KEGG   PATHWAY: pagc00260
Entry
pagc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pantoea agglomerans C410P1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pagc00260  Glycine, serine and threonine metabolism
pagc00260

Module
pagc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pagc00260]
pagc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pagc00260]
pagc_M00555  Betaine biosynthesis, choline => betaine [PATH:pagc00260]
pagc_M00621  Glycine cleavage system [PATH:pagc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pantoea agglomerans C410P1 [GN:pagc]
Gene
BEE12_08005  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BEE12_10055  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BEE12_06160  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BEE12_05380  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BEE12_10060  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BEE12_10065  threonine synthase [KO:K01733] [EC:4.2.3.1]
BEE12_13335  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BEE12_02135  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BEE12_19720  hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
BEE12_00040  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BEE12_14605  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BEE12_06945  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BEE12_02885  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BEE12_12665  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BEE12_10030  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BEE12_03265  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BEE12_19520  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BEE12_13445  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BEE12_09920  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BEE12_16845  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BEE12_06360  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BEE12_06355  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BEE12_03215  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BEE12_03225  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BEE12_10465  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BEE12_03220  glycine cleavage system protein H [KO:K02437]
BEE12_02520  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BEE12_17995  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BEE12_17990  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BEE12_17860  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BEE12_21810  pyridoxal-5'-phosphate-dependent protein [KO:K01754] [EC:4.3.1.19]
BEE12_06000  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BEE12_21330  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BEE12_17485  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BEE12_17480  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BEE12_20125  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BEE12_20120  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pagc00010  Glycolysis / Gluconeogenesis
pagc00020  Citrate cycle (TCA cycle)
pagc00230  Purine metabolism
pagc00250  Alanine, aspartate and glutamate metabolism
pagc00270  Cysteine and methionine metabolism
pagc00290  Valine, leucine and isoleucine biosynthesis
pagc00300  Lysine biosynthesis
pagc00330  Arginine and proline metabolism
pagc00460  Cyanoamino acid metabolism
pagc00470  D-Amino acid metabolism
pagc00564  Glycerophospholipid metabolism
pagc00600  Sphingolipid metabolism
pagc00620  Pyruvate metabolism
pagc00630  Glyoxylate and dicarboxylate metabolism
pagc00640  Propanoate metabolism
pagc00680  Methane metabolism
pagc00860  Porphyrin metabolism
pagc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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