KEGG   PATHWAY: jli00260
Entry
jli00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Janibacter limosus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
jli00260  Glycine, serine and threonine metabolism
jli00260

Module
jli_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:jli00260]
jli_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:jli00260]
jli_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:jli00260]
jli_M00621  Glycine cleavage system [PATH:jli00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Janibacter limosus [GN:jli]
Gene
EXU32_01185  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EXU32_04845  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EXU32_01190  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EXU32_10640  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EXU32_10630  homoserine kinase [KO:K00872] [EC:2.7.1.39]
EXU32_10635  threonine synthase [KO:K01733] [EC:4.2.3.1]
EXU32_09600  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EXU32_10595  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EXU32_08025  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EXU32_13810  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
EXU32_09375  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
EXU32_02415  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EXU32_13030  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EXU32_06230  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EXU32_06955  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EXU32_06960  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EXU32_06880  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EXU32_08080  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EXU32_04255  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EXU32_08090  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EXU32_06855  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EXU32_09635  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EXU32_02205  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
EXU32_08990  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EXU32_16650  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
EXU32_00560  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EXU32_05790  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EXU32_05785  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EXU32_06825  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
EXU32_06830  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EXU32_06820  ectoine synthase [KO:K06720] [EC:4.2.1.108]
EXU32_14775  decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
jli00010  Glycolysis / Gluconeogenesis
jli00020  Citrate cycle (TCA cycle)
jli00230  Purine metabolism
jli00250  Alanine, aspartate and glutamate metabolism
jli00270  Cysteine and methionine metabolism
jli00290  Valine, leucine and isoleucine biosynthesis
jli00300  Lysine biosynthesis
jli00330  Arginine and proline metabolism
jli00460  Cyanoamino acid metabolism
jli00470  D-Amino acid metabolism
jli00564  Glycerophospholipid metabolism
jli00620  Pyruvate metabolism
jli00630  Glyoxylate and dicarboxylate metabolism
jli00640  Propanoate metabolism
jli00680  Methane metabolism
jli00860  Porphyrin metabolism
jli00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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