KEGG PATHWAY: mana00541

PATHWAY: mana00541

Entry

mana00541                   Pathway

Name

Biosynthesis of various nucleotide sugars - Methylomusa anaerophila

Class

Metabolism; Glycan biosynthesis and metabolism

Pathway map

mana00541

Biosynthesis of various nucleotide sugars

Module

mana_M00063

CMP-3-deoxy-D-manno-octulosonate biosynthesis, ribulose-5P => CMP-KDO [PATH:mana00541]

mana_M00064

ADP-L-glycero-D-manno-heptose biosynthesis, sedoheptulose-7P => ADP-LDmanHep [PATH:mana00541]

mana_M00793

dTDP-L-rhamnose biosynthesis, glucose-1P => dTDP-L-Rha [PATH:mana00541]

Organism

Methylomusa anaerophila [GN:mana]

Gene

MAMMFC1_00758

gtaB_1; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]

MAMMFC1_00777

tuaD; UDP-glucose 6-dehydrogenase TuaD [KO:K00012] [EC:1.1.1.22]

MAMMFC1_00951

glmU; bifunctional protein GlmU [KO:K04042] [EC:2.7.7.23 2.3.1.157]

MAMMFC1_01060

rfbG; CDP-glucose 4,6-dehydratase [KO:K01709] [EC:4.2.1.45]

MAMMFC1_01061

rmlD_1; dTDP-4-dehydrorhamnose reductase [KO:K00067] [EC:1.1.1.133]

MAMMFC1_01062

rfbF; glucose-1-phosphate cytidylyltransferase [KO:K00978] [EC:2.7.7.33]

MAMMFC1_01063

rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [KO:K01790] [EC:5.1.3.13]

MAMMFC1_02193

mnaA; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]

MAMMFC1_02243

fcl_1; GDP-L-fucose synthase [KO:K02377] [EC:1.1.1.271]

MAMMFC1_02244

gmd_1; GDP-mannose 4,6-dehydratase [KO:K01711] [EC:4.2.1.47]

MAMMFC1_02257

kpsU; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]

MAMMFC1_02258

kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]

MAMMFC1_02259

kdsD; arabinose 5-phosphate isomerase KdsD [KO:K06041] [EC:5.3.1.13]

MAMMFC1_02260

kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC [KO:K03270] [EC:3.1.3.45]

MAMMFC1_02278

hldE_1; bifunctional protein HldE [KO:K21344] [EC:2.7.1.167]

MAMMFC1_02279

hldE_2; bifunctional protein HldE [KO:K21345] [EC:2.7.7.70]

MAMMFC1_02289

gmhA; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]

MAMMFC1_02290

hldE_3; bifunctional protein HldE [KO:K21344] [EC:2.7.1.167]

MAMMFC1_02291

hldD; ADP-L-glycero-D-manno-heptose-6-epimerase [KO:K03274] [EC:5.1.3.20]

MAMMFC1_02294

gmhB; D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase [KO:K03273] [EC:3.1.3.82 3.1.3.83]

MAMMFC1_02302

fcl_2; GDP-L-fucose synthase [KO:K02377] [EC:1.1.1.271]

MAMMFC1_02303

rmlA; glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]

MAMMFC1_02304

rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [KO:K01790] [EC:5.1.3.13]

MAMMFC1_02305

rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]

MAMMFC1_02306

rmlD_2; dTDP-4-dehydrorhamnose reductase [KO:K00067] [EC:1.1.1.133]

MAMMFC1_02326

gmd_2; GDP-mannose 4,6-dehydratase [KO:K01711] [EC:4.2.1.47]

MAMMFC1_02348

ywqF_1; UDP-glucose 6-dehydrogenase YwqF [KO:K00012] [EC:1.1.1.22]

MAMMFC1_02351

algA; alginate biosynthesis protein AlgA [KO:K16011] [EC:2.7.7.13 5.3.1.8]

MAMMFC1_02356

gtaB_2; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]

MAMMFC1_02386

legG; GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase [KO:K18429] [EC:3.2.1.184]

