Entry Name Biosynthesis of various antibiotics
Including Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Fumagillin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis - Nodularia spumigena
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map nsp00998 Biosynthesis of various antibiotics
Drug Organism Nodularia spumigena [GN:
nsp ]
Gene Compound C00129 Isopentenyl diphosphate
C00279 D-Erythrose 4-phosphate
C00353 Geranylgeranyl diphosphate
C00441 L-Aspartate 4-semialdehyde
C00448 trans,trans-Farnesyl diphosphate
C01179 3-(4-Hydroxyphenyl)pyruvate
C03401 L-2,3-Diaminopropanoate
C05933 N(omega)-Hydroxyarginine
C06451 2-Hydroxyethylphosphonate
C06452 (S)-2-Hydroxypropylphosphonate
C07027 N6,N6,O-Tridemethylpuromycin-5'-phosphate
C07028 N-Acetyl-N6,N6,O-tridemethylpuromycin-5'-phosphate
C07029 N-Acetyl-N6,O-didemethylpuromycin-5'-phosphate
C07030 N-Acetyl-O-demethylpuromycin-5'-phosphate
C07031 N-Acetyl-O-demethylpuromycin
C12115 3-Amino-4-hydroxybenzoate
C19815 Terpentedienyl diphosphate
C20400 1-Deoxy-11-oxopentalenate
C20403 1-Deoxy-11beta-hydroxypentalenate
C20668 3-Dehydro-D-glucose 6-phosphate
C20953 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate
C20961 N3-Fumaroyl-L-2,3-diaminopropanoate
C20966 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine
C21085 3-[(1E,4R)-4-Hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate
C21086 (3E)-3-[(1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate
C21087 3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate
C21141 4-Hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
C21559 N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate
C21646 8-Amino-8-demethylriboflavin
C21648 8-Demethyl-8-(methylamino)riboflavin
C21803 8-Demethyl-8-formylriboflavin 5'-phosphate
C21804 8-Carboxy-8-demethylriboflavin 5'-phosphate
C21805 8-Amino-8-demethylriboflavin 5'-phosphate
C22216 Cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate}
C22217 Cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate}
C22388 (2S)-2-Nitrobutanedioate
C22425 3-Amino-2-hydroxy-4-methoxybenzoate
C22455 3-Amino-2,4-dihydroxybenzoate
C22617 (+)-exo-beta-Bergamotene
C22629 5-Dehydro-6-demethoxyfumagillol
C22631 5-Dehydro-6-demethoxy-6-hydroxyfumagillol
C22651 Dodecapentaenoyl-[acyl-carrier protein]
Reference Authors Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
Title A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
Journal Reference Authors Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR
Title A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis.
Journal Reference Authors Ozcengiz G, Ogulur I
Title Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
Journal Reference Authors Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
Title The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
Journal Reference Authors Hollenhorst MA, Clardy J, Walsh CT
Title The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
Journal Reference Authors Schwarz J, Konjik V, Jankowitsch F, Sandhoff R, Mack M
Title Identification of the Key Enzyme of Roseoflavin Biosynthesis.
Journal Reference Authors Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
Title Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
Journal Reference Authors Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T
Title Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin.
Journal Reference Authors Quaderer R, Omura S, Ikeda H, Cane DE
Title Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.
Journal Reference Authors Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H
Title Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
Journal Reference Authors Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
Title Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Journal Related nsp00250 Alanine, aspartate and glutamate metabolism
nsp00260 Glycine, serine and threonine metabolism
nsp00400 Phenylalanine, tyrosine and tryptophan biosynthesis
nsp00440 Phosphonate and phosphinate metabolism
nsp00900 Terpenoid backbone biosynthesis
KO pathway
