KEGG   PATHWAY: ko00670
Entry
ko00670                     Pathway                                
Name
One carbon pool by folate
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00670  One carbon pool by folate
ko00670

Module
M00035  Methionine degradation [PATH:ko00670]
M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670]
M00140  C1-unit interconversion, prokaryotes [PATH:ko00670]
M00141  C1-unit interconversion, eukaryotes [PATH:ko00670]
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ko00670]
M00555  Betaine biosynthesis, choline => betaine [PATH:ko00670]
M00621  Glycine cleavage system [PATH:ko00670]
M00974  Betaine metabolism, animals, betaine => glycine [PATH:ko00670]
Drug
D00145  Trimethoprim (JAN/USP/INN)
D00488  Pyrimethamine (JAN/USP/INN)
D02387  Cycloguanil pamoate (USAN)
D02487  Proguanil hydrochloride (JAN/USP)
D03771  Diaveridine (USAN/INN)
D06097  Tetroxoprim (USAN/INN)
D06236  Trimethoprim sulfate (USP)
D07238  Brodimoprim (INN)
D08337  Iclaprim (USAN/INN)
D08428  Proguanil (INN)
D08563  Iclaprim mesylate (USAN)
D08644  Trimethoprim lactate
D11085  Trimethoprim hydrochloride
Other DBs
GO: 0035999
Orthology
K00108  betA, CHDH; choline dehydrogenase [EC:1.1.99.1]
K00130  betB, gbsA; betaine-aldehyde dehydrogenase [EC:1.2.1.8]
K00281  GLDC, gcvP; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
K00282  gcvPA; glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]
K00283  gcvPB; glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]
K00287  DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]
K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
K00289  ALDH1L; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]
K00295  MTD1; methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
K00297  metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]
K00300  mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+)
K00309  dmg; dimethylglycine oxidase
K00314  SARDH; sarcosine dehydrogenase [EC:1.5.8.3]
K00315  DMGDH; dimethylglycine dehydrogenase [EC:1.5.8.4]
K00382  DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00499  CMO; choline monooxygenase [EC:1.14.15.7]
K00544  BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5]
K00547  mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10]
K00548  metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
K00552  GNMT; glycine N-methyltransferase [EC:2.1.1.20]
K00560  thyA, TYMS; thymidylate synthase [EC:2.1.1.45]
K00600  glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]
K00601  E2.1.2.2; phosphoribosylglycinamide formyltransferase [EC:2.1.2.2]
K00602  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
K00603  fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2]
K00605  gcvT, AMT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
K00789  metK, MAT; S-adenosylmethionine synthetase [EC:2.5.1.6]
K01251  AHCY; adenosylhomocysteinase [EC:3.13.2.1]
K01433  purU; formyltetrahydrofolate deformylase [EC:3.5.1.10]
K01491  folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
K01492  purNH; phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3]
K01500  fchA; methenyltetrahydrofolate cyclohydrolase
K01697  CBS; cystathionine beta-synthase [EC:4.2.1.22]
K01746  E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]
K01758  CTH; cystathionine gamma-lyase [EC:4.4.1.1]
K01934  MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
K01938  fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3]
K02437  gcvH, GCSH; glycine cleavage system H protein
K03465  thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148]
K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
K11175  purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
K11440  gbsB; choline dehydrogenase [EC:1.1.1.1]
K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
K13402  MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]
K13403  MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
K13938  folM; dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3]
K13990  FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4]
K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
K17755  codA; choline oxidase [EC:1.1.3.17]
K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K24042  yitJ; methionine synthase / methylenetetrahydrofolate reductase (NADH)
K25004  MTHFR; methylenetetrahydrofolate reductase (NADPH)
K25007  metV; methylenetetrahydrofolate reductase (NADH) small subunit
K25008  rnfC2; ion-translocating oxidoreductase complex subunit C
K25009  E1.5.1.20; methylenetetrahydrofolate reductase [NAD(P)H]
K25221  mtgA; [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase
K25915  mtvA; [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase
K26930  mtqA; [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase
Compound
C00002  ATP
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00037  Glycine
C00065  L-Serine
C00073  L-Methionine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00155  L-Homocysteine
C00212  Adenosine
C00213  Sarcosine
C00234  10-Formyltetrahydrofolate
C00364  dTMP
C00365  dUMP
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00576  Betaine aldehyde
C00664  5-Formiminotetrahydrofolate
C00719  Betaine
C01026  N,N-Dimethylglycine
C02291  L-Cystathionine
C03479  Folinic acid
Related
pathway
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00790  Folate biosynthesis

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