KEGG   PATHWAY: aber00260
Entry
aber00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Acinetobacter bereziniae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aber00260  Glycine, serine and threonine metabolism
aber00260

Module
aber_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aber00260]
aber_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aber00260]
aber_M00555  Betaine biosynthesis, choline => betaine [PATH:aber00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Acinetobacter bereziniae [GN:aber]
Gene
BSR55_08575  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSR55_18800  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSR55_19630  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BSR55_01350  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BSR55_15895  phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
BSR55_19635  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSR55_06875  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSR55_07975  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BSR55_19100  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BSR55_08970  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BSR55_01175  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BSR55_18660  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BSR55_19665  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BSR55_14605  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSR55_19235  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSR55_13715  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BSR55_20705  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BSR55_15470  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSR55_16335  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSR55_17875  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSR55_11135  glycine cleavage system protein H [KO:K02437]
BSR55_18465  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BSR55_07170  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BSR55_10805  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSR55_14315  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSR55_17015  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSR55_09550  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSR55_18325  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
BSR55_05565  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BSR55_21015  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BSR55_18035  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BSR55_03085  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSR55_12250  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSR55_07650  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BSR55_07655  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aber00010  Glycolysis / Gluconeogenesis
aber00020  Citrate cycle (TCA cycle)
aber00230  Purine metabolism
aber00250  Alanine, aspartate and glutamate metabolism
aber00270  Cysteine and methionine metabolism
aber00290  Valine, leucine and isoleucine biosynthesis
aber00300  Lysine biosynthesis
aber00330  Arginine and proline metabolism
aber00460  Cyanoamino acid metabolism
aber00470  D-Amino acid metabolism
aber00564  Glycerophospholipid metabolism
aber00600  Sphingolipid metabolism
aber00620  Pyruvate metabolism
aber00630  Glyoxylate and dicarboxylate metabolism
aber00640  Propanoate metabolism
aber00680  Methane metabolism
aber00860  Porphyrin metabolism
aber00920  Sulfur metabolism
KO pathway
ko00260   
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