KEGG   PATHWAY: myd03013
Entry
myd03013                    Pathway                                
Name
Nucleocytoplasmic transport - Myotis davidii (David's myotis)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
myd03013  Nucleocytoplasmic transport
myd03013

Other DBs
GO: 0050658
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102751270  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
102751338  RANBP17; RAN binding protein 17 [KO:K24115]
102751750  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
102751838  NUP58; nucleoporin 58 [KO:K14307]
102751840  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
102751843  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
102752122  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
102752303  XPO4; exportin 4 [KO:K25203]
102752304  NUP62CL; nucleoporin 62 C-terminal like [KO:K14306]
102752620  [KO:K12160]
102752656  IPO4; importin 4 [KO:K20221]
102752916  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
102753118  NUP98; nucleoporin 98 [KO:K14297]
102753217  [KO:K03231]
102753509  [KO:K12879]
102754174  NUP37; nucleoporin 37 [KO:K14302]
102754254  PHAX; phosphorylated adaptor for RNA export [KO:K14291]
102754269  RAN; RAN, member RAS oncogene family [KO:K07936]
102754280  SAP18; Sin3A associated protein 18 [KO:K14324]
102754287  NXF1; nuclear RNA export factor 1 [KO:K14284]
102754778  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
102754807  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
102755015  TNPO3; transportin 3 [KO:K15436]
102755161  PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
102755276  THOC3; THO complex 3 [KO:K12880]
102755407  NUP88; nucleoporin 88 [KO:K14318]
102755652  SEH1L; SEH1 like nucleoporin [KO:K14299]
102755726  RAE1; ribonucleic acid export 1 [KO:K14298]
102756353  NUP210L; nucleoporin 210 like [KO:K14314]
102756756  NUP85; nucleoporin 85 [KO:K14304]
102756955  THOC1; THO complex 1 [KO:K12878]
102756965  [KO:K15043]
102757671  XPO6; exportin 6 [KO:K25204]
102757672  THOC2; THO complex 2 [KO:K12879]
102757850  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
102757892  XPO7; exportin 7 [KO:K18460]
102758290  [KO:K12160]
102758536  NUPL2; nucleoporin like 2 [KO:K14321]
102758860  [KO:K14327]
102758879  SUMO1; small ubiquitin-like modifier 1 [KO:K12160]
102759263  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
102759348  RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
102759625  [KO:K12160]
102759943  IPO11; importin 11 [KO:K25201]
102760210  IPO9; importin 9 [KO:K20224]
102760400  CASC3; cancer susceptibility candidate 3 [KO:K14323]
102760523  UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102761356  IPO5; importin 5 [KO:K20222]
102761510  NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
102761560  PNN; pinin, desmosome associated protein [KO:K13114]
102761812  NUP160; nucleoporin 160 [KO:K14303]
102761925  KPNB1; karyopherin subunit beta 1 [KO:K14293]
102762682  NUP214; nucleoporin 214 [KO:K14317]
102762699  TNPO1; transportin 1 [KO:K18752]
102762814  SUMO2; small ubiquitin-like modifier 2 [KO:K12160]
102762896  XPO1; exportin 1 [KO:K14290]
102763479  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
102763630  [KO:K14284]
102763970  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
102764395  NUP93; nucleoporin 93 [KO:K14309]
102764716  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
102764797  NUP43; nucleoporin 43 [KO:K14305]
102764966  EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
102765027  NUP153; nucleoporin 153 [KO:K14296]
102765371  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
102765531  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
102765856  NUP133; nucleoporin 133 [KO:K14300]
102766179  [KO:K13025] [EC:5.6.2.7]
102766228  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102766532  KPNA7; importin subunit alpha-8 [KO:K15043]
102766795  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
102767256  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
102767491  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
102767493  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
102767606  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
102767706  [KO:K12160]
102767785  [KO:K15043]
102767968  IL4I1; nuclear pore glycoprotein p62 [KO:K14306]
102768438  NUP155; nucleoporin 155 [KO:K14312]
102768744  POM121L2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
102768754  NUP188; nucleoporin 188 [KO:K14311]
102769335  XPOT; exportin for tRNA [KO:K14288]
102769485  CSE1L; chromosome segregation 1 like [KO:K18423]
102769762  XPO5; exportin 5 [KO:K14289]
102769862  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
102769879  NUP35; nucleoporin 35 [KO:K14313]
102769960  TMEM33; transmembrane protein 33 [KO:K20724]
102770268  THOC7; THO complex 7 [KO:K13176]
102770381  THOC5; THO complex 5 [KO:K13174]
102770914  DDX19B; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
102770920  NXF3; nuclear RNA export factor 3 [KO:K14284]
102770976  [KO:K14284]
102771113  THOC6; THO complex 6 [KO:K13175]
102771200  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
102771475  SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
102771477  NUP54; nucleoporin 54 [KO:K14308]
102771494  [KO:K14284]
102771505  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
102772120  NUP107; nucleoporin 107 [KO:K14301]
102772135  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
102772490  RBM8A; RNA binding motif protein 8A [KO:K12876]
102772510  EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
102772711  NXNL2; nucleoredoxin-like 2 [KO:K03231]
102773397  SNUPN; snurportin 1 [KO:K13151]
102773488  AHCTF1; AT-hook containing transcription factor 1 [KO:K25129]
102773555  GLE1; GLE1, RNA export mediator [KO:K18723]
102773994  IPO13; importin 13 [KO:K25202]
102774007  TNPO2; transportin 2 [KO:K18727]
102774681  RANBP2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
102774780  NXF2B; nuclear RNA export factor 2 [KO:K14284]
102774874  IPO8; importin 8 [KO:K18755]
102775153  [KO:K12881]
102775245  IPO7; importin 7 [KO:K20223]
102775285  NMD3; NMD3 ribosome export adaptor [KO:K07562]
102775295  NUP50; nucleoporin 50 [KO:K14295]
102775312  AAAS; aladin WD repeat nucleoporin [KO:K14320]
102775490  NUP205; nucleoporin 205 [KO:K14310]
102775549  NUP210; nucleoporin 210 [KO:K14314]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
myd03015  mRNA surveillance pathway
KO pathway
ko03013   

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