KEGG   Homo sapiens (human): 479
Entry
479               CDS       T01001                                 
Symbol
ATP12A, ATP1AL1, H-K-ATPase, HK
Name
(RefSeq) ATPase H+/K+ transporting non-gastric alpha2 subunit
  KO
K01544  non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    479 (ATP12A)
Enzymes [BR:hsa01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.19  H+/K+-exchanging ATPase
     479 (ATP12A)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Hydrolase Cation_ATPase_N Hydrolase_3 HAD HlyD_D23
Other DBs
NCBI-GeneID: 479
NCBI-ProteinID: NP_001667
OMIM: 182360
HGNC: 13816
Ensembl: ENSG00000075673
Pharos: P54707(Tchem)
UniProt: P54707 B4E0R9
LinkDB
Position
13:24680408..24712472
AA seq 1039 aa
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHK
LSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLW
VGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMI
PQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQ
PRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIA
IEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLS
LTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSED
HSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILG
DVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMING
EEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCF
VGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIA
HRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGC
QRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEG
RLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYE
KAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLIN
LRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIF
QQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEV
RKLFIRLYPGSWWDKNMYY
NT seq 3120 nt   +upstreamnt  +downstreamnt
atgcaccagaaaaccccagaaatttactccgtggagctcagcggaactaaggacatcgtg
aaaacagacaagggggatggcaaggagaagtataggggtctgaagaacaactgcctggaa
ctcaaaaagaaaaatcacaaagaggagtttcagaaagaactccatctggatgaccacaaa
ctcagcaatagggaattggaagagaaatatggcacagacatcattatgggtctctccagc
accagagctgccgagctcctggcccgggatgggcccaactccctcacccctcccaagcag
acgcctgagatcgtcaagttcctcaagcagatggtgggggggttctctatcctcctgtgg
gtgggcgcctttctctgttggattgcatatgggattcagtactccagcgacaagtctgca
tccctgaacaacgtgtacttgggctgtgtgcttggtctggtggtcattttaacggggatc
tttgcttattaccaagaggcaaaaagcaccaacatcatgtccagcttcaataagatgatc
cctcagcaagctctcgtcatccgagattccgagaagaagaccatcccttcagagcagctg
gtggtgggggacattgtggaggtcaaaggaggagaccagatccctgcagacatcagggtg
ctgtcttctcaggggtgtcgggtggataactcatctctcacgggggagtctgagccccag
ccccgctcctctgagtttacccatgaaaaccccctggaaacaaagaacatctgcttctat
tccacaacgtgtctggaaggcactgtcaccggcatggttatcaacacgggtgaccgcacc
atcattggccatattgcctcattggcctcaggagttggaaatgagaagacgcccattgcc
attgagatcgagcactttgttcacattgtggcaggagtggctgtctccatcggcatcctt
ttcttcatcatcgctgtgtccctgaagtatcaagtcctggactccatcatcttcctcatt
ggcatcattgtggccaatgtgcccgagggcctcctggccactgtcactgtgaccctgtcg
ctgacagcaaaacggatggccaagaagaactgcctggtgaagaacctggaggctgtggag
accctcggctccacctccatcatctgctcggacaagactgggacactgacccagaacagg
atgacagtggcccatctgtggttcgacaatcagatctttgtggctgacaccagtgaggac
cattcaaaccaagtctttgaccaaagctctaggacttgggcctccttatccaagataata
acattgtgtaaccgagcagagttcaagccaggacaggaaaatgtccccatcatgaagaaa
gctgtgattggagatgcctcagaaactgctcttttaaaattctcagaggtcattttgggt
