Homo sapiens (human): 6570 Help Entry 6570              CDS       T01001                                  Symbol SLC18A1, CGAT, VAT1, VMAT1 Name (RefSeq) solute carrier family 18 member A1   KO K08155   MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2 Organism hsa  Homo sapiens (human) Pathway hsa04721   Synaptic vesicle cycle hsa04726   Serotonergic synapse hsa04728   Dopaminergic synapse hsa05012   Parkinson disease hsa05030   Cocaine addiction hsa05031   Amphetamine addiction hsa05034   Alcoholism Network nt06422  Dopamine metabolism nt06463  Parkinson disease   Element N01040   Transport of dopamine to synaptic vesicle Drug target Metamfetamine (DG00968):  D02242<JP/US> D08187 Reserpine:  D00197 Tedatioxetine (DG01311):  D10170 D10171 Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09156 Nervous system    04728 Dopaminergic synapse     6570 (SLC18A1)    04726 Serotonergic synapse     6570 (SLC18A1)    04721 Synaptic vesicle cycle     6570 (SLC18A1)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     6570 (SLC18A1)   09165 Substance dependence    05030 Cocaine addiction     6570 (SLC18A1)    05031 Amphetamine addiction     6570 (SLC18A1)    05034 Alcoholism     6570 (SLC18A1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02000 Transporters [BR:hsa02000]     6570 (SLC18A1) Transporters [BR:hsa02000]  Solute carrier family (SLC)   SLC18: Vesicular amine transporter    6570 (SLC18A1)  Major facilitator superfamily (MFS)   Drug transporters    Drug:H+ antiporter-1 (12 spanner) (DHA1) family [TC:2.A.1.2]     6570 (SLC18A1) BRITE hierarchyBRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  MFS_1 CPP1-like Motif Other DBs NCBI-GeneID:  6570 NCBI-ProteinID:  NP_001129163 OMIM:  193002 HGNC:  10934 Ensembl:  ENSG00000036565 Pharos:  P54219(Tchem) UniProt:  P54219 Q96GL6 LinkDB All DBs Position 8:complement(20144855..20183136) Genome browser AA seq 525 aa AA seqDB search MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE NT seq 1578 nt NT seq  +upstreamnt  +downstreamnt atgctccggaccattctggatgctccccagcggttgctgaaggaggggagagcgtcccgg cagctggtgctggtggtggtattcgtcgctttgctcctggacaacatgctgtttactgtg gtggtgccaattgtgcccaccttcctatatgacatggagttcaaagaagtcaactcttct ctgcacctcggccatgccggaagttccccacatgccctcgcctctcctgccttttccacc atcttctccttcttcaacaacaacaccgtggctgttgaagaaagcgtacctagtggaata gcatggatgaatgacactgccagcaccatcccacctccagccactgaagccatctcagct cataaaaacaactgcttgcaaggcacaggtttcttggaggaagagattacccgggtcggg gttctgtttgcttcaaaggctgtgatgcaacttctggtcaacccattcgtgggccctctc accaacaggattggatatcatatccccatgtttgctggctttgttatcatgtttctctcc acagttatgtttgctttttctgggacctatactctactctttgtggcccgaacccttcaa ggcattggatcttcattttcatctgttgcaggtcttggaatgctggccagtgtctacact gatgaccatgagagaggacgagccatgggaactgctctggggggcctggccttggggttg ctggtgggagctccctttggaagtgtaatgtacgagtttgttgggaagtctgcacccttc ctcatcctggccttcctggcactactggatggagcactccagctttgcatcctacagcct tccaaagtctctcctgagagtgccaaggggactcccctctttatgcttctcaaagaccct tacatcctggtggctgcagggtccatctgctttgccaacatgggggtggccatcctggag cccacactgcccatctggatgatgcagaccatgtgctcccccaagtggcagctgggtcta gctttcttgcctgccagtgtgtcctacctcattggcaccaacctctttggtgtgttggcc aacaagatgggtcggtggctgtgttccctaatcgggatgctggtagtaggtaccagcttg ctctgtgttcctctggctcacaatatttttggtctcattggccccaatgcagggcttggc cttgccataggcatggtggattcttctatgatgcccatcatggggcacctggtggatcta cgccacacctcggtgtatgggagtgtctacgccatcgctgatgtggctttttgcatgggc tttgctataggtccatccaccggtggtgccattgtaaaggccatcggttttccctggctc atggtcatcactggggtcatcaacatcgtctatgctccactctgctactacctgcggagc cccccggcaaaggaagagaagcttgctattctgagtcaggactgccccatggagacccgg atgtatgcaacccagaagcccacgaaggaatttcctctgggggaggacagtgatgaggag cctgaccatgaggagtag

