KEGG   Homo sapiens (human): 27232
Entry
27232             CDS       T01001                                 
Symbol
GNMT, HEL-S-182mP
Name
(RefSeq) glycine N-methyltransferase
  KO
K00552  glycine N-methyltransferase [EC:2.1.1.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00184  Hypermethioninemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    27232 (GNMT)
   00270 Cysteine and methionine metabolism
    27232 (GNMT)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    27232 (GNMT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.20  glycine N-methyltransferase
     27232 (GNMT)
SSDB
Motif
Pfam: Methyltransf_25 Methyltransf_31 Methyltransf_12 Methyltransf_11 Methyltransf_23 TehB Ubie_methyltran MTS Methyltransf_15 PCMT TPMT CMAS
Other DBs
NCBI-GeneID: 27232
NCBI-ProteinID: NP_061833
OMIM: 606628
HGNC: 4415
Ensembl: ENSG00000124713
UniProt: Q14749 V9HW60
Structure
LinkDB
Position
6:42960754..42963880
AA seq 295 aa
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
NT seq 888 nt   +upstreamnt  +downstreamnt
atggtggacagcgtgtaccggacccgctccctgggggtggcggccgaagggctcccggac
cagtacgcggacggggaggcggcgcgcgtgtggcagctgtatatcggagacacccgcagc
cgcaccgccgagtacaaggcatggctgcttgggctgctgcgccagcacggctgccagcgg
gtgctcgacgtagcctgtggcactggggtggactccattatgctggtggaagagggcttc
agtgtgacgagtgtggatgccagtgacaagatgctgaagtatgcacttaaggagcgctgg
aaccggcggcacgagcccgccttcgacaagtgggtcatcgaagaagccaactggatgact
ctggacaaagatgtgccccagtcagcagagggtggctttgatgctgtcatctgccttgga
aacagtttcgctcacttgccagactgcaaaggggaccagagtgagcaccggctggcgctg
aaaaacattgcgagcatggtgcgggcagggggcctactggtcattgatcatcgcaactac
gaccacatcctcagtacaggctgtgcacccccagggaagaacatctactataagagtgac
ttgaccaaggacgtcacaacatcagtgctgatagtgaacaacaaggcccacatggtgacc
ctggactatacggtgcaggtgccgggggctggccaggatggctctcctggcttgagtaag
ttccggctctcctactacccacactgtctggcatccttcacggagctgctccaagcagcc
ttcggaggtaagtgccagcacagcgtcctgggcgacttcaagccttacaagccaggccaa
acctacattccctgctacttcatccacgtgctcaagaggacagactga

KEGG   Homo sapiens (human): 1786
Entry
1786              CDS       T01001                                 
Symbol
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
Name
(RefSeq) DNA methyltransferase 1
  KO
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00265  Hereditary sensory and autonomic neuropathy
H02940  Autosomal dominant cerebellar ataxia, deafness, and narcolepsy
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Roducitabine: D11740
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1786 (DNMT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1786 (DNMT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1786 (DNMT1)
   03032 DNA replication proteins [BR:hsa03032]
    1786 (DNMT1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1786 (DNMT1)
  09183 Protein families: signaling and cellular processes
   02048 Prokaryotic defense system [BR:hsa02048]
    1786 (DNMT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1786 (DNMT1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    1786 (DNMT1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1786 (DNMT1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1786 (DNMT1)
Prokaryotic defense system [BR:hsa02048]
 Restriction and modification system (R-M system)
  Type II R-M system
   DNA methyltransferases
    1786 (DNMT1)
SSDB
Motif
Pfam: BAH DNMT1-RFD DNA_methylase DMAP_binding zf-CXXC HTH_12
Other DBs
NCBI-GeneID: 1786
NCBI-ProteinID: NP_001370
OMIM: 126375
HGNC: 2976
Ensembl: ENSG00000130816
UniProt: P26358 I6L9H2
Structure
LinkDB
Position
19:complement(10133346..10194953)
AA seq 1616 aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
NT seq 4851 nt   +upstreamnt  +downstreamnt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcctgaaccttcacctagccccaggattacaaggaaa
agcaccaggcaaaccaccatcacatctcattttgcaaagggccctgccaaacggaaacct
caggaagagtctgaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccag
gatgagaagagacgtagagttacatccagagaacgagttgctagaccgcttcctgcagaa
gaacctgaaagagcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaa
gaagaaaagagactccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggag
gagccggacagagaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgag
aaagatgagaagaagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaa
gaaaaagaacctgaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaag
gaggagaagagacgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgcc
aaaacagtcatgaactccaagacccaccctcccaagtgcattcagtgcgggcagtacctg
gacgaccctgacctcaaatatgggcagcacccaccagacgcggtggatgagccacagatg
ctgacaaatgagaagctgtccatctttgatgccaacgagtctggctttgagagttatgag
gcgcttccccagcacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgt
cccatcgacaccggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaa
ccaatctatgatgatgacccatctcttgaaggtggtgttaatggcaaaaatcttggcccc
ataaatgaatggtggatcactggctttgatggaggtgaaaaggccctcatcggcttcagc
acctcatttgccgaatacattctgatggatcccagtcccgagtatgcgcccatatttggg
ctgatgcaggagaagatctacatcagcaagattgtggtggagttcctgcagagcaattcc
gactcgacctatgaggacctgatcaacaagatcgagaccacggttcctccttctggcctc
aacttgaaccgcttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcag
gtggagagttatgacgaggccggggacagtgatgagcagcccatcttcctgacaccctgc
atgcgggacctgatcaagctggctggggtcacgctgggacagaggcgagcccaggcgagg
cggcagaccatcaggcattctaccagggagaaggacaggggacccacgaaagccaccacc
accaagctggtctaccagatcttcgatactttcttcgcagagcaaattgaaaaggatgac
agagaagacaaggagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcag
cagcctgagtgtgggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtgga
cggagcaagcaggcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagat
gacgatgaggaagtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccag
gggaagaagaagaaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagact
gatgggaagaagagttactataagaaggtgtgcattgatgcggaaaccctggaagtgggg
gactgtgtctctgttattccagatgattcctcaaaaccgctgtatctagcaagggtcacg
gcgctgtgggaggacagcagcaacgggcagatgtttcacgcccactggttctgcgctggg
acagacacagtcctcggggccacgtcggaccctctggagctgttcttggtggatgaatgt
gaggacatgcagctttcatatatccacagcaaagtgaaagtcatctacaaagccccctcc
gaaaactgggccatggagggaggcatggatcccgagtccctgctggagggggacgacggg
aagacctacttctaccagctgtggtatgatcaagactacgcgagattcgagtcccctcca
aaaacccagccaacagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggct
gagatgaggcaaaaagaaatccccagggtcctggagcagctcgaggacctggatagccgg
gtcctctactactcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtac
ctgccccctgaggccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacgg
aaggagcccgtggatgaggacctgtacccagagcactaccggaaatactccgactacatc
aaaggcagcaacctggatgcccctgagccctaccgaattggccggatcaaagagatcttc
tgtcccaagaagagcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaag
ttctacaggcctgagaacacccacaagtccactccagcgagctaccacgcagacatcaac
ctgctctactggagcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgc
accgtggagtatggggaggacctgcccgagtgcgtccaggtgtactccatgggcggcccc
aaccgcttctacttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctccc
aaccatgcccgtagccctggaaacaaagggaagggcaagggaaaagggaagggcaagccc
aagtcccaagcctgtgagccgagcgagccagagatagagatcaagctgcccaagctgcgg
accctggatgtgttttctggctgcggggggttgtcggagggattccaccaagcaggcatc
tctgacacgctgtgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaac
aaccccggctccacagtgttcacagaggactgcaacatcctgctgaagctggtcatggct
ggggagaccaccaactcccgcggccagcggctgccccagaagggagacgtggagatgctg
tgcggcgggccgccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctac
tccaagttcaaaaactctctggtggtttccttcctcagctactgcgactactaccggccc
cggttcttcctcctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctg
aagctcaccctccgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcag
gccggtcagtacggcgtggcccagactaggaggcgggccatcatcctggccgcggcccct
ggagagaagctccctctgttcccggagccactgcacgtgtttgctccccgggcctgccag
ctgagcgtggtggtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggt
cctttccggaccatcacggtgcgagacacgatgtccgacctgccggaggtgcggaatgga
gcctcggcactggagatctcctacaacggggagcctcagtcctggttccagaggcagctc
cggggcgcacagtaccagcccatcctcagggaccacatctgtaaggacatgagtgcattg
gtggctgcccgcatgcggcacatccccttggccccagggtcagactggcgcgatctgccc
aacatcgaggtgcggctctcagacggcaccatggccaggaagctgcggtatacccaccat
gacaggaagaacggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaa
gccggcaaagcctgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctg
ccccacaccgggaaccggcacaaccactgggctggcctctatggaaggctcgagtgggac
ggcttcttcagcacaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctc
cacccagagcagcaccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccct
gacacctaccggctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtg
ccaccgcccctggccaaagccattggcttggagatcaagctttgtatgttggccaaagcc
cgagagagtgcctcagctaaaataaaggaggaggaagctgctaaggactag

KEGG   Homo sapiens (human): 1788
