KEGG   PATHWAY: mmab00260
Entry
mmab00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mucilaginibacter mali
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmab00260  Glycine, serine and threonine metabolism
mmab00260

Module
mmab_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mmab00260]
mmab_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmab00260]
mmab_M00621  Glycine cleavage system [PATH:mmab00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mucilaginibacter mali [GN:mmab]
Gene
HQ865_07980  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HQ865_10325  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HQ865_24035  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
HQ865_19880  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HQ865_09390  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HQ865_24030  homoserine kinase [KO:K00872] [EC:2.7.1.39]
HQ865_14915  threonine synthase [KO:K01733] [EC:4.2.3.1]
HQ865_24025  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HQ865_10630  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
HQ865_00300  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HQ865_09770  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HQ865_06055  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HQ865_09970  D-2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HQ865_16330  HAD-IB family phosphatase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HQ865_17460  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HQ865_22250  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HQ865_09975  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HQ865_04800  SDR family NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
HQ865_01025  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
HQ865_03015  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
HQ865_20160  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
HQ865_24840  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
HQ865_25410  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
HQ865_09585  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
HQ865_22390  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HQ865_19800  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HQ865_03140  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HQ865_18190  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HQ865_19095  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HQ865_25420  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HQ865_12390  CDP-alcohol phosphatidyltransferase family protein [KO:K17103] [EC:2.7.8.8]
HQ865_07835  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
HQ865_05875  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
HQ865_00430  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HQ865_05140  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
HQ865_12085  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HQ865_12090  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmab00010  Glycolysis / Gluconeogenesis
mmab00020  Citrate cycle (TCA cycle)
mmab00230  Purine metabolism
mmab00250  Alanine, aspartate and glutamate metabolism
mmab00270  Cysteine and methionine metabolism
mmab00290  Valine, leucine and isoleucine biosynthesis
mmab00300  Lysine biosynthesis
mmab00330  Arginine and proline metabolism
mmab00460  Cyanoamino acid metabolism
mmab00470  D-Amino acid metabolism
mmab00564  Glycerophospholipid metabolism
mmab00600  Sphingolipid metabolism
mmab00620  Pyruvate metabolism
mmab00630  Glyoxylate and dicarboxylate metabolism
mmab00640  Propanoate metabolism
mmab00680  Methane metabolism
mmab00860  Porphyrin metabolism
mmab00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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