KEGG   PATHWAY: msto00260
Entry
msto00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mycobacterium stomatepiae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
msto00260  Glycine, serine and threonine metabolism
msto00260

Module
msto_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:msto00260]
msto_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:msto00260]
msto_M00555  Betaine biosynthesis, choline => betaine [PATH:msto00260]
msto_M00621  Glycine cleavage system [PATH:msto00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycobacterium stomatepiae [GN:msto]
Gene
MSTO_01850  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MSTO_01910  [KO:K00865] [EC:2.7.1.165]
MSTO_06630  aao; amino acid oxidase [KO:K00273] [EC:1.4.3.3]
MSTO_07650  gcvP; putative glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MSTO_07710  gcvH; glycine cleavage system H protein [KO:K02437]
MSTO_10950  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
MSTO_10960  trpB_1; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
MSTO_11390  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
MSTO_16770  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
MSTO_18930  serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MSTO_19530  serB2; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MSTO_22750  aofH; putative flavin-containing monoamine oxidase AofH [KO:K00274] [EC:1.4.3.4]
MSTO_24010  betB_2; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MSTO_24060  betA_1; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
MSTO_24100  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MSTO_24110  soxB; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
MSTO_24120  soxD; sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
MSTO_24130  soxA; sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
MSTO_24140  soxG; sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
MSTO_24200  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MSTO_27360  [KO:K18897] [EC:2.1.1.157]
MSTO_28510  serA2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MSTO_29880  [KO:K00130] [EC:1.2.1.8]
MSTO_29950  [KO:K00130] [EC:1.2.1.8]
MSTO_31570  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
MSTO_31820  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MSTO_32170  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MSTO_42800  ask; aspartokinase [KO:K00928] [EC:2.7.2.4]
MSTO_42810  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MSTO_48690  serC; putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MSTO_51140  cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MSTO_51320  glyA1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
MSTO_51730  [KO:K00274] [EC:1.4.3.4]
MSTO_51840  trpB_2; tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
MSTO_54140  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MSTO_54150  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MSTO_54160  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
msto00010  Glycolysis / Gluconeogenesis
msto00020  Citrate cycle (TCA cycle)
msto00230  Purine metabolism
msto00250  Alanine, aspartate and glutamate metabolism
msto00270  Cysteine and methionine metabolism
msto00290  Valine, leucine and isoleucine biosynthesis
msto00300  Lysine biosynthesis
msto00330  Arginine and proline metabolism
msto00460  Cyanoamino acid metabolism
msto00470  D-Amino acid metabolism
msto00564  Glycerophospholipid metabolism
msto00600  Sphingolipid metabolism
msto00620  Pyruvate metabolism
msto00630  Glyoxylate and dicarboxylate metabolism
msto00640  Propanoate metabolism
msto00680  Methane metabolism
msto00860  Porphyrin metabolism
msto00920  Sulfur metabolism
KO pathway
ko00260   

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