gatgtgatggaaattagaaaaagaaaccgcaaagtagctgaaatcccttttaactctact
aataaatttcagctctccatccacgagatggatgacccccacggcaagcgcttcctcatg
gtgatgaagggggcccctgagcgcatcctagagaaatgcagcaccatcatgatcaacggc
gaggagcacccactggacaagagcactgccaagaccttccacacagcctacatggagctg
ggcgggttgggcgagcgtgtgctgggtttctgtcatctctacctgccagcagacgagttt
ccagaaacctactcatttgacatagacgctatgaactttccgacctccaacctctgtttt
gtgggactcttgtcaatgatcgatccccctcggtccaccgtgccagatgcagtcaccaaa
tgccggagtgcagggatcaaggttattatggttactggtgatcatcccatcacagccaaa
gctattgccaagagtgtggggatcatttcagccaacagtgaaacagtggaagacattgca
catcgcctcaacattgctgtggagcaagttaacaaacgggatgccaaggccgctgtggtg
actggcatggagctgaaggacatgagctcagaacagctggatgagatcttagccaactac
caggagattgtctttgcccggacatccccccagcagaagctgatcattgtggagggctgt
cagaggcaggatgctgttgttgctgtgaccggggatggagttaatgactctccggctcta
aagaaggcagacattgggattgccatggggatagcaggttctgatgcagccaaaaatgca
gccgacatggtcttgctggacgacaacttcgcatccatcgtcacaggggtggaggaaggt
cgcctgatctttgacaacctcaagaagactattgcttattccctgaccaagaacattgcc
gagctgtgcccctttctgatctacatcattgtcgggctccccctgcccattggcaccatc
accattctgttcattgacttggggacagacattatcccctccattgccttggcgtacgag
aaagctgaaagtgacatcatgaacaggaagcctcgccacaagaataaggacaggctggtg
aaccagccgctcgctgtgtactcatacctgcacattggcctcatgcaagccctgggagct
ttccttgtgtatttcaccgtctatgcacaagagggctttctgccccgcactctcattaac
ctgcgggtagaatgggagaaggactacgtgaatgacttgaaagacagctatgggcaggaa
tggacaaggtaccagagggaatacctagaatggacgggctacacggctttctttgttggc
atcctagtccagcaaatagcagatctgatcatcaggaaaacccggaggaattccatcttc
cagcagggtctcttcagaaataaagtcatctgggtggggatcacctcacagatcatcatt
ggtctgatcctctcctatggcctcggaagtgtcacagccttgagtttcaccatgcttagg
gctcagtactggtttgtggctgtgccgcacgccatcctgatctgggtgtatgatgaggtg
cggaagctcttcatcaggctctaccctggaagctggtgggataagaacatgtattattaa

KEGG   Homo sapiens (human): 495
Entry
495               CDS       T01001                                 
Symbol
ATP4A, ATP6A
Name
(RefSeq) ATPase H+/K+ transporting subunit alpha
  KO
K01542  H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Drug target
Dexlansoprazole (DG03298): D08903<US> D12816<US>
Esomeprazole (DG00023): D01984<JP/US> D04056<US> D07917 D09339 D10120<US> D11114<US>
Lansoprazole: D00355<JP/US>
Leminoprazole: D05906
Omeprazole (DG00020): D00455<JP/US> D01207 D05259<US> D05261<JP>
Pantoprazole (DG00021): D02593<US> D05353
Penaprazole sodium hydrate: D09837
Picoprazole: D05901
Rabeprazole (DG00022): D00724<JP/US> D08463
Revaprazan hydrochloride: D05722
Tegoprazan: D12246
Tenatoprazole: D01920
Timoprazole: D05900
Vonoprazan (DG03104): D10466<JP/US> D11784
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    495 (ATP4A)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    495 (ATP4A)
  09155 Excretory system
   04966 Collecting duct acid secretion
    495 (ATP4A)
Enzymes [BR:hsa01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.19  H+/K+-exchanging ATPase
     495 (ATP4A)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase H-K_ATPase_N Cation_ATPase_N Hydrolase Hydrolase_3 HAD
Other DBs
NCBI-GeneID: 495
NCBI-ProteinID: NP_000695
OMIM: 137216
HGNC: 819
Ensembl: ENSG00000105675
Pharos: P20648(Tclin)
UniProt: P20648 A0A384MR29 Q658V6
LinkDB
Position
19:complement(35550031..35563658)
AA seq 1035 aa
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVA
ELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAA
ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA
TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP
ECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIE
HFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK
RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ
TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMG
YRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP
LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV
SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLR
VPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLG
AIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIF
DNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES
DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQ
WEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGF
FRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLG
VRCCPGSWWDQELYY
NT seq 3108 nt   +upstreamnt  +downstreamnt
atggggaaggccgagaactatgagctctactcggtggagctgggtcctggccctggcggg
gacatggctgccaagatgagcaagaagaagaaggcgggtggcgggggtggcaagaggaag
gagaagctggagaacatgaagaaggagatggagattaacgaccaccagctgtcagtggcg
gagctggaacagaaataccagaccagtgccaccaagggcctctctgcgagcctggctgct
gagctgctgctgcgggatgggcccaacgcactgcggccaccacggggcaccccagagtac
gtcaagttcgcgaggcagctggccgggggcctgcagtgcctcatgtgggttgccgccgcc
atctgcctcatcgcctttgccatccaggctagtgagggggacctcaccaccgacgacaat
ctgtacctggcaatcgctctcattgctgtggttgtcgtcaccggctgctttggctactac
caggaattcaagagcaccaacatcatcgccagctttaagaaccttgtgccacagcaagcc
actgtcatccgcgatggagacaaattccagatcaacgctgaccaactggtggtgggcgac
ctggtggagatgaaaggtggggacagagtgcccgccgacatccgcatcctggcggcccag
ggctgcaaggtggacaactcctcgctgacaggggagtctgagccacagacccgctcaccc
gagtgcacgcacgagagccctctggagacccgcaacatcgccttcttctccaccatgtgc
cttgagggcaccgtgcagggcctggtggtgaacacgggcgaccgcaccatcattgggcgc
atcgcatcgctggcgtcgggggtggaaaacgagaagacacccatcgctatcgagatcgag
cattttgtggacatcatcgcgggcctggccattctcttcggtgccacattttttattgtg
gccatgtgcattggctacaccttcctgcgggccatggtcttcttcatggccatcgtggtg
gcctatgtgcctgaggggctgctggccactgtcacagtctgcctgtccctgacagccaag
cgcctggccagtaagaactgcgtggtcaagaacctggaggcggtggagacattgggctcc
acttcggtgatctgctcggacaagacagggactctcactcagaaccgcatgactgtgtcc
catctgtggtttgacaaccacatccacacagctgacaccacggaagaccagtcagggcag
acgtttgaccagtcctcggagacgtggcgggcgctgtgccgggtgctcaccctgtgcaac
cgcgccgccttcaagtccggccaggatgcagtgcctgtgcccaagcgcatcgtgattgga
gacgcatcggagacggcgctgctcaagttctcggagctgacgctgggcaacgccatgggc
taccgggaccgcttcccaaaagtctgcgagatacccttcaactccaccaacaagttccag
ctgtccatccatacgctggaggacccgcgggacccgcgacacttgctggtgatgaagggc
gcccccgagcgcgtgctggagcgctgcagctccatccttatcaagggccaggagctgccg
ctggacgagcagtggcgcgaggccttccagaccgcctacctcagcctgggaggcctgggc
gaacgcgtgctcggcttctgccagctctacctgaatgagaaggactacccgcctggctat
gccttcgacgtagaggccatgaactttccatctagcggcctctgctttgcgggacttgta
tccatgattgacccaccccgggccaccgtccctgatgctgtgctcaagtgtcgcaccgca
ggcatccgggtgatcatggtaacgggtgaccaccccatcaccgccaaggccattgcagcc
agtgtgggcatcatctcggaaggcagcgagacagtggaggacatcgctgcccgcctccgt
gtgcccgtagaccaggttaatcgcaaggatgcccgtgcctgtgtgatcaatggcatgcag
ctgaaggacatggacccatcggaactggtcgaggccctgcgcacccaccccgagatggtg
tttgcgcgcaccagcccccagcagaagctggtgatcgtggagagctgccagcggctgggt
gcgattgtggccgtcacgggggatggtgtgaatgactccccagctctgaagaaggcagac
atcggagtagccatgggcatcgctggctcagatgctgccaaaaatgcagctgacatgatc