Homo sapiens (human): 6571 Help Entry 6571              CDS       T01001                                  Symbol SLC18A2, PKDYS2, SVAT, SVMT, VAT2, VMAT2 Name (RefSeq) solute carrier family 18 member A2   KO K08155   MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2 Organism hsa  Homo sapiens (human) Pathway hsa04721   Synaptic vesicle cycle hsa04726   Serotonergic synapse hsa04728   Dopaminergic synapse hsa05012   Parkinson disease hsa05030   Cocaine addiction hsa05031   Amphetamine addiction hsa05034   Alcoholism Network nt06422  Dopamine metabolism nt06463  Parkinson disease   Element N01040   Transport of dopamine to synaptic vesicle N01041   Mutation-caused aberrant SNCA to transport of dopamine Drug target Amfetamine (DG00966):  D02074<US> D07445<US> Amphetamine aspartate monohydrate:  D11622 Benzfetamine (DG01755):  D07514 D07515<US> Deutetrabenazine:  D10701<US> Dexamfetamine (DG00967):  D02078<US> D03740<US> Dextroamphetamine saccharate:  D11623 Isometheptene:  D07097 Metamfetamine (DG00968):  D02242<JP/US> D08187 Midomafetamine:  D11172 Reserpine:  D00197 Tedatioxetine (DG01311):  D10170 D10171 Tetrabenazine:  D08575<JP/US> Valbenazine (DG02115):  D10675 D10999<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09156 Nervous system    04728 Dopaminergic synapse     6571 (SLC18A2)    04726 Serotonergic synapse     6571 (SLC18A2)    04721 Synaptic vesicle cycle     6571 (SLC18A2)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     6571 (SLC18A2)   09165 Substance dependence    05030 Cocaine addiction     6571 (SLC18A2)    05031 Amphetamine addiction     6571 (SLC18A2)    05034 Alcoholism     6571 (SLC18A2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02000 Transporters [BR:hsa02000]     6571 (SLC18A2) Transporters [BR:hsa02000]  Solute carrier family (SLC)   SLC18: Vesicular amine transporter    6571 (SLC18A2)  Major facilitator superfamily (MFS)   Drug transporters    Drug:H+ antiporter-1 (12 spanner) (DHA1) family [TC:2.A.1.2]     6571 (SLC18A2) BRITE hierarchyBRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  MFS_1 Sugar_tr Motif Other DBs NCBI-GeneID:  6571 NCBI-ProteinID:  NP_003045 OMIM:  193001 HGNC:  10935 Ensembl:  ENSG00000165646 Pharos:  Q05940(Tclin) UniProt:  Q05940 LinkDB All DBs Position 10:117241114..117279430 Genome browser AA seq 514 aa AA seqDB search MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD NT seq 1545 nt NT seq  +upstreamnt  +downstreamnt atggccctgagcgagctggcgctggtccgctggctgcaggagagccgccgctcgcggaag ctcatcctgttcatcgtgttcctggcgctgctgctggacaacatgctgctcactgtcgtg gtccccatcatcccaagttatctgtacagcattaagcatgagaagaatgctacagaaatc cagacggccaggccagtgcacactgcctccatctcagacagcttccagagcatcttctcc tattatgataactcgactatggtcaccgggaatgctaccagagacctgacacttcatcag accgccacacagcacatggtgaccaacgcgtccgctgttccttccgactgtcccagtgaa gacaaagacctcctgaatgaaaacgtgcaagttggtctgttgtttgcctcgaaagccacc gtccagctcatcaccaaccctttcataggactactgaccaacagaattggctatccaatt cccatatttgcgggattctgcatcatgtttgtctcaacaattatgtttgccttctccagc agctatgccttcctgctgattgccaggtcgctgcagggcatcggctcgtcctgctcctct gtggctgggatgggcatgcttgccagtgtctacacagatgatgaagagagaggcaacgtc atgggaatcgccttgggaggcctggccatgggggtcttagtgggcccccccttcgggagt gtgctctatgagtttgtggggaagacggctccgttcctggtgctggccgccctggtactc ttggatggagctattcagctctttgtgctccagccgtcccgggtgcagccagagagtcag aaggggacacccctaaccacgctgctgaaggacccgtacatcctcattgctgcaggctcc atctgctttgcaaacatgggcatcgccatgctggagccagccctgcccatctggatgatg gagaccatgtgttcccgaaagtggcagctgggcgttgccttcttgccagctagtatctct tatctcattggaaccaatatttttgggatacttgcacacaaaatggggaggtggctttgt gctcttctgggaatgataattgttggagtcagcattttatgtattccatttgcaaaaaac atttatggactcatagctccgaactttggagttggttttgcaattggaatggtggattcg tcaatgatgcctatcatgggctacctcgtagacctgcggcacgtgtccgtctatgggagt gtgtacgccattgcggatgtggcattttgtatggggtatgctataggtccttctgctggt ggtgctattgcaaaggcaattggatttccatggctcatgacaattattgggataattgat attctttttgcccctctctgcttttttcttcgaagtccacctgccaaagaagaaaaaatg gctattctcatggatcacaactgccctattaaaacaaaaatgtacactcagaataatatc cagtcatatccgataggtgaagatgaagaatctgaaagtgactga

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