KEGG T01001: 5829

Homo sapiens (human): 5829

Entry

5829              CDS       T01001

Symbol

PXN

Name

(RefSeq) paxillin

K05760

paxillin

Organism

hsa Homo sapiens (human)

Pathway

hsa04062

Chemokine signaling pathway

hsa04370

VEGF signaling pathway

hsa04510

Focal adhesion

hsa04670

Leukocyte transendothelial migration

hsa04810

Regulation of actin cytoskeleton

hsa05100

Bacterial invasion of epithelial cells

hsa05131

Shigellosis

hsa05135

Yersinia infection

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05203

Viral carcinogenesis

hsa05205

Proteoglycans in cancer

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia

Element

N00413

CXCR4-GNB/G-PLCB-PKC signaling pathway

N01068

ITGA/B-FAK-RAC signaling pathway

N01070

ITGA/B-FAK-CDC42 signaling pathway

N01080

ITGA/B-TALIN/VINCULIN signaling pathway

N01081

Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway

N01083

Shigella OspE to ITGA/B-TALIN/VINCULIN signaling pathway

N01109

Yersinia YopH to ITGA/B-FAK-RAC signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    5829 (PXN)
   04062 Chemokine signaling pathway
    5829 (PXN)
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5829 (PXN)
   05203 Viral carcinogenesis
    5829 (PXN)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    5829 (PXN)
   05163 Human cytomegalovirus infection
    5829 (PXN)
   05165 Human papillomavirus infection
    5829 (PXN)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    5829 (PXN)
   05135 Yersinia infection
    5829 (PXN)
   05100 Bacterial invasion of epithelial cells
    5829 (PXN)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    5829 (PXN)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
LIM domain-containing proteins
  Paxillin family proteins
   5829 (PXN)

SSDB

Motif

Pfam:

Paxillin LIM

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

12:complement(120210447..120265730)

AA seq 591 aa
MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAGWPRDGG
RSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGA
CKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYC
NGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCA
RAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQK
PITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC

NT seq 1776 nt +upstreamnt +downstreamnt
atggacgacctcgacgccctgctggcggacttggagtctaccacctcccacatctccaaa
cggcctgtgttcttgtcggaggagaccccctactcatacccaactggaaaccacacatac
caggagattgccgtgccaccccccgtccccccacccccgtccagcgaggccctcaatggc
acaatccttgaccccttagaccagtggcagcccagcagctcccgattcatccaccagcag
cctcagtcctcatcacctgtgtacggctccagtgccaaaacttccagtgtctccaaccct
caggacagtgttggctctccgtgctcccgagtgggtgaggaggagcacgtctacagcttc
cccaacaagcagaaatcagctgagccttcacccaccgtaatgagcacgtccctgggcagc
aacctttctgaactcgaccgcctgctgctggaactgaacgctgtacagcataacccgcca
ggcttccctgcagatgaggccaactcaagccccccgcttcctggggccctgagccccctc
tatggtgtcccagagactaacagccccttgggaggcaaagctgggcccctgacgaaagag
aagcctaagcggaatgggggccggggcctggaggacgtgcggcccagtgtggagagtctc
ttggatgaactggagagctccgtgcccagccccgtccctgccatcactgtgaaccagggc
gagatgagcagcccgcagcgcgtcacctccacccaacagcagacacgcatctcggcctcc
tctgccaccagggagctggacgagctgatggcttcgctgtcggatttcaagatccagggc
ctggagcaaagagcggatggggagcggtgctgggcggccggctggcctcgggacggcggg
cggagcagccccggagggcaggacgagggagggttcatggcccaggggaagacagggagc
agctcaccccctggggggcccccgaagcccgggagccagctggacagcatgctggggagc
ctgcagtctgacctgaacaagctgggggtcgccacagtcgccaaaggagtctgcggggcc
tgcaagaagcccatcgccgggcaggttgtgaccgccatggggaagacgtggcaccccgag
cacttcgtctgcacccactgccaggaggagatcggatcccggaacttcttcgagcgggat
ggacagccctactgtgaaaaggactaccacaacctcttctccccgcgctgctactactgc
aacggccccatcctggataaagtggtgacagcccttgaccggacgtggcaccctgaacac
ttcttctgtgcacagtgtggagccttctttggtcccgaagggttccacgagaaggacggc
aaggcctactgtcgcaaggactacttcgacatgttcgcacccaagtgtggcggctgcgcc
cgggccatcctggagaactatatctcagccctcaacacgctgtggcatcctgagtgcttt
gtgtgccgggaatgcttcacgccattcgtgaacggcagcttcttcgagcacgacgggcag
ccctactgtgaggtgcactaccacgagcggcgcggctcgctgtgttctggctgccagaag
cccatcaccggccgctgcatcaccgccatggccaagaagttccaccccgagcacttcgtc
tgtgccttctgcctcaagcagctcaacaagggcaccttcaaggagcagaacgacaagcct
tactgtcagaactgcttcctcaagctcttctgctag