ctgctggatgacaactttgcctccattgtgacaggcgtggagcagggtcgactgatcttc
gacaacctgaagaagtctattgcctacacattgaccaagaacatcccagagctgacaccc
tacctcatctacatcaccgtcagcgtgcccctgcccctcgggtgcatcaccatcctcttc
atcgaactctgcactgacattttcccatctgtgtccctggcatatgaaaaggccgagagt
gacatcatgcacctgcgtccacgcaacccaaagcgtgacagattggtcaacgagcccctg
gctgcctactcctacttccagattggtgccattcagtcctttgctggcttcactgactac
ttcacggcaatggcccaggagggctggttcccactgctgtgcgtggggctgcgggcgcag
tgggaggaccaccacctacaagatctgcaggacagctacggccaggagtggacattcggg
cagcgcctgtaccagcagtacacctgctacaccgtgttcttcatcagcattgaggtgtgc
cagatcgccgatgtcctcatccgcaagacgcgccgtctctctgccttccagcaaggcttc
ttcaggaataagatcctggtgatcgccatcgtgttccaggtctgcatcggctgcttcctg
tgctactgccccggcatgcccaacatcttcaacttcatgcccattcggttccagtggtgg
ctggtccccctgccctacggcatcctcatcttcgtctatgatgagatccggaagcttgga
gttcgctgttgcccagggagctggtgggaccaggaactctactattag

KEGG   Homo sapiens (human): 496
Entry
496               CDS       T01001                                 
Symbol
ATP4B, ATP6B
Name
(RefSeq) ATPase H+/K+ transporting subunit beta
  KO
K01543  H+/K+-exchanging ATPase subunit beta [EC:7.2.2.19]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Drug target
Dexlansoprazole (DG03298): D08903<US> D12816<US>
Esomeprazole (DG00023): D01984<JP/US> D04056<US> D07917 D09339 D10120<US> D11114<US>
Lansoprazole: D00355<JP/US>
Leminoprazole: D05906
Omeprazole (DG00020): D00455<JP/US> D01207 D05259<US> D05261<JP>
Pantoprazole (DG00021): D02593<US> D05353
Penaprazole sodium hydrate: D09837
Picoprazole: D05901
Rabeprazole (DG00022): D00724<JP/US> D08463
Revaprazan hydrochloride: D05722
Tegoprazan: D12246
Tenatoprazole: D01920
Timoprazole: D05900
Vonoprazan (DG03104): D10466<JP/US> D11784
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    496 (ATP4B)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    496 (ATP4B)
  09155 Excretory system
   04966 Collecting duct acid secretion
    496 (ATP4B)
Enzymes [BR:hsa01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.19  H+/K+-exchanging ATPase
     496 (ATP4B)
SSDB
Motif
Pfam: Na_K-ATPase
Other DBs
NCBI-GeneID: 496
NCBI-ProteinID: NP_000696
OMIM: 137217
HGNC: 820
Ensembl: ENSG00000186009
Pharos: P51164(Tclin)
UniProt: P51164
LinkDB
Position
13:complement(113648804..113658198)
AA seq 291 aa
MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
NT seq 876 nt   +upstreamnt  +downstreamnt
atggcggctctgcaggagaagaagacgtgtggccagcgcatggaggagttccagcgttac
tgctggaacccggacacggggcagatgctgggccgcaccctgtcccggtgggtgtggatc
agcctgtactacgtggccttctacgtggtgatgactgggctcttcgccctgtgcctctat
gtgctgatgcagacagtggacccgtacacaccggactaccaagaccagctacggtcacca
ggggtaaccttaaggccggatgtttacggggagaaaggcctggaaattgtctacaacgtc
tctgataacagaacctgggcagacctcacacagactctccacgccttcctagcaggctac
tctccagcagcccaggaggacagcatcaactgcacctccgagcagtacttcttccaggag
agtttccgcgctcccaaccacaccaagttctcctgcaagttcacggcagatatgctgcag
aactgctcaggcctggcggatcccaacttcggctttgaagaaggaaagccatgttttatt
attaaaatgaacaggatcgtcaagttcctccccagcaacggctcggcccccagagtggac
tgcgccttcctggaccagccccgcgagctcggccagccgctgcaggtcaagtactaccct
cccaacggcaccttcagtctgcactacttcccttattacgggaagaaagcccagccccac
tacagcaaccccctggtggcagcgaagctcctcaacatccccaggaacgctgaggtcgcc
atcgtgtgcaaggtcatggcggagcacgtgaccttcaacaatccccacgacccgtatgaa
gggaaagtggagttcaaactcaagattgagaagtga

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