KEGG   Homo sapiens (human): 25942
Entry
25942             CDS       T01001                                 
Symbol
SIN3A, CHR15DELq24, DEL15Q24, WITKOS
Name
(RefSeq) SIN3 transcription regulator family member A
  KO
K11644  paired amphipathic helix protein Sin3a
Organism
hsa  Homo sapiens (human)
Pathway
hsa04350  TGF-beta signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05016  Huntington disease
hsa05169  Epstein-Barr virus infection
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
nt06461  Huntington disease
  Element
N00118  TEL-AML1 fusion to transcriptional repression
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Disease
H01861  Chromosome 15q24 microdeletion syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    25942 (SIN3A)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    25942 (SIN3A)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    25942 (SIN3A)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    25942 (SIN3A)
  09164 Neurodegenerative disease
   05016 Huntington disease
    25942 (SIN3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    25942 (SIN3A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    Sin3A-HDAC complex
     25942 (SIN3A)
    REST complex
     25942 (SIN3A)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    25942 (SIN3A)
SSDB
Motif
Pfam: Sin3a_C PAH Sin3_corepress
Other DBs
NCBI-GeneID: 25942
NCBI-ProteinID: NP_001138829
OMIM: 607776
HGNC: 19353
Ensembl: ENSG00000169375
UniProt: Q96ST3
LinkDB
Position
15:complement(75369379..75455815)
AA seq 1273 aa
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
KYRVKYGTVFKAP
NT seq 3822 nt   +upstreamnt  +downstreamnt
atgaagcggcgtttggatgaccaggagtcaccggtgtatgcagcccagcagcgtcggatc
cctggcagcacagaggcttttcctcaccagcaccgggtgcttgcccctgcccctcctgtg
tatgaagcagtgtctgagaccatgcagtcagctacgggaattcagtactctgtaacaccc
agctaccaggtttcagccatgccacagagctccggcagtcatgggcccgctatagcagca
gttcatagcagccatcatcacccaacagcggtgcagccccacggaggccaggtggtccag
agtcatgctcatccagccccaccagttgcaccagtgcagggacagcagcaatttcagagg
ctgaaggtggaggatgcgctatcttatcttgaccaggtgaagctgcagtttggtagtcag
cctcaggtctacaatgatttccttgacatcatgaaggaatttaaatctcagagcatcgac
accccaggagtgattagtcgtgtgtcccagctattcaaaggccaccccgatctgataatg
ggattcaacaccttcttgccccctggctacaaaattgaggtgcaaaccaatgacatggtg
aatgtgacaactcctggccaggttcatcagattcccacccatggcatccagccacagcct
caaccaccaccccaacatccttcccagccttcagcccagtcagccccagctcctgcccag
ccagctcctcagcccccacctgccaaagtcagcaagccctcccaactgcaagcacatact
ccggccagtcagcagactcccccacttccaccgtatgcatccccacgttctccgccggtc
cagcctcacacaccagtgacaatctcgttgggaacggccccatccttgcagaacaatcaa
cctgtggagtttaatcatgccatcaactatgttaataagatcaagaacagatttcagggc
caaccagacatctacaaagcattcctggagattttgcacacatatcagaaagagcagaga
aatgccaaggaagctggaggaaactacactccagcattgacagagcaggaggtgtatgcc
caggttgctcgtctctttaaaaaccaggaagatttgttgtcagagtttggacaattccta
ccagatgccaacagctccgtgcttttaagcaaaacaactgctgagaaggttgattctgtg
agaaatgatcatggaggcactgtcaagaagccccaactgaacaacaagccgcagaggccc
agccagaatggctgccagatccgcagacatcctacaggaaccacccctccagttaagaag
aaacccaaactgctcaatctgaaggattcttctatggcagatgccagcaaacatggtggt
ggaacagaatcgttattttttgataaggtccgaaaggctcttcggagtgcagaagcctac
gaaaatttcctacgctgtcttgttatttttaaccaggaggtgatctctcgtgctgagctt
gtgcaactagtctctcctttcctggggaaattccctgagttgtttaattggtttaaaaac
tttctgggctataaggagtctgtacatctggaaacttatccaaaggagcgagccacagag
ggcattgctatggagatagattatgcttcttgtaaacgattgggctccagctatcgagcc
ttaccaaagagttaccagcagcccaagtgtacaggacggactcctctctgtaaagaggtt
ttaaatgatacctgggtttccttcccttcgtggtctgaggactctacctttgtgagttcc
aagaagactcaatatgaagaacatatttatcgttgtgaagatgaacgctttgagcttgat
gtagttttagagaccaatctggcaacaatccgggttctggaagcaatacagaagaagctt
tcccgcttgtctgctgaagaacaagccaaatttcgcttggacaacacccttgggggcaca
