Homo sapiens (human): 25942
Help
Entry
25942 CDS
T01001
Symbol
SIN3A, CHR15DELq24, DEL15Q24, WITKOS
Name
(RefSeq) SIN3 transcription regulator family member A
KO
K11644
paired amphipathic helix protein Sin3a
Organism
hsa
Homo sapiens (human)
Pathway
hsa04350
TGF-beta signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa05016
Huntington disease
hsa05169
Epstein-Barr virus infection
hsa05202
Transcriptional misregulation in cancer
Network
nt06240
Transcription (cancer)
nt06461
Huntington disease
Element
N00118
TEL-AML1 fusion to transcriptional repression
N00980
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Disease
H01861
Chromosome 15q24 microdeletion syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
25942 (SIN3A)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
25942 (SIN3A)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
25942 (SIN3A)
09172 Infectious disease: viral
05169 Epstein-Barr virus infection
25942 (SIN3A)
09164 Neurodegenerative disease
05016 Huntington disease
25942 (SIN3A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
25942 (SIN3A)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDAC complexes
Sin3A-HDAC complex
25942 (SIN3A)
REST complex
25942 (SIN3A)
Heterochromatin formation proteins
Other heterochromatin formation proteins
25942 (SIN3A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Sin3a_C
PAH
Sin3_corepress
Motif
Other DBs
NCBI-GeneID:
25942
NCBI-ProteinID:
NP_001138829
OMIM:
607776
HGNC:
19353
Ensembl:
ENSG00000169375
UniProt:
Q96ST3
LinkDB
All DBs
Position
15:complement(75369379..75455815)
Genome browser
AA seq
1273 aa
AA seq
DB search
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
KYRVKYGTVFKAP
NT seq
3822 nt
NT seq
+upstream
nt +downstream
nt
atgaagcggcgtttggatgaccaggagtcaccggtgtatgcagcccagcagcgtcggatc
cctggcagcacagaggcttttcctcaccagcaccgggtgcttgcccctgcccctcctgtg
tatgaagcagtgtctgagaccatgcagtcagctacgggaattcagtactctgtaacaccc
agctaccaggtttcagccatgccacagagctccggcagtcatgggcccgctatagcagca
gttcatagcagccatcatcacccaacagcggtgcagccccacggaggccaggtggtccag
agtcatgctcatccagccccaccagttgcaccagtgcagggacagcagcaatttcagagg
ctgaaggtggaggatgcgctatcttatcttgaccaggtgaagctgcagtttggtagtcag
cctcaggtctacaatgatttccttgacatcatgaaggaatttaaatctcagagcatcgac
accccaggagtgattagtcgtgtgtcccagctattcaaaggccaccccgatctgataatg
ggattcaacaccttcttgccccctggctacaaaattgaggtgcaaaccaatgacatggtg
aatgtgacaactcctggccaggttcatcagattcccacccatggcatccagccacagcct
caaccaccaccccaacatccttcccagccttcagcccagtcagccccagctcctgcccag
ccagctcctcagcccccacctgccaaagtcagcaagccctcccaactgcaagcacatact
ccggccagtcagcagactcccccacttccaccgtatgcatccccacgttctccgccggtc
cagcctcacacaccagtgacaatctcgttgggaacggccccatccttgcagaacaatcaa
cctgtggagtttaatcatgccatcaactatgttaataagatcaagaacagatttcagggc
caaccagacatctacaaagcattcctggagattttgcacacatatcagaaagagcagaga
aatgccaaggaagctggaggaaactacactccagcattgacagagcaggaggtgtatgcc
caggttgctcgtctctttaaaaaccaggaagatttgttgtcagagtttggacaattccta
ccagatgccaacagctccgtgcttttaagcaaaacaactgctgagaaggttgattctgtg
agaaatgatcatggaggcactgtcaagaagccccaactgaacaacaagccgcagaggccc
agccagaatggctgccagatccgcagacatcctacaggaaccacccctccagttaagaag
aaacccaaactgctcaatctgaaggattcttctatggcagatgccagcaaacatggtggt
