KEGG ORTHOLOGY: K12646

ORTHOLOGY: K12646

Entry

K12646                      KO

Symbol

RIGI, DDX58

Name

ATP-dependent RNA helicase DDX58 [EC:5.6.2.6]

Pathway

map04064

NF-kappa B signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease

Disease

H01571

Singleton-Merten syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   04623 Cytosolic DNA-sensing pathway
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05160 Hepatitis C
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05171 Coronavirus disease
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05164 Influenza A
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05162 Measles
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05168 Herpes simplex virus 1 infection
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
   05169 Epstein-Barr virus infection
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58
Pattern recognition receptors [BR:ko04054]
Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   K12646  RIGI, DDX58; ATP-dependent RNA helicase DDX58

Other DBs

GO:

0034458

Genes

HSA:	23586(RIGI)

PTR:	465035(RIGI)

PPS:	100967985(RIGI)

GGO:	101135326(RIGI)

PON:	100443290(RIGI)

PPYG:

129044712(RIGI)

NLE:	100587393(DDX58)

HMH:	116475391(RIGI)

SSYN:

129478535

MCC:	704638(DDX58)

MCF:	102141351(RIGI)

MTHB:

126937384

MNI:	105485638(DDX58)

CSAB:

103219311(DDX58)

CATY:

105590097(DDX58)

PANU:

100997060(DDX58)

TGE:	112607797(DDX58)

MLEU:

105539630(DDX58)

RRO:	104655060(DDX58)

RBB:	108529797(DDX58)

TFN:	117098707(DDX58)

PTEH:

111537232(DDX58)

CANG:

105516444(DDX58)

CJC:	100408692(RIGI)

SBQ:	101044233(DDX58)

CIMI:

108317669(DDX58)

ANAN:

105718782(RIGI)

CSYR:

103263504(DDX58)

MMUR:

105871184(DDX58)

LCAT:

123646234(DDX58)

ERUF:

138388385(RIGI)

PCOQ:

105819684(DDX58)

OGA:	100964728(DDX58)

MMU:	230073(Rigi)

MCAL:

110292323(Ddx58)

MPAH:

110338729(Ddx58)

RNO:	297989(Rig1)

MCOC:

116095818(Ddx58)

ANU:	117709414(Rigi)

ASYL:

127680643(Rigi)

MMIU:

308437484(RIGI)

CGE:	100766319(Ddx58)

MAUA:

101838597(Ddx58)

PROB:

127224502(Rigi)

PLEU:

114703265(Ddx58)

PMAV:

102916795(Rigi)

MORG:

121458250(Ddx58)

MFOT:

126503627

AAMP:

119826628(Ddx58)

CNL:	130888117(Rigi)

NGI:	103748447(Ddx58)

HGL:	101717131(Ddx58)

CPOC:

100718491(Ddx58)

CCAN:

109683803(Ddx58)

DORD:

105993403(Ddx58)

DSP:	122123200(Ddx58)

DMER:

138817789(Rigi)

PLOP:

125362109(Ddx58)

NCAR:

124964894

SVUL:

306644974(RIGI)

MMMA:

107147861(Ddx58)

ITI:	101957338(Ddx58)

SCIL:

308638355(RIGI) 308658111(LOC308658111)

MAVE:

308272180(RIGI)

OCU:	100347707(RIGI)

OPI:	101524783(DDX58)

OCZ:	121145084(DDX58)

GVR:	103603408(DDX58)

CFA:	100855560(DDX58)

CLUD:

112649835(RIGI)

VVP:	112927563(DDX58)

VLG:	121495389(DDX58)

NPO:	129494755(RIGI)

AML:	100469453(DDX58)

UMR:	103667020(DDX58)

UAH:	113260537(RIGI)

UAR:	123781168(DDX58)

ELK:

111146203

LLV:

125083628

MPUF:

101690315(DDX58)

MNP:	132024675(RIGI)

MLK:	131812515(RIGI)

NVS:	122917537(DDX58)

MMAQ:

308353148(RIGI)

ORO:	101383901(DDX58)

EJU:	114218167(DDX58)

ZCA:	113933994(DDX58)

MLX:	118018039(DDX58)

MANO:

123849704(RIGI)

NSU:	110581392(DDX58)

LWW:	102746318(DDX58)

FCA:	101095926(DDX58)

PYU:	121034557(DDX58)

PCOO:

112864196(DDX58)

PBG:	122474753(DDX58)

PVIV:

125150585(RIGI)

LRUF:

124501213

LGF:	123593145(DDX58)

AJU:	106976066(RIGI)

PTG:	102953066(DDX58)

PPAD:

109252056(DDX58)

PUC:

125918656

PLEZ:

122205240(DDX58)

HHV:	120241719(DDX58)