tcagaagtcatccatagaaaagcactccagaggatatatgctgataaagcagctgacatc
attgatggtctgagaaagaatccctccattgctgttccaattgtccttaaaaggttgaag
atgaaagaggaagaatggcgagaagctcagagaggctttaacaaagtatggcgagaacaa
aatgagaaatactacttgaagtctctggaccaccaggggatcaactttaaacagaatgac
accaaggtcctgaggtctaagagcttactcaatgagattgagagtatctatgatgagagg
caagagcaggctacggaggagaatgctggtgtacctgttggcccacacctctcacttgcg
tatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagagg
cagacaggcattcagaaggaggacaaatataagataaaacaaatcatgcatcattttatt
ccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaa
gagatggatgtagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagt
ccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaagaggaatggat
gaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccag
attctctgcctgaggctgctacggatttgttcccaagccgaacggcaaattgaagaagaa
aaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagc
cctgccattcagctacgtctcaaagaacctatggatgttgatgtagaagattattaccca
gctttcctggacatggtgcggagcctgctggatggcaacatagactcatcacagtatgaa
gattcactgagagagatgttcaccattcatgcctacattgcctttaccatggacaaactg
atccagagcattgtcagacagctgcagcatatcgtgagtgatgagatctgtgtgcaggtg
actgacctttacctggcagaaaataataatggggccaccggaggccagctgaacacacag
aactcaaggagcctcctggagtcaacgtatcagcggaaagctgagcagctaatgtcagat
gagaattgctttaagcttatgtttattcagagccaaggccaggtccagctgactattgag
cttctggacacagaagaggagaattcggatgaccctgtggaagcagagcgctggtcagac
tacgtggagcgatacatgaattcagatactacctcgcctgagcttcgtgaacatctagca
cagaaaccagtatttctccccaggaatctacggcggatccggaagtgtcaacgtggtcga
gagcagcaggaaaaggaagggaaggaaggaaacagcaagaagaccatggagaatgtggat
agtctggataagctggagtgtagattcaagctgaattcctacaagatggtgtatgtgatc
aaatcagaggactatatgtatcggaggaccgccctgctccgggctcatcagtcccatgag
cgtgtaagcaagcgtctacatcagagattccaggcctgggtagataaatggaccaaggag
catgtgccccgtgaaatggcagcagagaccagcaagtggctcatgggtgaggggctggag
ggcctggtgccctgtaccaccacctgtgatacagagaccctgcattttgtgagcattaac
aagtatcgtgtcaaatacggcacagtattcaaagccccttaa

KEGG   Homo sapiens (human): 23186
Entry
23186             CDS       T01001                                 
Symbol
RCOR1, COREST, RCOR
Name
(RefSeq) REST corepressor 1
  KO
K11829  REST corepressor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05016  Huntington disease
Network
nt06461  Huntington disease
  Element
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    23186 (RCOR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23186 (RCOR1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    BRAF-HDAC complex
     23186 (RCOR1)
    REST complex
     23186 (RCOR1)
SSDB
Motif
Pfam: REST_helical Myb_DNA-binding ELM2 Myb_DNA-bind_7 Myb_DNA-bind_6 Homeobox_KN
Other DBs
NCBI-GeneID: 23186
NCBI-ProteinID: NP_055971
OMIM: 607675
HGNC: 17441
Ensembl: ENSG00000089902
UniProt: Q9UKL0
Structure
LinkDB
Position
14:102592649..102730561
AA seq 485 aa
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS
NT seq 1458 nt   +upstreamnt  +downstreamnt
atgccggccatggtggagaagggccccgaggtctcagggaagcggagagggaggaacaac
gcggccgcctccgcctccgccgccgccgcctccgccgccgcctcggccgcctgcgcctcg
ccagccgccactgccgcctcgggcgccgccgcctcctcagcctcggccgccgccgcctca
gccgccgccgcccccaataatggccagaataaaagtttggcggcggcggcgcccaatggc
aacagcagcagcaactcctgggaggaaggcagctcgggctcgtccagcgacgaggagcac
ggtggcggtggcatgagggtcggaccccagtaccaggcggtggtgcccgacttcgacccc
gccaaactggcaagacgcagtcaagaacgggacaatcttggcatgttggtctggtcaccc
aatcaaaatctgtcagaagcaaagttggatgaatacattgccattgccaaagaaaagcat
gggtacaacatggaacaggctcttgggatgctcttctggcataaacataatatcgaaaag
tcattggctgatttgcccaactttacccctttcccagatgagtggactgtggaagataaa
gtcttatttgagcaagcctttagttttcatgggaaaacttttcatagaatccaacaaatg
cttccagataaatctatagcaagtctggtgaaattttactattcttggaagaagacgagg
actaaaactagtgtgatggatcgccatgcccggaaacaaaaacgggagcgggaggagagc
