KEGG   PATHWAY: mics00260
Entry
mics00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Microbacterium sp. SGAir0570
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mics00260  Glycine, serine and threonine metabolism
mics00260

Module
mics_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mics00260]
mics_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mics00260]
mics_M00621  Glycine cleavage system [PATH:mics00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Microbacterium sp. SGAir0570 [GN:mics]
Gene
C1N74_11115  aspartate kinase [KO:K00928] [EC:2.7.2.4]
C1N74_11095  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
C1N74_11500  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
C1N74_11490  homoserine kinase [KO:K00872] [EC:2.7.1.39]
C1N74_11110  threonine synthase [KO:K01733] [EC:4.2.3.1]
C1N74_11495  threonine synthase [KO:K01733] [EC:4.2.3.1]
C1N74_14280  threonine aldolase [KO:K01620] [EC:4.1.2.48]
C1N74_12590  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
C1N74_02970  glycerate kinase [KO:K00865] [EC:2.7.1.165]
C1N74_10600  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
C1N74_16230  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
C1N74_07265  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
C1N74_15440  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
C1N74_10355  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
C1N74_06225  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
C1N74_01705  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
C1N74_09010  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
C1N74_09020  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
C1N74_05690  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
C1N74_06530  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
C1N74_09015  gcvH; glycine cleavage system protein H [KO:K02437]
C1N74_13155  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
C1N74_03365  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
C1N74_03455  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
C1N74_09220  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
C1N74_08615  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
C1N74_08620  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mics00010  Glycolysis / Gluconeogenesis
mics00020  Citrate cycle (TCA cycle)
mics00230  Purine metabolism
mics00250  Alanine, aspartate and glutamate metabolism
mics00270  Cysteine and methionine metabolism
mics00290  Valine, leucine and isoleucine biosynthesis
mics00300  Lysine biosynthesis
mics00330  Arginine and proline metabolism
mics00460  Cyanoamino acid metabolism
mics00470  D-Amino acid metabolism
mics00564  Glycerophospholipid metabolism
mics00600  Sphingolipid metabolism
mics00620  Pyruvate metabolism
mics00630  Glyoxylate and dicarboxylate metabolism
mics00640  Propanoate metabolism
mics00680  Methane metabolism
mics00860  Porphyrin metabolism
mics00920  Sulfur metabolism
KO pathway
ko00260   
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