CCRU:

144229771(RIGI)

BTA:	504760(RIGI)

BOM:	102280551(RIGI)

BIU:	109562815(DDX58)

BJV:	133252459(RIGI)

BBUB:

102390873(DDX58)

BKE:	129649863(RIGI)

BBIS:

104988320(DDX58)

CHX:	102183788(DDX58)

OAS:	101107257(RIGI)

OCAN:

138432702(RIGI)

BTAX:

128052481(RIGI)

CSUM:

138080852(RIGI)

ODA:	120861484(DDX58)

CCAD:

122452766 122453331(DDX58)

MREE:

136148760(RIGI)

OVR:	110128281(RIGI)

MBEZ:

129557515(RIGI)

SSC:	396723(DDX58)

CFR:	102524392(DDX58)

CBAI:

105078736(DDX58)

CDK:	105085563(DDX58)

VPC:	102535469(DDX58)

BACU:

103020032(DDX58)

BMUS:

118896522(DDX58)

LVE:	103089123(DDX58)

OOR:	101277446(RIGI)

LALB:

132523706(RIGI)

GMF:	115840163(RIGI)

DDP:	132426701(RIGI)

SCOO:

307188882(RIGI)

PCAD:

102977378(RIGI)

PPHC:

136124106(RIGI)

ECB:	100067920(DDX58)

EPZ:	103550256(RIGI)

EAI:	106841474(DDX58)

MYB:	102242345 102244773(DDX58)

MYD:	102751776(DDX58)

MMYO:

118667402(DDX58)

MLF:	102439039(DDX58)

MDT:	132212055(RIGI)

MYUM:

139021134(RIGI)

PKL:	118716422(DDX58)

EFUS:

103286489(RIGI)

POTS:

308249410(RIGI)

MNA:	107544982(DDX58)

DRO:	112304475(DDX58)

SHON:

118979610(DDX58)

AJM:	119060014(RIGI)

PDIC:

114511471(DDX58)

PHAS:

123819737(DDX58)

MMF:	118629855(DDX58)

PPAM:

129078222(RIGI)

HAI:	109371521(DDX58)

RFQ:	117032444(DDX58)

RHII:

308504558(RIGI)

PALE:

102881037(DDX58)

PGIG:

120612927(DDX58)

PVP:	105306475(DDX58)

RAY:	107502800(DDX58)

MJV:	108400836(RIGI)

SARA:

101557300(DDX58)

SFUM:

130026507(RIGI)

LAV:	100661613(DDX58)

TMU:

101340796

DNM:	101411955(DDX58)

PCW:	110200846(DDX58)

TVP:	118831001(DDX58)

PBRV:

138163059(RIGI)

MLAO:

141498778(RIGI)

OAA:	100078060(DDX58)

TACU:

119947815(DDX58)

APLA:

101789567(DDX58)

AACU:

137847645(RIGI)

OJA:	118155890(DDX58)

BCLA:

308455266(RIGI)

ACYG:

106040220(RIGI)

ABRC:

308185161(RIGI)

CATA:

118256226(RIGI)

AFUL:

116500398(DDX58)

TGU:	100222705(DDX58)

LSR:	110474055(RIGI)

VMC:	128821549(RIGI)

VCHA:

128802499(RIGI)

AIB:	137464565(RIGI)

SCAN:

103821258(DDX58)

PMOA:

120513581(DDX58)

OTC:	121332691(DDX58)

PRUF:

121363780(DDX58)

ATRC:

139588850(RIGI)

MAEN:

136568841(RIGI)

GFR:	102040159(DDX58)

FAB:	101809434(DDX58)

OMA:	130265551(RIGI)

PHI:	102107316(DDX58)

PMAJ:

107216072(DDX58)

CCAE:

111941344(DDX58)

CCW:	104689783(DDX58)

CBRC:

103616425(DDX58)

ACOE:

138103574(RIGI)

ETL:	114057888(DDX58)

ZAB:	102062854(DDX58)

ZLE:	135459785(RIGI)

ACHL:

103804374(DDX58)

SVG:	106860340(DDX58)

MMEA:

130577580(RIGI)

LCAI:

146424588(RIGI)

HRT:	120765687(RIGI)

SATI:

136373943(RIGI)

CFAI:

136288409(RIGI)

CCIC:

134056289(RIGI)

SHAB:

115619851(DDX58)

POCC:

134156432(RIGI)

PECH:

308232256(RIGI)

FPG:	101917977(DDX58)

CCRI:

104165244(DDX58)

ACUN:

113490198(DDX58)

SURA:

141937474(RIGI)

TALA:

104360113(DDX58)

ACHC:

115336860(DDX58)

HALD:

104311658(DDX58)

HLE:	104838385(DDX58)