Entry
1788              CDS       T01001                                 
Symbol
DNMT3A, DNMT3A2, HESJAS, M.HsaIIIA, TBRS
Name
(RefSeq) DNA methyltransferase 3 alpha
  KO
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa04148  Efferocytosis
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
nt06535  Efferocytosis
  Element
N01607  Methionine degradation
N01773  PTGS2-PGE2-TGFB1 pathway
N01774  ERK-DUSP4 negative feedback pathway
Disease
H00003  Acute myeloid leukemia
H01892  Peripheral T cell lymphoma
H02294  Tatton-Brown-Rahman syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02668  Heyn-Sproul-Jackson syndrome
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1788 (DNMT3A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1788 (DNMT3A)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1788 (DNMT3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1788 (DNMT3A)
   03032 DNA replication proteins [BR:hsa03032]
    1788 (DNMT3A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1788 (DNMT3A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1788 (DNMT3A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1788 (DNMT3A)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1788 (DNMT3A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1788 (DNMT3A)
SSDB
Motif
Pfam: DNM3A_N ADD_DNMT3 DNMT3_ADD_GATA1-like DNA_methylase PWWP
Other DBs
NCBI-GeneID: 1788
NCBI-ProteinID: NP_072046
OMIM: 602769
HGNC: 2978
Ensembl: ENSG00000119772
UniProt: Q9Y6K1
Structure
LinkDB
Position
2:complement(25227874..25342590)
AA seq 912 aa
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV
NT seq 2739 nt   +upstreamnt  +downstreamnt
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggag
gaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagag
cccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtg
gaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccag
gactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccag
ccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggt
gcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaag
gagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatcc
atgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctc
cgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaag
cgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtc
attgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggag
gaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctacc
acgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgac
gagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactg
cggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccga
gcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgt
gttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaac
aagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcg
gggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggag
gtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaag
ggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgg
gtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagc
acagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtg
tacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctc
aatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgc
tttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgc
tgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtg
gagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccc
tggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggac
tggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctcca
aaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctcttt
gatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctac
attgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaag
atcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggccca
ttcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgc
aagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgat
gcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggcc
atgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgatt
gatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggt
atgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggag
catggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccata
aagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatgg
tgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatg
agccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccac
ctcttcgctccgctgaaggagtattttgcgtgtgtgtaa

KEGG   Homo sapiens (human): 1789
Entry
1789              CDS       T01001                                 
Symbol
DNMT3B, FSHD4, ICF, ICF1, M.HsaIIIB
Name
(RefSeq) DNA methyltransferase 3 beta
  KO
K17399  DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
nt06512  Chromosome cohesion and segregation
  Element
N01497  Condensin loading
N01607  Methionine degradation
Disease
H00087  Other humoral immunodeficiencies
H00591  Facioscapulohumeral muscular dystrophy
H02308  Immunodeficiency-centromeric instability-facial anomalies syndrome
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1789 (DNMT3B)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1789 (DNMT3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1789 (DNMT3B)
   03032 DNA replication proteins [BR:hsa03032]
    1789 (DNMT3B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1789 (DNMT3B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1789 (DNMT3B)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    1789 (DNMT3B)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1789 (DNMT3B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1789 (DNMT3B)
SSDB
Motif
Pfam: ADD_DNMT3 DNMT3_ADD_GATA1-like DNA_methylase PWWP
Other DBs
NCBI-GeneID: 1789
NCBI-ProteinID: NP_008823
OMIM: 602900
HGNC: 2979
Ensembl: ENSG00000088305
UniProt: Q9UBC3
Structure
LinkDB
Position
20:32762385..32809356
AA seq 853 aa
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
NT seq 2562 nt   +upstreamnt  +downstreamnt
atgaagggagacaccaggcatctcaatggagaggaggacgccggcgggagggaagactcg
atcctcgtcaacggggcctgcagcgaccagtcctccgactcgcccccaatcctggaggct
atccgcaccccggagatcagaggccgaagatcaagctcgcgactctccaagagggaggtg
tccagtctgctaagctacacacaggacttgacaggcgatggcgacggggaagatggggat
ggctctgacaccccagtcatgccaaagctcttccgggaaaccaggactcgttcagaaagc
ccagctgtccgaactcgaaataacaacagtgtctccagccgggagaggcacaggccttcc
ccacgttccacccgaggccggcagggccgcaaccatgtggacgagtcccccgtggagttc
ccggctaccaggtccctgagacggcgggcaacagcatcggcaggaacgccatggccgtcc
cctcccagctcttaccttaccatcgacctcacagacgacacagaggacacacatgggacg
ccccagagcagcagtaccccctacgcccgcctagcccaggacagccagcaggggggcatg
gagtccccgcaggtggaggcagacagtggagatggagacagttcagagtatcaggatggg
aaggagtttggaataggggacctcgtgtggggaaagatcaagggcttctcctggtggccc
gccatggtggtgtcttggaaggccacctccaagcgacaggctatgtctggcatgcggtgg
gtccagtggtttggcgatggcaagttctccgaggtctctgcagacaaactggtggcactg
gggctgttcagccagcactttaatttggccaccttcaataagctcgtctcctatcgaaaa
gccatgtaccatgctctggagaaagctagggtgcgagctggcaagaccttccccagcagc
cctggagactcattggaggaccagctgaagcccatgttggagtgggcccacgggggcttc
aagcccactgggatcgagggcctcaaacccaacaacacgcaaccagtggttaataagtcg
aaggtgcgtcgtgcaggcagtaggaaattagaatcaaggaaatacgagaacaagactcga
agacgcacagctgacgactcagccacctctgactactgccccgcacccaagcgcctcaag
acaaattgctataacaacggcaaagaccgaggggatgaagatcagagccgagaacaaatg
gcttcagatgttgccaacaacaagagcagcctggaagatggctgtttgtcttgtggcagg
aaaaaccccgtgtccttccaccctctctttgagggggggctctgtcagacatgccgggat
cgcttccttgagctgttttacatgtatgatgacgatggctatcagtcttactgcactgtg
tgctgcgagggccgagagctgctgctttgcagcaacacgagctgctgccggtgtttctgt
gtggagtgcctggaggtgctggtgggcacaggcacagcggccgaggccaagcttcaggag
ccctggagctgttacatgtgtctcccgcagcgctgtcatggcgtcctgcggcgccggaag
gactggaacgtgcgcctgcaggccttcttcaccagtgacacggggcttgaatatgaagcc
cccaagctgtaccctgccattcccgcagcccgaaggcggcccattcgagtcctgtcattg
tttgatggcatcgcgacaggctacctagtcctcaaagagttgggcataaaggtaggaaag
tacgtcgcttctgaagtgtgtgaggagtccattgctgttggaaccgtgaagcacgagggg
aatatcaaatacgtgaacgacgtgaggaacatcacaaagaaaaatattgaagaatggggc
ccatttgacttggtgattggcggaagcccatgcaacgatctctcaaatgtgaatccagcc
aggaaaggcctgtatgagggtacaggccggctcttcttcgaattttaccacctgctgaat
tactcacgccccaaggagggtgatgaccggccgttcttctggatgtttgagaatgttgta
gccatgaaggttggcgacaagagggacatctcacggttcctggagtgtaatccagtgatg
attgatgccatcaaagtttctgctgctcacagggcccgatacttctggggcaacctaccc
gggatgaacaggcccgtgatagcatcaaagaatgataaactcgagctgcaggactgcttg
gaatacaataggatagccaagttaaagaaagtacagacaataaccaccaagtcgaactcg
atcaaacaggggaaaaaccaacttttccctgttgtcatgaatggcaaagaagatgttttg
tggtgcactgagctcgaaaggatctttggctttcctgtgcactacacagacgtgtccaac
atgggccgtggtgcccgccagaagctgctgggaaggtcctggagcgtgcctgtcatccga
cacctcttcgcccctctgaaggactactttgcatgtgaatag

DBGET integrated database retrieval system