Homo sapiens (human): 4067
Help
Entry
4067 CDS
T01001
Symbol
LYN, JTK8, SAIDV, p53Lyn, p56Lyn
Name
(RefSeq) tyrosine-protein kinase Lyn isoform A
KO
K05854
tyrosine-protein kinase Lyn [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04517
IgSF CAM signaling
hsa04611
Platelet activation
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagosome formation
hsa04730
Long-term depression
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05203
Viral carcinogenesis
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06533
Chemokine signaling
nt06537
TCR/BCR signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
N01695
BCR-BCAP/CD19-PI3K signaling pathway
N01767
CXCR4-GNAI-Src signaling pathway
Disease
H02672
Systemic autoinflammatory disease with vasculitis
Drug target
Bafetinib:
D10202
Birelentinib:
D13253
Tolimidone:
D06182
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
4067 (LYN)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
4067 (LYN)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
4067 (LYN)
04662 B cell receptor signaling pathway
4067 (LYN)
04664 Fc epsilon RI signaling pathway
4067 (LYN)
04666 Fc gamma R-mediated phagosome formation
4067 (LYN)
04062 Chemokine signaling pathway
4067 (LYN)
09156 Nervous system
04730 Long-term depression
4067 (LYN)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
4067 (LYN)
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
4067 (LYN)
05169 Epstein-Barr virus infection
4067 (LYN)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
4067 (LYN)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4067 (LYN)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
4067 (LYN)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4067 (LYN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
4067 (LYN)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
4067 (LYN)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
4067 (LYN)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_2
SH3_9
ABC1
SH3_3
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
4067
NCBI-ProteinID:
NP_002341
OMIM:
165120
HGNC:
6735
Ensembl:
ENSP00000428924.1
UniProt:
P07948
Q6NUK7
A8K379
Structure
PDB
PDBj
LinkDB
All DBs
Position
8:55879835..56014169
Genome browser
AA seq
512 aa
AA seq
DB search
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
NT seq
1539 nt
NT seq
+upstream
nt +downstream
nt
atgggatgtataaaatcaaaagggaaagacagcttgagtgacgatggagtagatttgaag
actcaaccagtacgtaatactgaaagaactatttatgtgagagatccaacgtccaataaa
cagcaaaggccagttccagaatctcagcttttacctggacagaggtttcaaactaaagat
ccagaggaacaaggagacattgtggtagccttgtacccctatgatggcatccacccggac
gacttgtctttcaagaaaggagagaagatgaaagtcctggaggagcatggagaatggtgg
aaagcaaagtcccttttaacaaaaaaagaaggcttcatccccagcaactatgtggccaaa
ctcaacaccttagaaacagaagagtggtttttcaaggatataaccaggaaggacgcagaa
aggcagcttttggcaccaggaaatagcgctggagctttccttattagagaaagtgaaaca
ttaaaaggaagcttctctctgtctgtcagagactttgaccctgtgcatggtgatgttatt
aagcactacaaaattagaagtctggataatgggggctattacatctctccacgaatcact
tttccctgtatcagcgacatgattaaacattaccaaaagcaggcagatggcttgtgcaga
agattggagaaggcttgtattagtcccaagccacagaagccatgggataaagatgcctgg
gagatcccccgggagtccatcaagttggtgaaaaggcttggcgctgggcagtttggggaa
gtctggatgggttactataacaacagtaccaaggtggctgtgaaaaccctgaagccagga
actatgtctgtgcaagccttcctggaagaagccaacctcatgaagaccctgcagcatgac
aagctcgtgaggctctacgctgtggtcaccagggaggagcccatttacatcatcaccgag
tacatggccaagggcagtttgctggatttcctgaagagcgatgaaggtggcaaagtgctg
cttccaaagctcattgacttttctgctcagattgcagagggaatggcatacatcgagcgg
aagaactacattcaccgggacctgcgagcagctaatgttctggtctccgagtcactcatg
tgcaaaattgcagattttggccttgctagagtaattgaagataatgagtacacagcaagg
gaaggtgctaagttccctattaagtggacggctccagaagcaatcaactttggatgtttc
actattaagtctgatgtgtggtcctttggaatcctcctatacgaaattgtcacctatggg
aaaattccctacccagggagaactaatgccgacgtgatgaccgccctgtcccagggctac
aggatgccccgtgtggagaactgcccagatgagctctatgacattatgaaaatgtgctgg
aaagaaaaggcagaagagagaccaacgtttgactacttacagagcgtcctggatgatttc
tacacagccacggaagggcaataccagcagcagccttag
Homo sapiens (human): 6850
Help
Entry
6850 CDS
T01001
Symbol
SYK, IMD82, p72-Syk
Name
(RefSeq) tyrosine-protein kinase SYK isoform Syk(L)
KO
K05855
spleen tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04145
Phagocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04380
Osteoclast differentiation
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04625
C-type lectin receptor signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagosome formation
hsa05152
Tuberculosis
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease
hsa05203
Viral carcinogenesis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06537
TCR/BCR signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
N01695
BCR-BCAP/CD19-PI3K signaling pathway
Disease
H02526
Disorders of adaptive immunity
Drug target
Entospletinib:
D11209
Fostamatinib (
DG01419
):
D09347
D09348
<JP/US>
Gusacitinib (
DG03080
):
D11676
D11677
Mivavotinib (
DG03106
):
D11789
D11790
Sovleplenib (
DG03321
):
D12953
D12954
Tuspetinib:
D12476
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6850 (SYK)
04072 Phospholipase D signaling pathway
6850 (SYK)
04151 PI3K-Akt signaling pathway
6850 (SYK)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagocytosis
6850 (SYK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6850 (SYK)
04613 Neutrophil extracellular trap formation
6850 (SYK)
04625 C-type lectin receptor signaling pathway
6850 (SYK)
04650 Natural killer cell mediated cytotoxicity
6850 (SYK)
04662 B cell receptor signaling pathway
6850 (SYK)
04664 Fc epsilon RI signaling pathway
6850 (SYK)
04666 Fc gamma R-mediated phagosome formation
6850 (SYK)
09158 Development and regeneration
04380 Osteoclast differentiation
6850 (SYK)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
6850 (SYK)
09172 Infectious disease: viral
05171 Coronavirus disease
6850 (SYK)
05168 Herpes simplex virus 1 infection
6850 (SYK)
05167 Kaposi sarcoma-associated herpesvirus infection
6850 (SYK)
05169 Epstein-Barr virus infection
6850 (SYK)
09171 Infectious disease: bacterial
05152 Tuberculosis
6850 (SYK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6850 (SYK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6850 (SYK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SYK family
6850 (SYK)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
Kdo
ABC1
Motif
Other DBs
NCBI-GeneID:
6850
NCBI-ProteinID:
NP_001167638
OMIM:
600085
HGNC:
11491
UniProt:
P43405
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:90801600..90898549
Genome browser
AA seq
635 aa
AA seq
DB search
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
NT seq
1908 nt
NT seq
+upstream
nt +downstream
nt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa
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integrated database retrieval system
