Homo sapiens (human): 6715
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Entry
6715 CDS
T01001
Symbol
SRD5A1, S5AR_1
Name
(RefSeq) steroid 5 alpha-reductase 1
KO
K12343
3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:
1.3.1.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
Module
hsa_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019
Steroid hormone biosynthesis
Element
N01541
Testosterone biosynthesis
N01802
Dihydrotestosterone biosynthesis
Drug target
Alfatradiol:
D07121
Bexlosteride:
D03107
Dutasteride:
D03820
<JP/US>
Epristeride:
D01134
Idronoxil:
D04498
Izonsteride:
D04646
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
6715 (SRD5A1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
6715 (SRD5A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Steroid_dh
DUF1295
PEMT
Motif
Other DBs
NCBI-GeneID:
6715
NCBI-ProteinID:
NP_001038
OMIM:
184753
HGNC:
11284
Ensembl:
ENSG00000145545
UniProt:
P18405
LinkDB
All DBs
Position
5:6633440..6674386
Genome browser
AA seq
259 aa
AA seq
DB search
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
NT seq
780 nt
NT seq
+upstream
nt +downstream
nt
atggcaacggcgacgggggtggcggaggagcgcctgctggccgcgctcgcctacctgcag
tgcgccgtgggctgcgcggtcttcgcgcgcaatcgtcagacgaactcagtgtacggccgc
cacgcgctgcccagccacaggctccgagtgccggcgcgggccgcctgggtggtgcaggag
ctgccctcgctggccctgccgctctaccagtacgccagcgagtccgccccgcgtctccgc
agcgcgcccaactgcatcctcctggccatgttcctcgtccactacgggcatcggtgctta
atttacccatttctgatgcgaggaggaaagcctatgccactgttggcgtgtacaatggcg
attatgttctgtacctgtaacggctatttgcaaagcagatacttgagccattgtgcagtg
tatgctgatgactgggtaacagatccccgttttctaataggttttggcttgtggttaacg
ggcatgttgataaacatccattcagatcatatcctaaggaatctcagaaaaccaggagat
actggatacaaaataccaaggggaggcttatttgaatacgtaactgcagccaactatttt
ggagaaatcatggagtggtgtggctatgccctggccagctggtctgtccaaggcgcggct
tttgctttcttcacgttttgttttttatctggtagagcaaaagagcatcatgagtggtac
ctccggaaatttgaagagtatccaaagttcagaaaaattataattccatttttgttttaa
Homo sapiens (human): 6716
Help
Entry
6716 CDS
T01001
Symbol
SRD5A2
Name
(RefSeq) steroid 5 alpha-reductase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
hsa05215
Prostate cancer
Module
hsa_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Network
nt06019
Steroid hormone biosynthesis
Element
N01541
Testosterone biosynthesis
Disease
H00608
46,XY disorder of sex development due to testosterone secretion defect
Drug target
Alfatradiol:
D07121
Dutasteride:
D03820
<JP/US>
Epristeride:
D01134
Estramustine (
DG00724
):
D02398
D04066
D06397
<JP/US>
Finasteride:
D00321
<JP/US>
Idronoxil:
D04498
Izonsteride:
D04646
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
6716 (SRD5A2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
6716 (SRD5A2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
6716 (SRD5A2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Steroid_dh
DUF1295
DUF6832
PEMT
Motif
Other DBs
NCBI-GeneID:
6716
NCBI-ProteinID:
NP_000339
OMIM:
607306
HGNC:
11285
Ensembl:
ENSG00000277893
UniProt:
P31213
Structure
PDB
LinkDB
All DBs
Position
2:complement(31522480..31663009)
Genome browser
AA seq
254 aa
AA seq
DB search
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
NT seq
765 nt
NT seq
+upstream
nt +downstream
nt
