KEGG   PATHWAY: mym00260
Entry
mym00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Myxococcus hansupus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mym00260  Glycine, serine and threonine metabolism
mym00260

Module
mym_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mym00260]
mym_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mym00260]
mym_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mym00260]
mym_M00621  Glycine cleavage system [PATH:mym00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Myxococcus hansupus [GN:mym]
Gene
A176_002007  Aspartokinase [KO:K00928] [EC:2.7.2.4]
A176_003458  Aspartokinase [KO:K00928] [EC:2.7.2.4]
A176_004771  Aspartokinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
A176_006006  Aspartokinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
A176_003956  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A176_004479  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A176_004520  Homoserine kinase [KO:K02204] [EC:2.7.1.39]
A176_003521  Threonine synthase [KO:K01733] [EC:4.2.3.1]
A176_005549  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
A176_002126  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A176_006736  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
A176_001371  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
A176_001411  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
A176_004466  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
A176_005754  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
A176_004337  Phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
A176_000545  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A176_001944  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
A176_005879  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
A176_007685  3-hydroxypropionate dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
A176_004467  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
A176_006148  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
A176_001960  amine oxidase [KO:K00274] [EC:1.4.3.4]
A176_003963  Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
A176_003965  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
A176_002681  Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase [KO:K00382] [EC:1.8.1.4]
A176_003964  Glycine cleavage system H protein [KO:K02437]
A176_004104  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A176_005544  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A176_004957  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
A176_004962  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
A176_000718  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
A176_001029  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A176_000728  L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
A176_000824  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
A176_000825  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
A176_000052  L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
A176_005296  Siderophore biosynthesis L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mym00010  Glycolysis / Gluconeogenesis
mym00020  Citrate cycle (TCA cycle)
mym00230  Purine metabolism
mym00250  Alanine, aspartate and glutamate metabolism
mym00270  Cysteine and methionine metabolism
mym00290  Valine, leucine and isoleucine biosynthesis
mym00300  Lysine biosynthesis
mym00330  Arginine and proline metabolism
mym00460  Cyanoamino acid metabolism
mym00470  D-Amino acid metabolism
mym00564  Glycerophospholipid metabolism
mym00600  Sphingolipid metabolism
mym00620  Pyruvate metabolism
mym00630  Glyoxylate and dicarboxylate metabolism
mym00640  Propanoate metabolism
mym00680  Methane metabolism
mym00860  Porphyrin metabolism
mym00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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