gaggatgaactggaagaggcaaatggaaacaatcccattgacattgaggttgatcaaaac
aaggaaagcaaaaaggaggttccccctactgagacagttcctcaggtcaaaaaagaaaaa
catagcacacaagctaaaaatagagcaaaaaggaaacctccaaaaggaatgtttctttct
caagaagatgtggaggctgtttctgccaatgccactgctgctaccacggtgctgagacaa
ctagacatggaattggtttcagtcaaacgacagatccagaatattaaacagacaaacagt
gctctcaaagaaaaacttgatggtggaatagaaccatatcgacttccagaggtcattcag
aaatgtaatgcacgttggactacagaagagcagcttctcgccgtacaagccatcaggaaa
tatggccgagattttcaggcaatctcagacgtgattgggaacaaatcagtggtacaagtg
aaaaacttttttgtaaattatcgacgccgcttcaacatagatgaagttttacaagaatgg
gaggcagaacatggtaaagaagagaccaatgggcccagtaaccagaagcctgtgaagtcc
ccagataattccattaagatgcccgaagaggaagacgaggctcctgttctggatgtcaga
tatgcatctgcctcctga

KEGG   Homo sapiens (human): 3065
Entry
3065              CDS       T01001                                 
Symbol
HDAC1, GON-10, HD1, KDAC1, RPD3, RPD3L1
Name
(RefSeq) histone deacetylase 1
  KO
K06067  histone deacetylase 1/2 [EC:3.5.1.98]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa03083  Polycomb repressive complex
hsa04110  Cell cycle
hsa04213  Longevity regulating pathway - multiple species
hsa04330  Notch signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04613  Neutrophil extracellular trap formation
hsa04919  Thyroid hormone signaling pathway
hsa05016  Huntington disease
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05165  Human papillomavirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05206  MicroRNAs in cancer
hsa05220  Chronic myeloid leukemia
Network
nt06166  Human papillomavirus (HPV)
nt06240  Transcription (cancer)
nt06461  Huntington disease
nt06516  TNF signaling
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N00118  TEL-AML1 fusion to transcriptional repression
N00375  HPV E7 to TNF-IRF1 signaling pathway
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Abexinostat (DG01402): D10060 D10084
Belinostat: D08870<US>
Bocodepsin (DG03260): D12551 D12552
Entinostat: D09338
Fimepinostat: D11319
Givinostat (DG03284): D12742 D12743<US>
Mocetinostat (DG01404): D09357 D09641
Nanatinostat: D11442
Panobinostat (DG01403): D10019 D10319
Quisinostat (DG01407): D10321 D10322
Remetinostat: D10977
Romidepsin: D06637<JP/US>
Tacedinaline: D05988
Tinostamustine: D11182
Tucidinostat: D10993<JP>
Vorinostat: D06320<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    3065 (HDAC1)
   03083 Polycomb repressive complex
    3065 (HDAC1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    3065 (HDAC1)
   04350 TGF-beta signaling pathway
    3065 (HDAC1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    3065 (HDAC1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    3065 (HDAC1)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    3065 (HDAC1)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3065 (HDAC1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3065 (HDAC1)
   05202 Transcriptional misregulation in cancer
    3065 (HDAC1)
   05206 MicroRNAs in cancer
    3065 (HDAC1)
   05203 Viral carcinogenesis
    3065 (HDAC1)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    3065 (HDAC1)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    3065 (HDAC1)
   05165 Human papillomavirus infection
    3065 (HDAC1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    3065 (HDAC1)
  09165 Substance dependence
   05031 Amphetamine addiction
    3065 (HDAC1)
   05034 Alcoholism
    3065 (HDAC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3065 (HDAC1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     3065 (HDAC1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     3065 (HDAC1)
   HDAC complexes
    Sin3A-HDAC complex
     3065 (HDAC1)
    BRAF-HDAC complex
     3065 (HDAC1)
