KEGG   NETWORK: N01874
Entry
N01874                      Network                                
Name
NRG-ERBB2/ERBB3 pathway (RAS-ERK signaling)
Definition
NRG -- ERBB3 -- ERBB2 -> (SHC+GRB2) -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(3084,9542) -- 2065 -- 2064 -> (6464+2885) -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06543 NRG-ERBB signaling
Type
Reference
Pathway
hsa04012  ErbB signaling pathway
Gene
3084  NRG1; neuregulin 1
9542  NRG2; neuregulin 2
2065  ERBB3; erb-b2 receptor tyrosine kinase 3
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
6464  SHC1; SHC adaptor protein 1
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
PMID:31351986
  Authors
Black LE, Longo JF, Carroll SL
  Title
Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.
  Journal
Am J Pathol 189:1898-1912 (2019)
DOI:10.1016/j.ajpath.2019.06.008
Reference
PMID:35247506
  Authors
Zhang C, Mei W, Zeng C
  Title
Oncogenic Neuregulin 1 gene (NRG1) fusions in cancer: A potential new therapeutic opportunities.
  Journal
Biochim Biophys Acta Rev Cancer 1877:188707 (2022)
DOI:10.1016/j.bbcan.2022.188707
Reference
PMID:39123493
  Authors
Kucharczyk T, Nicos M, Kucharczyk M, Kalinka E
  Title
NRG1 Gene Fusions-What Promise Remains Behind These Rare Genetic Alterations? A Comprehensive Review of Biology, Diagnostic Approaches, and Clinical  Implications.
  Journal
Cancers (Basel) 16:cancers16152766 (2024)
DOI:10.3390/cancers16152766
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