AGEN:

126036296

HHAR:

128136509(RIGI)

BBUT:

142027481(RIGI)

GCL:

127027565

MNB:	103773506(DDX58)

DPUB:

104300081(DDX58)

PPUS:

135173222(RIGI)

IIN:	128979437(RIGI)

AVIT:

104277406(DDX58)

BRHI:

104494917(DDX58)

EGZ:	104135075(DDX58)

NNI:	104011949(DDX58)

PLEC:

309602915(RIGI)

PCRI:

104034427(DDX58)

PCAO:

104039496(DDX58)

PARX:

142050579(RIGI)

PADL:

103921071(DDX58)

AFOR:

103903790(DDX58)

FGA:	104074927(DDX58)

CBOR:

142075525(RIGI)

CBOY:

140651262(RIGI)

MAME:

142422024(RIGI)

CLV:	102098789(DDX58)

CNIC:

136001423(RIGI)

NMAY:

308051848(RIGI)

PGUU:

104469262(DDX58)

PLET:

104624790(DDX58)

CMAC:

104473297(DDX58)

CUCA:

104059512(RIGI)

TEO:	104380257(DDX58)

BREG:

104640537(DDX58)

GAME:

129199146(RIGI)

OHA:	104337928(DDX58)

HEK:	139790287(RIGI)

CVF:	104286640(DDX58)

RTD:	128902314(RIGI)

CRID:

134509043(RIGI)

LMIC:

141735911(RIGI)

NARQ:

141476927(RIGI)

AAM:	106486905(DDX58)

AROW:

112963181(DDX58)

DNE:	112983411(DDX58)

SCAM:

104145884(DDX58)

ASN:	102388849(DDX58)

AMJ:	102565282(DDX58)

CPOO:

109323611(DDX58)

GGN:	109297325(DDX58)

PSS:	102452744(RIGI)

CIZ:	142013385(RIGI)

CMY:	102936061(DDX58)

CCAY:

125637340(DDX58)

LKP:	140911781(RIGI)

NDS:	141987763(RIGI)

DCC:	119856319(DDX58)

CPIC:

101952584(RIGI)

TST:	117879311(DDX58)

CABI:

116828923(RIGI)

MRV:	120407650(DDX58)

EMQ:	137156405(RIGI)

ACS:	100565793(ddx58)

ASAO:

132767481(RIGI)

PVT:	110084585(DDX58)

SUND:

121923815(DDX58)

PBI:	103062221(DDX58)

PMUR:

107296930(DDX58)

CTIG:

120310315 120310323(DDX58)

TSR:	106553815(DDX58)

PGUT:

117661563(RIGI)

PCAE:

139311151(RIGI)

APRI:

131190142(RIGI)

PTEX:

113444625(DDX58)

NSS:	113415036(DDX58)

VKO:	123022380(DDX58)

PMUA:

114587535(DDX58)

PRAF:

128404984(RIGI)

ZVI:	118097520(DDX58)

HCG:	128348245(RIGI)

GJA:	107113238(DDX58)

STOW:

125436211(DDX58)

EMC:	129334781(RIGI)

XLA:	108713708(ddx58.L)

XTR:	100495207(ddx58)

NPR:	108785404(DDX58)

RTEM:

120945831(DDX58)

ACAT:

141148909 141148939

PADS:

140326101(RIGI)

BBUF:

120989261(DDX58)

BGAR:

122921482(DDX58)

DTC:	141055766(RIGI)

PWL:	138300381(RIGI)

MUO:	115463329(RIGI)

GSH:	117351436(RIGI)

DRE:	100333797(rigi)

DAES:

130216999(rigi)

SRX:	107737973(ddx58)

SANH:

107702171(ddx58)

SGH:	107570187(ddx58)

CCAR:

109081892

CAUA:

113041644 113088745

CGIB:

127944512 127970783 128011571

PTET:

122334542(ddx58)

LROH:

127154769(rigi)

GRF:	141290926(rigi)

OMC:	131532555(rigi)

PPRM:

120484091(ddx58)

RKG:	130071740(rigi)

SCEP:

307145571(rigi)

CIDE:

127505465

CERY:

137008914(rigi)

MASI:

127419350 127420273

TROS:

130545050(rigi)

TDW:	130408874(rigi)

MANU:

129431014(rigi)

PDAB:

135764983(rigi)

IPU:	101154681(ddx58)

IFU:	128619563(rigi)

PHYP:

113530538(ddx58)

SMEO:

124399288(ddx58)

TFD:	113652988(ddx58)

TVC:	132862031(rigi)

CGAR:

128510153(rigi)

NGRA:

132896761(rigi)

TRN:	134333384(rigi)

AMEX:

103047126(ddx58)

CMAO:

118822688(ddx58)

EEE:	113590353(ddx58)

SASA:

100302577(ddx58)

STRU:

115194763(rigi)

OTW:	112239684(ddx58)

OMY:	110514337(ddx58)

OGO:	124007771(ddx58)

OKI:	109886956(ddx58)

OKE:	118383869(rigi)

OMM:

135510180

OCLA:

139415771

SNH:	120037993(ddx58)

SFON:

129835542(rigi)

CCLU:

121554442(ddx58)

ELS:	105006239(ddx58)

OEP:	134009625(rigi)

SFM:	108926073(ddx58)

PKI:	111859270(ddx58)

AANG:

118213307 118232448(ddx58)

AROT:

135239301 135260079(rigi)

CCOG:

133135903(rigi) 133142358

LOC:	102684584 102686328(ddx58)

PSPA:

121296206(ddx58) 121313904

ARUT:

117403785 117403804 117409459 117970430

LCM:	102361129(DDX58)

CMK:	103187211(ddx58)

RTP:	109926970(ddx58)

CPUN:

140488628(rigi)

SCAU:

119970102(rigi)

CMAM:

144667825(rigi)

LERI:

129695487(rigi)

HAKA:

140729132(rigi)

PMRN:

116952446(DDX58)

LRJ:	133353942(RIGI)

BFO:	118413655 118414564 118414565

BBEL:

109466897 109478412

CIN:	100178210 100183773

SCLV:

120335367 120342670 120342672 120343477 120343478

CLEP:

143448212 143448213 143448847 143449987 143450861

SPU:	100889139 105441555 115918131 115920007 115923425 574972 575036 577076 578285 583008 589320 591092 591972

LPIC:

129260363

LVG:	121421319 121423318 121424758 121429221

AJJ:	139961680 139961681 139962221

APLC:

110981269 110982617 110986383 110986394

ARUN:

117294413 117294712 117306870

AAMU:

139940480 139940573 139948613 139950360 139950390

AFIL:

140147800 140147801 140162600 140162601 140170891

SKO:

102805200

PFLL:

139114615 139115804 139120310 139123542

CEL:	CELE_D2005.5(drh-3)

CBR:	CBG_08270(Cbr-drh-3)

CRQ:	GCK72_000397

BMY:	BM_BM3027(Bma-drh-3)

LOA:	LOAG_02330 LOAG_06406

HRO:	HELRODRAFT_114400 HELRODRAFT_74403

LGI:	LOTGIDRAFT_164234 LOTGIDRAFT_211354

PVUL:

126816398 126816399 126816520

PCAN:

112564108 112564504 112564867 112565084 112575931

LSAX:

138978636 138981153 138981620 138982296 138982298

BARL:

143286997 143293632 143296370 143296634 143297008

BGT:	106061291 106061307 106061308 106061310 106068471

GAE:

121382731

HRF:	124110410 124138716 124141220

HRJ:	124253608 124272850 124272975

HASI:

137265123 137265797 137281985 137296044

HCRA:

139452736 139455714 139455794

CRG:	105324078 105324080 105333315 105333990 136275451

CANU:

128157792 128160738 128164376 128168502 128168525 128179382

CVN:	111111488 111130870 111134586

OED:	125645626 125648370 125648371 125657636 125658758 125683108 125683109

MYI:	110460504 110460513

PMAX:

117316381 117339537 117339546

AIRR:

138335493 138335495

YBA:	132549565 132549590

MMER:

123525132 123527491 123527494 123535110 123546059 123546060 123546418 123546680 123546752 123546753 123556563 123558007

RPHI:

132719017 132722233 132722737 132724617 132724618 132724623 132730865 132737165 132740903 132742512 132758322

DPOL:

127857816 127857817 127880562 127881974

MAEA:

128210237 128210871 128211229 128211374 128211376 128211490 128211492 128211493 128211526 128211527 128211529 128211696 128211717 128212223 128212298 128212455

OBI:

106868709

OSN:

115232631

LJP:	135467643 135469388 135469389

LAK:	106159386 106159387 106165417 106168940 106168943

LLON:

135489054 135489746 135490041 135490043

EPA:

ATEN:

ADF:

XEN:

Reference

PMID:15208624

Authors

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T

Title

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Journal

Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087

Reference

PMID:11890704

Authors

Imaizumi T, Aratani S, Nakajima T, Carlson M, Matsumiya T, Tanji K, Ookawa K, Yoshida H, Tsuchida S, McIntyre TM, Prescott SM, Zimmerman GA, Satoh K

Title

Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.

Journal

Biochem Biophys Res Commun 292:274-9 (2002)
DOI:10.1006/bbrc.2002.6650

Sequence

[hsa:23586]

LinkDB

DBGET integrated database retrieval system