KEGG PATHWAY: mmi00260

PATHWAY: mmi00260

Entry

mmi00260                    Pathway

Name

Glycine, serine and threonine metabolism - Mycobacterium marinum M

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mmi00260

Glycine, serine and threonine metabolism

Module

mmi_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mmi00260]

mmi_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mmi00260]

mmi_M00621

Glycine cleavage system [PATH:mmi00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Mycobacterium marinum M [GN:mmi]

Gene

MMAR_0166

gabT_2; 4-aminobutyrate aminotransferase, GabT_2 [KO:K00836] [EC:2.6.1.76]

MMAR_0167

[KO:K13745] [EC:4.1.1.86]

MMAR_0207

sdaA; L-serine dehydratase SdaA [KO:K01752] [EC:4.3.1.17]

MMAR_0208

glyA2; serine hydroxymethyltransferase GlyA2 [KO:K00600] [EC:2.1.2.1]

MMAR_0209

gcvH_1; glycine cleavage system H protein GcvH_1 [KO:K02437]

MMAR_0210

gcvT_1; aminomethyltransferase GcvT_1ne [KO:K00605] [EC:2.1.2.10]

MMAR_0211

gcvB_1; glycine dehydrogenase GcvB_1 [KO:K00281] [EC:1.4.4.2]

MMAR_0753

pssA; CDP-diacylglycerol--serine o-phosphatidyltransferase PssA [KO:K17103] [EC:2.7.8.8]

MMAR_0785

lpd; dihydrolipoamide dehydrogenase Lpd [KO:K00382] [EC:1.8.1.4]

MMAR_0814

gpm1; phosphoglycerate mutase 1 Gpm1 [KO:K01834] [EC:5.4.2.11]

MMAR_0861

[KO:K24071]

MMAR_1065

serA2; D-3-phosphoglycerate dehydrogenase SerA2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

MMAR_1389

aofH; flavin-containing monoamine oxidase AofH (amine oxidase) [KO:K00274] [EC:1.4.3.4]

MMAR_1462

[KO:K00273] [EC:1.4.3.3]

MMAR_1652

serB2; phosphoserine phosphatase SerB2 [KO:K01079] [EC:3.1.3.3]

MMAR_1715

serA1; D-3-phosphoglycerate dehydrogenase SerA1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

MMAR_1724

bioF2_2; 8-amino-7-oxononanoate synthase BioF2_2 [KO:K00639] [EC:2.3.1.29]

MMAR_2374

ilvA; threonine dehydratase IlvA [KO:K01754] [EC:4.3.1.19]

MMAR_2414

trpB; tryptophan synthase, beta subunit TrpB [KO:K01696] [EC:4.2.1.20]

MMAR_2415

trpA; tryptophan synthase, alpha subunit TrpA [KO:K01695] [EC:4.2.1.20]

MMAR_2477

aao_1; D-amino acid oxidase Aao_1 [KO:K00273] [EC:1.4.3.3]

MMAR_2608

maoX; copper methylamine oxidase precursor, MaoX [KO:K00276] [EC:1.4.3.21]

MMAR_2610

[KO:K00130] [EC:1.2.1.8]

MMAR_2703

gcvH; glycine cleavage system H protein GcvH [KO:K02437]

MMAR_2708

gcvB; glycine dehydrogenase GcvB [KO:K00281] [EC:1.4.4.2]

MMAR_2801

aao; D-amino acid oxidase Aao [KO:K00273] [EC:1.4.3.3]

MMAR_3249

[KO:K00865] [EC:2.7.1.165]

MMAR_3256

gcvT; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]

MMAR_3362

aofH_1; flavin-containing monoamine oxidase AofH_1 [KO:K00274] [EC:1.4.3.4]

MMAR_3556

[KO:K00130] [EC:1.2.1.8]

MMAR_4101

thrB; homoserine kinase ThrB [KO:K00872] [EC:2.7.1.39]

MMAR_4102

thrC; threonine synthase ThrC [KO:K01733] [EC:4.2.3.1]

MMAR_4103

thrA; homoserine dehydrogenase ThrA [KO:K00003] [EC:1.1.1.3]

MMAR_4375

glyA1; serine hydroxymethyltransferase 1 GlyA1 [KO:K00600] [EC:2.1.2.1]

MMAR_4390

cbs; cystathionine beta-synthase Cbs [KO:K01697] [EC:4.2.1.22]

MMAR_4420

gcvT_2; aminomethyltransferase GcvT_2 [KO:K00309]

MMAR_4421

[KO:K00301] [EC:1.5.3.1]

MMAR_4628

bioF2_1; 8-amino-7-oxononanoate synthase BioF2_1 [KO:K00639] [EC:2.3.1.29]

MMAR_4648

serC; phosphoserine aminotransferase SerC [KO:K00831] [EC:2.6.1.52]

MMAR_5221

asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]

MMAR_5222

ask; aspartate kinase Ask [KO:K00928] [EC:2.7.2.4]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721