atgcaggttcagtgccagcagagcccagtgctggcaggcagcgccactttggtcgccctt
ggggcactggccttgtacgtcgcgaagccctccggctacgggaagcacacggagagcctg
aagccggcggctacccgcctgccagcccgcgccgcctggttcctgcaggagctgccttcc
ttcgcggtgcccgcggggatcctcgcccggcagcccctctccctcttcgggccacctggg
acggtacttctgggcctcttctgcctacattacttccacaggacatttgtgtactcactg
ctcaatcgagggaggccttatccagctatactcattctcagaggcactgccttctgcact
ggaaatggagtccttcaaggctactatctgatttactgtgctgaataccctgatgggtgg
tacacagacatacggtttagcttgggtgtcttcttatttattttgggaatgggaataaac
attcatagtgactatatattgcgccagctcaggaagcctggagaaatcagctacaggatt
ccacaaggtggcttgtttacgtatgtttctggagccaatttcctcggtgagatcattgaa
tggatcggctatgccctggccacttggtccctcccagcacttgcatttgcatttttctca
ctttgtttccttgggctgcgagcttttcaccaccataggttctacctcaagatgtttgag
gactaccccaaatctcggaaagcccttattccattcatcttttaa
Homo sapiens (human): 79644
Help
Entry
79644 CDS
T01001
Symbol
SRD5A3, CDG1P, CDG1Q, KRIZI, S5AR, S5AR_3, SRD5A2L, SRD5A2L1
Name
(RefSeq) steroid 5 alpha-reductase 3
KO
K12345
3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:
1.3.1.22
1.3.1.94
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa00510
N-Glycan biosynthesis
hsa01100
Metabolic pathways
Module
hsa_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Network
nt06015
N-Glycan biosynthesis
nt06019
Steroid hormone biosynthesis
Element
N00675
N-Glycan precursor biosynthesis, farnesy-PP to P-Dol
N01541
Testosterone biosynthesis
Disease
H00118
Congenital disorders of glycosylation type I
Drug target
Idronoxil:
D04498
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
79644 (SRD5A3)
09107 Glycan biosynthesis and metabolism
00510 N-Glycan biosynthesis
79644 (SRD5A3)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
79644 (SRD5A3)
1.3.1.94 polyprenol reductase
79644 (SRD5A3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Steroid_dh
Motif
Other DBs
NCBI-GeneID:
79644
NCBI-ProteinID:
NP_078868
OMIM:
611715
HGNC:
25812
Ensembl:
ENSG00000128039
UniProt:
Q9H8P0
LinkDB
All DBs
Position
4:55346242..55373100
Genome browser
AA seq
318 aa
AA seq
DB search
MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
SKFVSYPKHRKAFLPFLF
NT seq
957 nt
NT seq
+upstream
nt +downstream
nt
atggctccctgggcggaggccgagcactcggcgctgaacccgctgcgcgcggtgtggctc
acgctgaccgccgccttcctgctgaccctactgctgcagctcctgccgcccggcctgctc
ccgggctgcgcgatcttccaggacctgatccgctatgggaaaaccaagtgtggggagccg
tcgcgccccgccgcctgccgagcctttgatgtccccaagagatatttttcccacttttat
atcatctcagtgctgtggaatggcttcctgctttggtgccttactcaatctctgttcctg
ggagcaccttttccaagctggcttcatggtttgctcagaattctcggggcggcacagttc
cagggaggggagctggcactgtctgcattcttagtgctagtatttctgtggctgcacagc
ttacgaagactcttcgagtgcctctacgtcagtgtcttctccaatgtcatgattcacgtc
gtgcagtactgttttggacttgtctattatgtccttgttggcctaactgtgctgagccaa
gtgccaatggatggcaggaatgcctacataacagggaaaaatctattgatgcaagcacgg
tggttccatattcttgggatgatgatgttcatctggtcatctgcccatcagtataagtgc
catgttattctcggcaatctcaggaaaaataaagcaggagtggtcattcactgtaaccac
aggatcccatttggagactggtttgaatatgtttcttcccctaactacttagcagagctg
atgatctacgtttccatggccgtcacctttgggttccacaacttaacttggtggctagtg
gtgacaaatgtcttctttaatcaggccctgtctgcctttctcagccaccaattctacaaa
agcaaatttgtctcttacccgaagcataggaaagctttcctaccatttttgttttaa
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integrated database retrieval system