MAMMFC1_02390

neuA; N-acylneuraminate cytidylyltransferase [KO:K18431] [EC:2.7.7.82]

Compound

C00029

UDP-glucose

C00043

UDP-N-acetyl-alpha-D-glucosamine

C00096

GDP-mannose

C00103

D-Glucose 1-phosphate

C00128

CMP-N-acetylneuraminate

C00167

UDP-glucuronate

C00199

D-Ribulose 5-phosphate

C00203

UDP-N-acetyl-D-galactosamine

C00270

N-Acetylneuraminate

C00275

D-Mannose 6-phosphate

C00325

GDP-L-fucose

C00501

CDP-glucose

C00636

D-Mannose 1-phosphate

C00645

N-Acetyl-D-mannosamine

C00688

dTDP-4-dehydro-beta-L-rhamnose

C00842

dTDP-glucose

C00996

Ferricytochrome b5

C00999

Ferrocytochrome b5

C01112

D-Arabinose 5-phosphate

C01170

UDP-N-acetyl-D-mannosamine

C01187

3-Deoxy-D-manno-octulosonate

C01219

CDP-4-dehydro-6-deoxy-D-glucose

C01222

GDP-4-dehydro-6-deoxy-D-mannose

C01788

CDP-abequose

C02199

UDP-L-rhamnose

C02330

UDP-L-iduronate

C02977

GDP-6-deoxy-D-talose

C03117

GDP-6-deoxy-D-mannose

C03187

dTDP-6-deoxy-beta-L-talose

C03319

dTDP-L-rhamnose

C03410

N-Glycoloyl-neuraminate

C03598

CDP-3,6-dideoxy-D-glucose

C03599

CDP-3,6-dideoxy-D-mannose

C03691

CMP-N-glycoloylneuraminate

C04089

UDP-4-dehydro-6-deoxy-D-glucose

C04121

CMP-3-deoxy-D-manno-octulosonate

C04257

N-Acetyl-D-mannosamine 6-phosphate

C04268

dTDP-4-amino-4,6-dideoxy-D-glucose

C04297

CDP-4-dehydro-3,6-dideoxy-D-glucose

C04346

dTDP-4-amino-4,6-dideoxy-D-galactose

C04478

3-Deoxy-D-manno-octulosonate 8-phosphate

C04501

N-Acetyl-alpha-D-glucosamine 1-phosphate

C04573

UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate

C04613

UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose

C04630

UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose

C05382

Sedoheptulose 7-phosphate

C06018

dTDP-4-acetamido-4,6-dideoxy-D-glucose

C06240

UDP-N-acetyl-D-mannosaminouronate

C06241

N-Acetylneuraminate 9-phosphate

C06397

ADP-D-glycero-beta-D-manno-heptose

C06398

ADP-L-glycero-beta-D-manno-heptose

C07277

dTDP-D-fucose

C07836

D-glycero-beta-D-manno-Heptose 7-phosphate

C07838

D-glycero-beta-D-manno-Heptose 1-phosphate

C11472

D-glycero-beta-D-manno-Heptose 1,7-bisphosphate

C11907

dTDP-4-oxo-6-deoxy-D-glucose

C11908

3,6-Dideoxy-3-oxo-dTDP-D-glucose

C11925

dTDP-3-amino-3,6-dideoxy-D-glucose

C13952

UDP-N-acetyl-D-galactosaminuronic acid

C16153

UDP-L-Ara4N

C16154

UDP-L-Ara4FN

C16155

UDP-L-Ara4O

C16156

Undecaprenyl phosphate alpha-L-Ara4FN

C16157

Undecaprenyl phosphate alpha-L-Ara4N

C17326

CDP-4-dehydro-3,6-dideoxy-D-glucose epimer

C17327

CDP-ascarylose

C17328

UDP-4-keto-rhamnose

C19725

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

C19745

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate

C19823

UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose

C19878

D-glycero-alpha-D-manno-Heptose 7-phosphate

C19879

D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate

C19880

D-glycero-alpha-D-manno-Heptose 1-phosphate

C19881

GDP-D-glycero-alpha-D-manno-heptose

C19947

dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose

C19960

dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose

C19961

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine

C19971

UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose

C19972

2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose

C20082

Pseudaminic acid

C20083

CMP-pseudaminic acid

C20156

dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose

C20357

UDP-N,N'-diacetylbacillosamine

C20359

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate

C20395

UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate

C20415

dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose

C20418

N,N'-Diacetyllegionaminate

C20419

CMP-N,N'-diacetyllegionaminate

C20424

2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose

C20612

GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose

C20613

GDP-beta-L-colitose

C20638