    REST complex
     3065 (HDAC1)
    SHIP complex
     3065 (HDAC1)
    MiDAC complex
     3065 (HDAC1)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     3065 (HDAC1)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    3065 (HDAC1)
  Chromatin remodeling factors
   NuRD complex
    3065 (HDAC1)
SSDB
Motif
Pfam: Hist_deacetyl
Other DBs
NCBI-GeneID: 3065
NCBI-ProteinID: NP_004955
OMIM: 601241
HGNC: 4852
Ensembl: ENSG00000116478
UniProt: Q13547 Q6IT96
Structure
LinkDB
Position
1:32292083..32333626
AA seq 482 aa
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
NT seq 1449 nt   +upstreamnt  +downstreamnt
atggcgcagacgcagggcacccggaggaaagtctgttactactacgacggggatgttgga
aattactattatggacaaggccacccaatgaagcctcaccgaatccgcatgactcataat
ttgctgctcaactatggtctctaccgaaaaatggaaatctatcgccctcacaaagccaat
gctgaggagatgaccaagtaccacagcgatgactacattaaattcttgcgctccatccgt
ccagataacatgtcggagtacagcaagcagatgcagagattcaacgttggtgaggactgt
ccagtattcgatggcctgtttgagttctgtcagttgtctactggtggttctgtggcaagt
gctgtgaaacttaataagcagcagacggacatcgctgtgaattgggctgggggcctgcac
catgcaaagaagtccgaggcatctggcttctgttacgtcaatgatatcgtcttggccatc
ctggaactgctaaagtatcaccagagggtgctgtacattgacattgatattcaccatggt
gacggcgtggaagaggccttctacaccacggaccgggtcatgactgtgtcctttcataag
tatggagagtacttcccaggaactggggacctacgggatatcggggctggcaaaggcaag
tattatgctgttaactacccgctccgagacgggattgatgacgagtcctatgaggccatt
ttcaagccggtcatgtccaaagtaatggagatgttccagcctagtgcggtggtcttacag
tgtggctcagactccctatctggggatcggttaggttgcttcaatctaactatcaaagga
cacgccaagtgtgtggaatttgtcaagagctttaacctgcctatgctgatgctgggaggc
ggtggttacaccattcgtaacgttgcccggtgctggacatatgagacagctgtggccctg
gatacggagatccctaatgagcttccatacaatgactactttgaatactttggaccagat
ttcaagctccacatcagtccttccaatatgactaaccagaacacgaatgagtacctggag
aagatcaaacagcgactgtttgagaaccttagaatgctgccgcacgcacctggggtccaa
atgcaggcgattcctgaggacgccatccctgaggagagtggcgatgaggacgaagacgac
cctgacaagcgcatctcgatctgctcctctgacaaacgaattgcctgtgaggaagagttc
tccgattctgaagaggagggagaggggggccgcaagaactcttccaacttcaaaaaagcc
aagagagtcaaaacagaggatgaaaaagagaaagacccagaggagaagaaagaagtcacc
gaagaggagaaaaccaaggaggagaagccagaagccaaaggggtcaaggaggaggtcaag
ttggcctga

KEGG   Homo sapiens (human): 3066
Entry
3066              CDS       T01001                                 
Symbol
HDAC2, HD2, KDAC2, RPD3, YAF1
Name
(RefSeq) histone deacetylase 2
  KO
K06067  histone deacetylase 1/2 [EC:3.5.1.98]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa03083  Polycomb repressive complex
hsa04110  Cell cycle
hsa04213  Longevity regulating pathway - multiple species
hsa04330  Notch signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04613  Neutrophil extracellular trap formation
hsa04919  Thyroid hormone signaling pathway
hsa05016  Huntington disease
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05165  Human papillomavirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05206  MicroRNAs in cancer
hsa05220  Chronic myeloid leukemia
Network
nt06166  Human papillomavirus (HPV)
nt06240  Transcription (cancer)
nt06461  Huntington disease
nt06516  TNF signaling
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N00118  TEL-AML1 fusion to transcriptional repression
N00375  HPV E7 to TNF-IRF1 signaling pathway
N00980  Mutation-caused aberrant Htt to REST-mediated transcriptional repression
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Abexinostat (DG01402): D10060 D10084
Belinostat: D08870<US>
Bocodepsin (DG03260): D12551 D12552
Entinostat: D09338
Fimepinostat: D11319
Givinostat (DG03284): D12742 D12743<US>
Mocetinostat (DG01404): D09357 D09641
Nanatinostat: D11442
Panobinostat (DG01403): D10019 D10319
Quisinostat (DG01407): D10321 D10322
Remetinostat: D10977
Romidepsin: D06637<JP/US>
Tinostamustine: D11182
