KEGG   NETWORK: N00053
Entry
N00053                      Network                                
Name
Cytokine-Jak-STAT signaling pathway
Definition
Cytokine -> Receptor -> JAK -> STAT => PIM1
  Expanded
(3558,3562,3565,3567,3569,3574,3592,3593,3596,3600,51561,2056,3439,3458) -> (3559,3560,3561,3563,3566,1439,3568,3570,3572,3575,3594,3595,3597,3601,149233,2057,3454,3455,3459,3460) -> (3716,3717,3718) -> (6772,6773,6774,6775,6776,6777,6778) => 5292
Class
nt06263 Hepatocellular carcinoma
nt06266 Non-small cell lung cancer
nt06276 Chronic myeloid leukemia
nt06219 JAK-STAT signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06162 Hepatitis B virus (HBV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3558  IL2; interleukin 2
3562  IL3; interleukin 3
3565  IL4; interleukin 4
3567  IL5; interleukin 5
3569  IL6; interleukin 6
3574  IL7; interleukin 7
3592  IL12A; interleukin 12A
3593  IL12B; interleukin 12B
3596  IL13; interleukin 13
3600  IL15; interleukin 15
51561  IL23A; interleukin 23 subunit alpha
2056  EPO; erythropoietin
3439  IFNA1; interferon alpha 1
3458  IFNG; interferon gamma
3559  IL2RA; interleukin 2 receptor subunit alpha
3560  IL2RB; interleukin 2 receptor subunit beta
3561  IL2RG; interleukin 2 receptor subunit gamma
3563  IL3RA; interleukin 3 receptor subunit alpha
3566  IL4R; interleukin 4 receptor
1439  CSF2RB; colony stimulating factor 2 receptor beta common subunit
3568  IL5RA; interleukin 5 receptor subunit alpha
3570  IL6R; interleukin 6 receptor
3572  IL6ST; interleukin 6 signal transducer
3575  IL7R; interleukin 7 receptor
3594  IL12RB1; interleukin 12 receptor subunit beta 1
3595  IL12RB2; interleukin 12 receptor subunit beta 2
3597  IL13RA1; interleukin 13 receptor subunit alpha 1
3601  IL15RA; interleukin 15 receptor subunit alpha
149233  IL23R; interleukin 23 receptor
2057  EPOR; erythropoietin receptor
3454  IFNAR1; interferon alpha and beta receptor subunit 1
3455  IFNAR2; interferon alpha and beta receptor subunit 2
3459  IFNGR1; interferon gamma receptor 1
3460  IFNGR2; interferon gamma receptor 2
3716  JAK1; Janus kinase 1
3717  JAK2; Janus kinase 2
3718  JAK3; Janus kinase 3
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
6774  STAT3; signal transducer and activator of transcription 3
6775  STAT4; signal transducer and activator of transcription 4
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
6778  STAT6; signal transducer and activator of transcription 6
5292  PIM1; Pim-1 proto-oncogene, serine/threonine kinase
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:23576269
  Authors
Narlik-Grassow M, Blanco-Aparicio C, Carnero A
  Title
The PIM family of serine/threonine kinases in cancer.
  Journal
Med Res Rev 34:136-59 (2014)
DOI:10.1002/med.21284
Reference
PMID:21508344
  Authors
Tamiya T, Kashiwagi I, Takahashi R, Yasukawa H, Yoshimura A
  Title
Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3.
  Journal
Arterioscler Thromb Vasc Biol 31:980-5 (2011)
DOI:10.1161/ATVBAHA.110.207464
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