Homo sapiens (human): 1398

Entry

1398              CDS       T01001

Symbol

CRK, CRKII, p38

Name

(RefSeq) CRK proto-oncogene, adaptor protein

K04438

C-crk adapter molecule crk

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04012

ErbB signaling pathway

hsa04015

Rap1 signaling pathway

hsa04062

Chemokine signaling pathway

hsa04148

Efferocytosis

hsa04510

Focal adhesion

hsa04666

Fc gamma R-mediated phagocytosis

hsa04722

Neurotrophin signaling pathway

hsa04810

Regulation of actin cytoskeleton

hsa04910

Insulin signaling pathway

hsa04935

Growth hormone synthesis, secretion and action

hsa05100

Bacterial invasion of epithelial cells

hsa05131

Shigellosis

hsa05135

Yersinia infection

hsa05163

Human cytomegalovirus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

hsa05206

MicroRNAs in cancer

hsa05211

Renal cell carcinoma

hsa05220

Chronic myeloid leukemia

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06214  PI3K signaling (cancer)
nt06276  Chronic myeloid leukemia
nt06535  Efferocytosis

Element

N00048

BCR-ABL fusion kinase to PI3K signaling pathway

N00413

CXCR4-GNB/G-PLCB-PKC signaling pathway

N01068

ITGA/B-FAK-RAC signaling pathway

N01090

IGG-FCGR-RAC signaling pathway

N01761

Activation of CRK-DOCK-Rac1 pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    1398 (CRK)
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1398 (CRK)
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1398 (CRK)
   04062 Chemokine signaling pathway
    1398 (CRK)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    1398 (CRK)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    1398 (CRK)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1398 (CRK)
   05206 MicroRNAs in cancer
    1398 (CRK)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    1398 (CRK)
   05211 Renal cell carcinoma
    1398 (CRK)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1398 (CRK)
   05163 Human cytomegalovirus infection
    1398 (CRK)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    1398 (CRK)
   05135 Yersinia infection
    1398 (CRK)
   05100 Bacterial invasion of epithelial cells
    1398 (CRK)

SSDB

Motif

Pfam:

SH3_2 SH2 SH3_1 SH3_9 SH3_10 DUF3804

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

P46108 L7RT18 A0A0S2Z3Q4

Structure

LinkDB

Position

17:complement(1420693..1456232)

AA seq 304 aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS

NT seq 915 nt +upstreamnt +downstreamnt
atggcgggcaacttcgactcggaggagcggagtagctggtactgggggaggttgagtcgg
caggaggcggtggcgctgctgcagggccagcggcacggggtgttcctggtgcgggactcg
agcaccagccccggggactatgtgctcagcgtctcagagaactcgcgcgtctcccactac
atcatcaacagcagcggcccgcgcccgccggtgccaccgtcgcccgcccagcctccgccc
ggggtgagcccctccagactccgaataggagatcaagagtttgattcattgcctgcttta
ctggaattctacaaaatacactatttggacactacaacgttgatagaaccagtttccaga
tccaggcagggtagtggagtgattctcaggcaggaggaggcggagtatgtgcgagccctc
tttgactttaatgggaatgatgaggaagatcttccctttaagaaaggagacatcttgaga
atccgggacaagcctgaagagcagtggtggaatgcggaggacagcgaaggcaagagaggg
atgattccagtcccttacgtcgagaagtatagacctgcctccgcctcagtatcggctctg
attggaggtaaccaggagggttcccacccacagccactgggtgggccggagcctgggccc
tatgcccaacccagcgtcaacactccgctccctaacctccagaatgggcccatatatgcc
agggttatccagaagcgagtccccaatgcctacgacaagacagccttggctttggaggtc
ggtgagctggtaaaggttacgaagattaatgtgagtggtcagtgggaaggggagtgtaat
ggcaaacgaggtcacttcccattcacacatgtccgtctgctggatcaacagaatcccgat
gaggacttcagctga

Homo sapiens (human): 9564

Entry

9564              CDS       T01001

Symbol

BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas

Name

(RefSeq) BCAR1 scaffold protein, Cas family member

K05726

breast cancer anti-estrogen resistance 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04015

Rap1 signaling pathway

hsa04062

Chemokine signaling pathway

hsa04148

Efferocytosis

hsa04510

Focal adhesion

hsa04670

Leukocyte transendothelial migration

hsa04810

Regulation of actin cytoskeleton

hsa04935

Growth hormone synthesis, secretion and action

hsa05100

Bacterial invasion of epithelial cells

hsa05131

Shigellosis

hsa05135

Yersinia infection

hsa05163

Human cytomegalovirus infection

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06535  Efferocytosis

Element

N00413

CXCR4-GNB/G-PLCB-PKC signaling pathway

N01068

ITGA/B-FAK-RAC signaling pathway

N01110

Yersinia YopH to ITGA/B-FAK-RAC signaling pathway

N01761

Activation of CRK-DOCK-Rac1 pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    9564 (BCAR1)
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    9564 (BCAR1)
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    9564 (BCAR1)
   04062 Chemokine signaling pathway
    9564 (BCAR1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    9564 (BCAR1)
09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    9564 (BCAR1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    9564 (BCAR1)
   05135 Yersinia infection
    9564 (BCAR1)
   05100 Bacterial invasion of epithelial cells
    9564 (BCAR1)