Tucidinostat: D10993<JP>
Vorinostat: D06320<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    3066 (HDAC2)
   03083 Polycomb repressive complex
    3066 (HDAC2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    3066 (HDAC2)
   04350 TGF-beta signaling pathway
    3066 (HDAC2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    3066 (HDAC2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    3066 (HDAC2)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    3066 (HDAC2)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3066 (HDAC2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3066 (HDAC2)
   05202 Transcriptional misregulation in cancer
    3066 (HDAC2)
   05206 MicroRNAs in cancer
    3066 (HDAC2)
   05203 Viral carcinogenesis
    3066 (HDAC2)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    3066 (HDAC2)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    3066 (HDAC2)
   05165 Human papillomavirus infection
    3066 (HDAC2)
  09164 Neurodegenerative disease
   05016 Huntington disease
    3066 (HDAC2)
  09165 Substance dependence
   05031 Amphetamine addiction
    3066 (HDAC2)
   05034 Alcoholism
    3066 (HDAC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3066 (HDAC2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     3066 (HDAC2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     3066 (HDAC2)
   HDAC complexes
    Sin3A-HDAC complex
     3066 (HDAC2)
    BRAF-HDAC complex
     3066 (HDAC2)
    REST complex
     3066 (HDAC2)
    SHIP complex
     3066 (HDAC2)
    MiDAC complex
     3066 (HDAC2)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     3066 (HDAC2)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    3066 (HDAC2)
  Chromatin remodeling factors
   NuRD complex
    3066 (HDAC2)
SSDB
Motif
Pfam: Hist_deacetyl
Other DBs
NCBI-GeneID: 3066
NCBI-ProteinID: NP_001518
OMIM: 605164
HGNC: 4853
Ensembl: ENSG00000196591
UniProt: Q92769
Structure
LinkDB
Position
6:complement(113933028..113971148)
AA seq 488 aa
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
NT seq 1467 nt   +upstreamnt  +downstreamnt
atggcgtacagtcaaggaggcggcaaaaaaaaagtctgctactactacgacggtgatatt
ggaaattattattatggacagggtcatcccatgaagcctcatagaatccgcatgacccat
aacttgctgttaaattatggcttatacagaaaaatggaaatatataggccccataaagcc
actgccgaagaaatgacaaaatatcacagtgatgagtatatcaaatttctacggtcaata
agaccagataacatgtctgagtatagtaagcagatgcagagatttaatgttggagaagat
tgtccagtgtttgatggactctttgagttttgtcagctctcaactggcggttcagttgct
ggagctgtgaagttaaaccgacaacagactgatatggctgttaattgggctggaggatta
catcatgctaagaaatcagaagcatcaggattctgttacgttaatgatattgtgcttgcc
atccttgaattactaaagtatcatcagagagtcttatatattgatatagatattcatcat
ggtgatggtgttgaagaagctttttatacaacagatcgtgtaatgacggtatcattccat
aaatatggggaatactttcctggcacaggagacttgagggatattggtgctggaaaaggc
aaatactatgctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcag
atatttaagcctattatctcaaaggtgatggagatgtatcaacctagtgctgtggtatta
cagtgtggtgcagactcattatctggtgatagactgggttgtttcaatctaacagtcaaa
ggtcatgctaaatgtgtagaagttgtaaaaacttttaacttaccattactgatgcttgga
ggaggtggctacacaatccgtaatgttgctcgatgttggacatatgagactgcagttgcc
cttgattgtgagattcccaatgagttgccatataatgattactttgagtattttggacca
gacttcaaactgcatattagtccttcaaacatgacaaaccagaacactccagaatatatg
gaaaagataaaacagcgtttgtttgaaaatttgcgcatgttacctcatgcacctggtgtc
cagatgcaagctattccagaagatgctgttcatgaagacagtggagatgaagatggagaa
gatccagacaagagaatttctattcgagcatcagacaagcggatagcttgtgatgaagaa
ttctcagattctgaggatgaaggagaaggaggtcgaagaaatgtggctgatcataagaaa
ggagcaaagaaagctagaattgaagaagataagaaagaaacagaggacaaaaaaacagac
gttaaggaagaagataaatccaaggacaacagtggtgaaaaaacagataccaaaggaacc
aaatcagaacagctcagcaacccctga

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