KEGG   Homo sapiens (human): 4085
Entry
4085              CDS       T01001                                 
Symbol
MAD2L1, HSMAD2, MAD2
Name
(RefSeq) mitotic arrest deficient 2 like 1
  KO
K02537  mitotic spindle assembly checkpoint protein MAD2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa05166  Human T-cell leukemia virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00493  Spindle assembly checkpoint signaling
N01529  Recruitment and formation of the MCC
N01532  Kinetochore targeting of MAD1-MAD2
N01533  Disassembly of MCC
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4085 (MAD2L1)
   04114 Oocyte meiosis
    4085 (MAD2L1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    4085 (MAD2L1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    4085 (MAD2L1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    4085 (MAD2L1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     4085 (MAD2L1)
SSDB
Motif
Pfam: HORMA ATG13 bacHORMA_2
Other DBs
NCBI-GeneID: 4085
NCBI-ProteinID: NP_002349
OMIM: 601467
HGNC: 6763
Ensembl: ENSG00000164109
Pharos: Q13257(Tbio)
UniProt: Q13257
Structure
LinkDB
Position
4:complement(120055623..120066848)
AA seq 205 aa
MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLE
LIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKS
QKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEE
VRLRSFTTTIHKVNSMVAYKIPVND
NT seq 618 nt   +upstreamnt  +downstreamnt
atggcgctgcagctctcccgggagcagggaatcaccctgcgcgggagcgccgaaatcgtg
gccgagttcttctcattcggcatcaacagcattttatatcagcgtggcatatatccatct
gaaacctttactcgagtgcagaaatacggactcaccttgcttgtaactactgatcttgag
ctcataaaatacctaaataatgtggtggaacaactgaaagattggttatacaagtgttca
gttcagaaactggttgtagttatctcaaatattgaaagtggtgaggtcctggaaagatgg
cagtttgatattgagtgtgacaagactgcaaaagatgacagtgcacccagagaaaagtct
cagaaagctatccaggatgaaatccgttcagtgatcagacagatcacagctacggtgaca
tttctgccactgttggaagtttcttgttcatttgatctgctgatttatacagacaaagat
ttggttgtacctgaaaaatgggaagagtcgggaccacagtttattaccaattctgaggaa
gtccgccttcgttcatttactactacaatccacaaagtaaatagcatggtggcctacaaa
attcctgtcaatgactga

KEGG   Homo sapiens (human): 10459
Entry
10459             CDS       T01001                                 
Symbol
MAD2L2, FANCV, MAD2B, POLZ2, REV7
Name
(RefSeq) mitotic arrest deficient 2 like 2
  KO
K13728  mitotic spindle assembly checkpoint protein MAD2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa05100  Bacterial invasion of epithelial cells
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06508  Interstrand crosslink repair
  Element
N00493  Spindle assembly checkpoint signaling
N01465  Lesion bypass by TLS and DSB formation
Disease
H00238  Fanconi anemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    10459 (MAD2L2)
   04114 Oocyte meiosis
    10459 (MAD2L2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    10459 (MAD2L2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    10459 (MAD2L2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10459 (MAD2L2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     10459 (MAD2L2)
SSDB
Motif
Pfam: HORMA DUF4376
Other DBs
NCBI-GeneID: 10459
NCBI-ProteinID: NP_001120797
OMIM: 604094
HGNC: 6764
Ensembl: ENSG00000116670
Pharos: Q9UI95(Tbio)
UniProt: Q9UI95
Structure
LinkDB
Position
1:complement(11674480..11691830)
AA seq 211 aa
MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPEL
NQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSISSDSLLSHVE
QLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVH
MHDPRLIPLKTMTSDILKMQLYVEERAHKGS
NT seq 636 nt   +upstreamnt  +downstreamnt
atgaccacgctcacacgacaagacctcaactttggccaagtggtggccgatgtgctctgc
gagttcctggaggtggctgtgcatctcatcctctacgtgcgcgaggtctaccccgtgggc
atcttccagaaacgcaagaagtacaacgtgccggtccagatgtcctgccacccggagctg
aatcagtatatccaggacacgctgcactgcgtcaagccactcctggagaagaatgatgtg
gagaaagtggtggtggtgattttggataaagagcaccgcccagtggagaaattcgtcttt
gagatcacccagcctccactgctgtccatcagctcagactcgctgttgtctcatgtggag
cagctgctccgggccttcatcctgaagatcagcgtgtgcgatgccgtcctggaccacaac
cccccaggctgtaccttcacagtcctggtgcacacgagagaagccgccactcgcaacatg
gagaagatccaggtcatcaaggatttcccctggatcctggcggatgagcaggatgtccac
atgcatgacccccggctgataccactaaaaaccatgacgtcggacattttaaagatgcag