SSDB

Motif

Pfam:

CAS_C Serine_rich SH3_1 SH3_9 SH3_2 Vinculin RedAm-like_C DUF7783

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

16:complement(75228181..75268007)

AA seq 870 aa
MSVPNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
SAAQDMVERVKELGHSTQQFRRVLGQLAAA

NT seq 2613 nt +upstreamnt +downstreamnt
atgtccgtgcctaacgtgctggccaaagcgctctatgacaatgtggccgagtccccggat
gagctctccttccgcaagggtgacatcatgacggtgctggagcaggacacgcagggcctg
gacggctggtggctctgctcgctgcatgggcgccagggcatcgtgcctgggaaccgcctc
aagatcttggtgggcatgtatgataagaagccagcagggcctggccccggccctcccgcc
accccggcccagcctcagcctggcctccatgccccagcgcctccggcctcccagtacacg
cccatgctccccaacacctaccagccccagccagacagcgtctacctggtgcccactccc
agcaaggctcagcaaggcctctaccaagtcccgggtcccagccctcagttccagtctccc
ccagccaagcagacatccaccttctcgaagcagacaccccatcacccgtttcccagcccg
gccacagacctgtaccaggtgcccccagggcctggaggccctgcccaggatatttaccag
gtgccaccttctgccgggatggggcatgacatctaccaggtccccccgtccatggacaca
cgcagctgggagggcacgaagcccccggcaaaggtggtggtgcccacccgcgtggggcag
ggctatgtatacgaggccgcccagccggagcaggacgagtacgacatcccgcgacacctg
ctggccccggggccacaggacatctatgatgtgcccccggttcgggggctgcttcccagc
cagtatggccaggaggtgtatgacacaccccccatggctgtcaagggtcccaatggccga
gacccgttgctggaggtgtatgacgtgccccccagtgtggagaagggcctgccaccgtcc
aaccaccacgcagtctacgacgttcctccatcggtgagcaaggatgtgcccgatggccca
ctgctgcgtgaggagacctacgatgtgccccccgccttcgccaaggccaagccctttgac
ccggcccgcaccccactggtactggctgcgccccctccagactccccgccggccgaggac
gtgtatgacgtgccgcccccggctcctgacctctacgacgtgccccctggcttgcggcgg
cctggcccgggcaccctgtacgatgtgccccgtgaacgggtgcttcctcctgaggtggct
gatggtggcgtggtcgacagtggtgtgtatgcggtgcctcccccagctgaacgtgaagcc
ccggcagagggcaagcgcctgtcggcctccagcaccggcagcacacgcagcagccagtct
gcgtcctccttggaggtggcagggccgggccgggaacccctggagctggaagttgctgtg
gaggccctggcacggctgcagcagggtgtgagcgccaccgttgcccaccttctggacctg
gcaggcagcgccggtgcgactgggagctggcgtagcccctctgagccacaggagccgctg
gtgcaggacctgcaggctgctgtggccgctgtccagagtgccgtccacgagctgttggag
tttgcccgcagcgcggtgggcaatgctgcccacacatctgaccgtgccctgcatgccaag
cttagccggcagctgcagaagatggaggacgtgcaccagacgctggtggcacatggtcag
gccctcgacgctggccggggaggctctggagccacccttgaggacctggaccggctggtg
gcctgctcgcgggctgtgcccgaggacgccaagcagctggcctccttcctgcacggcaat
gcctcactgctcttcagacggaccaaggccactgccccggggcctgaggggggtggcacc
ctgcaccccaaccccactgacaagaccagcagcatccagtcacgacccctgccctcaccc
cctaagttcacctcccaggactcgccagatgggcagtacgagaacagcgaggggggctgg
atggaggactatgactacgtccacctacaggggaaggaggagtttgagaagacccagaag
gagctgctggaaaagggcagcatcacgcggcagggcaagagccagctggagttgcagcag
ctgaagcagtttgaacgactggaacaggaggtgtcacggcccatagaccacgacctggcc
aactggacgccagcccaacccctggccccggggcgaacaggcggcctggggccctcggac
cggcagctgctgctcttctacctggagcagtgtgaggccaacctgaccacactgaccaac
gccgtggacgccttctttaccgccgtggccaccaaccagccgcccaagatctttgtggcg
cacagcaagttcgtcatcctcagcgcccacaagctggtgttcatcggggacacactgtca
cggcaggccaaggctgctgacgtgcgcagccaggtgacccactacagcaacctgctgtgc
gacctcctgcgcggcatcgtggccaccaccaaggccgctgccttgcagtacccatcgcct
tccgcggcccaggacatggtggagagggtcaaggagctgggccacagcacccagcagttc
cgccgcgtcctaggccagctggcagccgcctga

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