PATHWAY: ko04013 Help
Entry Name MAPK signaling pathway - fly
Description The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map ko04013 MAPK signaling pathway - fly
Other DBs Orthology K02104 AOS; protein giant-lens (argos)
K03211 ETV6_7, yan; ETS translocation variant 6/7
K04352 RASA1, RASGAP; Ras GTPase-activating protein 1
K04364 GRB2; growth factor receptor-bound protein 2
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2 ]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04417 MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25 ]
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25 ]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04428 MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25 ]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2 ]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2 ]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 JUN; transcription factor AP-1
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04508 TBL1; transducin (beta)-like 1
K04623 BOSS; bride of sevenless protein
K04662 BMP4; bone morphogenetic protein 4
K06279 SHC1; SHC-transforming protein 1
K06689 UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23 ]
K07293 PTPN11, SHP2; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K07827 KRAS, KRAS2; GTPase KRas
K08545 NR2E1, TLX, tll; nuclear receptor subfamily 2 group E member 1
K08601 CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12 ]
K09031 FOSLN; fos-like antigen, invertebrate
K09260 MEF2A; MADS-box transcription enhancer factor 2A
K12377 TSL; torso-like protein
K12380 RASA3; Ras GTPase-activating protein 3
K13578 BMPR1B, ALK6, CDw293; bone morphogenetic protein receptor type-1B [EC:2.7.11.30 ]
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K17383 SPRY2; protein sprouty homolog 2
K17536 CNKSR2, CNK2, KSR2; connector enhancer of kinase suppressor of Ras 2
K17608 STRN1_3_4; striatin 1/3/4
K20016 HID; cell death protein hid
K20210 RREB1; ras-responsive element-binding protein 1
K20211 PROX1; prospero homeobox 1
K20214 LZ; RUNX transcription factor Lozenge
K20223 IPO7, RANBP7; importin-7
K20225 CIC; capicua transcriptional repressor
K20227 FS1M3; female sterile (1) M3, polehole
K20228 FS1N; female sterile (1) Nasrat
K20231 DOS; protein daughter of sevenless
K20232 EDL; ETS-domain lacking
K20234 DOK2; docking protein 2
K28209 SAMD10_12, AVE; sterile alpha motif domain-containing protein 10/12
Reference Authors Sopko R, Perrimon N
Title Receptor tyrosine kinases in Drosophila development.
Journal Reference Authors Li WX
Title Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
Journal Reference Authors Shilo BZ
Title Signaling by the Drosophila epidermal growth factor receptor pathway during development.
Journal Reference Authors Raabe T
Title The sevenless signaling pathway: variations of a common theme.
Journal Reference Authors Rios-Barrera LD, Riesgo-Escovar JR
Title Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
Journal Reference Authors Igaki T, Miura M
Title The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
Journal Reference Authors Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
Title Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
Journal Reference Authors Stronach BE, Perrimon N
Title Stress signaling in Drosophila.
Journal Reference Authors Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrancois M, Kurinov I, Fronzes R, Sicheri F, Therrien M
Title The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
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