ctttacgtggaagagcgcgctcataaaggcagctga

KEGG   Homo sapiens (human): 701
Entry
701               CDS       T01001                                 
Symbol
BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
Name
(RefSeq) BUB1 mitotic checkpoint serine/threonine kinase B
  KO
K06637  mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa05166  Human T-cell leukemia virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00493  Spindle assembly checkpoint signaling
N01529  Recruitment and formation of the MCC
N01533  Disassembly of MCC
N01535  Kinetochore microtubule attachment
Disease
H00020  Colorectal cancer
H01288  Mosaic variegated aneuploidy syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    701 (BUB1B)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    701 (BUB1B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    701 (BUB1B)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    701 (BUB1B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     701 (BUB1B)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  BUB family
   701 (BUB1B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     701 (BUB1B)
SSDB
Motif
Pfam: Mad3_BUB1_I Pkinase Mad3_BUB1_II PK_Tyr_Ser-Thr
Other DBs
NCBI-GeneID: 701
NCBI-ProteinID: NP_001202
OMIM: 602860
HGNC: 1149
Ensembl: ENSG00000156970
Pharos: O60566(Tbio)
UniProt: O60566
Structure
LinkDB
Position
15:40161069..40221123
AA seq 1050 aa
MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKR
AFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPR
FLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQ
QKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARA
PIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPM
PRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEP
SINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVF
RKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKL
QIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKK
NKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVT
ICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIY
SQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQS
PWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKL
FWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYIN
CFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDC
NKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLA
HLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMN
GVFDTTFQSHLNKALWKVGKLTSPGALLFQ
NT seq 3153 nt   +upstreamnt  +downstreamnt
atggcggcggtgaagaaggaagggggtgctctgagtgaagccatgtccctggagggagat
gaatgggaactgagtaaagaaaatgtacaacctttaaggcaagggcggatcatgtccacg
cttcagggagcactggcacaagaatctgcctgtaacaatactcttcagcagcagaaacgg
gcatttgaatatgaaattcgattttacactggaaatgaccctctggatgtttgggatagg
tatatcagctggacagagcagaactatcctcaaggtgggaaggagagtaatatgtcaacg
ttattagaaagagctgtagaagcactacaaggagaaaaacgatattatagtgatcctcga
tttctcaatctctggcttaaattagggcgtttatgcaatgagcctttggatatgtacagt
tacttgcacaaccaagggattggtgtttcacttgctcagttctatatctcatgggcagaa
gaatatgaagctagagaaaactttaggaaagcagatgcgatatttcaggaagggattcaa
cagaaggctgaaccactagaaagactacagtcccagcaccgacaattccaagctcgagtg
tctcggcaaactctgttggcacttgagaaagaagaagaggaggaagtttttgagtcttct
gtaccacaacgaagcacactagctgaactaaagagcaaagggaaaaagacagcaagagct
ccaatcatccgtgtaggaggtgctctcaaggctccaagccagaacagaggactccaaaat
ccatttcctcaacagatgcaaaataatagtagaattactgtttttgatgaaaatgctgat
gaggcttctacagcagagttgtctaagcctacagtccagccatggatagcaccccccatg
cccagggccaaagagaatgagctgcaagcaggcccttggaacacaggcaggtccttggaa
cacaggcctcgtggcaatacagcttcactgatagctgtacccgctgtgcttcccagtttc
actccatatgtggaagagactgcacgacagccagttatgacaccatgtaaaattgaacct
agtataaaccacatcctaagcaccagaaagcctggaaaggaagaaggagatcctctacaa
agggttcagagccatcagcaagcgtctgaggagaagaaagagaagatgatgtattgtaag
gagaagatttatgcaggagtaggggaattctcctttgaagaaattcgggctgaagttttc
cggaagaaattaaaagagcaaagggaagccgagctattgaccagtgcagagaagagagca
gaaatgcagaaacagattgaagagatggagaagaagctaaaagaaatccaaactactcag
caagaaagaacaggtgatcagcaagaagagacgatgcctacaaaggagacaactaaactg
caaattgcttccgagtctcagaaaataccaggaatgactctatccagttctgtttgtcaa
gtaaactgttgtgccagagaaacttcacttgcggagaacatttggcaggaacaacctcat
tctaaaggtcccagtgtacctttctccatttttgatgagtttcttctttcagaaaagaag