ggaacagaatcgttattttttgataaggtccgaaaggctcttcggagtgcagaagcctac
gaaaatttcctacgctgtcttgttatttttaaccaggaggtgatctctcgtgctgagctt
gtgcaactagtctctcctttcctggggaaattccctgagttgtttaattggtttaaaaac
tttctgggctataaggagtctgtacatctggaaacttatccaaaggagcgagccacagag
ggcattgctatggagatagattatgcttcttgtaaacgattgggctccagctatcgagcc
ttaccaaagagttaccagcagcccaagtgtacaggacggactcctctctgtaaagaggtt
ttaaatgatacctgggtttccttcccttcgtggtctgaggactctacctttgtgagttcc
aagaagactcaatatgaagaacatatttatcgttgtgaagatgaacgctttgagcttgat
gtagttttagagaccaatctggcaacaatccgggttctggaagcaatacagaagaagctt
tcccgcttgtctgctgaagaacaagccaaatttcgcttggacaacacccttgggggcaca
tcagaagtcatccatagaaaagcactccagaggatatatgctgataaagcagctgacatc
attgatggtctgagaaagaatccctccattgctgttccaattgtccttaaaaggttgaag
atgaaagaggaagaatggcgagaagctcagagaggctttaacaaagtatggcgagaacaa
aatgagaaatactacttgaagtctctggaccaccaggggatcaactttaaacagaatgac
accaaggtcctgaggtctaagagcttactcaatgagattgagagtatctatgatgagagg
caagagcaggctacggaggagaatgctggtgtacctgttggcccacacctctcacttgcg
tatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagagg
cagacaggcattcagaaggaggacaaatataagataaaacaaatcatgcatcattttatt
ccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaa
gagatggatgtagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagt
ccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaagaggaatggat
gaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccag
attctctgcctgaggctgctacggatttgttcccaagccgaacggcaaattgaagaagaa
aaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagc
cctgccattcagctacgtctcaaagaacctatggatgttgatgtagaagattattaccca
gctttcctggacatggtgcggagcctgctggatggcaacatagactcatcacagtatgaa
gattcactgagagagatgttcaccattcatgcctacattgcctttaccatggacaaactg
atccagagcattgtcagacagctgcagcatatcgtgagtgatgagatctgtgtgcaggtg
actgacctttacctggcagaaaataataatggggccaccggaggccagctgaacacacag
aactcaaggagcctcctggagtcaacgtatcagcggaaagctgagcagctaatgtcagat
gagaattgctttaagcttatgtttattcagagccaaggccaggtccagctgactattgag
cttctggacacagaagaggagaattcggatgaccctgtggaagcagagcgctggtcagac
tacgtggagcgatacatgaattcagatactacctcgcctgagcttcgtgaacatctagca
cagaaaccagtatttctccccaggaatctacggcggatccggaagtgtcaacgtggtcga
gagcagcaggaaaaggaagggaaggaaggaaacagcaagaagaccatggagaatgtggat
agtctggataagctggagtgtagattcaagctgaattcctacaagatggtgtatgtgatc
aaatcagaggactatatgtatcggaggaccgccctgctccgggctcatcagtcccatgag
cgtgtaagcaagcgtctacatcagagattccaggcctgggtagataaatggaccaaggag
catgtgccccgtgaaatggcagcagagaccagcaagtggctcatgggtgaggggctggag
ggcctggtgccctgtaccaccacctgtgatacagagaccctgcattttgtgagcattaac
aagtatcgtgtcaaatacggcacagtattcaaagccccttaa
Homo sapiens (human): 23186
Help
Entry
23186 CDS
T01001
Symbol
RCOR1, COREST, RCOR
Name
(RefSeq) REST corepressor 1
KO
K11829
REST corepressor 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa05016
Huntington disease
Network
nt06461
Huntington disease
Element
N00980
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05016 Huntington disease
23186 (RCOR1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
23186 (RCOR1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDAC complexes
BRAF-HDAC complex
23186 (RCOR1)
REST complex
23186 (RCOR1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
