaggaggaaggctggttccgtggctttttggatgccctagaccatgca
ggttattctggactttatgaagccattgaaagttgggatttcaaaaaaattgaaaagttg
gaggagtatagattacttttaaaacgtttacaaccagaatttaaaaccagaattatccca
accgatatcatttctgatctgtctgaatgtttaattaatcaggaatgtgaagaaattcta
cagatttgctctactaaggggatgatggcaggtgcagagaaattggtggaatgccttctc
agatcagacaaggaaaactggcccaaaactttgaaacttgctttggagaaagaaaggaac
aagttcagtgaactgtggattgtagagaaaggtataaaagatgttgaaacagaagatctt
gaggataagatggaaacttctgacatacagattttctaccaagaagatccagaatgccag
aatcttagtgagaattcatgtccaccttcagaagtgtctgatacaaacttgtacagccca
tttaaaccaagaaattaccaattagagcttgctttgcctgctatgaaaggaaaaaacaca
ataatatgtgctcctacaggttgtggaaaaacctttgtttcactgcttatatgtgaacat
catcttaaaaaattcccacaaggacaaaaggggaaagttgtcttttttgcgaatcagatc
ccagtgtatgaacagcagaaatctgtattctcaaaatactttgaaagacatgggtataga
gttacaggcatttctggagcaacagctgagaatgtcccagtggaacagattgttgagaac
aatgacatcatcattttaactccacagattcttgtgaacaaccttaaaaagggaacgatt
ccatcactatccatctttactttgatgatatttgatgaatgccacaacactagtaaacaa
cacccgtacaatatgatcatgtttaattatctagatcagaaacttggaggatcttcaggc
ccactgccccaggtcattgggctgactgcctcggttggtgttggggatgccaaaaacaca
gatgaagccttggattatatctgcaagctgtgtgcttctcttgatgcgtcagtgatagca
acagtcaaacacaatctggaggaactggagcaagttgtttataagccccagaagtttttc
aggaaagtggaatcacggattagcgacaaatttaaatacatcatagctcagctgatgagg
gacacagagagtctggcaaagagaatctgcaaagacctcgaaaacttatctcaaattcaa
aatagggaatttggaacacagaaatatgaacaatggattgttacagttcagaaagcatgc
atggtgttccagatgccagacaaagatgaagagagcaggatttgtaaagccctgttttta
tacacttcacatttgcggaaatataatgatgccctcattatcagtgagcatgcacgaatg
aaagatgctctggattacttgaaagacttcttcagcaatgtccgagcagcaggattcgat
gagattgagcaagatcttactcagagatttgaagaaaagctgcaggaactagaaagtgtt
tccagggatcccagcaatgagaatcctaaacttgaagacctctgcttcatcttacaagaa
gagtaccacttaaacccagagacaataacaattctctttgtgaaaaccagagcacttgtg
gacgctttaaaaaattggattgaaggaaatcctaaactcagttttctaaaacctggcata
ttgactggacgtggcaaaacaaatcagaacacaggaatgaccctcccggcacagaagtgt
atattggatgcattcaaagccagtggagatcacaatattctgattgccacctcagttgct
gatgaaggcattgacattgcacagtgcaatcttgtcatcctttatgagtatgtgggcaat
gtcatcaaaatgatccaaaccagaggcagaggaagagcaagaggtagcaagtgcttcctt
ctgactagtaatgctggtgtaattgaaaaagaacaaataaacatgtacaaagaaaaaatg
atgaatgactctattttacgccttcagacatgggacgaagcagtatttagggaaaagatt
ctgcatatacagactcatgaaaaattcatcagagatagtcaagaaaaaccaaaacctgta
cctgataaggaaaataaaaaactgctctgcagaaagtgcaaagccttggcatgttacaca
gctgacgtaagagtgatagaggaatgccattacactgtgcttggagatgcttttaaggaa
tgctttgtgagtagaccacatcccaagccaaagcagttttcaagttttgaaaaaagagca
aagatattctgtgcccgacagaactgcagccatgactggggaatccatgtgaagtacaag
acatttgagattccagttataaaaattgaaagttttgtggtggaggatattgcaactgga
gttcagacactgtactcgaagtggaaggactttcattttgagaagataccatttgatcca
gcagaaatgtccaaatga

KEGG   Homo sapiens (human): 64135
Entry
64135             CDS       T01001                                 
Symbol
IFIH1, AGS7, Hlcd, IDDM19, IMD95, MDA-5, MDA5, RLR-2, SGMRT1
Name
(RefSeq) interferon induced with helicase C domain 1
