KEGG   PATHWAY: myd03015
Entry
myd03015                    Pathway                                
Name
mRNA surveillance pathway - Myotis davidii (David's myotis)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
myd03015  mRNA surveillance pathway
myd03015

Other DBs
GO: 0071028
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102751270  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
102751658  CPSF2; cleavage and polyadenylation specific factor 2 [KO:K14402]
102751988  [KO:K13126]
102752122  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
102752844  PCF11; PCF11 cleavage and polyadenylation factor subunit [KO:K14400]
102752916  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
102753112  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102753772  RNMT; RNA guanine-7 methyltransferase [KO:K00565] [EC:2.1.1.56]
102753915  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
102754280  SAP18; Sin3A associated protein 18 [KO:K14324]
102754287  NXF1; nuclear RNA export factor 1 [KO:K14284]
102754778  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
102754807  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
102754952  FUS; FUS RNA binding protein [KO:K13098]
102755161  PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
102755295  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
102755781  SMG7; SMG7, nonsense mediated mRNA decay factor [KO:K14409]
102755816  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
102756348  SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase [KO:K08873] [EC:2.7.11.1]
102756870  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102757208  [KO:K13126]
102757850  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
102758104  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102758648  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102758764  MSI1; musashi RNA binding protein 1 [KO:K14411]
102758797  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
102758860  [KO:K14327]
102759017  PABPN1L; poly(A) binding protein nuclear 1 like, cytoplasmic [KO:K14396]
102759263  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
102759408  ETF1; eukaryotic translation termination factor 1 [KO:K03265]
102759462  PELO; pelota homolog (Drosophila) [KO:K06965]
102759670  DAZAP1; DAZ associated protein 1 [KO:K14411]
102759758  PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
102759837  [KO:K14398]
102759958  CPSF3; cleavage and polyadenylation specific factor 3 [KO:K14403] [EC:3.1.27.-]
102760260  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102760400  CASC3; cancer susceptibility candidate 3 [KO:K14323]
102760523  UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102761428  CLP1; cleavage and polyadenylation factor I subunit 1 [KO:K14399] [EC:2.7.1.78]
102761432  CPSF7; cleavage and polyadenylation specific factor 7 [KO:K14398]
102761560  PNN; pinin, desmosome associated protein [KO:K13114]
102761846  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102761910  WDR82; WD repeat domain 82 [KO:K14962]
102762679  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102762748  SMG6; SMG6, nonsense mediated mRNA decay factor [KO:K11124] [EC:3.1.-.-]
102762854  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102763577  FIP1L1; factor interacting with PAPOLA and CPSF1 [KO:K14405]
102763581  [KO:K14399] [EC:2.7.1.78]
102763599  PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
102763630  [KO:K14284]
102764317  SMG5; SMG5, nonsense mediated mRNA decay factor [KO:K11125]
102764391  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102764511  GSPT1; G1 to S phase transition 1 [KO:K03267]
102764748  PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
102764993  HBS1L; HBS1 like translational GTPase [KO:K14416]
102765037  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
102765371  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
102765531  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
102765775  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102765959  PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
102766179  [KO:K13025] [EC:5.6.2.7]
102766324  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
102766638  NUDT21; nudix hydrolase 21 [KO:K14397]
102767107  [KO:K03267]
102767336  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102767491  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
102767522  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102767606  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
102767688  TARDBP; TAR DNA binding protein [KO:K23600]
102767728  WDR33; WD repeat domain 33 [KO:K15542]
102768208  CPSF1; cleavage and polyadenylation specific factor 1 [KO:K14401]
102769834  PABPC5; poly(A) binding protein cytoplasmic 5 [KO:K13126]
102770072  MSI2; musashi RNA binding protein 2 [KO:K14411]
102770429  CPSF4L; cleavage and polyadenylation specific factor 4 like [KO:K14404]
102770454  RNGTT; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:2.7.7.50 3.6.1.74]
102770914  DDX19B; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
102770920  NXF3; nuclear RNA export factor 3 [KO:K14284]
102770963  SYMPK; symplekin [KO:K06100]
102770976  [KO:K14284]
102771200  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
102771223  [KO:K14400]
102771494  [KO:K14284]
102771505  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
102771671  SSU72; SSU72 homolog, RNA polymerase II CTD phosphatase [KO:K15544] [EC:3.1.3.16]
102771922  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102772135  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
102772253  [KO:K14399] [EC:2.7.1.78]
102772409  PABPC4L; poly(A) binding protein cytoplasmic 4 like [KO:K13126]
102772490  RBM8A; RNA binding motif protein 8A [KO:K12876]
102772844  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102772888  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
102772972  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
102773081  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102773555  GLE1; GLE1, RNA export mediator [KO:K18723]
102773953  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102774780  NXF2B; nuclear RNA export factor 2 [KO:K14284]
102774976  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102774983  CPSF6; cleavage and polyadenylation specific factor 6 [KO:K14398]
102775047  [KO:K06269] [EC:3.1.3.16]
102775153  [KO:K12881]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
myd03013  Nucleocytoplasmic transport
myd03018  RNA degradation
myd03040  Spliceosome
KO pathway
ko03015   

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