REST_helical
Myb_DNA-binding
ELM2
Myb_DNA-bind_7
Myb_DNA-bind_6
Homeobox_KN
Motif
Other DBs
NCBI-GeneID:
23186
NCBI-ProteinID:
NP_055971
OMIM:
607675
HGNC:
17441
Ensembl:
ENSG00000089902
UniProt:
Q9UKL0
Structure
PDB
LinkDB
All DBs
Position
14:102592649..102730561
Genome browser
AA seq
485 aa
AA seq
DB search
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS
NT seq
1458 nt
NT seq
+upstream
nt +downstream
nt
atgccggccatggtggagaagggccccgaggtctcagggaagcggagagggaggaacaac
gcggccgcctccgcctccgccgccgccgcctccgccgccgcctcggccgcctgcgcctcg
ccagccgccactgccgcctcgggcgccgccgcctcctcagcctcggccgccgccgcctca
gccgccgccgcccccaataatggccagaataaaagtttggcggcggcggcgcccaatggc
aacagcagcagcaactcctgggaggaaggcagctcgggctcgtccagcgacgaggagcac
ggtggcggtggcatgagggtcggaccccagtaccaggcggtggtgcccgacttcgacccc
gccaaactggcaagacgcagtcaagaacgggacaatcttggcatgttggtctggtcaccc
aatcaaaatctgtcagaagcaaagttggatgaatacattgccattgccaaagaaaagcat
gggtacaacatggaacaggctcttgggatgctcttctggcataaacataatatcgaaaag
tcattggctgatttgcccaactttacccctttcccagatgagtggactgtggaagataaa
gtcttatttgagcaagcctttagttttcatgggaaaacttttcatagaatccaacaaatg
cttccagataaatctatagcaagtctggtgaaattttactattcttggaagaagacgagg
actaaaactagtgtgatggatcgccatgcccggaaacaaaaacgggagcgggaggagagc
gaggatgaactggaagaggcaaatggaaacaatcccattgacattgaggttgatcaaaac
aaggaaagcaaaaaggaggttccccctactgagacagttcctcaggtcaaaaaagaaaaa
catagcacacaagctaaaaatagagcaaaaaggaaacctccaaaaggaatgtttctttct
caagaagatgtggaggctgtttctgccaatgccactgctgctaccacggtgctgagacaa
ctagacatggaattggtttcagtcaaacgacagatccagaatattaaacagacaaacagt
gctctcaaagaaaaacttgatggtggaatagaaccatatcgacttccagaggtcattcag
aaatgtaatgcacgttggactacagaagagcagcttctcgccgtacaagccatcaggaaa
tatggccgagattttcaggcaatctcagacgtgattgggaacaaatcagtggtacaagtg
aaaaacttttttgtaaattatcgacgccgcttcaacatagatgaagttttacaagaatgg
gaggcagaacatggtaaagaagagaccaatgggcccagtaaccagaagcctgtgaagtcc
ccagataattccattaagatgcccgaagaggaagacgaggctcctgttctggatgtcaga
tatgcatctgcctcctga
Homo sapiens (human): 3065
Help
Entry
3065 CDS
T01001
Symbol
HDAC1, GON-10, HD1, KDAC1, RPD3, RPD3L1
Name
(RefSeq) histone deacetylase 1
KO
K06067
histone deacetylase 1/2 [EC:
3.5.1.98
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03082
ATP-dependent chromatin remodeling
hsa03083
Polycomb repressive complex
hsa04110
Cell cycle
hsa04213
Longevity regulating pathway - multiple species
hsa04330
Notch signaling pathway
hsa04350
TGF-beta signaling pathway
hsa04613
Neutrophil extracellular trap formation
hsa04919
Thyroid hormone signaling pathway
hsa05016
Huntington disease
hsa05031
Amphetamine addiction
hsa05034
Alcoholism
hsa05165
Human papillomavirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
hsa05220
Chronic myeloid leukemia
Network
nt06166
Human papillomavirus (HPV)
nt06240
Transcription (cancer)
nt06461
Huntington disease
nt06516
TNF signaling
nt06523
Epigenetic regulation by Polycomb complexes
Element
N00118
TEL-AML1 fusion to transcriptional repression
N00375
HPV E7 to TNF-IRF1 signaling pathway
N00980
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
N01614
Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Abexinostat (
DG01402
):
D10060
D10084
Belinostat:
D08870
<US>
Bocodepsin (
DG03260
):
D12551
D12552
Entinostat:
D09338
Fimepinostat:
D11319
Givinostat (
DG03284
):
D12742
D12743
<US>
Mocetinostat (
DG01404
):
D09357
D09641
Nanatinostat:
D11442
Panobinostat (
DG01403
):
D10019
D10319
Quisinostat (
DG01407
):
D10321
D10322
Remetinostat:
D10977
Romidepsin:
D06637
<JP/US>
Tacedinaline:
D05988
Tinostamustine:
D11182
Tucidinostat:
D10993
<JP>
Vorinostat:
D06320
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09126 Chromosome
03082 ATP-dependent chromatin remodeling
3065 (HDAC1)
03083 Polycomb repressive complex
3065 (HDAC1)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
3065 (HDAC1)
04350 TGF-beta signaling pathway
3065 (HDAC1)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
3065 (HDAC1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
3065 (HDAC1)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
3065 (HDAC1)
09149 Aging
04213 Longevity regulating pathway - multiple species
3065 (HDAC1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3065 (HDAC1)
05202 Transcriptional misregulation in cancer
3065 (HDAC1)
05206 MicroRNAs in cancer
3065 (HDAC1)
05203 Viral carcinogenesis
3065 (HDAC1)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
3065 (HDAC1)
09172 Infectious disease: viral
05169 Epstein-Barr virus infection
3065 (HDAC1)
05165 Human papillomavirus infection
3065 (HDAC1)
09164 Neurodegenerative disease
05016 Huntington disease
3065 (HDAC1)
09165 Substance dependence
05031 Amphetamine addiction
3065 (HDAC1)
05034 Alcoholism
3065 (HDAC1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
3065 (HDAC1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.98 histone deacetylase
3065 (HDAC1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
Class I HDACs
3065 (HDAC1)
HDAC complexes
Sin3A-HDAC complex
3065 (HDAC1)
BRAF-HDAC complex
3065 (HDAC1)
REST complex
3065 (HDAC1)
SHIP complex
3065 (HDAC1)
MiDAC complex
3065 (HDAC1)
Polycomb repressive complex (PRC) and associated proteins
Noncanonical PRC1 (PRC1.6)
3065 (HDAC1)
Heterochromatin formation proteins
Other heterochromatin formation proteins
3065 (HDAC1)
Chromatin remodeling factors
NuRD complex
3065 (HDAC1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hist_deacetyl
Motif
Other DBs
NCBI-GeneID:
3065
NCBI-ProteinID:
NP_004955
OMIM:
601241
HGNC:
4852
Ensembl:
ENSG00000116478
UniProt:
Q13547
Q6IT96
Structure
PDB
LinkDB
All DBs
Position
1:32292083..32333626
Genome browser
AA seq
482 aa
AA seq
DB search
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
NT seq
1449 nt
NT seq
+upstream
nt +downstream
nt
atggcgcagacgcagggcacccggaggaaagtctgttactactacgacggggatgttgga
aattactattatggacaaggccacccaatgaagcctcaccgaatccgcatgactcataat
ttgctgctcaactatggtctctaccgaaaaatggaaatctatcgccctcacaaagccaat
gctgaggagatgaccaagtaccacagcgatgactacattaaattcttgcgctccatccgt
ccagataacatgtcggagtacagcaagcagatgcagagattcaacgttggtgaggactgt
ccagtattcgatggcctgtttgagttctgtcagttgtctactggtggttctgtggcaagt
gctgtgaaacttaataagcagcagacggacatcgctgtgaattgggctgggggcctgcac
catgcaaagaagtccgaggcatctggcttctgttacgtcaatgatatcgtcttggccatc
ctggaactgctaaagtatcaccagagggtgctgtacattgacattgatattcaccatggt