aataaaagtcctcctgcagatcccccacgagttttagctcaacgaagaccccttgcagtt
ctcaaaacctcagaaagcatcacctcaaatgaagatgtgtctccagatgtttgtgatgaa
tttacaggaattgaacccttgagcgaggatgccattatcacaggcttcagaaatgtaaca
atttgtcctaacccagaagacacttgtgactttgccagagcagctcgttttgtatccact
ccttttcatgagataatgtccttgaaggatctcccttctgatcctgagagactgttaccg
gaagaagatctagatgtaaagacctctgaggaccagcagacagcttgtggcactatctac
agtcagactctcagcatcaagaagctgagcccaattattgaagacagtcgtgaagccaca
cactcctctggcttctctggttcttctgcctcggttgcaagcacctcctccatcaaatgt
cttcaaattcctgagaaactagaacttactaatgagacttcagaaaaccctactcagtca
ccatggtgttcacagtatcgcagacagctactgaagtccctaccagagttaagtgcctct
gcagagttgtgtatagaagacagaccaatgcctaagttggaaattgagaaggaaattgaa
ttaggtaatgaggattactgcattaaacgagaatacctaatatgtgaagattacaagtta
ttctgggtggcgccaagaaactctgcagaattaacagtaataaaggtatcttctcaacct
gtcccatgggacttttatatcaacctcaagttaaaggaacgtttaaatgaagattttgat
catttttgcagctgttatcaatatcaagatggctgtattgtttggcaccaatatataaac
tgcttcacccttcaggatcttctccaacacagtgaatatattacccatgaaataacagtg
ttgattatttataaccttttgacaatagtggagatgctacacaaagcagaaatagtccat
ggtgacttgagtccaaggtgtctgattctcagaaacagaatccacgatccctatgattgt
aacaagaacaatcaagctttgaagatagtggacttttcctacagtgttgaccttagggtg
cagctggatgtttttaccctcagcggctttcggactgtacagatcctggaaggacaaaag
atcctggctaactgttcttctccctaccaggtagacctgtttggtatagcagatttagca
catttactattgttcaaggaacacctacaggtcttctgggatgggtccttctggaaactt
agccaaaatatttctgagctaaaagatggtgaattgtggaataaattctttgtgcggatt
ctgaatgccaatgatgaggccacagtgtctgttcttggggagcttgcagcagaaatgaat
ggggtttttgacactacattccaaagtcacctgaacaaagccttatggaaggtagggaag
ttaactagtcctggggctttgctctttcagtga

KEGG   Homo sapiens (human): 9184
Entry
9184              CDS       T01001                                 
Symbol
BUB3, BUB3L, hBUB3
Name
(RefSeq) BUB3 mitotic checkpoint protein
  KO
K02180  cell cycle arrest protein BUB3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa05166  Human T-cell leukemia virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00493  Spindle assembly checkpoint signaling
N01529  Recruitment and formation of the MCC
N01533  Disassembly of MCC
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9184 (BUB3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9184 (BUB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    9184 (BUB3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    9184 (BUB3)
Spliceosome [BR:hsa03041]
 Complex A
  Other components
   Complex A specific factors
    9184 (BUB3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     9184 (BUB3)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 PQQ_3
Other DBs
NCBI-GeneID: 9184
NCBI-ProteinID: NP_004716
OMIM: 603719
HGNC: 1151
Ensembl: ENSG00000154473
Pharos: O43684(Tbio)
UniProt: O43684
LinkDB
Position
10:123154402..123170467
AA seq 328 aa
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL
DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV
KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY
QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI
SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE
MDDTEHPEDGIFIRQVTDAETKPKSPCT
NT seq 987 nt   +upstreamnt  +downstreamnt
atgaccggttctaacgagttcaagctgaaccagccacccgaggatggcatctcctccgtg
aagttcagccccaacacctcccagttcctgcttgtctcctcctgggacacgtccgtgcgt
ctctacgatgtgccggccaactccatgcggctcaagtaccagcacaccggcgccgtcctg
gactgcgccttctacgatccaacgcatgcctggagtggaggactagatcatcaattgaaa
atgcatgatttgaacactgatcaagaaaatcttgttgggacccatgatgcccctatcaga
tgtgttgaatactgtccagaagtgaatgtgatggtcactggaagttgggatcagacagtt
aaactgtgggatcccagaactccttgtaatgctgggaccttctctcagcctgaaaaggta
tataccctctcagtgtctggagaccggctgattgtgggaacagcaggccgcagagtgttg
gtgtgggacttacggaacatgggttacgtgcagcagcgcagggagtccagcctgaaatac
cagactcgctgcatacgagcgtttccaaacaagcagggttatgtattaagctctattgaa
ggccgagtggcagttgagtatttggacccaagccctgaggtacagaagaagaagtatgcc
ttcaaatgtcacagactaaaagaaaataatattgagcagatttacccagtcaatgccatt
tcttttcacaatatccacaatacatttgccacaggtggttctgatggctttgtaaatatt
tgggatccatttaacaaaaagcgactgtgccaattccatcggtaccccacgagcatcgca
tcacttgccttcagtaatgatgggactacgcttgcaatagcgtcatcatatatgtatgaa
atggatgacacagaacatcctgaagatggtatcttcattcgccaagtgacagatgcagaa
acaaaacccaagtcaccatgtacttga

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