GDP-4-amino-4,6-dideoxy-alpha-D-mannose

C20672

GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose

C20682

dTDP-alpha-D-fucofuranose

C20768

UDP-2-acetamido-2,6-dideoxy-beta-L-talose

C20769

UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-4-hexulose

C20774

UDP-N-acetyl-beta-L-fucosamine

C20934

3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate

C21383

3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate

C21384

CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate

C22245

UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide

C22246

UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic acid

C22247

UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucopyranose

C22248

UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose

C22249

2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose

C22250

5-N-Acetyl-7-N-(D-alanyl)-legionaminic acid

C22251

CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic acid

C22252

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose

C22253

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose

C22254

2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose

C22255

5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid

C22256

CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic acid

C22257

dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose

C22259

UDP-2-acetamido-2,6-dideoxy-beta-L-mannose

C22260

UDP-2-acetamido-2,6-dideoxy-beta-L-glucose

C22261

UDP-2-acetamido-2,6-dideoxy-alpha-D-galactose

C22262

UDP-2-acetamido-2,6-dideoxy-alpha-D-glucose

C22270

UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose

C22276

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine

C22397

GDP-N-formyl-alpha-D-perosamine

C22575

UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-galactose

C22576

UDP-2-acetamido-2-deoxy-L-altruronic acid

C22938

UDP-N-acetyl-alpha-D-xylosamine

C22973

UDP-yelosamine

Reference

PMID:14670712

Authors

Samuel G, Reeves P

Title

Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly.

Journal

Carbohydr Res 338:2503-19 (2003)
DOI:10.1016/j.carres.2003.07.009

Reference

PMID:8939432

Authors

Burrows LL, Charter DF, Lam JS

Title

Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster.

Journal

Mol Microbiol 22:481-95 (1996)
DOI:10.1046/j.1365-2958.1996.1351503.x

Reference

PMID:10627048

Authors

Belanger M, Burrows LL, Lam JS

Title

Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.

Journal

Microbiology 145 ( Pt 12):3505-21 (1999)
DOI:10.1099/00221287-145-12-3505

Reference

PMID:10828401

Authors

Dean CR, Goldberg JB

Title

The wbpM gene in Pseudomonas aeruginosa serogroup O17 resides on a cryptic copy of the serogroup O11 O antigen gene locus.

Journal

FEMS Microbiol Lett 187:59-63 (2000)
DOI:10.1111/j.1574-6968.2000.tb09137.x

Reference

PMID:15629947

Authors

Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L

Title

Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.

Journal

J Bacteriol 187:758-64 (2005)
DOI:10.1128/JB.187.2.758-764.2005

Reference

PMID:18621892

Authors

Westman EL, Preston A, Field RA, Lam JS

Title

Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters.

Journal

J Bacteriol 190:6060-9 (2008)
DOI:10.1128/JB.00579-08

Reference

PMID:19710102

Authors

King JD, Kocincova D, Westman EL, Lam JS

Title

Review: Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa.

Journal

Innate Immun 15:261-312 (2009)
DOI:10.1177/1753425909106436

Reference

PMID:20331420

Authors

Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA

Title

Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid.

Journal

Biochemistry (Mosc) 75:19-24 (2010)
DOI:10.1134/s0006297910010037

Reference

PMID:26207987

Authors

Hwang S, Aronov A, Bar-Peled M

Title

The Biosynthesis of UDP-D-QuiNAc in Bacillus cereus ATCC 14579.

Journal

PLoS One 10:e0133790 (2015)
DOI:10.1371/journal.pone.0133790

Reference

PMID:30315110