  KO
K12647  interferon-induced helicase C domain-containing protein 1 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06519  RLR signaling
  Element
N00565  HSV US11 to RIG-I-like receptor signaling pathway
N00685  MV V to RIG-I-IRF7/3 signaling pathway
N01308  MDA5-IRF7/3 signaling pathway
N01309  SARS-CoV-2 nsp3 to MDA5-IRF7/3 signaling pathway
N01564  Post-translational modifications of RIG-I and MDA5
Disease
H00290  Aicardi-Goutieres syndrome
H00408  Type 1 diabetes mellitus
H01571  Singleton-Merten syndrome
H02525  Disorders of innate immunity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    64135 (IFIH1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    64135 (IFIH1)
   05171 Coronavirus disease - COVID-19
    64135 (IFIH1)
   05164 Influenza A
    64135 (IFIH1)
   05162 Measles
    64135 (IFIH1)
   05168 Herpes simplex virus 1 infection
    64135 (IFIH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    64135 (IFIH1)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     64135 (IFIH1)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   64135 (IFIH1)
SSDB
Motif
Pfam: CARD_2 RIG-I_C-RD RIG-I_C ResIII DEAD Helicase_C CARD SNF2-rel_dom SWI2_SNF2 DUF3638 Cas3-like_C_2
Other DBs
NCBI-GeneID: 64135
NCBI-ProteinID: NP_071451
OMIM: 606951
HGNC: 18873
Ensembl: ENSG00000115267
Pharos: Q9BYX4(Tbio)
UniProt: Q9BYX4
Structure
LinkDB
Position
2:complement(162267074..162318684)
AA seq 1025 aa
MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVE
LLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNL
LQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSA
FLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGM
ENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARA
SPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVI
VLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENS
LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP
LPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFA
IADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVC
AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDE
DDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESAR
GIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRT
GKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGV
IEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNP
SLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEI
ICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCL
FSDED
NT seq 3078 nt   +upstreamnt  +downstreamnt
atgtcgaatgggtattccacagacgagaatttccgctatctcatctcgtgcttcagggcc
agggtgaaaatgtacatccaggtggagcctgtgctggactacctgacctttctgcctgca
gaggtgaaggagcagattcagaggacagtcgccacctccgggaacatgcaggcagttgaa
ctgctgctgagcaccttggagaagggagtctggcaccttggttggactcgggaattcgtg
gaggccctccggagaaccggcagccctctggccgcccgctacatgaaccctgagctcacg
gacttgccctctccatcgtttgagaacgctcatgatgaatatctccaactgctgaacctc
