KEGG   Homo sapiens (human): 3972
Entry
3972              CDS       T01001                                 
Symbol
LHB, CGB4, HH23, LSH-B, LSH-beta
Name
(RefSeq) luteinizing hormone subunit beta
  KO
K08521  lutropin subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04912  GnRH signaling pathway
hsa04913  Ovarian steroidogenesis
hsa04917  Prolactin signaling pathway
hsa04929  GnRH secretion
Network
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06361  Hypogonadotropic hypogonadism
  Element
N00873  GnRH-GnRHR-PLCB-PKC signaling pathway
N00875  Mutation-inactivated GnRHR to GnRH-GnRHR-PLCB-PKC signaling pathway
N00885  LHCGR-GNAS-PKA signaling pathway
Disease
H00255  Hypogonadotropic hypogonadism
H01973  Fertile eunuch syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    3972 (LHB)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3972 (LHB)
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    3972 (LHB)
   04912 GnRH signaling pathway
    3972 (LHB)
   04913 Ovarian steroidogenesis
    3972 (LHB)
   04917 Prolactin signaling pathway
    3972 (LHB)
SSDB
Motif
Pfam: Cys_knot
Other DBs
NCBI-GeneID: 3972
NCBI-ProteinID: NP_000885
OMIM: 152780
HGNC: 6584
Ensembl: ENSG00000104826
Pharos: P01229(Tbio)
CPD: C18183
UniProt: P01229 A0A0F7RQE6
LinkDB
Position
19:complement(49015980..49019498)
AA seq 141 aa
MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPT
MMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDC
GGPKDHPLTCDHPQLSGLLFL
NT seq 426 nt   +upstreamnt  +downstreamnt
atggagatgctccaggggctgctgctgttgctgctgctgagcatgggcggggcatgggca
tccagggagccgcttcggccatggtgccaccccatcaatgccatcctggctgtcgagaag
gagggctgcccagtgtgcatcaccgtcaacaccaccatctgtgccggctactgccccacc
atgatgcgcgtgctgcaggcggtcctgccgcccctgcctcaggtggtgtgcacctaccgt
gatgtgcgcttcgagtccatccggctccctggctgcccgcgtggtgtggaccccgtggtc
tccttccctgtggctctcagctgtcgctgtggaccctgccgccgcagcacctctgactgt
gggggtcccaaagaccaccccttgacctgtgaccacccccaactctcaggcctcctcttc
ctctaa

KEGG   Homo sapiens (human): 1081
Entry
1081              CDS       T01001                                 
Symbol
CGA, CG-ALPHA, FSHA, GPA1, GPHA1, GPHa, HCG, LHA, TSHA
Name
(RefSeq) glycoprotein hormones, alpha polypeptide
  KO
K08522  glycoprotein hormones alpha chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04912  GnRH signaling pathway
hsa04913  Ovarian steroidogenesis
hsa04917  Prolactin signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04923  Regulation of lipolysis in adipocytes
hsa04929  GnRH secretion
hsa05320  Autoimmune thyroid disease
Network
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06361  Hypogonadotropic hypogonadism
  Element
N00873  GnRH-GnRHR-PLCB-PKC signaling pathway
N00875  Mutation-inactivated GnRHR to GnRH-GnRHR-PLCB-PKC signaling pathway
N00885  LHCGR-GNAS-PKA signaling pathway
N00922  FSHR-GNAS-PKA signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    1081 (CGA)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1081 (CGA)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    1081 (CGA)
   04929 GnRH secretion
    1081 (CGA)
   04912 GnRH signaling pathway
    1081 (CGA)
   04913 Ovarian steroidogenesis
    1081 (CGA)
   04917 Prolactin signaling pathway
    1081 (CGA)
   04918 Thyroid hormone synthesis
    1081 (CGA)
 09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    1081 (CGA)
SSDB
Motif
Pfam: Hormone_6
Other DBs
NCBI-GeneID: 1081
NCBI-ProteinID: NP_000726
OMIM: 118850
HGNC: 1885
Ensembl: ENSG00000135346
Pharos: P01215(Tbio)
CPD: C18184 C18185 C18183 C18182
UniProt: P01215 Q6I9S8
Structure
LinkDB
Position
6:complement(87085498..87095106)
AA seq 116 aa
MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRA
YPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
NT seq 351 nt   +upstreamnt  +downstreamnt
atggattactacagaaaatatgcagctatctttctggtcacattgtcggtgtttctgcat
gttctccattccgctcctgatgtgcaggattgcccagaatgcacgctacaggaaaaccca
ttcttctcccagccgggtgccccaatacttcagtgcatgggctgctgcttctctagagca
tatcccactccactaaggtccaagaagacgatgttggtccaaaagaacgtcacctcagag
tccacttgctgtgtagctaaatcatataacagggtcacagtaatggggggtttcaaagtg
gagaaccacacggcgtgccactgcagtacttgttattatcacaaatcttaa

KEGG   Homo sapiens (human): 2488
Entry
2488              CDS       T01001                                 
Symbol
FSHB, HH24
Name
(RefSeq) follicle stimulating hormone subunit beta
  KO
K05250  follitropin subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04912  GnRH signaling pathway
hsa04913  Ovarian steroidogenesis
Network
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06361  Hypogonadotropic hypogonadism
  Element
N00873  GnRH-GnRHR-PLCB-PKC signaling pathway
N00875  Mutation-inactivated GnRHR to GnRH-GnRHR-PLCB-PKC signaling pathway
N00922  FSHR-GNAS-PKA signaling pathway
Disease
H00255  Hypogonadotropic hypogonadism
H01253  Isolated follicle-stimulating hormone deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2488 (FSHB)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2488 (FSHB)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    2488 (FSHB)
   04913 Ovarian steroidogenesis
    2488 (FSHB)
SSDB
Motif
Pfam: Cys_knot
Other DBs
NCBI-GeneID: 2488
NCBI-ProteinID: NP_000501
OMIM: 136530
HGNC: 3964
Ensembl: ENSG00000131808
Pharos: P01225(Tbio)
CPD: C18184
UniProt: P01225 A0A0F7RQE8
Structure
LinkDB
Position
11:30231014..30235194
AA seq 129 aa
MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDP
ARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPS
YCSFGEMKE
NT seq 390 nt   +upstreamnt  +downstreamnt
atgaagacactccagtttttcttccttttctgttgctggaaagcaatctgctgcaatagc
tgtgagctgaccaacatcaccattgcaatagagaaagaagaatgtcgtttctgcataagc
atcaacaccacttggtgtgctggctactgctacaccagggatctggtgtataaggaccca
gccaggcccaaaatccagaaaacatgtaccttcaaggaactggtatacgaaacagtgaga
gtgcccggctgtgctcaccatgcagattccttgtatacatacccagtggccacccagtgt
cactgtggcaagtgtgacagcgacagcactgattgtactgtgcgaggcctggggcccagc
tactgctcctttggtgaaatgaaagaataa

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