PATHWAY: ko00998 Help
Entry Name Biosynthesis of various antibiotics
Including Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Fumagillin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map ko00998 Biosynthesis of various antibiotics
Module M00785 Cycloserine biosynthesis, arginine/serine => cycloserine [PATH:ko00998 ]
M00787 Bacilysin biosynthesis, prephenate => bacilysin [PATH:ko00998 ]
M00788 Terpentecin biosynthesis, GGAP => terpentecin [PATH:ko00998 ]
M00819 Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone [PATH:ko00998 ]
M00848 Aurachin biosynthesis, anthranilate => aurachin A [PATH:ko00998 ]
M00877 Kanosamine biosynthesis, glucose 6-phosphate => kanosamine [PATH:ko00998 ]
M00890 Roseoflavin biosynthesis, FMN => roseoflavin [PATH:ko00998 ]
M00903 Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin [PATH:ko00998 ]
M00904 Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C [PATH:ko00998 ]
M00951 Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin [PATH:ko00998 ]
M00969 Fumagillin biosynthesis, farnesyl-PP => fumagillin [PATH:ko00998 ]
Drug Orthology K01957 ddaH; N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase
K02078 acpP, acpM; acyl carrier protein
K12628 pur10; puromycin biosynthesis protein Pur10 [EC:1.-.-.-]
K12629 pur7; puromycin biosynthesis protein Pur7 [EC:3.-.-.-]
K12630 pur4; puromycin biosynthesis protein Pur4 [EC:2.-.-.-]
K12631 pur6; puromycin biosynthesis protein Pur6
K12632 pac; puromycin N-acetyltransferase [EC:2.3.-.-]
K12633 pur5; N-methyl-transferase [EC:2.1.1.-]
K12634 pur3; puromycin biosynthesis protein Pur3
K12636 napH; N-acetylpuromycin N-acetylhydrolase
K12901 fomC; phosphonoacetaldehyde reductase
K14245 auaC; PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
K14246 auaD; PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
K17747 ptlF; 1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340 ]
K18653 ntdA; 3-dehydro-glucose-6-phosphate---glutamate transaminase [EC:2.6.1.104 ]
K19547 bacB; 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase [EC:5.3.3.19 ]
K19549 bacF; bacilysin biosynthesis transaminase BacF [EC:2.6.1.-]
K19550 bacG; bacilysin biosynthesis oxidoreductase BacG [EC:1.3.1.-]
K19741 dcsA; Nomega-hydroxy-L-arginine synthase [EC:1.14.-.-]
K21721 sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase [EC:1.5.1.51 ]
K21949 sbnA; N-(2-amino-2-carboxyethyl)-L-glutamate synthase [EC:2.5.1.140 ]
K22113 ddaG; fumarate---(S)-2,3-diaminopropanoate ligase [EC:6.3.2.46 ]
K22269 rosA; 8-amino-8-demethylriboflavin N,N-dimethyltransferase [EC:2.1.1.343 ]
K22571 AF390-400, fmaD; 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase [EC:2.1.1.387 ]
K22573 AF370; fumagillin biosynthesis polyketide synthase
K22574 AF380; fumagillin biosynthesis transferase
K22575 AF470; fumagillin biosynthesis monooxygenase
K22598 rosB; 8-demethyl-8-aminoriboflavin-5'-phosphate synthase [EC:2.6.1.114 ]
K22798 auaE; anthranilate-CoA-ACP transferase [EC:6.2.1.-]
K22799 auaA; 2-methyl-4-hydroxyquinoline prenyltransferase [EC:2.5.1.-]
K22800 auaF; aurachin D monooxygenase [EC:1.14.13.-]
K22801 auaJ; aurachin B monooxygenase [EC:1.14.13.-]
K22802 auaI; aurichin B epoxide hydrolase
K23999 fom1; phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
K24000 fomD; HPP-CMP hydrolase
K25562 creE; L-aspartate N-monooxygenase (nitrosuccinate-forming)
K25563 creL, ptmB3; 3-amino-4-hydroxybenzoate 2-monooxygenase
K25594 creN; 3-amino-4-hydroxybenzoate 4-O-methyltransferase
K25597 creD; nitrosuccinate lyase
K25598 creM; 3-amino-2-hydroxy-4-methoxybenzoate diazotase
Compound C00129 Isopentenyl diphosphate
C00279 D-Erythrose 4-phosphate
C00353 Geranylgeranyl diphosphate
C00441 L-Aspartate 4-semialdehyde
C00448 trans,trans-Farnesyl diphosphate
C01179 3-(4-Hydroxyphenyl)pyruvate
C03401 L-2,3-Diaminopropanoate
C05933 N(omega)-Hydroxyarginine
C06451 2-Hydroxyethylphosphonate
C06452 (S)-2-Hydroxypropylphosphonate
C07027 N6,N6,O-Tridemethylpuromycin-5'-phosphate
C07028 N-Acetyl-N6,N6,O-tridemethylpuromycin-5'-phosphate
C07029 N-Acetyl-N6,O-didemethylpuromycin-5'-phosphate
C07030 N-Acetyl-O-demethylpuromycin-5'-phosphate
C07031 N-Acetyl-O-demethylpuromycin
C12115 3-Amino-4-hydroxybenzoate
C19815 Terpentedienyl diphosphate
C20400 1-Deoxy-11-oxopentalenate
C20403 1-Deoxy-11beta-hydroxypentalenate
C20668 3-Dehydro-D-glucose 6-phosphate
C20953 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate
C20961 N3-Fumaroyl-L-2,3-diaminopropanoate
C20966 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine
C21085 3-[(1E,4R)-4-Hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate
C21086 (3E)-3-[(1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate
C21087 3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate
C21141 4-Hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
C21559 N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate
C21646 8-Amino-8-demethylriboflavin
C21648 8-Demethyl-8-(methylamino)riboflavin
C21803 8-Demethyl-8-formylriboflavin 5'-phosphate
C21804 8-Carboxy-8-demethylriboflavin 5'-phosphate
C21805 8-Amino-8-demethylriboflavin 5'-phosphate
C22216 Cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate}
C22217 Cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate)
C22388 (2S)-2-Nitrobutanedioate
C22425 3-Amino-2-hydroxy-4-methoxybenzoate
C22455 3-Amino-2,4-dihydroxybenzoate
C22617 (+)-exo-beta-Bergamotene
C22629 5-Dehydro-6-demethoxyfumagillol
C22631 5-Dehydro-6-demethoxy-6-hydroxyfumagillol
C22651 Dodecapentaenoyl-[acyl-carrier protein]
Reference Authors Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
Title A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
Journal Reference Authors Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR
Title A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis.
Journal Reference Authors Ozcengiz G, Ogulur I
Title Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
Journal Reference Authors Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
Title The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
Journal Reference Authors Hollenhorst MA, Clardy J, Walsh CT
Title The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
Journal Reference Authors Schwarz J, Konjik V, Jankowitsch F, Sandhoff R, Mack M
Title Identification of the Key Enzyme of Roseoflavin Biosynthesis.
Journal Reference Authors Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
Title Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
Journal Reference Authors Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T
Title Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin.
Journal Reference Authors Quaderer R, Omura S, Ikeda H, Cane DE
Title Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.
Journal Reference Authors Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H
Title Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
Journal Reference Authors Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
Title Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00250 Alanine, aspartate and glutamate metabolism
ko00260 Glycine, serine and threonine metabolism
ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis
ko00440 Phosphonate and phosphinate metabolism
ko00900 Terpenoid backbone biosynthesis