cttcagcccactctggtggacaagcttctagttagagacgtcttggataagtgcatggag
gaggaactgttgacaattgaagacagaaaccggattgctgctgcagaaaacaatggaaat
gaatcaggtgtaagagagctactaaaaaggattgtgcagaaagaaaactggttctctgca
tttctgaatgttcttcgtcaaacaggaaacaatgaacttgtccaagagttaacaggctct
gattgctcagaaagcaatgcagagattgagaatttatcacaagttgatggtcctcaagtg
gaagagcaacttctttcaaccacagttcagccaaatctggagaaggaggtctggggcatg
gagaataactcatcagaatcatcttttgcagattcttctgtagtttcagaatcagacaca
agtttggcagaaggaagtgtcagctgcttagatgaaagtcttggacataacagcaacatg
ggcagtgattcaggcaccatgggaagtgattcagatgaagagaatgtggcagcaagagca
tccccggagccagaactccagctcaggccttaccaaatggaagttgcccagccagccttg
gaagggaagaatatcatcatctgcctccctacagggagtggaaaaaccagagtggctgtt
tacattgccaaggatcacttagacaagaagaaaaaagcatctgagcctggaaaagttata
gttcttgtcaataaggtactgctagttgaacagctcttccgcaaggagttccaaccattt
ttgaagaaatggtatcgtgttattggattaagtggtgatacccaactgaaaatatcattt
ccagaagttgtcaagtcctgtgatattattatcagtacagctcaaatccttgaaaactcc
ctcttaaacttggaaaatggagaagatgctggtgttcaattgtcagacttttccctcatt
atcattgatgaatgtcatcacaccaacaaagaagcagtgtataataacatcatgaggcat
tatttgatgcagaagttgaaaaacaatagactcaagaaagaaaacaaaccagtgattccc
cttcctcagatactgggactaacagcttcacctggtgttggaggggccacgaagcaagcc
aaagctgaagaacacattttaaaactatgtgccaatcttgatgcatttactattaaaact
gttaaagaaaaccttgatcaactgaaaaaccaaatacaggagccatgcaagaagtttgcc
attgcagatgcaaccagagaagatccatttaaagagaaacttctagaaataatgacaagg
attcaaacttattgtcaaatgagtccaatgtcagattttggaactcaaccctatgaacaa
tgggccattcaaatggaaaaaaaagctgcaaaagaaggaaatcgcaaagaacgtgtttgt
gcagaacatttgaggaagtacaatgaggccctacaaattaatgacacaattcgaatgata
gatgcgtatactcatcttgaaactttctataatgaagagaaagataagaagtttgcagtc
atagaagatgatagtgatgagggtggtgatgatgagtattgtgatggtgatgaagatgag
gatgatttaaagaaacctttgaaactggatgaaacagatagatttctcatgactttattt
tttgaaaacaataaaatgttgaaaaggctggctgaaaacccagaatatgaaaatgaaaag
ctgaccaaattaagaaataccataatggagcaatatactaggactgaggaatcagcacga
ggaataatctttacaaaaacacgacagagtgcatatgcgctttcccagtggattactgaa
aatgaaaaatttgctgaagtaggagtcaaagcccaccatctgattggagctggacacagc
agtgagttcaaacccatgacacagaatgaacaaaaagaagtcattagtaaatttcgcact
ggaaaaataaatctgcttatcgctaccacagtggcagaagaaggtctggatattaaagaa
tgtaacattgttatccgttatggtctcgtcaccaatgaaatagccatggtccaggcccgt
ggtcgagccagagctgatgagagcacctacgtcctggttgctcacagtggttcaggagtt
atcgaacatgagacagttaatgatttccgagagaagatgatgtataaagctatacattgt
gttcaaaatatgaaaccagaggagtatgctcataagattttggaattacagatgcaaagt
ataatggaaaagaaaatgaaaaccaagagaaatattgccaagcattacaagaataaccca
tcactaataactttcctttgcaaaaactgcagtgtgctagcctgttctggggaagatatc
catgtaattgagaaaatgcatcacgtcaatatgaccccagaattcaaggaactttacatt
gtaagagaaaacaaagcactgcaaaagaagtgtgccgactatcaaataaatggtgaaatc
atctgcaaatgtggccaggcttggggaacaatgatggtgcacaaaggcttagatttgcct
tgtctcaaaataaggaattttgtagtggttttcaaaaataattcaacaaagaaacaatac
aaaaagtgggtagaattacctatcacatttcccaatcttgactattcagaatgctgttta
tttagtgatgaggattag

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