KEGG   PATHWAY: npo03440
Entry
npo03440                    Pathway                                
Name
Homologous recombination - Nyctereutes procyonoides (raccoon dog)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
npo03440  Homologous recombination
npo03440

Other DBs
GO: 0000724
Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129494860  RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
129495037  [KO:K10740]
129495746  RAD54B; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
129495771  NBN; nibrin isoform X1 [KO:K10867]
129496054  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
129496318  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
129496600  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
129497259  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
129498112  RPA3; replication protein A 14 kDa subunit [KO:K10740]
129498270  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
129500715  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
129501802  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
129503062  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
129503223  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
129503447  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
129504185  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
129504614  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
129504631  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
129504638  [KO:K10881]
129506747  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
129506811  POLD3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
129507141  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
129508009  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
129508022  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
129508640  RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
129508783  RBBP8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
129508930  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
129509468  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
129509573  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
129510514  BLM; recQ-like DNA helicase BLM isoform X1 [KO:K10901] [EC:5.6.2.4]
129510745  BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
129513926  RPA2; replication protein A 32 kDa subunit [KO:K10739]
129515687  POLD2; DNA polymerase delta subunit 2 isoform X1 [KO:K02328]
129515807  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 [KO:K03111]
129515920  XRCC2; DNA repair protein XRCC2 [KO:K10879]
129516864  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
129516969  SYCP3; synaptonemal complex protein 3 isoform X1 [KO:K19528]
129518140  [KO:K19528]
129518240  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
129519970  PALB2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
129520544  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
129522464  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
129522973  BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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