KEGG   PATHWAY: aare00260
Entry
aare00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Azospirillum argentinense
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aare00260  Glycine, serine and threonine metabolism
aare00260

Module
aare_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aare00260]
aare_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aare00260]
aare_M00621  Glycine cleavage system [PATH:aare00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Azospirillum argentinense [GN:aare]
Gene
D3093_20445  aspartate kinase [KO:K00928] [EC:2.7.2.4]
D3093_11570  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
D3093_16680  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
D3093_01750  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
D3093_04630  homoserine kinase [KO:K02204] [EC:2.7.1.39]
D3093_04675  threonine synthase [KO:K01733] [EC:4.2.3.1]
D3093_15445  threonine synthase [KO:K01733] [EC:4.2.3.1]
D3093_32690  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
D3093_04775  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
D3093_03275  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
D3093_07300  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
D3093_01900  glycerate kinase [KO:K11529] [EC:2.7.1.165]
D3093_21845  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
D3093_07050  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
D3093_05070  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
D3093_04825  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
D3093_00460  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
D3093_07475  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
D3093_04595  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
D3093_04590  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
D3093_04605  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
D3093_07135  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D3093_16345  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D3093_04600  gcvH; glycine cleavage system protein GcvH [KO:K02437]
D3093_05095  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
D3093_30555  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
D3093_30565  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
D3093_30560  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
D3093_00715  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
D3093_05205  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
D3093_18650  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
D3093_27520  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
D3093_32425  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
D3093_08445  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
D3093_08450  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aare00010  Glycolysis / Gluconeogenesis
aare00020  Citrate cycle (TCA cycle)
aare00230  Purine metabolism
aare00250  Alanine, aspartate and glutamate metabolism
aare00270  Cysteine and methionine metabolism
aare00290  Valine, leucine and isoleucine biosynthesis
aare00300  Lysine biosynthesis
aare00330  Arginine and proline metabolism
aare00460  Cyanoamino acid metabolism
aare00470  D-Amino acid metabolism
aare00564  Glycerophospholipid metabolism
aare00620  Pyruvate metabolism
aare00630  Glyoxylate and dicarboxylate metabolism
aare00640  Propanoate metabolism
aare00680  Methane metabolism
aare00860  Porphyrin metabolism
aare00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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