gacggcgtggaagaggccttctacaccacggaccgggtcatgactgtgtcctttcataag
tatggagagtacttcccaggaactggggacctacgggatatcggggctggcaaaggcaag
tattatgctgttaactacccgctccgagacgggattgatgacgagtcctatgaggccatt
ttcaagccggtcatgtccaaagtaatggagatgttccagcctagtgcggtggtcttacag
tgtggctcagactccctatctggggatcggttaggttgcttcaatctaactatcaaagga
cacgccaagtgtgtggaatttgtcaagagctttaacctgcctatgctgatgctgggaggc
ggtggttacaccattcgtaacgttgcccggtgctggacatatgagacagctgtggccctg
gatacggagatccctaatgagcttccatacaatgactactttgaatactttggaccagat
ttcaagctccacatcagtccttccaatatgactaaccagaacacgaatgagtacctggag
aagatcaaacagcgactgtttgagaaccttagaatgctgccgcacgcacctggggtccaa
atgcaggcgattcctgaggacgccatccctgaggagagtggcgatgaggacgaagacgac
cctgacaagcgcatctcgatctgctcctctgacaaacgaattgcctgtgaggaagagttc
tccgattctgaagaggagggagaggggggccgcaagaactcttccaacttcaaaaaagcc
aagagagtcaaaacagaggatgaaaaagagaaagacccagaggagaagaaagaagtcacc
gaagaggagaaaaccaaggaggagaagccagaagccaaaggggtcaaggaggaggtcaag
ttggcctga
Homo sapiens (human): 3066
Help
Entry
3066 CDS
T01001
Symbol
HDAC2, HD2, KDAC2, RPD3, YAF1
Name
(RefSeq) histone deacetylase 2
KO
K06067
histone deacetylase 1/2 [EC:
3.5.1.98
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03082
ATP-dependent chromatin remodeling
hsa03083
Polycomb repressive complex
hsa04110
Cell cycle
hsa04213
Longevity regulating pathway - multiple species
hsa04330
Notch signaling pathway
hsa04350
TGF-beta signaling pathway
hsa04613
Neutrophil extracellular trap formation
hsa04919
Thyroid hormone signaling pathway
hsa05016
Huntington disease
hsa05031
Amphetamine addiction
hsa05034
Alcoholism
hsa05165
Human papillomavirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
hsa05220
Chronic myeloid leukemia
Network
nt06166
Human papillomavirus (HPV)
nt06240
Transcription (cancer)
nt06461
Huntington disease
nt06516
TNF signaling
nt06523
Epigenetic regulation by Polycomb complexes
Element
N00118
TEL-AML1 fusion to transcriptional repression
N00375
HPV E7 to TNF-IRF1 signaling pathway
N00980
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
N01614
Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Abexinostat (
DG01402
):
D10060
D10084
Belinostat:
D08870
<US>
Bocodepsin (
DG03260
):
D12551
D12552
Entinostat:
D09338
Fimepinostat:
D11319
Givinostat (
DG03284
):
D12742
D12743
<US>
Mocetinostat (
DG01404
):
D09357
D09641
Nanatinostat:
D11442
Panobinostat (
DG01403
):
D10019
D10319
Quisinostat (
DG01407
):
D10321
D10322
Remetinostat:
D10977
Romidepsin:
D06637
<JP/US>
Tinostamustine:
D11182
Tucidinostat:
D10993
<JP>
Vorinostat:
D06320
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09126 Chromosome
03082 ATP-dependent chromatin remodeling
3066 (HDAC2)
03083 Polycomb repressive complex
3066 (HDAC2)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
3066 (HDAC2)
04350 TGF-beta signaling pathway
3066 (HDAC2)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
3066 (HDAC2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
3066 (HDAC2)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
3066 (HDAC2)
09149 Aging
04213 Longevity regulating pathway - multiple species
3066 (HDAC2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3066 (HDAC2)
