KEGG   PATHWAY: leri00053
Entry
leri00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Leucoraja erinacea (little skate)
Class
Metabolism; Carbohydrate metabolism
Pathway map
leri00053  Ascorbate and aldarate metabolism
leri00053

Module
leri_M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:leri00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129701545  UDP-glucose 6-dehydrogenase-like isoform X1 [KO:K00012] [EC:1.1.1.22]
129698339  ugdh; LOW QUALITY PROTEIN: UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
129712240  gkup; glucuronokinase with putative uridyl pyrophosphorylase [KO:K16190] [EC:2.7.1.43]
129705278  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129705279  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129705280  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129695342  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129698935  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129698936  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129698937  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129712786  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712787  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712788  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712789  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712791  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712792  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712795  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712796  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712797  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712799  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712800  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712802  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712803  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712804  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712805  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712806  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129710804  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
129698027  kl; klotho [KO:K14756] [EC:3.2.1.31]
129707833  miox; inositol oxygenase isoform X1 [KO:K00469] [EC:1.13.99.1]
129695960  akr1a1a; aldo-keto reductase family 1 member A1-A isoform X1 [KO:K00002] [EC:1.1.1.2]
129700891  akr1a1b; aldo-keto reductase family 1 member A1-B isoform X1 [KO:K00002] [EC:1.1.1.2]
129697829  regucalcin-like isoform X1 [KO:K01053] [EC:3.1.1.17]
129697832  rgn; regucalcin [KO:K01053] [EC:3.1.1.17]
129699371  L-gulonolactone oxidase-like [KO:K00103] [EC:1.1.3.8]
129709155  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
129713971  aldehyde dehydrogenase family 16 member A1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
129710558  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129710561  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129695789  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
129701198  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
leri00020  Citrate cycle (TCA cycle)
leri00040  Pentose and glucuronate interconversions
leri00051  Fructose and mannose metabolism
leri00520  Amino sugar and nucleotide sugar metabolism
leri00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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