KEGG   PATHWAY: ko00400
Entry
ko00400                     Pathway                                
Name
Phenylalanine, tyrosine and tryptophan biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00400

Module
M00022  Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:ko00400]
M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:ko00400]
M00024  Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:ko00400]
M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:ko00400]
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine [PATH:ko00400]
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine [PATH:ko00400]
Other DBs
GO: 0009094 0006571 0000162
Orthology
K00014  aroE; shikimate dehydrogenase [EC:1.1.1.25]
K00211  TYR1; prephenate dehydrogenase (NADP+) [EC:1.3.1.13]
K00220  tyrC; cyclohexadieny/prephenate dehydrogenase [EC:1.3.1.43 1.3.1.12]
K00270  pdh; phenylalanine dehydrogenase [EC:1.4.1.20]
K00500  phhA, PAH; phenylalanine-4-hydroxylase [EC:1.14.16.1]
K00766  trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]
K00800  aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
K00811  ASP5; aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspB; aspartate aminotransferase [EC:2.6.1.1]
K00813  aspC; aspartate aminotransferase [EC:2.6.1.1]
K00815  TAT; tyrosine aminotransferase [EC:2.6.1.5]
K00817  hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K00891  aroK, aroL; shikimate kinase [EC:2.7.1.71]
K01609  trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]
K01626  E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
K01656  TRP3; anthranilate synthase / indole-3-glycerol phosphate synthase [EC:4.1.3.27 4.1.1.48]
K01657  trpE; anthranilate synthase component I [EC:4.1.3.27]
K01658  trpG; anthranilate synthase component II [EC:4.1.3.27]
K01694  TRP; tryptophan synthase [EC:4.2.1.20]
K01695  trpA; tryptophan synthase alpha chain [EC:4.2.1.20]
K01696  trpB; tryptophan synthase beta chain [EC:4.2.1.20]
K01713  pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]
K01735  aroB; 3-dehydroquinate synthase [EC:4.2.3.4]
K01736  aroC; chorismate synthase [EC:4.2.3.5]
K01817  trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]
K01850  E5.4.99.5; chorismate mutase [EC:5.4.99.5]
K03334  IL4I1; L-amino-acid oxidase [EC:1.4.3.2]
K03785  aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]
K03786  aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]
K03856  AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
K04092  tyrA1; chorismate mutase [EC:5.4.99.5]
K04093  pheA1; chorismate mutase [EC:5.4.99.5]
K04516  AROA1, aroA; chorismate mutase [EC:5.4.99.5]
K04517  tyrA2; prephenate dehydrogenase [EC:1.3.1.12]
K04518  pheA2; prephenate dehydratase [EC:4.2.1.51]
K05358  quiA; quinate dehydrogenase (quinone) [EC:1.1.5.8]
K05359  ADT, PDT; arogenate/prephenate dehydratase [EC:4.2.1.91 4.2.1.51]
K05821  ARO9; aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
K05887  ydiB; quinate/shikimate dehydrogenase [EC:1.1.1.282]
K06001  trpB; tryptophan synthase beta chain [EC:4.2.1.20]
K06208  aroH; chorismate mutase [EC:5.4.99.5]
K06209  pheB; chorismate mutase [EC:5.4.99.5]
K09483  quiC; 3-dehydroshikimate dehydratase [EC:4.2.1.118]
K09484  QUTB, QA-3; quinate dehydrogenase [EC:1.1.1.24]
K11358  yhdR; aspartate aminotransferase [EC:2.6.1.1]
K11646  K11646; 3-dehydroquinate synthase II [EC:1.4.1.24]
K13497  trpGD; anthranilate synthase/phosphoribosyltransferase [EC:4.1.3.27 2.4.2.18]
K13498  trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24]
K13501  TRP1; anthranilate synthase / indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.3.27 4.1.1.48 5.3.1.24]
K13503  trpEG; anthranilate synthase [EC:4.1.3.27]
K13829  aroKB; shikimate kinase / 3-dehydroquinate synthase [EC:2.7.1.71 4.2.3.4]
K13830  ARO1; pentafunctional AROM polypeptide [EC:4.2.3.4 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19]
K13832  aroDE, DHQ-SDH; 3-dehydroquinate dehydratase / shikimate dehydrogenase [EC:4.2.1.10 1.1.1.25]
K13853  aroG, aroA; 3-deoxy-7-phosphoheptulonate synthase / chorismate mutase [EC:2.5.1.54 5.4.99.5]
K14170  pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]
K14187  tyrA; chorismate mutase / prephenate dehydrogenase [EC:5.4.99.5 1.3.1.12]
K14454  GOT1, AAT2; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K15226  tyrAa; arogenate dehydrogenase (NADP+) [EC:1.3.1.78]
K15227  TYRAAT; arogenate dehydrogenase (NADP+), plant [EC:1.3.1.78]
K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
K17748  hphA; benzylmalate synthase [EC:2.3.3.-]
K17749  hphCD; 3-benzylmalate isomerase [EC:4.2.1.-]
K17750  hphB; 3-benzylmalate dehydrogenase [EC:1.1.1.-]
K18239  fkbO, rapK; chorismatase [EC:3.3.2.13]
K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45]
K24017  priA; phosphoribosyl isomerase A
K24018  K24018; cyclohexadieny/prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase
K25901  qsuD; quinate/shikimate dehydrogenase (NAD+)
K26400  quiC1, QA-4; 3-dehydroshikimate dehydratase
Compound
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00108  Anthranilate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00166  Phenylpyruvate
C00230  3,4-Dihydroxybenzoate
C00251  Chorismate
C00254  Prephenate
C00279  D-Erythrose 4-phosphate
C00296  Quinate
C00354  D-Fructose 1,6-bisphosphate
C00441  L-Aspartate 4-semialdehyde
C00463  Indole
C00493  Shikimate
C00587  3-Hydroxybenzoate
C00826  L-Arogenate
C00944  3-Dehydroquinate
C01094  D-Fructose 1-phosphate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01269  5-O-(1-Carboxyvinyl)-3-phosphoshikimate
C01302  1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
C02637  3-Dehydroshikimate
C03175  Shikimate 3-phosphate
C03506  Indoleglycerol phosphate
C04302  N-(5-Phospho-D-ribosyl)anthranilate
C04691  2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
C16848  6-Deoxy-5-ketofructose 1-phosphate
C16850  2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid
C17235  L-Homophenylalanine
C20327  2-Oxo-4-phenylbutyric acid
C20653  2-Benzylmalic acid
C20654  3-Benzylmalic acid
C20710  (4R,5R)-4,5-Dihydroxycyclohexa-1(6),2-diene-1-carboxylate
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00362  Benzoate degradation
ko00380  Tryptophan metabolism
ko00402  Benzoxazinoid biosynthesis
ko00403  Indole diterpene alkaloid biosynthesis
ko00404  Staurosporine biosynthesis
ko00710  Carbon fixation by Calvin cycle
ko00790  Folate biosynthesis
ko00901  Indole alkaloid biosynthesis
ko00940  Phenylpropanoid biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ko00966  Glucosinolate biosynthesis
ko01053  Biosynthesis of siderophore group nonribosomal peptides
ko01059  Biosynthesis of enediyne antibiotics

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