05202 Transcriptional misregulation in cancer
3066 (HDAC2)
05206 MicroRNAs in cancer
3066 (HDAC2)
05203 Viral carcinogenesis
3066 (HDAC2)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
3066 (HDAC2)
09172 Infectious disease: viral
05169 Epstein-Barr virus infection
3066 (HDAC2)
05165 Human papillomavirus infection
3066 (HDAC2)
09164 Neurodegenerative disease
05016 Huntington disease
3066 (HDAC2)
09165 Substance dependence
05031 Amphetamine addiction
3066 (HDAC2)
05034 Alcoholism
3066 (HDAC2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
3066 (HDAC2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.98 histone deacetylase
3066 (HDAC2)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
Class I HDACs
3066 (HDAC2)
HDAC complexes
Sin3A-HDAC complex
3066 (HDAC2)
BRAF-HDAC complex
3066 (HDAC2)
REST complex
3066 (HDAC2)
SHIP complex
3066 (HDAC2)
MiDAC complex
3066 (HDAC2)
Polycomb repressive complex (PRC) and associated proteins
Noncanonical PRC1 (PRC1.6)
3066 (HDAC2)
Heterochromatin formation proteins
Other heterochromatin formation proteins
3066 (HDAC2)
Chromatin remodeling factors
NuRD complex
3066 (HDAC2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hist_deacetyl
Motif
Other DBs
NCBI-GeneID:
3066
NCBI-ProteinID:
NP_001518
OMIM:
605164
HGNC:
4853
Ensembl:
ENSG00000196591
UniProt:
Q92769
Structure
PDB
LinkDB
All DBs
Position
6:complement(113933028..113971148)
Genome browser
AA seq
488 aa
AA seq
DB search
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
NT seq
1467 nt
NT seq
+upstream
nt +downstream
nt
atggcgtacagtcaaggaggcggcaaaaaaaaagtctgctactactacgacggtgatatt
ggaaattattattatggacagggtcatcccatgaagcctcatagaatccgcatgacccat
aacttgctgttaaattatggcttatacagaaaaatggaaatatataggccccataaagcc
actgccgaagaaatgacaaaatatcacagtgatgagtatatcaaatttctacggtcaata
agaccagataacatgtctgagtatagtaagcagatgcagagatttaatgttggagaagat
tgtccagtgtttgatggactctttgagttttgtcagctctcaactggcggttcagttgct
ggagctgtgaagttaaaccgacaacagactgatatggctgttaattgggctggaggatta
catcatgctaagaaatcagaagcatcaggattctgttacgttaatgatattgtgcttgcc
atccttgaattactaaagtatcatcagagagtcttatatattgatatagatattcatcat
ggtgatggtgttgaagaagctttttatacaacagatcgtgtaatgacggtatcattccat
aaatatggggaatactttcctggcacaggagacttgagggatattggtgctggaaaaggc
aaatactatgctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcag
atatttaagcctattatctcaaaggtgatggagatgtatcaacctagtgctgtggtatta
cagtgtggtgcagactcattatctggtgatagactgggttgtttcaatctaacagtcaaa
ggtcatgctaaatgtgtagaagttgtaaaaacttttaacttaccattactgatgcttgga
ggaggtggctacacaatccgtaatgttgctcgatgttggacatatgagactgcagttgcc
cttgattgtgagattcccaatgagttgccatataatgattactttgagtattttggacca
gacttcaaactgcatattagtccttcaaacatgacaaaccagaacactccagaatatatg
gaaaagataaaacagcgtttgtttgaaaatttgcgcatgttacctcatgcacctggtgtc
cagatgcaagctattccagaagatgctgttcatgaagacagtggagatgaagatggagaa
gatccagacaagagaatttctattcgagcatcagacaagcggatagcttgtgatgaagaa
ttctcagattctgaggatgaaggagaaggaggtcgaagaaatgtggctgatcataagaaa
ggagcaaagaaagctagaattgaagaagataagaaagaaacagaggacaaaaaaacagac
gttaaggaagaagataaatccaaggacaacagtggtgaaaaaacagataccaaaggaacc
aaatcagaacagctcagcaacccctga
DBGET
integrated database retrieval system